Medical Advocates

HCV Infection/Disease

 
Sofosbuvir


Internet Books and Documents
Journal Citations


Ledipasvir/Sofosbuvir  
 

   

HCV Drugs Main New/Newsworthy    Home Page    

Last Update:  April 23, 2018
Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader


News Releases
 

  U.S. Food and Drug Administration Approves Gilead’s Sovaldi™ (Sofosbuvir) for the Treatment of Chronic Hepatitis C
Gilead
Dec. 6, 2013
News

internet Books and Documents
 

  iNTERNET DOCUMENT
Triple Therapy for Hepatitis C in Previous Non-responders: A Review of the Clinical Effectiveness and Safety
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health;
2014 Dec 08.
.
Document

INTERNET BOOK
Sofosbuvir (Sovaldi): Sofosbuvir is Indicated for the Treatment of Chronic Hepatitis C Virus (CHC) Infection in Adult Patients With Compensated Liver Disease,
Including Cirrhosis [Internet].
Ottawa (ON): Canadian Agency for Drugs and Technologies in Health;
2014 Oct
.
Book


Journal Papers, Abstracts, and Commentaries
 

 
Generic sofosbuvir based direct-acting antivirals in hepatitis C virus infected patients with chronic kidney disease.
Sharma MK, Nayak SL, Gupta E,et al
Liver Int. 2018 Apr 20.
Abstract

Sofosbuvir plus Daclatasvir with or without ribavirin for treatment of chronic HCV genotype 4 patients: real-life experience.
Shiha G, Soliman R, ElBasiony M,
Hepatol Int. 2018 Apr 16.
Abstract

Investigation of anti-Hepatitis C virus, sofosbuvir and daclatasvir, in pure form, human plasma and human urine using micellar monolithic HPLC-UV method and application to pharmacokinetic study.
Zidan DW, Hassan WS, Elmasry MS, Shalaby AA. 
J Chromatogr B Analyt Technol Biomed Life Sc
i
. 2018 Apr 7
Abstract

FULL-TEXT ARTICLE
A case report of sofosbuvir and daclatasvir to treat a patient with acute hepatitis C virus genotype 2 monoinfection.
Li C, Hu J.

Medicine (Baltimore). 2018 Apr;97(15):e0416.
Paper

A sofosbuvir-based quadruple regimen is highly effective in HCV type 4-infected Egyptian patients with DAA treatment failure.
Abdel-Moneim A, Aboud A, Abdel-Gabbar M, et al;
J Hepatol. 2018 Apr 3.
Abstract

Retreatment Efficacy of Sofosbuvir/Ombitasvir/Paritaprevir/Ritonavir + Ribavirin for Hepatitis C Virus Genotype 4 Patients.
Abdel-Moneim A, Aboud A, Abdel-Gabbar M,  et al
Dig Dis Sci. 2018 Mar 15.
Abstract

High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance-associated substitutions in hepatitis C genotype 3 infection.
von Felden J, Vermehren J, Ingiliz P,  et al
Aliment Pharmacol Ther. 2018 Mar 14.
Abstract

Potential nephrotoxicity of based treatment in patients infected with hepatitis C virus: a review on incidence, type and risk factors.
Dashti-Khavidaki S, Khalili H, Nasiri-Toosi M.
Expert Rev Clin Pharmacol. 2018 Mar 13.
Abstract

Successful treatment of HCV-related glomerulonephritis with sofosbuvir and daclatasvir.
Chia XX, Cherepanoff S, Danta M, Furlong T.
Nephrology (Carlton). 2018 Apr;23(4):379-380.
Abstract

Drug-Drug Interactions Studies between HCV Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted HIV Antiretroviral Regimens in Healthy Volunteers.
Mogalian E, Stamm LM, Osinusi A,
Clin Infect Dis. 2018 Mar 7.
Abstract

Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study.
Cusato J, De Nicolò A, Boglione L, Favata F,  et al
J Antimicrob Chemother. 2018 Mar 2.
Abstract


Low-Dose Sofosbuvir Is Safe and Effective in Treating Chronic Hepatitis C in Patients with Severe Renal Impairment or End-Stage Renal Disease.
Taneja S, Duseja A, De A, Mehta M,  et al
Dig Dis Sci. 2018 Feb 26. l
Abstract

Sofosbuvir-Based Direct-Acting Antiviral Therapies for HCV in People Receiving Opioid Substitution Therapy: An Analysis of Phase 3 Studies.
Grebely J, Feld JJ, Wyles D,  etnal
Open Forum Infect Dis. 2018 Feb 9;5
Abstract

Sofosbuvir plus ribavirin with or without peginterferon for the treatment of HCV: Results from a Phase 3b study in China.
Wei L, Xie Q, Hou JL, Jia J,  et al
J Gastroenterol Hepatol. 2018 Jan 30.
Abstract

Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial.
Grebely J, Dalgard O, Conway B,  et al
Lancet Gastroenterol Hepatol. 2018 Jan 5

Abstract

FULL-TEXT ARTICLE
Efficacy and safety of Sofosbuvir-containing regimens in patients co-infected with chronic hepatitis C virus and human immunodeficiency virus: a meta-analysis.
Li G, Zang K, Zhang G, Zhu D, Deng X.
Virol J. 2018 Jan 19;15(1):19
Paper

Efficacy and safety of sofosbuvir-based therapies in patients with advanced liver disease in a real-life cohort.
Kutala BK, Mouri F, Castelnau C, et al
Hepat Med. 2017 Dec 18;9:67-73.
Abstract

Sofosbuvir and velpatasvir with or without voxilaprevir in direct-acting antiviral-naïve chronic hepatitis C: patient-reported outcomes from POLARIS 2 and 3.
Younossi ZM, Stepanova M, Jacobson IM, et al
Aliment Pharmacol Ther. 2017 Nov 27.
Abstract

Sofosbuvir/Velpatasvir/Voxilaprevir: A Pan-Genotypic Direct-Acting Antiviral Combination for Hepatitis C.
Chahine EB, Kelley D, Childs-Kean LM.
Ann Pharmacother. 2017 Nov 1:
Abstract

FULL-TEXT ARTICLE
Real-life results of sofosbuvir based therapy in chronic hepatitis C -naïve and -experienced patients in Egypt.
Nagaty A, Abd El-Wahab EW.
PLoS One. 2017 Oct 5;12(10):e0184654.
Paper

Safety and efficacy of sofosbuvir plus velpatasvir with or without ribavirin for chronic hepatitis C virus infection: A systematic review and meta-analysis.
Ahmed H, Abushouk AI, Attia A,et al
J Infect Public Health. 2017 Sep 29
Abstract

The Italian Compassionate use of Sofosbuvir in HCV patients waitlisted for liver transplantation: a national real-life experience.
Martini S, Donato MF, Mazzarelli C, et al
Liver Int. 2017 Sep 16.

