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Telaprevir


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Last Update:  March 15, 2018
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Journal Papers, Abstracts, and Commentaries
 

 

The effect of the first-generation HCV-protease inhibitors boceprevir and telaprevir and the relation to baseline NS3 resistance mutations in genotype 1: experience from a small Swedish cohort.
Kjellin M, Wesslén T, Löfblad E,et al
Ups J Med Sci. 2018 Mar 14:1-7
Abstract

Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning.
Cuypers L, Libin P, Schrooten Y, et al
Infect Genet Evol
. 2017 May 9.
Abstract

Efficacy and safety profile of boceprevir- or telaprevir-based triple therapy or dual peginterferon alfa-2a or alfa-2b plus ribavirin therapy in chronic hepatitis C: the real-world PegBase observational study.
Mangia A, Foster GR, Berg CP, et al 
Ann Gastroenterol
. 2017;30(3):327-343.
Abstract

Rapid virological response of telaprevir and boceprevir in a Brazilian cohort of HCV genotype 1 patients: a multicenter longitudinal study.
Borba HH, Wiens A, Steimbach LM,
Ther Clin Risk Manag. 2017 Jan 10;
Abstract

Boceprevir or telaprevir in hepatitis C virus chronic infection: The Italian real life experience.
Cleo Study Group, Ascione A, et al
i LE,World J Hepatol. 2016 Aug 8;
Abstract

Optimisation of triple therapy for patients with chronic hepatitis C: a systematic review.
Pecoraro V, Cariani E, Villa E, Trenti T.
Eur J Clin Invest. 2016 Aug;46(8):737-48.
Abstract

Efficacy of telaprevir-based therapy in stable liver transplant patients with chronic genotype 1 hepatitis C.
Xavier F, Didier S, Mutimer D, et al
Ann Hepatol. 2016 Jul-Aug;15(4):512-23.
Abstract

Telaprevir-containing regimen for treatment of hepatitis C virus infection in patients with hepatocellular carcinoma awaiting liver transplantation: a case series
Torres HA, Kaseb A, Mahale P, et al
J Hepatocell Carcinoma. 2014 Jul 16;1:109-14.
Abstract

FULL-TEXT ARTICLE
Sustained Virologic Response at 24 Weeks after the End of Treatment Is a Better Predictor for Treatment Outcome in Real-World HCV-Infected Patients Treated by HCV NS3/4A Protease Inhibitors with Peginterferon plus Ribavirin.
Kanda T, Nakamoto S, Sasaki R,  et al
Int J Med Sci
. 2016 Apr 10;13(4):310-5.
Paper

Retreatment of Chronic Hepatitis C Infection with Telaprevir : Turkey Experience.
Pekgöz M, Gürel S, Kiyici M,
Acta Gastroenterol Belg. 2016 Jan-Mar;79(1):18-22.
Abstract

No correspondence between resistance mutations in the HCV-NS3 protease at baseline and early telaprevir-based triple therapy.
Hoffmann L, Faffe DS, Lima JF,  et al
BBA Clin. 2015 Jan 30;3:146-151.
Abstract

Impact of telaprevir in HCV patients with cirrhosis and RVR: real-life data from Boceprevir or Telaprevir based "triple therapy" experience in southern Italy.
Morisco F, Masarone M, Rosato V, et al
Rev Recent Clin Trials. 2015 Dec 17
Abstract

FULL-TEXT ARTICLE
Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study
About F, Oudot-Mellakh T, Niay J,  et al
PLoS One
. 2015 Dec 15;10(12):e0145105.

Paper

FULL-TEXT ARTICLE
Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C.

Hiramine S, Furusyo N, Ogawa E,  et al
World J Hepatol. 2015 Nov 18;7(26):2688-2695.
Paper

Telaprevir-based therapy in patients coinfected with chronic hepatitis C virus infection and HIV: INSIGHT study.
Montes ML, Nelson M, Girard PM,  et al
J Antimicrob Chemother
. 2015 Oct 19.
Abstract

Efficacy and Safety of Telaprevir, Pegylated Interferon α-2b and Ribavirin Triple Therapy in Japanese Patients Infected with Hepatitis C Virus Genotype 1b.
Kawaguchi Y, Iwane S, Kumagai T, et al
Intern Med
. 2015;54(20):2551-60.
Abstract

FULL-TEXT ARTICLE
Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis.
Lepida A, Colombo M, Fernandez I, et al
PLoS One
. 2015 Sep 23;10(9):e0138503.
Paper

Randomized trials of ombitasvir/paritaprevir/r+dasabuvir±ribavirin vs telaprevir+pegIFN/ribavirin in adults with genotype 1 HCV.
Dore GJ, Conway B, Luo Y, et al  
J Hepatol
. 2015 Aug 27.
Abstract

The clinical significance of HCV core antigen detection during Telaprevir/Peg-Interferon/Ribavirin therapy in patients with HCV 1 genotype infection.
Garbuglia AR, Lionetti R, Lapa D,  et al
J Clin Virol
. 2015 Aug;69:68-73.
Abstract

