HCV Extrahepatic Manifestations

Medical Advocates
HCV Infection/Disease

Metabolic Disorders

General Reports
Diabetes
Hypercholesterolemia
Hyperglycemia
Hyperuricemia
Hyperlipidemia
Insulin Resistance
Metabolic Syndrome

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Last Update: August 08, 2017
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General Reports

Journal Papers, Abstracts, and Commentaries

Pretreatment glucose status determines HCC development in HCV patients with mild liver disease after curative antiviral therapy.
Huang CF, Yeh ML, Huang CY, et al
Medicine (Baltimore). 2016 Jul;95(27):e4157..
Abstract

FULL-TEXT ARTICLE
Metabolic alterations and hepatitis C: From bench to bedside.
Chang ML.
World J Gastroenterol. 2016 Jan 28;22(4):1461-76.
Paper

FULL-TEXT ARTICLE
Modulation of host lipid metabolism by hepatitis C virus: Role of new therapies.
Del Campo JA, Romero-Gómez M.
World J Gastroenterol. 2015 Oct 14;21(38):10776-82
Papers

FULL-TEXT ARTICLE
Metabolic syndrome in chronic hepatitis C infection: does it still matter in the era of directly acting antiviral therapy?
Lim T.
Hepat Med. 2014 Dec 3;6:113-8..
Paper

FULL-TEXT PDF ARTICLE
FTO rs9939609 polymorphism is associated with metabolic disturbances and response to HCV therapy in HIV/HCV-coinfected patients.
Pineda-Tenor D, Berenguer J, Jiménez-Sousa MA, et al
BMC Med. 2014 Nov 3;12
Paper

FULL-TEXT ARTICLE
Interaction between hepatitis C virus and metabolic factors.
Kawaguchi Y, Mizuta T.
World J Gastroenterol. 2014 Mar 21;20(11):2888-2901.
Paper

FULL-TEXT ARTICLE
Hepatitis C virus and metabolic disorder interactions towards liver damage and atherosclerosis.
Vespasiani-Gentilucci U, Gallo P, Vincentis AD, et al
World J Gastroenterol. 2014 Mar 21;20(11):2825-2838
Paper

FULL-TEXT ARTICLE
Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C?
Grasso A, Malfatti F, Testa R.
World J Gastroenterol. 2013 Nov 7;19(41):6947-56.
Paper

Evaluation of early cerebral metabolic, perfusion and microstructural changes in HCV-positive patients: a pilot study.
Bladowska J, Zimny A, Knysz B, et al
J Hepatol. 2013 May 13.
Abstract

Associations of chronic hepatitis C with metabolic and cardiac outcomes.
Younossi ZM, Stepanova M, Nader F, et al
Aliment Pharmacol Ther. 2013 Feb 5.
Abstract

Abnormalities of lipid metabolism in hepatitis C virus infection.
Negro F.
Gut. 2010 Jul 26
Abstract

Hepatitis C and metabolic syndrome.
Aparcero López R, Campo JA, Romero-Gómez M.
Gastroenterol Hepatol. 2010 Mar 3
Abstract

HCV/Diabetes

Journal Papers, Abstracts, and Commentaries

Significant disparities in risks of diabetes mellitus and metabolic syndrome among chronic hepatitis C virus patients in the U.S.
Banks DE, Bogler Y, Bhuket T, et al
Diabetes Metab Syndr. 2016 Dec 13.
Abstract

Diabetes, hepatocellular carcinoma, and mortality in hepatitis C-infected patients: a population-based cohort study.
Huang TS, Lin CL, Shyu YC, et al
J Gastroenterol Hepatol. 2016 Dec 8.
Abstract

Chronic Hepatitis C Virus Infection and the Risk for Diabetes: A Community-Based Prospective Study.
Lin YJ, Shaw TG, Yang HI, et al
Liver Int. 2016 Jul 1.
Abstract

Rapid Decline of Fasting Glucose in HCV Diabetic Patients Treated with Direct Acting Antiviral Agents.
Pavone P, Tieghi T, d'Ettorre G, Lichtner M,
Clin Microbiol Infect. 2016 Jan 23
Abstract