Abstract

Sofosbuvir-based Regimens in HIV/HCV Coinfected Patients after Liver Transplantation: Results from the ANRS CO23 CUPILT Study.
Antonini TM, Coilly A, Rossignol E, et al
Transplantation. 2017 Aug 24.
Abstract

Sofosbuvir as treatment against dengue?
Gan CS, Lim SK, Chee CF, et al
Chem Biol Drug Des. 2017 Aug 21
Abstract

Serious Adverse Events with Sofosbuvir Combined with Interferon and Ribavirin: Real-Life Egyptian Experience.
Elbaz T, Elserafy M, Elakel W, et al
J Interferon Cytokine Res. 2017 Aug;37(8):348-353
Abstract

Efficacy and safety of sofosbuvir-based, interferon-free therapy : The Management of rheumatologic extrahepatic manifestations associated with chronic hepatitis C virus infection.
Shahin AA, Zayed HS, Said M, Amer SA.  
Z Rheumatol
. 2017 Aug 9.

Abstract

Evaluation of sofosbuvir, velpatasvir plus voxilaprevir as fixed-dose co-formulation for treating hepatitis C.
Soriano V, Benítez-Gutiérrez L, Arias A,  et al
Expert Opin Drug Metab Toxicol. 2017 Jul 28:1-8.
Abstract

Sofosbuvir-velpatasvir: A single-tablet treatment for hepatitis C infection of all genotypes
Miller MM.
Am J Health Syst Pharm. 2017 Jul 15;74(14):1045-105
Abstract

Real-world effectiveness of sofosbuvir-based treatment regimens for chronic hepatitis C genotype 3 infection: results from the multicenter German hepatitis C cohort (GECCO-03).
Wehmeyer MH, Ingiliz P, Christensen S,  et al  
J Med Virol. 2017 Jul 15

Abstract

FULL-TEXT ARTICLE
Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections-A Scandinavian real-life study.
Dalgard O, Weiland O, Noraberg G,  et al
PLoS One. 2017 Jul 13;12(7):e0179764.

Paper

Improvement of glycemic state among responders to Sofosbuvir - based treatment regimens: Single center experience
Abdel Alem S, Elsharkawy A, . et al
J Med Virol. 2017 Jul 8.
Abstract

Sofosbuvir, Velpatasvir and Voxilaprevir combination for the treatment of hepatitis C.
Voaklander R, Jacobson IM.
Expert Rev Gastroenterol Hepatol
. 2017 Jul 4.

Abstract

FULL-TEXT ARTICLE
Changes in renal function indices in cirrhotic chronic hepatitis C patients treated with sofosbuvir-containing regimens
Chen J, Zhang X, Luo H, et al
Oncotarget. 2017 Jun 28.
Paper

Efficacy and Safety of Sofosbuvir-Based Direct Acting Antivirals for Hepatitis C in Septuagenarians and Octogenarians
Snyder HS, Ali B, Gonzalez HC,  et al
J Clin Exp Hepatol. 2017 Jun;7(2):93-96.
Abstract

Sofosbuvir and velpatasvir for the treatment of hepatitis C.
Jackson WE, Everson GT.
Expert Rev Gastroenterol Hepatol. 2017 Jun;11(6):501-505

Abstract

Increased warfarin requirements in a patient with chronic hepatitis C infection receiving sofosbuvir and ribavirin.
Peterson D, Van Ermen A.
Am J Health Syst Pharm. 2017 Jun 15;
Abstract

Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure
Walker A, Filke S, Lübke N, et al  
Virol J
. 2017 Jun 8;14(1):106
Abstract

Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.
Bourlière M, Gordon SC, Flamm SL, et al

N Engl J Med
. 2017 Jun 1;376(22):2134-2146
Abstract

The frequency of acute kidney injury in patients with chronic hepatitis C virus infection treated with sofosbuvir-based regimens.
Maan R, Al Marzooqi SH, Klair JS,  et al
Aliment Pharmacol Ther. 2017 May 3.
Abstract

Rising relapse rate in hepatitis C virus type 3a-infected patients against sofosbuvir and ribavirin combination therapy: a Pakistani experience.
Wahid B, Saleem K, Ali A, Rafique S, Idrees M.
 
Eur J Gastroenterol Hepatol
. 2017 May 3.
Abstract

Combination of sofosbuvir, pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection: a systematic review and meta-analysis.
Dolatimehr F, Karimi-Sari H, Rezaee-Zavareh MS, et al
Daru. 2017 Apr 20;25(1):11
Abstract

Efficacy and safety outcomes of sofosbuvir-based treatment regimens for hepatitis C virus-infected patients with or without cirrhosis from phase III clinical trials.
Yang YM, Choi EJ.
Ther Clin Risk Manag. 2017 Apr 12;13:477-497.
Abstract

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir In Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials.
Jacobson IM, Lawitz E, Gane EJ, Willems BE, et al
Gastroenterology
. 2017 Apr 5.
Abstract

Sofosbuvir-based treatment is safe and effective in Indian hepatitis C patients on maintenance haemodialysis: a retrospective study.
Akhil MS, Kirushnan B, Martin M,
Nephrology (Carlton). 2017 Mar 24
Abstract

Sofosbuvir/velpatasvir fixed-dose combination for the treatment of chronic hepatitis C virus infection.
Nehra V, Rizza SA, Temesgen Z.
Drugs Today (Barc). 2017 Mar;53(3):177-189.
Abstract

Real-World Efficacy of Daclatasvir and Sofosbuvir, With and Without Ribavirin, in HIV/HCV Co-Infected Patients With Advanced Liver Disease in a French Early-Access Cohort.
Lacombe K, Fontaine H, Dhiver C, et al
J Acquir Immune Defic Syndr. 2017 Mar 6.
Abstract

In vitro selection of resistance to sofosbuvir in HCV replicons of genotype 1 to 6.
Xu S, Doehle B, Rajyaguru S,  et al
Antivir Ther. 2017 Mar 1
Abstract

Predictors of treatment efficacy and ALT non-normalization with sofosbuvir/ribavirin therapy for patients with hepatitis C virus genotype 2
Watanabe T, Tokumoto Y, Joko K, et
J Med Virol
. 2017 Feb 6.
Abstract