IL28B genotype predicts response to chronic hepatitis C triple therapy with telaprevir or boceprevir in treatment naïve and treatment-experienced patients other than prior partial- and null-responders.
Calisti G, Tavares A, Macartney MJ,  et al
Springerplus. 2015 Jul 16;4:357.
Abstract

A case report: antiviral triple therapy with telaprevir in a haemodialysed HCV patient in Turkey.
Akhan S, Sayan M, Sargin Altunok E,  et al
Acta Clin Belg. 2015 Jul 6
Abstract

Retreatment of Chronic Hepatitis C Infection with Telaprevir: Preliminary Results in Turkey.
Aygen B, Yıldız O, Akhan S,  et al
Balkan Med J
. 2015 Jul;32(3):266-72.
Abstract

FULL-TEXT ARTICLE
Management of telaprevir-based triple therapy for hepatitis C virus recurrence post liver transplant.
Herzer K, Papadopoulos-Köhn A, Achterfeld A, et al
World J Hepatol
. 2015 May 28;7(9):1287-96.
Paper

High efficacy and safety of triple therapy in HCV genotype 1 and moderate fibrosis: a multicenter study of clinical practice in Spain.
Crespo J, Diago M, Cabezas J, et al  
Ann Hepatol
. 2015 ;14(4):477-486.
Abstract

Pharmacokinetic and pharmacodynamic evaluation of telaprevir for the treatment of hepatitis C.
Rivero-Juarez A, Camacho A, Rivero A.
Expert Opin Drug Metab Toxicol. 2015 May 25:1-9

Abstract

Does elevation of serum creatinine in patients with chronic hepatitis C under therapy of telaprevir mean renal impairment?
Matsui K, Kamijo-Ikemori A, Sugaya T, et al
Nephrology (Carlton)
. 2015 May 22. 
Abstract

Telaprevir may induce adverse cutaneous reactions by a T cell immune-mediated mechanism.
Federico A, Aitella E, Sgambato D,  et al 
Ann Hepatol
. 2015 May-Jun 2015;14(3):420-424.

Abstract

Intracellular and Plasma Trough Concentration and Pharmacogenetics of Telaprevir.
Cusato J, Allegra S, De Nicolò A, et al
J Pharm Pharm Sci
. 2015 Apr-Jun;18(2):171-176.
Abstract

Treatment Patterns, Health Care Resource Utilization, and Costs in U.S. Patients Diagnosed with Chronic Hepatitis C Infection Who Received Telaprevir or Boceprevir.
Le TK, Kalsekar A, Macaulay D, et al
J Manag Care Spec Pharm
. 2015 Apr;21(4):308-318.
Abstract

Telaprevir and ribavirin interaction: higher ribavirin levels are not only due to renal dysfunction during triple therapy.
Gutierrez-Valencia A, Ruiz-Valderas R, Ben-Marzouk-Hidalgo OJ, et al
Antimicrob Agents Chemother
. 2015 Mar 23.

Abstract

Successful treatment with telaprevir of post-transplant fibrosing cholestatic hepatitis C in an HIV co-infected patient.
Marciano S, Galdame OA, Barcan LA, Gadano AC.
Acta Gastroenterol Latinoam. 2015 Mar;45(1):76-9.
Abstract

FULL-TEXT ARTICLE
First-generation protease inhibitor-triple therapy: SVR 24, safety, and predictors of response in a large single center cohort.
Werner CR, Franz C, Egetemeyr DP,  et al
Virol J
. 2015 Mar 3;12(1):37.
Paper

Telaprevir- and Boceprevir-Based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study.
Verna EC, Saxena V, Burton JR Jr,  et al
Transplantation. 2015 Feb 24.

Abstract

An OPTIMIZE Study Retrospective Analysis for the Management of Telaprevir-Treated HCV Patients Using the Abbott RealTime HCV RNA Assay.
Sarrazin C, Dierynck I, Cloherty G, et al
J Clin Microbiol. 2015 Feb 4
Abstract

Virological outcomes and treatment algorithms utilisation in observational study of patients with chronic hepatitis C treated with boceprevir or telaprevir.
Sterling RK, Kuo A, Rustgi VK,  et al
Aliment Pharmacol Ther. 2015 Jan 28
Abstract

Early virological assessment during telaprevir- or boceprevir-based triple therapy in hepatitis C cirrhotic patients who failed a previous interferon based regimen - The ANRS CO20-CUPIC study.
Bailly F, Virlogeux V, Dufour C,  et al
Clin Res Hepatol Gastroenterol. 2015 Jan 27. pii: S2210-7401(15)00002-9

Abstract

Determination of the HCV protease inhibitor telaprevir in plasma and dried blood spot by liquid chromatography tandem mass spectrometry.
Verweij-van Wissen CP, de Graaff-Teulen MJ, et al
Ther Drug Monit
. 2015 Jan 26.

Abstract

Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis.
Manzano-Robleda MD, Ornelas-Arroyo V,   et al
Ann Hepatol. 2015 Jan-Feb 2015;14(1):46-57.Z
Abstract

Effects on anemia of drug adjustment in patients with chronic hepatitis C during telaprevir-combined therapy.
Tamori A, Kioka K, Sakaguchi H, et al
Ann Hepatol. 2015 Jan-Feb 2015;14(1):28-35.

