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HCV Infection/Disease
  Diagnostic Challenges

General Reports
Depression
Cirrhosis
Cryoglobulinemia
Fibrosis
Alpha-Interferon-Ribavirin-Associated Retinopathy
Hepatocellular Carcinoma
Steatohepatitis

 

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Last Update:  July 15, 2017
 
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General Reports
       

     Journal Papers, Abstracts, and Commentaries

 
Diagnostic Dilemmas in Hepatitis C Virus Infection for Hemodialysis Patients.
Komitova RT, Atanasova MV, Pavlova TA, et al
Folia Med (Plovdiv). 2017 Mar 1;59(1):70-77.
Abstract

FULL-TEXT ARTICLE
Diagnostic non-invasive model of large risky esophageal varices in cirrhotic hepatitis C virus patients.
Elalfy H, Elsherbiny W, Abdel Rahman A,
World J Hepatol
. 2016 Aug 28;8(24):1028-37.
Paper  

PCR-Based Molecular Diagnosis of Hepatitis Virus (HBV and HDV) in HCV Infected Patients and Their Biochemical Study.
Riaz MN, Faheem M, Anwar MA, et al
J Pathog. 2016;2016:3219793.
Abstract

Validation of the FIB-4 index for evaluation of fibrosis in patients with recurrent hepatitis C after living donor liver transplantation: a single center experience.
Kitajima T, Kaido T, Hamaguchi Y,  et al
Hepatol Res. 2015 Nov 19.
Abstract

FULL-TEXT ARTICLE
Diagnostics for hepatitis C: an urgent need for action.
Denkinger CM, Kessel M.
Lancet Glob Health
. 2015 Apr;3(4):e195.
Paper  

Quantification of C4d deposition and hepatitis C virus RNA in tissue in cases of graft rejection and hepatitis C recurrence after liver transplantation.
Song AT, Mello ES, Alves VA, et al
Mem Inst Oswaldo Cruz
. 2015 Feb 13;0:0.
Abstract

Differentiation of acute from chronic hepatitis C virus infection by NS5B deep sequencing: A population-level tool for incidence estimation.
Montoya V, Olmstead A, Janjua NZ,  et al
Hepatology
. 2015 Feb 2.
Abstract

FULL-TEXT ARTICLE
Diagnostically untypable hepatitis C virus variants: It is time to resolve the problem.
Afzal MS, Khan MY, Ammar M, . et al
World J Gastroenterol
. 2014 Dec 14;20(46):17690-2.
Paper

A Diagnostic Score for the Prediction of Spontaneous Resolution of Acute Hepatitis C Virus Infection.
Beinhardt S, Anna Payer B, Datz C,  et al
J Hepatol
. 2013 Jul 10
Abstract

Significance of Anti-HCV Signal-to-Cutoff Ratio in Predicting Hepatitis C Viremia.
Seo YS, Jung ES, Kim JH, et al
Korean J Intern Med
. 2009 Dec;24(4):302-8
Abstract

Occult HCV infection revisited with ultra-sensitive real-time PCR assay.
Halfon P, Bourlière M, Ouzan D, et al  
J Clin Microbiol. 2008 Apr 30
Abstract

Significance of hepatitis C virus core protein in the diagnosis of hepatitis C virus infection
in different liver diseases
.
Irshad M, Dhar I, Joshi YK.
 
J Investig Med
. 2006 Dec;54(8):478-83.

Abstract


Depression
       

   Journal Papers, Abstracts, and Commentaries

  Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?
Patterson AL, Morasco BJ, Fuller BE, et al

Gen Hosp Psychiatry
. 2011 Jul-Aug;33(4):354-62.
Abstract

Assessment of the PHQ-9 as a Screening Tool for Depression in Patients with Chronic Hepatitis C.
Dbouk N, Arguedas MR, Sheikh A. 
Dig Dis Sci.
2007 Oct 13;

Abstract


Cirrhosis
       

  Journal Papers, Abstracts, and Commentaries

 

Quantification of fibrosis by collagen proportionate area predicts hepatic decompensation in hepatitis C cirrhosis.
Calvaruso V, Di Marco V, Bavetta MG,  et al
Aliment Pharmacol Ther
. 2015 Jan 11
Abstract

Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are
also useful in patients with non-alcoholic steatohepatitis.
Fujii H, Enomoto M, Fukushima W, et al
J Gastroenterol
. 2009 Apr 10.
Abstract

A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic
hepatitis C.