Safety and effectiveness of a 12-week course of sofosbuvir and simeprevir ± ribavirin in HCV-infected patients with or without HIV infection: a multicentre observational study.
Bruno G, Saracino A, Fabrizio C, Scudeller L, et al
Int J Antimicrob Agents. 2017 Fe
b 2
Abstract

Efficacy of Ledipasvir Plus Sofosbuvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2 Infection.
Gane EJ, Hyland RH, Yang Y, et al
Gastroenterology. 2017 Jan 27
Abstract

Comparative Validation of the Determination of Sofosbuvir in Pharmaceuticals by Several Inexpensive Ecofriendly Chromatographic, Electrophoretic, and Spectrophotometric Methods.
El-Yazbi AF.
J AOAC Int. 2017 Jan 20.
Abstract

Sofosbuvir in combination with daclatasvir in liver transplant recipients with HCV infection: A systematic review and meta-analysis.
Liao H, Tan P, Zhu Z, Yan X, Huang J.
Clin Res Hepatol Gastroenterol. 2017 Jan 9
Abstract

FULL-TEXT ARTICLE
Cost-Effectiveness of Treating Hepatitis C with Sofosbuvir/Ledipasvir in Germany
Stahmeyer JT, Rossol S, Liersch S, et al
PLoS One. 2017 Jan 3;12(1):e0169401.
Paper

FULL-TEXT ARTICLE
Efficacy and Safety of Ledipasvir/Sofosbuvir with and without Ribavirin in Patients with Chronic Hepatitis C Virus Genotype 1 Infection: a meta-analysis.
Tao T, Jiang X, Chen Y, Song Y.
Int J Infect Dis. 2016 Dec 28.
Paper

FULL-TEXT ARTICLE
Concurrent Systemic Chemoimmunotherapy and Sofosbuvir-Based Antiviral Treatment in a Hepatitis C Virus-Infected Patient With Diffuse Large B-Cell Lymphoma.
Ewers EC, Shah PA, Carmichael MG, Ferguson TM.
Open Forum Infect Dis. 2016 Dec 20;3(4):ofw223.
Paper

FULL-TEXT ARTICLE
Hepatitis C eradication with sofosbuvir leads to significant metabolic changes.
Morales AL, Junga Z, Singla MB, Sjogren M, Torres D.
World J Hepatol. 2016 Dec 18;8(35):1557-1563.
Paper

Effectiveness and safety of sofosbuvir-based regimens plus an NS5A inhibitor for patients with HCV genotype 3 infection and cirrhosis. Results of a multicenter real-life cohort.
Alonso S, Riveiro-Barciela M, Fernandez I
J Viral Hepat. 2016 Dec 9.
Abstract

The FDA-approved drug sofosbuvir inhibits Zika virus infection.
Bullard-Feibelman KM, Govero J, et al
Antiviral Re
s
. 2016 Nov 27.
Abstract

FULL-TEXT ARTICLE
Safe and effective sofosbuvir-based therapy in patients with mental health disease on hepatitis C virus treatment.
Tang LS, Masur J, Sims Z, et al
World J Hepatol
. 2016 Nov 8;8(31):1318-1326
Paper

Short-duration Treatment With Elbasvir/Grazoprevir and Sofosbuvir for Hepatitis C: A Randomized Trial.
Lawitz E, Poordad F, Gutierrez JA, et al
Hepatology. 2016 Oct 22.

Abstract


Real life Egyptian experience of efficacy and safety of Simeprevir\ Sofosbuvir therapy in 6211 chronic HCV genotype IV infected patients
Eletreby R, Elakel W, Said M, et al
Liver Int. 2016 Oct 6.
Abstract


Sofosbuvir and ribavirin for six weeks is not effective among people with recent HCV infection: The DARE-C II study.
Martinello M, Gane E, Hellard M, et al
Hepatology
. 2016 Sep 17.
Abstract

Comparison of the Abbott RealTime HCV and Roche COBAS Ampliprep/COBAS TaqMan HCV assays for the monitoring of sofosbuvir-based therapy.
Ogawa E, Furusyo N, Murata M, et al
Antivir Ther
. 2016 Sep 15
Abstract

Cost-utility analysis of sofosbuvir for the treatment of genotype 2 chronic hepatitis C in Japan.
Igarashi A, Tang W, Cure S, et al
Curr Med Res Opin
. 2016 Sep 8:1-10.
Abstract

Effectiveness and tolerability of simeprevir and sofosbuvir in nontransplant and post-liver transplant patients with hepatitis C genotype 1.
Lutchman G, Nguyen NH, Chang CY, et al
Aliment Pharmacol Ther. 2016 Aug 10.
Abstract

FULL-TEXT PDF ARTICLE
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients with Genotype 1 Hepatitis C Virus Infection in an Open-label, Phase 2 Trial
Lawitz E, Reau N, Hinestrosa F,  et al
Gastroenterology
. 2016 Jul 30.

Paper

FULL-TEXT PDF ARTICLE
Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients with HCV Genotype 2, 3, 4, or 6 Infections in an Open-label, Phase 2 Trial.
Gane E, Kowdley KV, Pound D,  et al
Gastroenterology. 2016 Jul 30.
Paper

Sofosbuvir-Based Therapy for Genotype 4 HCV Recurrence Post-Liver Transplant Treatment-Experienced Patients.
Ajlan A, Al-Jedai A, Elsiesy H, et al
Can J Gastroenterol Hepatol. 2016;2016:2872371.
Abstract

Ribavirin-Free Regimen With Sofosbuvir and Velpatasvir is Associated With High Efficacy and Improvement of Patient-Reported Outcomes in Patients With Genotypes 2 and 3 Chronic Hepatitis C: Results From Astral-2 and 3 Clinical Trials.
Younossi ZM, Stepanova M, Sulkowski M, et al
Clin Infect Dis. 2016 Jul 20. pii: ciw496
Abstract

FULL-TEXT ARTICLE
Sofosbuvir/velpatasvir: A promising combination.
Bonaventura A, Montecucco F.
World J Hepatol. 2016 Jul 8;8(19):785-9.
Paper

Treatment of HCV genotype 2 with sofosbuvir and ribavirin results in lower SVR rates in real life than expected from clinical trials.
Tacke F, Günther R, Buggisch P, et al
Liver Int. 2016 Jul 18.
Abstract

FULL-TEXT ARTICLE
Successful sofosbuvir treatment with ribavirin dose reduction for chronic hepatitis C virus genotype 2 infection in a patient with ulcerative colitis: a case report.
Ohta Y, Kanda T, Katsuno T, Yasui S, et al
BMC Gastroenterol. 2016 Jul 11;16(1):66.
Paper