Abstract

Successful treatment with telaprevir-based regimens for chronic hepatitis C results in significant improvements to serum markers of liver fibrosis.
Haseltine EL, Penney MS, George S, Kieffer TL.
J Viral Hepat
. 2015 Jan 13.
Abstract

SLC29A1 polymorphism and prediction of anaemia severity in patients with chronic hepatitis C receiving triple therapy with telaprevir.
Milazzo L, Peri AM, Mazzali C, et al
J Antimicrob Chemother
. 2015 Jan 11. pii: dku519
Abstract

Multicenter Prospective Study to Optimize the Efficacy of Triple Therapy with Telaprevir in Patients with Genotype 1b HCV Infection According to
an Algorithm Based on the Drug Adherence, IL28B Gene Allele and Viral Response: the AG & RGT Trial.

Sugawara K, Koushima Y, Inao M, et al
Hepatol Res. 2015 Jan 9
Abstract

Telaprevir enhances ribavirin-induced anaemia through renal function impairment.
Cotte L, Barrail-Tran A, Vincent C, et al
Antivir Ther
. 2014 Jan 6
Abstract

Telaprevir-based triple therapy for hepatitis C null responders among living donor liver transplant recipients.
Kaneko J, Sugawara Y, Yamaguchi T, Harada N,  et al
Biosci Trends
. 2014;8(6):339-45.
Abstract

Kinetics of hepatitis C virus RNA decay, quasispecies evolution and risk of virological failure during telaprevir-based triple therapy in clinical practice.
Cento V, Tontodonati M, Di Maio VC,  et al
Dig Liver Dis. 2014 Dec 27
Abstract

Virologic response and haematologic toxicity of boceprevir- and telaprevir-containing regimens in actual clinical settings.
Butt AA, Yan P, Shaikh OS,  et al
J Viral Hepat
. 2014 Dec 18.
Abstract

Efficacy and Safety of Telaprevir-Based Antiviral Treatment for Elderly Patients with Hepatitis C Virus.
Takita M, Hagiwara S, Kudo M, et al
Oncology
. 2014;87 Suppl 1:110-117.
Abstract

Relationship between HCV dynamics and sustained virological responses in chronic hepatitis C genotype 1b patients treated with telaprevir-based triple therapy.
Nakagawa A, Atsukawa M, Tsubota A, et al
Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1329-1334.
Paper

Drug-drug interactions of telaprevir and boceprevir in HCV-monoinfected and HIV/HCV-coinfected patients can modify the adherence.
Gonzalez-Colominas E, Broquetas T, et al
Liver Int. 2014 Nov 10.

Abstract

Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection.
Farnik H, Ferreirós N, Labocha S, et al
Scand J Gastroenterol
. 2014 Nov 11:1-7.

Abstract

Relationship between HCV dynamics and sustained virological responses in chronic hepatitis C genotype 1b patients treated with telaprevir-based triple therapy.
Nakagawa A, Atsukawa M, Tsubota A, et al
Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1329-1334.
Abstract

Adjusting the starting dose of telaprevir according to renal function decreases adverse effects and affects the sustained virological response rate.
Morihara D, Watanabe H, Takata K, et al
Eur J Gastroenterol Hepatol. 2014 Nov 3
Abstract

Drug-drug Interaction with Telaprevir or Boceprevir in Liver Transplant Patients: About Four Cases
Delaborde L, Logerot S, Fonrose X.
Therapie
. 2014 Oct 17
Abstract

Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions
Suda G, Yamamoto Y, Nagasaka A, et al
Hepatol Res
. 2014 Sep 11.
Abstract

Safety Profile of Boceprevir and Telaprevir in Chronic Hepatitis C: Real-World Experience From HCV-TARGET.
Gordon SC, Muir AJ, Lim JK,  et al
J Hepatol
. 2014 Sep 9. pii: S0168-8278(14)00647-3
Abstract

FULL-TEXT ARTICLE
The Dynamic Relationship between Innate Immune Biomarkers and Interferon-Based Treatment Effects and Outcome in Hepatitis C Virus Infection Is Altered by Telaprevir.
Malone DF, Falconer K, Weiland O, Sandberg JK.
PLoS One
. 2014 Aug 28;9(8):e105665
Paper

Lack of Clinically Significant Pharmacokinetic Interaction Between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir.
Wire MB, Fang L, Hussaini A, et al.
Antimicrob Agents Chemother
. 2014 Aug 25.
Abstract

FULL-TEXT ARTICLE
Modeling Viral Evolutionary Dynamics after Telaprevir-Based Treatment.
Haseltine EL, De Meyer S, Dierynck I, et al 
PLoS Comput Biol
. 2014 Aug 7
Paper

Costs of Telaprevir-based Triple Therapy for Hepatitis C: $189,000 per Sustained Virologic Response.
Bichoupan K, Martel-Laferriere V, Sachs D,  et al
Hepatology. 2014 Jul 28.
Abstract

Effect of telaprevir on the metabolism and hepatic uptake of tacrolimus (FK506).
Oda K, Yamano K.
Biopharm Drug Dispos
. 2014 Jul 24
Abstract

Hepatitis C virus NS3 protease genotyping and drug concentration determination during triple therapy with telaprevir or boceprevir for chronic infection with genotype 1 viruses, southeastern France.
Aherfi S, Solas C, Motte A,  et al
J Med Virol. 2014 Jul 23.