Huang H, Shiffman ML, Friedman S, et al
Hepatology.
2007 Apr 26;
Abstract

A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients
with chronic hepatitis C.
Wai CT, Greenson JK, Fontana RJ, et al
 
Hepatology.
2003 Aug;38(2):518-26.
Abstract

Cirrhosis or Chronic Hepatitis: Evaluation of Small (</=2-cm) Early-Enhancing Hepatic
Lesions with Serial Contrast-enhanced Dynamic MR Imaging.

Shimizu A, Ito K, Koike S, et al
Radiology
2003 Feb;226(2):550-5
Abstract

Cryoglobulinemia
       

     Journal Papers, Abstracts, and Commentaries

  Detection, using a novel method, of a high prevalence of cryoglobulinemia in persistent hepatitis
C virus infection.
Okuse C, Yotsuyanagi H, Okazaki T, et al 
Hepatol Res.
2003 Sep;27(1):18-22.
Abstract

Fibrosis
       

     Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
Routine Laboratory Blood Tests May Diagnose Significant Fibrosis in Liver Transplant Recipients with Chronic Hepatitis C: A 10 Year Experience
S
heen V, Nguyen H, Jimenez M, et al
J Clin Transl Hepatol
. 2016 Mar 28;4(1):20-5.
Paper

FULL-TEXT ARTICLE
Overestimate of Fibrosis by FIBROSpect® II in African Americans Complicates the Management of their Chronic Hepatitis C.
Tama M, Naylor P, Patel S,
J Clin Transl Hepatol. 2016 Mar 28;4(1):12-9.
Paper

FULL-TEXT ARTICLE
Non-Invasive Evaluation of Hepatic Fibrosis: The Diagnostic Performance of Magnetic Resonance Elastography in Patients with Viral Hepatitis B or C.
Wu WP, Chou CT, Chen RC, et al
PLoS One
. 2015 Oct 15;10(10):e0140068.
Paper

Supersonic Shear Imaging and Transient Elastography with the XL Probe Accurately Detect Fibrosis in Overweight or Obese Patients with Chronic Liver Disease.
Yoneda M, Thomas E, Sclair SN,  et al
Clin Gastroenterol Hepatol. 2015 Mar 21.
Abstract

Noninvasive Diagnosis of Liver Fibrosis: Utility of Data Mining of Both Ultrasound Elastography and Serological Findings to Construct a Decision Tree.
Yada N, Kudo M, Kawada N,  et al
Oncology
. 2014;87 Suppl 1:63-72
Abstract

Value of Egy-Score in Diagnosis of Significant, Advanced Hepatic Fibrosis and Cirrhosis Compared to Apri, Fib-4 and Forns'index in Chronic HCVc.
Alboraie M, Khairy M, Elsharkawy M, et al
Hepatol Res
. 2014 Jul 3.
Abstract

FULL-TEXT ARTICLE
Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging.
Saludes V, González V, Planas R,  et al
World J Gastroenterol. 2014 Apr 7;20(13):3431-3442.
Paper

FULL-TEXT ARTICLE
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C.
Schiavon LD, Narciso-Schiavon JL, de Carvalho-Filho RJ.
World J Gastroenterol
. 2014 Mar 21;20(11):2854-2866
Paper

Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest) and transient elastography (FibroScan).
Poynard T, Vergniol J, Ngo Y,  et al
J Hepatol
. 2013 Nov 26.
Abstract