Ledipasvir and sofosbuvir for HCV-infection in patients coinfected with HBV.
Gane EJ, Hyland RH, An D, et al
Antivir Ther
. 2016 Jul 1
Abstract

FULL-TEXT ARTICLE
Role of ledipasvir/sofosbuvir combination for genotype 1 hepatitis C virus infection.
Sundaram V, Kowdley KV.
Hepat Med
. 2016 Jun 28;8:75-80.
Paper

Role of ledipasvir/sofosbuvir combination for genotype 1 hepatitis C virus infection.
Sundaram V, Kowdley KV.
Hepat Med. 2016 Jun 28;8:75-80.
Abstract

Sofosbuvir-based treatment of hepatitis C with severe fibrosis (METAVIR F3/F4) after liver transplantation: Results from the CO23 ANRS CUPILT study.
Dumortier J, Leroy V, Duvoux C,  et al
Liver Transpl
. 2016 Jun 27.
Abstract

Effectiveness and safety of sofosbuvir-based regimens for chronic HCV genotype 3 infection: results of the HCV-TARGET study.
Feld JJ, Maan R, Zeuzem S, et al
Clin Infect Dis. 2016 Jun 19.
Abstract

Colitis during new direct-acting antiviral agents (DAAs) therapy with sofosbuvir, simeprevir and ribavirin for genotype 1b hepatitis C.
Izzo I, Zanotti P, Chirico C, et al
Infection. 2016 Jun 16.
Abstract

Sofosbuvir and ledipasvir improve patient-reported outcomes in patients co-infected with hepatitis C and human immunodeficiency virus.
Younossi ZM, Stepanova M, Sulkowski M,  et al
J Viral Hepat
. 2016 Jun 13.
Abstract

FULL-TEXT ARTICLE
Will Sofosbuvir/Ledipasvir (Harvoni) Be Cost-Effective and Affordable for Chinese Patients Infected with Hepatitis C Virus? An Economic Analysis Using Real-World Data.
Chen GF, Wei L, Chen J,  et al
PLoS One
. 2016 Jun 8;11(6):e0155934.
Paper

Effectiveness of Sofosbuvir, Ledipasvir/Sofosbuvir, or Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir Regimens for Treatment of Patients With Hepatitis C in the Veterans Affairs National Healthcare System.
Ioannou GN, Beste LA, Chang MF,  et al
Gastroenterology. 2016 Jun 4
Abstract

A UHPLC-MS/MS method for the quantification of direct antiviral agents simeprevir, daclatasvir, ledipasvir, sofosbuvir/GS-331007, dasabuvir, ombitasvir and paritaprevir, together with ritonavir, in human plasma.
Ariaudo A, Favata F, De Nicolò A. et al
J Pharm Biomed Anal
. 2016 Jun 5;125:369-75.
Abstract

Quantification of sofosbuvir in human serum by liquid chromatography with negative ionization mass spectrometry using the parent peak and its source-induced fragment: Application to a bioequivalence study.
Bahrami MT, Mohammadi B, Miraghaei S, et al
J Sep Sci. 2016 Jun 3.
Abstract

Multicentre experience using daclatasvir and sofosbuvir to treat hepatitis C recurrence after liver transplantation - The CO23 ANRS CUPILT study.
Coilly A, Fougerou-Leurent C, de Ledinghen V,  et al
J Hepatol. 2016 Jun 1
Abstract

Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-naïve or Previously Treated Patients with HCV Genotype 1 or 3 Infections.
Gane EJ, Schwabe C, Hyland RH, Yang Y,  et al
Gastroenterology
. 2016 May 27.
Abstract

Clearance of HCV Virus After Fixed Dose Combination Ledipasvir/Sofosbuvir in an Adolescent Female with Decompensated Cirrhosis.
Smith SK, Rosenthal P.
J Pediatr Gastroenterol Nutr
. 2016 May 27
Abstract

Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-naïve or Previously Treated Patients with HCV Genotype 1 or 3 Infections.
Gane EJ, Schwabe C, Hyland RH, et al
Gastroenterology
.
2016 May 27.
Abstract

Efficacy of Sofosbuvir Plus Ribavirin in Veterans With Hepatitis C Virus Genotype 2 Infection, Compensated Cirrhosis, and Multiple Comorbidities.
Ho SB, Monto A, Peyton A, et al  
Clin Gastroenterol Hepatol
. 2016 May 26.
Abstract

Resistance Analyses of Japanese Hepatitis C-Infected Patients Receiving Sofosbuvir or Ledipasvir/Sofosbuvir Containing Regimens in Phase 3 Studies.
Mizokami M, Dvory-Sobol H, Izumi N,  et al
J Viral Hepat
. 2016 May 15.
Abstract

Safety, Efficacy, and Tolerability of Sofosbuvir and Ribavirin in Management of Recurrent Hepatitis C Virus Genotype 4 After Living Donor Liver Transplant in Egypt: What Have We Learned so far?
Dabbous HM, Montasser IF, Sakr MA,
 et al
Hepat Mon
. 2016 Apr 30;16(5):e35339.
Abstract

Emergence of HCV resistance-associated variants in patients failing sofosbuvir-based regimens: an observational cohort.
André-Garnier E, Ribeyrol O, Gournay J,  et al
Antivir Ther
. 2016 Apr 29.
Abstract

Treatment of severe recurrent hepatitis C after liver transplantation in HIV infected patients using sofosbuvir-based therapy.
Campos-Varela I, Moreno A, Morbey A. et al
Aliment Pharmacol Ther
. 2016 Apr 21
Abstract

Barrier-independent, fitness-associated differences in sofosbuvir-efficacy against hepatitis C virus.
Gallego I, Sheldon J, Moreno E, et al
Antimicrob Agents Chemother. 2016 Apr 11.
Abstract

Sofosbuvir plus ribavirin in Asian patients with chronic genotype 2 hepatitis C virus infection: history of a success?
Sáez-Royuela F, Badia E.
Liver Int
. 2016 Apr 5.
Abstract

FULL-TEXT ARTICLE
Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia
Papadopoulos N, Deutsch M, Georgalas A, et al
Case Rep Hematol. 2016;2016:7635128
Paper

Sofosbuvir and Simeprevir without Ribavirin Effectively Treat Hepatitis C Virus Genotype 1 Infection after Liver Transplantation in a Two-Center Experience.
Jackson WE, Hanouneh M, Apfel T, et al
Clin Transplant. 2016 Mar 28.
Abstract

Severe Pulmonary Arterial Hypertension in Patients Treated for Hepatitis C With Sofosbuvir
Renard S, Borentain P, Salaun E, Benhaourech S, et al
Chest. 2016 Mar;149(3):e69-73
Abstract

Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus.
Patel N, Bichoupan K, Ku L,  et al
World J Gastroenterol. 2016 Mar 7;22(9):2844-54.
Abstract

Sofosbuvir/Velpatasvir Improves Patient-Reported Outcomes in HCV Patients: Results from ASTRAL-1 Placebo-Controlled Trial
Younossi ZM, Stepanova M, Feld J, et aj 
J Hepatol. 2016 Mar 5
Abstract

Sofosbuvir-containing regimen for HCV infection in hemodialysis patients: 400 mg daily or only on the day of hemodialysis.
Desnoyer A, Pospai D, Lê MP, et al

J Hepatol. 2016 Mar 4.
Abstract.