Abstract


Using pharmacokinetic and viral kinetic modeling to estimate the antiviral effectiveness of telaprevir, boceprevir and Peg-IFN during triple therapy in treatment-experienced HCV infected cirrhotic patients (ANRS CO20-CUPIC).
Laouénan C, Marcellin P, Lapalus M,  et al
Antimicrob Agents Chemother
. 2014 Jun 30.
Abstract


Sustained Virological Response with Telaprevir in 1078 Patients With Advanced Hepatitis C: The International Telaprevir Access Program.
Colombo M, Strasser SI, Moreno C, et al
J Hepatol
. 2014 Jun 16.
Abstract

Pharmacodynamic monitoring of immunosuppressive effects indicates reduced cyclosporine activity during telaprevir therapy.
Roos K, Gotthardt D, Giese T,  et al
Liver Transpl. 2014 Jun 3.
Abstract

Factors associated with sustained virological response in 24-week telaprevir-based triple therapy for chronic hepatitis C genotype 1b patients with the IL28B minor genotype.
Abe H, Tsubota A, Shimada N, Atsukawa M,  et al
Hepatol Res. 2014 May 22.
Abstract

Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir.
Johnson M, Borland J, Chen S, et al
Br J Clin Pharmacol. 2014 May 16
Abstract

Efficacy and safety of splenectomy in telaprevir-based triple therapy for chronic hepatitis C patients with thrombocytopenia and advanced fibrosis.
Ogawa E, Furusyo N, Nakamuta M, et al
J Gastroenterol Hepatol
. 2014 Apr 14.

Abstract

Telaprevir With Peginterferon/Ribavirin For Retreatment Of Null Responders With Advanced Fibrosis Post Orthotopic Liver Transplant.
Kwo PY, Ghabril M, Lacerda MA,  et al  C
lin Transplant
. 2014 Apr 8.

Abstract

Effectiveness of Telaprevir or Boceprevir in Treatment-experienced Patients with HCV Genotype 1 Infection and Cirrhosis.
Hezode C, Fontaine H, Dorival C, et al
Gastroenterology. 2014 Apr 3.
Abstract

Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis.
Saxena V, Manos MM, Yee HS, et al
Aliment Pharmacol Ther
. 2014 Mar 24

Abstract

Significant early higher ribavirin plasma concentrations in patients receiving a triple therapy with pegylated interferon, ribavirin and telaprevir.
Boglione L, De Nicolò A, Cusato J,  et al
J Viral Hepat
. 2014 Apr;21(4):260-3. 
Abstract

FULL-TEXT ARTICLE
Cost-effectiveness of Telaprevir Combination Therapy for Chronic Hepatitis C
Brogan AJ, Talbird SE, Thompson JR,  et al
PLoS One
. 2014 Mar 6;9(3):e90295.
Paper

Telaprevir or Boceprevir Based Therapy for Chronic Hepatitis C Infection: Development of Resistance Associated Variants in Treatment Failure.
Macartney MJ, Irish D, Bridge SH, Garcia-Diaz A,  et al
Antiviral Res. 2014 Mar 1.
Abstract

α-Fetoprotein is a surrogate marker for predicting treatment failure in telaprevir-based triple combination therapy for genotype 1b chronic hepatitis C
Japanese patients with the IL28B minor genotype.
Shimada N, Tsubota A, Atsukawa M,  et al
J Med Virol. 2014 Mar;86(3):461-72.
Abstract

Virological response rates for telaprevir-based hepatitis C triple therapy in patients with and without HIV coinfection.
Martel-Laferrière V, Brinkley S, Bichoupan K,  et al
HIV Med
. 2014 Feb;15(2):108-15.
Abstract

Telaprevir-Induced DRESS.
Kesar V, Kesar V, Khaitova V,  et al
J Drugs Dermato
l
. 2014 Feb 1;13(2):199-200.
Abstract

Risk factors predictive of anemia development during telaprevir plus peginterferon/ribavirin therapy in treatment-experienced patients.
Zeuzem S, Demasi R, Baldini A, et al
J Hepatol. 2014 Jan 28
Abstract

Influence of low-density lipoprotein cholesterol on virological response to telaprevir-based triple therapy for chronic HCV genotype 1b infection.
Ogawa E, Furusyo N, Kajiwara E,  et al
Antiviral Res
. 2014 Jan 22.
Abstract

Virological response rates for telaprevir-based hepatitis C triple therapy in patients with and without HIV coinfection.
Martel-Laferrière V, Brinkley S, Bichoupan K,  et al
HIV Med. 2014 Feb;15(2):108-15.
Abstract