Non-invasive assessment of liver steatosis and fibrosis in HIV/HCV- and HCV- infected patients.
Li Vecchi V, Giannitrapani L, Di Carlo P,  et al
Ann Hepatol
. 2013 Sep-Oct;12(5):740-8.
Abstract

Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C.
Shlomai A, Halfon P, Goldiner I,  et al
J Viral Hepat. 2013 Feb;20(2):95-102
Abstract

Validation and comparison of simple noninvasive models for the prediction of liver fibrosis in chronic hepatitis C  .
Amorim TG, Staub GJ, Lazzarotto C,  et al
Ann Hepatol
. 2012 Nov;11(6):855-61
Abstract

'Fibro-α score as a simple and useful non-invasive test for predicting significant liver fibrosis
in chronic hepatitis C patients.
Omran MM, Farid K, Emran TM, Attallah AA.

Arab J Gastroenterol
. 2011 Jun;12(2):74-9
Abstract

Non-invasive assessment of fibrosis in liver grafts due to hepatitis C virus recurrence.
J S Cross T, Jothimani D, Heneghan MA, Harrison PM.

Clin Transplant
. 2011 Apr 25.
Abstract

Non-invasive evaluation of the fibrosis stage in chronic hepatitis C:
a comparative analysis of nine scoring methods.
Ladero JM, Delkader J, Ortega L, et al

Scand J Gastroenterol
. 2010;45(1):51-9.
Abstract

Utility of biochemical models predictive of liver fibrosis grade in inmates with hepatitis C.
Portilla J, López-Burgos A, Saiz-De-La-Hoya-Zamácola P, et al  
Gastroenterol Hepatol
. 2009 May 26
Abstract

Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians:
comparison with liver biopsy and aspartate transaminase platelet ratio index (APRI).
Chang JP, Lui HF, Chau YP, et al
Aliment Pharmacol T
her. 2008 Apr 11
Abstract
 

Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic
hepatitis C.

Pinzani M, Arena U, Vizzutti F, et al 
Gut.
2008 Apr 30

 
Role of AST to platelet ratio index in the detection of liver fibrosis in patients with recurrent hepatitis
C after liver transplantation.

Toniutto P, Fabris C, Bitetto D, et al
J Gastroenterol Hepatol
. 2007 Nov;22(11):1904-8.
Abstract
 
Immunochemical identification and detection of serum fibronectin in liver fibrosis patients with
chronic hepatitis C.

Attallah AM, Zahran F, Ismail H, et al
J Immunoassay Immunochem. 2007;28(4):331-42.
Abstract
 
FibroTest and FibroScan for the Prediction of Hepatitis C-Related Fibrosis: A Systematic Review
of Diagnostic Test Accuracy.

Shaheen AA, Wan AF, Myers RP. et al
Am J Gastroenterol. 2010 Sep 10;
Abstract
 
FULL TEXT ARTICLE
Noninvasive diagnosis of hepatic fibrosis in chronic hepatitis
C.Stauber RE, Lackner C. 
World J Gastroenterol.
2007 Aug 28;13(32):4287-9
Paper
 
Transient elastography for patients with chronic hepatitis B and C virus infection: Non-invasive,
quantitative assessment of liver fibrosis.

Ogawa E, Furusyo N, Toyoda K, et al
Hepatol Res.
2007 Jul 1;
Abstract
 
FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with
liver biopsy and fibrotest.
Vallet-Pichard A, Mallet V, Nalpas B, et al
Hepatology. 2007 Jun 13;
Abstract
 
The APRI may be enhanced by the use of the FIBROSpect II in the estimation of fibrosis in
chronic hepatitis C.

Snyder N, Nguyen A, Gajula L, et al
Clin Chim Acta. 2007 Mar 19;
Abstract
 
FULL TEXT PDF ARTICLE
The FibroTest Value in Discriminating between Insignificant and Significant Fibrosis in
Chronic Hepatitis C Patients. The Romanian Experience.