Sofosbuvir-Based Antiviral Therapy Is Highly Effective In Recurrent Hepatitis C in Liver Transplant Recipients: Canadian Multicenter "Real-Life" Experience.
Faisal N, Bilodeau M, Aljudaibi B, et al
Transplantation
. 2016 Mar 4.
Abstract.

FULL-TEXT ARTICLE
Lower response to simeprevir and sofosbuvir in HCV genotype 1 in routine practice compared with clinical trials.
Yee BE, Nguyen NH, Jin M, et al
BMJ Open Gastroenterol
. 2016 Mar 2;3(1):e000056
Paper

Treatment Adherence and Virologic Response Rates in HCV Infected Persons Treated with Sofosbuvir-based Regimens: Results from ERCHIVES.
Butt AA, Yan P, Shaikh OS, et al  
Liver Int
. 2016 Mar 1.
Abstract.

Retreatment with sofosbuvir and simeprevir of patients with HCV GT1 or 4 who previously failed a daclatasvir-containing regimen.
Hézode C, Chevaliez S, Scoazec G,  et al
Hepatology
. 2016 Feb 8.
Abstract.

Simeprevir and Sofosbuvir (SMV-SOF) for 12 Weeks for the Treatment of Chronic Hepatitis C Genotype 1 Infection: A Real World (Transplant) Hepatology Practice Experience
Pillai AA, Wedd J, Norvell JP,  et al
Am J Gastroenterol
. 2016 Feb 2

Abstract
.

FULL-TEXT ARTICLE
Simeprevir Plus Sofosbuvir (12 and 8 Weeks) in HCV Genotype 1-Infected Patients Without Cirrhosis: OPTIMIST-1, a Phase 3, Randomized Study.
Kwo P, Gitlin N, Nahass R, Bernstein D, et al
Hepatology
. 2016 Jan 22.
Paper

Sofosbuvir treatment and hepatitis C virus infection.
Nakamura M, Kanda T, Haga Y, et al
World J Hepatol
. 2016 Jan 28;8(3):183-90
Abstract

FULL-TEXT ARTICLE
Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis.
Nguyen NH, Yee BE, Chang C, et al
BMJ Open Gastroenterol. 2016 Jan 4;3(1):e000066.
Paper

A model-based meta-analysis of sofosbuvir-based treatments in chronic hepatitis C patients.
Pérez-Pitarch A, Guglieri-López B, Ferriols-Lisart R, Merino-Sanjuán M.
Int J Antimicrob Agents. 2016 Jan 12. pii: S0924-8579(16)00003-0.
Abstract

Interferon-free treatment with sofosbuvir/daclatasvir achieves sustained virologic response in 100% of HIV/HCV-coinfected patients with advanced liver disease.
Mandorfer M, Schwabl P, Steiner S,  et al  
AIDS
. 2016 Jan 11.
Abstract

Adverse Events Associated with Ribavirin in Sofosbuvir Based Therapies for Patients with Chronic Hepatitis C: A Community Practice Experience.
Tong MJ, Chang PW, Huynh TT, et al
J Dig Dis. 2016 Jan 8.
Abstract

Successful sofosbuvir-based therapy in HIV/hepatitis C virus coinfected liver transplant recipients with recurrent hepatitis C virus infection.
Grant JL, Hawkins C, Brooks H,  et al
AIDS. 2016 Jan 2;30(1):93-98.
Abstract

FULL-TEXT ARTICLE
Budget impact analysis of sofosbuvir-based regimens for the treatment of HIV/HCV-coinfected patients in northern Italy: a multicenter regional simulation.
Cenderello G, Artioli S, Viscoli C, et al
Clinicoecon Outcomes Res. 2015 Dec 31;8:15-21.
Paper

FULL-TEXT ARTICLE
Sofosbuvir-based therapy for patients with chronic hepatitis C: Early experience of its efficacy and safety in Korea.
Cho Y, Cho EJ, Lee JH, et al
Clin Mol Hepatol. 2015 Dec;21(4):358-64.
Paper

Defining the possibilities: is short duration treatment of chronic hepatitis C genotype 1 with sofosbuvir-containing regimens likely to be as effective as current regimens?
Nafisi S, Roy S, Gish R, et al
Expert Rev Anti Infect Ther. 2015 Dec 14:1-16
Abstract

The discovery of sofosbuvir: a revolution for therapy of chronic hepatitis C.
Gentile I, Maraolo AE, Buonomo AR, et al
Expert Opin Drug Disco
v
. 2015 Dec;10(12):1363-77
Abstract

Sofosbuvir-based Regimens in Clinical Practice Achieve SVR Rates Closer to Clinical Trials: Results from ERCHIVES.
Butt AA, Yan P, Shaikh OS, et al
Liver Int. 2015 Nov 29.
Abstract

Efficacy and Safety of Sofosbuvir-Based Antiviral Therapy to Treat Hepatitis C Virus Infection After Kidney Transplantation.
Kamar N, Marion O, Rostaing L, et al 
Am J Transplant
. 2015 Nov 20.
Abstract

Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection.
Feld JJ, Jacobson IM, Hézode C,  et al
N Engl J Med
. 2015 Nov 16.