Patterns of viral load decline with telaprevir-based therapy in patients with genotype 1 chronic HCV infection.
Picchio G, De Meyer S, Dierynck I, et al.
J Clin Virol. 2014 Jan 6.
Abstract

FULL-TEXT PDF ARTICLE
Evaluation of the potency of telaprevir and its metabolites as inhibitors of renal organic cation transporters, a potential mechanism for elevation of serum creatinine.f
Nakada T, Kito T, Inoue K, et al
Drug Metab Pharmacokinet
. 2013 Dec 31.
Paper

Homeostasis model assessment of insulin resistance does not seem to predict response to telaprevir in chronic hepatitis C in the REALIZE trial.
Younossi Z, Negro F, Serfaty L,  et al
Hepatology. 2013 Dec;58(6):1897-906
Abstract

Successful telaprevir treatment in combination of cyclosporine against recurrence of hepatitis C in the Japanese liver transplant patients.
M, Okuda Y, Ueda Y, Nishioka Y, et al
Biol Pharm Bull
. 2013 Dec 26.
Abstract

Increased plasma concentration of Ribavirin as a result of renal dysfunction in HCV patients treated with telaprevir.
Tempestilli M, D'Offizi G, Lionetti R, et al
Hepatology. 2013 Dec 21
Abstract

Similar Effectiveness of Boceprevir and Telaprevir Treatment Regimens for Hepatitis C Virus Infection, Based on a Nationwide Study of Veterans.
Ioannou GN, Beste LA, Green PK.
Clin Gastroenterol Hepatol
. 2013 Dec 17
Abstract

The Effects of Boceprevir and Telaprevir on the  Pharmacokinetics of Maraviroc: An Open Label, Fixed -Sequence Study in Healthy Volunteers.
Vourvahis M, Plotka A, Kantaridis C,  et al
J Acquir Immune Defic Syndr. 2013 Dec 16.
Abstract

Telaprevir in the Treatment of Acute Hepatitis C Virus Infection in HIV-Infected Men.
Fierer DS, Dieterich DT, Mullen MP, et al
Clin Infect Dis. 2013 Dec 13.
Abstract

Telaprevir Twice Daily is Noninferior to Telaprevir Every 8 hrs for Patients with Chronic Hepatitis C.
Buti M, Agarwal K, Horsmans Y, et al
Gastroenterology
. 2013 Dec 4.
Abstract

Effect of fibrosis on adverse events in patients with hepatitis C treated with telaprevir.
Bichoupan K, Schwartz JM, Martel-Laferriere V, et al
Aliment Pharmacol Ther. 2013 Nov 24
Abstract


Hepatitis C virus NS3 inhibitors: current and future perspectives.
Salam KA, Akimitsu N.
Biomed Res Int. 2013;2013:467869..
Abstract

Efficacy and safety of telaprevir and boceprevir in patients with hepatitis C genotype 1: a meta-analysis.
Park C, Jiang S, Lawson KA.
J Clin Pharm Ther
. 2013 Nov 16
Abstract

FULL-TEXT ARTICLE
Feasibility of Telaprevir-Based Triple Therapy in Liver Transplant Patients with Hepatitis C Virus: SVR 24 Results.
Werner CR, Egetemeyr DP, Lauer UM,  et al
PLoS One. 2013 Nov 12;8(11):e80528
Paper

Utility of Telaprevir-Resistant Variant Detection for Prediction of Treatment Efficacy in HCV Genotype 1.
Akuta N, Suzuki F, Fukushima T,et al
J Clin Microbiol. 2013 Nov 6
Abstract

Telaprevir is effective given every 12 hours at 750 mg with peginterferon-alfa-2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT.
Kawakami Y, Suzuki F, Karino Y,  et al
Antivir Ther
. 2013 Nov 5.
Abstract

Very short course of triple therapy including telaprevir for chronic hepatitis C: a possible strategy in selected patients.
Corti G, Salomoni E, Baragli F.
Int J Infect Dis. 2013 Oct 25.
Abstract

Seizures in Patients with Chronic Hepatitis C Treated with NS3/4A Protease Inhibitors: Does Pharmacological Interaction Play a Role?
Milazzo L, Falvella FS, Magni C, et al
Pharmacology
. 2013 Oct 31;92(5-6):235-237
z
Abstract

Sustained Virological Response After 4 Weeks of Telaprevir, Peginterferon, and Ribavirin in an Asian Patient with Genotype 1 Chronic Hepatitis C and IL28B Genotype CC.
Brulotte N, Hahn H, Lee M.
Dig Dis Sci
. 2013 Oct 10.
Abstract

In Vitro Phenotypic Characterization of Hepatitis C Virus NS3 Protease Variants Observed in Clinical Studies of Telaprevir.
Jiang M, Mani N, Lin C,  et al
Antimicrob Agents Chemother
. 2013 Oct 7.
Abstract

Haemophagocytic syndrome in a liver transplant patient during treatment with Telaprevir.
Rodríguez-Medina B, Blanes M,  et al
Ann Hepatol
. 2013 Nov-Dec 2013;12(6):974-978
Abstract

Therapeutic drug monitoring of telaprevir in chronic hepatitis C patients receiving telaprevir-based triple therapy is useful for predicting virological response.
Furusyo N, Ogawa E, Murata M,  et al. J
Antimicrob Chemother
. 2013 Oct 3.