Grigorescu M, Rusu M, Neculoiu D, et al
J Gastrointestin Liver Dis. 2007 Mar;16(1):31-37
Paper
 
Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patients.
Zaman A, Rosen HR, Ingram K, et al
Am J Med. 2007 Mar;120(3):280.
Abstract
 
Significant liver damage in patients with bleeding disorders and chronic hepatitis C:
non-invasive assessment of liver fibrosis using transient elastography.
Posthouwer D, Mauser-Bunschoten EP. et al  
J Thromb Haemost. 2007 Jan;5(1):25-30.
Abstract
 
Evaluating Liver Fibrosis Progression and the Impact of Antiretroviral Therapy in HIV
and Hepatitis C Coinfection Using a Noninvasive Marker.

Al-Mohri H, Murphy T, Lu Y,

J Acquir Immune Defic Syndr.
2007 Jan 4;
Abstract
 
A novel panel of blood markers to assess the degree of liver fibrosis.
Cales P, Oberti F, Michalak S, et al
Hepatology. 2005 Nov 29;42(6):1373-1381

Abstract
 
Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic
hepatitis C.
Lackner C, Struber G, Liegl B. et al 
Hepatology. 2005 May 24;41(6):1376-1382
Abstract
 
FULL-TEXT PDF ARTICLE
Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV
FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C.
P
oynard T, Imbert-Bismut F, Munteanu M  
Comp Hepatol. 2004 Sep 23;3(1):8.

Paper

A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with
chronic hepatitis C.
Wai CT, Greenson JK, Fontana RJ, et al
 
Hepatology.
2003 Aug;38(2):518-26.
Abstract


Alpha-Interferon-Ribavirin-Associated Retinopathy
       

   Journal Papers, Abstracts, and Commentaries

  Retinopathy-associated alpha-interferon-ribavirin therapy and the importance of the electro-
oculogram: a case report
Crochet M, Ingster-Moati I, Even G, Dupuy P. 
J Fr Ophtalmol. 2004 Mar;27(3):257-62.
Abstract

Hepatocellular Carcinoma
       

   Journal Papers, Abstracts, and Commentaries

 
Late hepatitis B and C diagnosis in relation to disease decompensation and hepatocellular carcinoma development.
Samji H, Yu A, Kuo M,  et al
J Hepatol. 2017 Jul 3.
Abstract

Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study.
Liu YJ, Zhou Y, Yeh MM.
Mol Cytogenet. 2014 Nov 25;7(1):81.
Abstract

Total serum glycan analysis is superior to Lectin-FLISA for the early detection of hepatocellular carcinoma.
Comunale MA, Wang M, Anbarasan N,  et al
Proteomics Clin Appl
. 2013
Abstract

Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using
contrast-enhanced ultrasonography.
Tanaka H, Iijima H, Nouso K,  et al

Hepatol Res
. 2012 Jan 3.

Abstract

Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma.
Abu El Makarem MA, Abdel-Aleem A, Ali A, Saber R,  et al

Ann Hepatol
. 2011 Jun 1;10(3):296-305

Abstract

Usefulness of serum alpha-fetoprotein (AFP) as a marker for hepatocellular carcinoma (HCC)
in hepatitis C virus related cirrhosis: analysis of the factors influencing AFP elevation
without hcc development

Kim KA, Lee JS, Jung ES, et al
Korean J Gastroenterol. 2006 Nov;48(5):321-6.

Abstract


Steatohepatitis/Steatosis
       

   Journal Papers, Abstracts, and Commentaries

  Non-invasive assessment of liver steatosis and fibrosis in HIV/HCV- and HCV- infected patients.
Li Vecchi V, Giannitrapani L, Di Carlo P,  et al

Ann Hepatol
. 2013 Sep-Oct;12(5):740-8.
Abstract

Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are
also useful in patients with non-alcoholic steatohepatitis.
Fujii H, Enomoto M, Fukushima W, et al
J Gastroenterol
. 2009 Apr 10.
Abstract

 

 


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