Abstract

FULL-TEXT ARTICLE
Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis.
Curry MP, O'Leary JG, Bzowej N,  et al
N Engl J Med
. 2015 Nov 16
Paper

Sofosbuvir Plus Velpatasvir Combination Therapy for Treatment-Experienced Patients With Genotype 1 or 3 Hepatitis C Virus Infection: A Randomized Trial.
Pianko S, Flamm SL, Shiffman ML,  et al 
Ann Intern Med
. 2015 Nov 10.
Abstract

Sofosbuvir With Velpatasvir in Treatment-Naive Noncirrhotic Patients With Genotype 1 to 6 Hepatitis C Virus Infection: A Randomized Trial.
Everson GT, Towner WJ, Davis MN,  et al
Ann Intern Med
. 2015 Nov 10.
Abstract

Course of hepatitis C virus (HCV) RNA and HCV core antigen testing are predictors for reaching sustained virologic response in liver transplant recipients undergoing sofosbuvir treatment in a real-life setting.
Pischke S, Polywka S, Proske VM, et al
Transpl Infect Dis. 2015 Oct 20.
Abstract

Successful treatment of hepatitis C virus infection with sofosbuvir and simeprevir in the early phase of an allogeneic stem cell transplant.
Piñana JL, Serra MÁ, Hernández-Boluda JC,  et al
Transpl Infect Dis. 2015 Oct 20.
Abstract

Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents.
Sise ME, Bloom AK, Wisocky J, et al
Hepatology
. 2015 Oct 17.
Abstract

Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C.
Sarkar S, Mitchell KA, Lim JK, et al
ACG Case Rep J. 2015 Oct 9;3(1):42-4.
Abstract

Sofosbuvir-Induced Erythrodermic Pityriasis Rubra Pilaris-Like Drug Eruption.
Cheung EJ, Jedrych JJ, English JC.
J Drugs Dermato
l
. 2015 Oct 1;14(10):1161-2.
Abstract

Sofosbuvir plus Simeprevir Treatment of Recurrent Genotype 1 Hepatitis C after Liver Transplant.
Punzalan CS, Barry C, Zacharias I,  et al
Clin Transplant
. 2015 Sep 11
Abstract

Dysregulation of Distal Cholesterol Biosynthesis in Association with Relapse and Advanced Disease in CHC Genotype 2 and 3 Treated with Sofosbuvir and Ribavirin.
Younossi ZM, Stepanova M, Estep M,  et al 
J Hepatol
. 2015 Sep 1.
Abstract

FULL-TEXT ARTICLE

Liver Toxicity Associated with Sofosbuvir, an NS5A Inhibitor and Ribavirin Use.
Dyson JK, Hutchinson J, Harrison L,  et al
J Hepatol. 2015 Aug 29. pii: S0168-8278(15)00589-9.
Paper

FULL-TEXT ARTICLE
Drug Authorization for Sofosbuvir/Ledipasvir (Harvoni) for Chronic HCV Infection in a Real-World Cohort: A New Barrier in the HCV Care Cascade.
Do A, Mittal Y, Liapakis A,  et al
PLoS One
. 2015 Aug 27;10(8):e0135645.
Paper

Development of sofosbuvir for the treatment of hepatitis C virus infection.
Lawitz E, Jacobson IM, Nelson DR, et al
Ann N Y Acad Sci
. 2015 Jul 31.
Abstract

Treating Fibrosing Cholestatic Hepatitis C with Sofosbuvir and Ribavirin: A Matched Analysis
Saab S, Jimenez M, Bau S,  et al
Clin Transplant. 2015 Jul 4.
Abstract

Temporal dynamics of inflammatory cytokines/chemokines during Sofosbuvir and Ribavirin therapy for Genotype 2 and 3 Hepatitis C infection.
Carlin AF, Aristizabal P, Song Q, et al
Hepatology. 2015 Jul 3
Abstract

'Restrictions for Medicaid Reimbursement of Sofosbuvir for the Treatment of Hepatitis C Virus Infection in the United States
Barua S, Greenwald R, Grebely J, et al
Ann Intern Med
. 2015 Jun 30
Abstract

Cost-Effectiveness of New Direct-Acting Antivirals to Prevent Post-Liver Transplant Recurrent Hepatitis.
Cortesi PA, Mantovani LG, Ciaccio A, et al
Am J Transplant
. 2015 Jul;15(7):1817-26
Abstract

A New Standard of Care? Standard Dose Sofosbuvir in an HCV-Infected Liver Transplant Recipient Undergoing Hemodialysis.
Perumpail RB, Wong RJ, Pham EA, et al 
Dig Dis Sci. 2015 Jun 17.
Abstract

Efficacy of Sofosbuvir and Daclatasvir in Patients with Fibrosing Cholestatic Hepatitis C After Liver Transplantation.
Leroy V, Dumortier J, Coilly A,  et al
Clin Gastroenterol Hepatol. 2015 Jun 1
Abstract

FULL-TEXT ARTICLE
Treatment of Recurrent Hepatitis C Genotype-4 Post-Liver Transplantation with Sofosbuvir plus Simeprevir.
Ascha M, Ascha M, Zein NN,
Int J Organ Transplant Med
. 2015;6(2):86-90.
Paper

Sofosbuvir Plus Ribavirin for Treating Egyptian Patients With Hepatitis C Genotype 4.
Doss W, Shiha G, Hassany M,  et al
Hepatol. 2015 Apr 30
Abstract

FULL-TEXT ARTICLE
Sofosbuvir and ribavirin before liver re-transplantation for graft failure due to recurrent hepatitis C: a case report.
Vionnet J, Pascual M, Chtioui H,
BMC Gastroenterol. 2015 Mar 26;15(1):38.
Paper

Cost-Effectiveness and Budget Impact of Hepatitis C Virus Treatment With Sofosbuvir and Ledipasvir in the United States.
Chhatwal J, Kanwal F, Roberts MS, Dunn MA.
Ann Intern Med
. 2015 Mar 17;162(6):397-406
Abstract

Perspectives of fixed daily dose of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C.
Floreani A.
Expert Opin Pharmacother
. 2015 Mar 1:1-4
Abstract

Fixed-dose combination of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C genotype 1.
Kumari R, Nguyen MH.
Expert Opin Pharmacother. 2015 Feb 13:1-10
Abstract

FULL-TEXT ARTICLE
Ledipasvir and sofosbuvir: Interferon free therapy for hepatitis C virus genotype 1 infection.
Waheed Y.
World J Virol
. 2015 Feb 12;4(1):33-5.
Paper

Optimal duration to pre-liver transplantation anti-hepatitis C treatment with direct-acting agent Sofosbuvir.
Donato MF, Malinverno F, Monico S.
Liver Int
. 2015 Feb 11.

Abstract

Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study.
Molina JM, Orkin C, Iser DM, et al
Lancet. 2015 Feb 3. pii: S0140-6736(14)62483-1
Abstract

Assessing safety and efficacy of sofosbuvir for the treatment of hepatitis C.
D'Ambrosio R, Aghemo A, Colombo M.
Expert Opin Drug Saf
. 2015 Feb 3:1-12.