Abstract

Impact of IL28B polymorphisms on 24-week telaprevir-based combination therapy for Asian chronic hepatitis C patients with HCV genotype 1b.
Tsubota A, Shimada N, Atsukawa M, et al
J Gastroenterol Hepatol
. 2013 Oct 3.
Abstract

Telaprevir-induced, but not pegylated interferon-associated, retinopathy as a noteworthy adverse effect during triple antiviral therapy in patients with chronic hepatitis C.
Sugawara K, Inao M, Nakayama N, Mochida S.
J Gastroenterol
. 2013 Oct 1
Abstract

Diabetes Mellitus and Advanced Liver Fibrosis Are Risk Factors for Severe Anemia During Telaprevir-based Triple Therapy.
Crismale JF, Martel-Laferrière V, Bichoupan K, et al
Liver In
t
. 2013 Oct 1.
Abstract

Virological response rates for telaprevir-based hepatitis C triple therapy in patients with and without HIV coinfection.
Martel-Laferrière V, Brinkley S, Bichoupan K,  et al.
HIV Med. 2013 Sep 11.
Abstract
 

 

Reply to: Renal impairment is frequent in chronic hepatitis C patients under triple therapy with telaprevir or boceprevir.
Véronique LR, Paul C, Chanlina V, Marie E.
Hepatology
. 2013 Sep 3
Abstract

Pharmacokinetic interactions of telaprevir with other drug
Berenguer Berenguer J, González-García J.
Enferm Infecc Microbiol Clin. 2013 Jul;31 Suppl 3:37-48
Abstract
 
Clinical use of telaprevir: stopping rules, predicting response, treatment length, and management of adverse effects.
Tural C, Planas R.
Enferm Infecc Microbiol Clin. 2013 Jul;31 Suppl 3:19-25
Abstract
 
Safety and efficacy of telaprevir in patients with HIV and hepatitis C virus coinfection
Macías J, Rivero A.
Enferm Infecc Microbiol Clin. 2013 Jul;31 Suppl 3:33-6.
Abstract

Telaprevir in HCV-monoinfected patients with failure to prior treatment
Solà R, Forns X.
Enferm Infecc Microbiol Clin. 2013 Jul;31 Suppl 3:14-8.
Abstract
 
Telaprevir in treatment-naïve patients with HCV monoinfection
Cabezas J, Crespo J, Selmo J, Luis Calleja

Enferm Infecc Microbiol Clin. 2013 Jul;31 Suppl 3:7-13.
Abstract
 
Telaprevir resistance
Poveda E, García F.
Enferm Infecc Microbiol Clin
. 2013 Jul;31 Suppl 3:26-32
Abstract

Potential P-glycoprotein Pharmacokinetic Interaction of Telaprevir With Morphine or Methadone.
Fudin J, Fontenelle DV, Fudin HR, et al
J Pain Palliat Care Pharmacother
. 2013 Jul 24
Abstract

A pilot study of triple therapy with telaprevir, peginterferon and ribavirin for elderly patients with genotype 1 chronic hepatitis C.
Hara T, Akuta N, Suzuki F, et al
J Med Virol
. 2013 Jul 16
Abstract

Meta-analysis of the efficacy and safety of telaprevir combined with peginterferon alfa plus ribavirin in patients with chronic hepatitis C.]
Yan SS, Xu DH, Zhang PJ, et al
Zhonghua Gan Zang Bing Za Zhi
. 2013 Jul;21(7):506-509
Abstract

High incidence of serious adverse events in HIV-infected patients treated with a telaprevir-based hepatitis C virus treatment regimen.
Cachay ER, Wyles DL, Torriani FJ,  et al
AIDS. 2013 Jul 9.
Abstract

Renal impairment is frequent in chronic hepatitis C patients under triple therapy with telaprevir or boceprevir.
Mauss S, Hueppe D, Alshuth U.
Hepatology
. 2013 Jun 28.
Abstract

FULL-TEXT ARTICLE
Coadministration of telaprevir and transcatheter arterial chemoembolization in hepatitis C virus-associated hepatocellular carcinoma.
Torres HA, Mahale P, Miller ED, et al 
World J Hepatol
. 2013 Jun 27;5(6):332-335.
Paper

Telaprevir Activity in Treatment-Naive Genotype 4 Hepatitis C-Infected Patients: A Randomized Trial.
Benhamou Y, Moussalli J, Ratziu V,  et al
J Infect Dis
. 2013 Jun 24.
Abstract

Prediction of Treatment Efficacy and Telaprevir-Resistant Variants after Triple Therapy in Patients Infected with HCV Genotype 1.
Akuta N, Suzuki F, Fukushima T,  et al
J Clin Microbiol
. 2013 Jun 19
Abstract

Efficacy and tolerance of telaprevir in HIV-hepatitis C virus genotype 1-coinfected patients failing previous antihepatitis C virus therapy: 24-week results.
Lacombe K, Valin N, Stitou H,  et al
AIDS
. 2013 May 15;27(8):1356-1359.
Abstract

