Gwen hated mopping the floors of a local Dairy Queen when she was in high school. So she quit and joined her brother Eric's band No Doubt. After the band's lead singer, John Spence, committed suicide, Gwen became the lead singer. She began a long-term relationship with the band's bassist, Tony Kanal, during which she earned two Grammy Awards. Gwen broke up with Tony after seven years and several of the songs on No Doubt's "Tragic Kingdom" CD are about their break-up including "Don't Speak" and "Sunday Morning." Gwen later explained "My songs are basically my diaries. Some of my best songwriting has come out of time when I've been going through a personal nightmare."

Gwen took a break from her No Doubt gig in 2004 and bean recording solo albums Her first was Love. Angel. Music. Baby .with sales of over seven million copies. She received five Grammy Awards nominations as solo artist on 8 December 2005: Best Pop Vocal Album, Best Female Pop Performance, Album Of The Year, Record Of The Year and Best Rap/Sung Collaboration. Several other solo albums followed. In an interview with Entertainment Weekly on June 6, 2011, Gwen explained that that she would no longer continue work as a solo artist, stating, "That was a moment in time [...] It went on a little longer than we all thought it would, because it was inspired and you have to go with wherever you're at in that time in your life... [But] everything works out how it should."

Gwen is almost equally noted as a fashion entrepreneur currently with two clothing lines.- a more conservative line called L.A.M.B. and her Harajuku Lovers line which is based on here interpretation Japanese street fashion scene that so impressed her upon first visiting Tokyo in 1996. Harajuku is a street in Tokyo's Shibuya district which has long been the Japanese center of new and often bizarre youth culture and style.

Gwen told the November issue of InStyle that “I’m conscious of what I eat, but some days I cave and have cookies. On fun nights with the family, my husband [musician Gavin Rossdale] cooks amazing things and there will be carbs.” So to celebrate Gwen's birthday, we suggest making some of Pillsbury's Chocolate Spider Web Cookies as a co tribute her hit song Spiderwebs. For a film treat, we suggest watching her in The Aviator (2004), of which she commented. I'd like to stress that I only have a small role. Oh, who am I kidding? There are no small roles in a Martin Scorsese film."