Abstract

A Cross-Sectional Study Comparing the Frequency of Drug Interactions After Adding Simeprevir- or Sofosbuvir-Containing Therapy to Medication Profiles of Hepatitis C Monoinfected Patients.
Patel N, Nasiri M, Koroglu A, et al
Infect Dis Ther
. 2015 Jan 28.
Abstract

Sofosbuvir (Sovaldi°). Active against hepatitis C virus, but evaluation is incomplete
[No authors listed]
Prescrire Int. 2015 Jan;24(156):5-10.
Abstract

Simeprevir and Sofosbuvir for Treatment of Chronic Hepatitis C Infection.
Childs-Kean LM, Hand EO.
Clin Ther. 2015 Jan 16. pii: S0149-2918(14)00870-4
Abstract

Sofosbuvir compassionate use program for patients with severe recurrent hepatitis C following liver transplantation.
Forns X, Charlton M, Denning J,  et al
Hepatology
. 2014 Dec 29.
Abstract

The Combination of Simeprevir and Sofosbuvir is More Effective Than That of Peginterferon, Ribavirin, and Sofosbuvir for Patients with Hepatitis C-related Child's Class A Cirrhosis.
Pearlman BL, Ehleben C, Perrys M.
Gastroenterology
. 2014 Dec 31. pii: S0016-5085(14)01579-0.
Abstract

Sofosbuvir-based treatment regimens for chronic, genotype 1 hepatitis C virus infection in US. Incarcerated populations: a cost-effectiveness analysis.
Liu S, Watcha D, Holodniy M, Goldhaber-Fiebert JD.
Ann Intern Med. 2014 Oct 21;161(8):546-53.
Abstract

FULL-TEXT ARTICLE
Sofosbuvir: A novel treatment option for chronic hepatitis C infection.
Bhatia HK, Singh H, Grewal N, Natt NK.
J Pharmacol Pharmacother
. 2014 Oct;5(4):278-284.

Paper

Sofosbuvir with peginterferon-ribavirin for 12 weeks in previously treated patients with hepatitis C genotype 2 or 3 and cirrhosis.
Lawitz E, Poordad F, Brainard DM, et al 
Hepatology. 2014 Oct 16
Abstract

Concordance of Sustained Virologic Response 4, 12, and 24 Weeks Post-Treatment With Sofosbuvir-Containing Regimens for Hepatitis C Virus.
Yoshida EM, Sulkowski MS, Gane EJ,  et al
Hepatology
. 2014 Oct 14
Abstract

FULL-TEXT ARTICLE
Sofosbuvir: A novel treatment option for chronic hepatitis C infection.
Bhatia HK, Singh H, Grewal N, Natt NK.
J Pharmacol Pharmacother. 2014 Oct;5(4):278-284.
Paper

Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation.
Charlton M, Gane E, Manns MP, et al
Gastroenterology
. 2014 Oct 7.
Abstract

Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study.
Curry MP, Forns X, Chung RT, Terrault NA, et al.
Gastroenterology. 2014 Sep 24
Abstract

Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic HCV, genotype-1 infected patients.
Meissner EG, Lee YJ, Osinusi A,  et al
Hepatology
. 2014 Sep 9
Abstract

CON Sofosbuvir and Ribavirin Use in Wait-Listed Patients with Hepatitis C Should be Selective.
Price JC, Terrault NA.
Liver Int. 2014 Sep 2.
Abstract

Sofosbuvir, a novel nucleotide analogue inhibitor used for the treatment of hepatitis C virus.
Summers BB, Beavers JW, Klibanov OM.

J Pharm Pharmacol
. 2014 Aug 31.

Abstract

Successful treatment with sofosbuvir of fibrosing cholestatic hepatitis C after liver transplantation in HIV-HCV coinfected patient.
Borentain P, Colson P, Dhiver C,  et al
Antivir Ther. 2014 Aug 8.
Abstract

FULL-TEXT ARTICLE
Relationship of ethnicity and overall survival in patients treated with sorafenib for advanced hepatocellular carcinoma.
Peixoto RD, Renouf DJ, Gill S,  et al J
Gastrointest Oncol
. 2014 Aug;5(4):259-64
Paper

Cost-effectiveness analysis of sofosbuvir plus peginterferon/ribavirin in the treatment of chronic hepatitis C virus genotype 1 infection.
Saab S, Gordon SC, Park H,  et al
Aliment Pharmacol Ther
. 2014 Jul 28
Abstract

Ledipasvir/Sofosbuvir administration achieves very high rate of viral clearance in patients with HCV genotype 1 infection without cirrhosis, regardless of ribavirin co-administration or length of treatment.
Gentile I, Borgia G.
Evid Based Med. 2014 Jul 15.
Abstract

Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: Potent antiviral activity but no clinical benefit if treatment is given late.
Pellicelli AM, Montalbano M, Lionetti R, et al
Dig Liver Dis. 2014 Jul 2.
Abstract

Sofosbuvir for the treatment of chronic hepatitis C virus infection.
Temesgen Z, Talwani R, Rizza SA.
Drugs Today (Barc). 2014 Jun;50(6):421-434.|
Abstract

Lack of a Clinically Important Pharmacokinetic Interaction Between Sofosbuvir or Ledipasvir and Hormonal Oral Contraceptives Norgestimate/Ethinyl Estradiol in HCV-Uninfected Female Subjects.
German P, Moorehead L, Pang PS, et al
J Clin Pharmacol
. 2014 Jun 13
Abstract

Sofosbuvir: A Nucleotide NS5B Inhibitor for the Treatment of Chronic Hepatitis C Infection.
Rose L, Bias TE, Mathias CB,  et al
Ann Pharmacother. 2014 May 8
Abstract

FULL-TEXT ARTICLE
Sofosbuvir, a NS5B polymerase inhibitor in the treatment of hepatitis C: a review of its clinical potential.

Stedman C.
Therap Adv Gastroenterol
. 2014 May;7(3):131-140.
Paper

FULL-TEXT ARTICLE
Sofosbuvir and Ribavirin in HCV Genotypes 2 and 3.
Zeuzem S, Dusheiko GM, Salupere R, et sl
N Engl J Med. 2014 May 4.
Paper

Beyond sofosbuvir: What opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?
Sofia MJ.
Antiviral Res. 2014 May 2.
Abstract

Sofosbuvir for the treatment of chronic hepatitis C: between current evidence and future perspectives.
Degasperi E, Aghemo A.