Cost-effectiveness of boceprevir or telaprevir for previously treated patients with genotype 1 chronic hepatitis C.
Cammà C, Petta S, Cabibbo G, et al
J Hepatol. 2013 May 23.
Abstract

Triple combination therapy for hepatitis C with telaprevir exhibits greater early antiviral activity than with boceprevir.
Benito JM, Sánchez-Parra C, et al
Antivir Ther
. 2013 May 3. |
Abstract

A Multiplex LC-MS/MS Assay for the Simultaneous Therapeutic Drug Monitoring of Ribavirin, Boceprevir and Telaprevir.
Aouri M, Moradpour D, Cavassini M, et al
Antimicrob Agents Chemother
. 2013 Apr 29.
Abstract

A Small Percentage of Patients with Hepatitis C Receive Triple Therapy with Boceprevir or Telaprevir.
Chen EY, Sclair SN, Czul F, et al
Clin Gastroenterol Hepatol. 2013 Apr 16.
Abstract

Telaprevir: Changing the standard of care of chronic hepatitis C.
Rajani AK, Ravindra BK, Dkhar SA.
J Postgrad Med
. 2013 Jan-Mar;59(1):42-7
Abstract

Telaprevir Versus Boceprevir in Chronic Hepatitis C: A Meta-Analysis of Data From Phase II and III Trials.
Clin Ther. 2013 Jan 29
Abstract

Review of drug interactions with telaprevir and antiretrovirals.
van Heeswijk RP, Beumont M, Kauffman RS, Garg V.
Antivir Ther
. 2013 Jan 23.
Abstract

Serious neuropsychiatric adverse effects in a hepatitis C virus/hepatitis B virus/HIV-coinfected patient receiving bosentan and telaprevir.
Lê MP, Gervais A, Le Beller C, et al
J Antimicrob Chemother. 2013 Jan 20.

Abstract

Optimal treatment with telaprevir for chronic HCV infection.
Jesudian AB, Jacobson IM.
Liver Int
. 2013 Feb;33 Suppl 1:3-13
Abstract

FULL-TEXT ARTICLE
Efficacy and tolerability of telaprevir for chronic hepatitis virus C genotype 1 infection: a meta-analysis.
Kong Y, Wang X, Shang Y, , et al
PLoS One
. 2012;7(12):e52158.
Paper

Telaprevir-based triple-therapy in patients with chronic hepatitis C in Germany: a 12-week interim analysis of real-life data.
Berg T, Buggisch P, Hueppe D,  et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18424.
Abstract

Exploratory study on telaprevir given every 8 h at 500 mg or 750 mg with peginterferon-alpha-2b and ribavirin in hepatitis C patients.
Suzuki F, Suzuki Y, Sezaki H, et al
Hepatol Res
. 2012 Nov 29.
Abstract

The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir.
Marks KM, Jacobson IM.
Antivir Ther
.
2012;17(6 Pt B):1119-31.
Abstract

Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: Is it feasible?
Dumortier J, Guillaud O, Gagnieu MC, et al
J Clin Virol
. 2012 Nov 10.
Abstract

The Relative Efficacy of Boceprevir and Telaprevir in the Treatment of HCV Genotype 1.
Schmitz S, O'Leary A, Walsh C, Bergin C, Norris S.
Clin Infect Dis. 2012 Oct 16.
Abstract

Short report: Telaprevir-based triple therapy in liver transplanted HCV patients: A 12 week pilot study
providing safety and efficacy.
Werner CR, Egetemeyr DP, Lauer UM, et al
Liver Transpl
. 2012 Sep 1.
Abstract

Triple therapy with boceprevir or telaprevir for treatment naïve HCV patients.
Esteban R, Buti M.
Best Pract Res Clin Gastroenterol.

Abstract

Triple therapy with boceprevir or telaprevir for prior HCV non-responders.
Asselah T.
Best Pract Res Clin Gastroenterol
. 2012 Aug;26(4):455-62
Abstract

The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir.
Marks KM, Jacobson IM.
Antivir Ther
. 2012;17(6 Pt B):1119-31.
Abstract

Safety of Telaprevir for Chronic Hepatitis C Virus Infection: A Meta-Analysis of Randomized Controlled Trials.
Qin H, Li H, Zhou X,  et al
Clin Drug Investig. 2012 Aug 14.

Abstract

Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with
HCV genotype 1.
Akuta N, Suzuki F, Seko Y,  et al
J Med Virol
. 2012 Jul;84(7):1097-105.

Abstract

Review of boceprevir and telaprevir for the treatment of chronic hepatitis C.
Wilby KJ, Partovi N, Ford JA, Greanya E, Yoshida EM.
Can J Gastroenterol
. 2012 Apr;26(4):205-10.
Abstract

Telaprevir: a review of its use in the management of genotype 1 chronic hepatitis C.
Perry CM.
Drugs
. 2012 Mar 26;72(5):619-41.

Abstract

Efficacy and safety of telaprevir in patients with genotype 1 hepatitis C infection.
Cunningham M, Foster GR.
Therap Adv Gastroenterol
. 2012 Mar;5(2):139-51.

Abstract


A review of drug interactions with boceprevir and telaprevir: implications for HIV and transplant patients.
Wilby KJ, Greanya ED, Ford JA,, et al
Ann Hepatol
. 2012 Mar;11(2):179-85.
Abstract

Telaprevir for the treatment of hepatitis C.
Forestier N, Zeuzem S.
Expert Opin Pharmacother
. 2012 Feb 15
Abstract

Expert opinion on boceprevir- and telaprevir-based triple therapies of chronic hepatitis C.
Sarrazin C, Berg T, Cornberg M,  et al
Z Gastroenterol
. 2012 Jan;50(1):57-72.
Abstract

Triple therapy for HCV genotype 1 infection: telaprevir or boceprevir?
Shiffman ML, Esteban R.
Liver Int
. 2012 Feb;32 Suppl 1:54-60.
Abstract

Telaprevir user's guide.
Liapakis AM, Jacobson I.
Liver Int. 2012 Feb;32 Suppl 1:17-25
Abstract

Telaprevir for the treatment of chronic hepatitis C infection.
Muir AJ.
Expert Rev Anti Infect Ther
. 2011 Dec;9(12):1105-14.
Abstract

Specific Detection of Naturally Occurring Telaprevir and Boceprevir (Protease Inhibitors)
HCV Resistant Mutants among Treatment Naive Infected Individuals.
Fonseca-Coronado S, Escobar-Gutiérrez A, Ruiz-Tovar K, et al
J Clin Microbiol
. 2011 Nov 23.
Abstract

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
Kwong AD, Kauffman RS, Hurter P, Mueller P.
Nat Biotechnol
. 2011 Nov 8;29(11):993-1003.
Abstract

The Pharmacokinetic Interaction Between an Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone and the HCV Protease Inhibitor Telaprevir.
Garg V, van Heeswijk R, Yang Y,  et al
J Clin Pharmacol. 2011 Oct 30.

Abstract

Formulary management of the protease inhibitors boceprevir and telaprevir for chronic hepatitis C virus.
Tungol A, Rademacher K, Schafer JA.
J Manag Care Pharm
. 2011 Nov;17(9):685-94.
Abstract

Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response.
Muir AJ, Poordad FF, McHutchison JG, et al
H epatology
. 2011 Nov;54(5):1538-46.
Abstract

Telaprevir for Chronic Hepatitis C with Genotype 1: A Meta-Analysis.
Dang SS, Wang WJ, Wang XF,
Hepatogastroenterology
. 2011 Aug 10;59(114).
Abstract

Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir.
Susser S, Vermehren J, Forestier N, et al
J Clin Virol
. 2011 Sep 14.

Abstract

Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan.
Kumada H, Toyota J, Okanoue T,  et al
J Hepatol
. 2011 Aug 6
Abstract

Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir  (VX-950) and danoprevir (ITMN-191).
Imhof I, Simmonds P.
Hepatology
. 2011 Apr;53(4):1090-9
Abstract

Second phase HCV RNA decline during telaprevir based therapy increases with drug effectiveness: Implications for treatment duration.
Guedj J, Perelson AS.
Hepatology. 2011 Mar 7.

Abstract

The efficacy and safety of telaprevir - a new protease inhibitor against hepatitis C virus.
Gentile I, Carleo MA, Borgia F, et al
Expert Opin Investig Drugs
. 2010 Jan;19(1):151-9.
Abstract
 
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients.
Susser S, Welsch C, Wang Y, et al
Hepatology
. 2009 Dec;50(6):1709-18.
Abstract

Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeks.
Suzuki F, Akuta N, Suzuki Y, et al
Hepatol Res
. 2009 Nov;39(11):1056-63
Abstract
 
Sustained virological response in a patient with chronic hepatitis C treated by monotherapy with the NS3-4A protease inhibitor telaprevir.
Suzuki F, Suzuki Y, Akuta N,
et al
Clin Virol
. 2009 Oct 24.
Abstract

Telaprevir: hope on the horizon, getting closer.
Weisberg IS, Jacobson IM.
Clin Liver Dis
. 2009 Aug;13(3):441-52
Abstract
 
FULL-TEXT ARTICLE
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
Hézode C, Forestier N, Dusheiko G, et al
N Engl J Med
. 2009 Apr 30;360(18):1839-50
Paper

Telaprevir for previously treated chronic HCV infection.
McHutchison JG, Manns MP, Muir AJ, et al
N Engl J Med
. 2010 Apr 8;362(14):1292-30
3.
Abstract

Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
Hézode C, Forestier N, Dusheiko G, et al
N Engl J Med
. 2009 Apr 30;360(18):1839-50
Abstract

Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection.
McHutchison JG, Everson GT, Gordon SC, et al
N Engl J Med
. 2009 Apr 30;360(18):1827-38
Abstract
 
Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection.
Gentile I, Viola C, Borgia F, Castaldo G, Borgia G.
Curr Med Chem. 2009;16(9):1115-21.

Abstract

 

 


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