Hepat Med
. 2014 Apr 29;6:25-33
Abstract

Sofosbuvir in the Treatment of Chronic Hepatitis C: New Dog, New Tricks.
Abraham GM, Spooner LM.
Clin Infect Dis. 2014 Apr 18
Abstract

Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection.
Afdhal N, Zeuzem S, Kwo P,  et al
N Engl J Med
. 2014 Apr 11.
Abstract

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection.
Afdhal N, Reddy KR, Nelson DR,  et al
N Engl J Med. 2014 Apr 11
Abstract

Patient-reported outcomes in chronic hepatitis C patients with cirrhosis treated with sofosbuvir-containing regimens.
Younossi ZM, Stepanova M, Nader F,  et al
Hepatology. 2014 Apr 8.
Abstract

FULL-TEXT PDF ARTICLE
[MUST BE DOWNLOADED DIRECTLY FROM SITE)

Benefit-risk assessment of new and emerging treatments for hepatitis C: focus on simeprevir and sofosbuvir
Gaetano JN.
Drug Healthc Patient Saf. 2014 Mar 31;
Paper

Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 HCV in interferon ineligible/intolerant individuals.
Hagan LM, Sulkowski MS, Schinazi RF.
Hepatology
. 2014 Mar 28.
Abstract

Hepatitis C virus: Here comes all-oral treatment.
Dugum M, O'Shea R.
Cleve Clin J Med
. 2014 Mar;81(3):159-72.
Abstract

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors
Mericitabine and Sofosbuvir.

Tong X, Le Pogam S, Li L, et al
J Infect Dis. 2014 Mar;209(5):668-75.

Abstract

Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection.
Koff RS.
Aliment Pharmacol Ther
. 2014 Mar;39(5):478-87
Abstract

Analysis of the hepatitis C viral kinetics during administration of two nucleotide analogues: sofosbuvir (GS-7977) and GS-0938.
Guedj J, Pang PS, Denning J, Rodriguez-Torres M,  et al
Antivir Ther
. 2014 Jan 24.

Abstract

Sofosbuvir for the treatment of hepatitis C virus.
Asselah T.
Expert Opin Pharmacother
. 2014 Jan;15
Abstract

Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection
Koff RS.
Aliment Pharmacol Ther
. 2014 Jan 6.

Abstract

IFNL4-ΔG Genotype is Associated with Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated with Sofosbuvir and Ribavirin.
Meissner EG, Bon D, Prokunina-Olsson L,  et al
J Infect Dis. 2013 Dec 23.

Abstract

FULL-TEXT ARTICLE

Sofosbuvir has come out of the magic box.
Alavian SM.
Hepat Mon. 2013
16;13(12):e16916.
Paper


Sofosbuvir with ribavirin is safe and effective in hepatitis C genotype 1 with unfavourable pretreatment characteristics.
Ferguson MC.
Evid Based Med
. 2013 Dec 12.
Abstract

Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection.
Rodríguez-Torres M.
Expert Rev Anti Infect Ther
. 2013 Dec;11(12):1269-79.
Abstract

Effects of Sofosbuvir-based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C.
Younossi ZM, Stepanova M, Henry L,  et al
Clin Gastroenterol Hepatol
. 2013 Dec 5.
Abstract

Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection.
Rodríguez-Torres M.
Expert Rev Anti Infect Ther
. 2013 Dec;11(12):1269-79.
Abstract

Efficacy of Nucleotide Polymerase Inhibitor Sofosbuvir plus the NS5A Inhibitor Ledipasvir or the NS5B Non-nucleoside Inhibitor GS-9669 Against HCV Genotype 1 Infection.
Gane EJ, Stedman CA, Hyland RH, et al
Gastroenterology
. 2013 Nov 18.
Abstract

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir.
Tong X, Le Pogam S, Li L,et al
J Infect Dis
. 2013 Nov 11
Abstract

Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial.
Lawitz E, Poordad FF, Pang PS, et al
Lancet. 2013 Nov 1.

Abstract

Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir.
McPhee F, Hernandez D, Yu F,  et al
Hepatology
. 2013 Sep;58(3):902-11
Abstract

Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial.
Osinusi A, Meissner EG, Lee YJ,  et al
JAMA
. 2013 Aug 28;310(8):804-11
Abstract

FULL-TEXT ARTICLE
Sofosbuvir and ABT-450: Terminator of hepatitis C virus?
Zeng QL, Zhang JY, Zhang Z, et al
World J Gastroenterol
. 2013 Jun 7;19(21):3199-206
Paper

Sofosbuvir and daclatasvir combination therapy in a liver transplant recipient with severe recurrent cholestatic hepatitis C.
Fontana RJ, Hughes EA, Bifano M, et al
Am J Transplant
. 2013 Jun;13(6
Abstract

Sofosbuvir-Based Antiviral Therapy for Treatment Naïve Hepatitis C Genotypes 1, 2, and 3.
Sharma P.
Gastroenterology
. 2013 May 27.
Abstract

FULL-TEXT ARTICLE
Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir.
Wang C, Sun JH, O'Boyle DR 2nd, et aL
Antimicrob Agents Chemother. 2013 May;57(5):2054-65
Paper

Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection:
a randomised, double-blind, phase 2 trial.
Lawitz E, Lalezari JP, Hassanein T,  et al
Lancet Infect Dis
. 2013 May;13(5):401-8.
Abstract

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection.
Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M,  et al
N Engl J Med. 2013 Apr 23.
Abstract

FULL-TEXT ARTICLE
Sofosbuvir, a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infection.
Herbst DA Jr, Reddy KR.
Expert Opin Investig Drugs
. 2013 Apr;22(4):527-36.
Abstract
 

Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options.
Jacobson IM, Gordon SC, Kowdley KV,  et al
N Engl J Med
. 2013 Apr 23.
Abstract

Sofosbuvir , a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infection.
Herbst DA Jr, Reddy KR.
Expert Opin Investig Drugs
. 2013 Mar 1.

Abstract

Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised,
multicentre phase 2 trial.
Kowdley KV, Lawitz E, Crespo I,  et al
Lancet. 2013 Mar 14
Abstract

   
 

Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.
Gane EJ, Stedman CA, Hyland RH, et al
N Engl J Med
. 2013 Jan 3;368(1):34-44.
Abstract

  Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: A randomized, 28-day, dose-ranging trial.
Rodriguez-Torres M, Lawitz E,  et al
J Hepatol. 2012 Nov 23.

Abstract
   
 

FULL-TEXT ARTICLE
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
Lam AM, Espiritu C, Bansal S, Micolochick S
Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68
Paper

 

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.
Chun BK, Du J, Zhang HR,
Nucleosides Nucleotides Nucleic Acids. 2011 Nov;30(11):886-96
Abstract

 
   

 Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader

   

HCV Drugs Main New/Newsworthy    Home Page    

Sofosbuvir
 
HCV Indications

 

.