Successful Hepatitis C Antiviral Therapy Induces Remission of Type 2 Diabetes: A Case Report.
Doyle MA, Cooper C.
Am J Case Rep. 2015 Oct 20;16:745-50.
Abstract

The association of hepatitis C virus infection and post-liver transplant diabetes: data from 17 000 HCV-infected transplant recipients.
Younossi Z, Stepanova M, Saab S, et al
Aliment Pharmacol Ther. 2014 Nov 21
Abstract

FULL-TEXT ARTICLE
Hepatitis C virus infection and type 1 and type 2 diabetes mellitus.
Antonelli A, Ferrari SM, Giuggioli D, et al
World J Diabetes. 2014 Oct 15;5(5):586-600.
Paper

The Relationship of Hepatitis C Virus Infection with Diabetes in the United States Population.
Ruhl CE, Menke A, Cowie CC, Everhart JE.
Hepatology. 2014 Feb 5
Abstract

Diabetes patients benefit from antiviral treatment for hepatitis C infection.
[No authors listed]
Nurs Stand. 2014 Jan 29;28(22):16.
Abstract

Hepatitis C virus infection and type 2 diabetes.
Fallahi P, Ferrari SM, Colaci M, R et al
Clin Ter. 2013 Sep-Oct;164(5):e393-404.
Abstract

FULL-TEXT ARTICLE
Inauspicious contribution of hepatitis C virus and diabetes mellitus targeting kidneys: an update.
Alavian SM, Taheri S.
Iran J Kidney Dis. 2012 Jul;6(4):236-54..
Paper

A Community-Based Cross-Sectional Study: The Association of Lipids with Hepatitis C Seropositivity and Diabetes Mellitus.
Liu JL, Chen JY, Chen CT, et al
J Gastroenterol Hepatol. 2012 Jun 28.
Abstract

Association of hepatitis C virus infection and diabetes.
Rouabhia S, Malek R, Bounecer H.
World J Gastroenterol. 2009 Oct 28
Abstract

Hepatitis C virus and type 2 diabetes.
Negro F, Alaei M.
World J Gastroenterol. 2009 Apr 7;15(13):1537-47
Abstract

Diabetes Mellitus Is Associated with Impaired Response to Antiviral Therapy in Chronic Hepatitis
C Infection.
Elgouhari HM, Zein CO, Hanouneh I,et al
Dig Dis Sci. 2009 Jan 16.
Abstract

Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis.
White DL, Ratziu V, El-Serag HB.
J Hepatol. 2008 Aug 21
Abstract

Prevalence of hepatitis C infection and risk factors in hospitalized diabetic patients: results of
a cross-sectional study. [France]
Cadranel JF, Di Martino V, Lambrey G, et al
Eur J Gastroenterol Hepatol. 2008 Sep;20(9):829-36.
Abstract

Incidence of Type 2 Diabetes Mellitus and Glucose Abnormalities in Patients With Chronic Hepatitis C Infection
by Response to Treatment: Results of a Cohort Study.
Giordanino C, Bugianesi E, Smedile A, et al
Am J Gastroenterol. 2008 Aug 8.
Abstract

Risk factors for the development of diabetes mellitus in chronic hepatitis C virus genotype 4 infection.
Chehadeh W, Abdella N, Ben-Nakhi A, et al
J Gastroenterol Hepatol. 2008 Aug 20
Abstract

Hepatitis C virus infection in Nigerians with diabetes mellitus.
Nwokediuko SC, Oli JM.
Niger J Clin Pract. 2008 Jun;11(2):94-9.
Abstract

Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison
with hepatitis B virus-infected and hepatitis C virus-cleared patients.
Imazeki F, Yokosuka O, Fukai K,
Liver Int. 2008 Mar;28(3):355-62.
Abstract

FULL-TEXT ARTICLE
Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil.
da Costa LM, Mussi AD, Brianeze MR, Souto FJ.
Braz J Infect Dis. 2008 Feb;12(1):24-6.
Paper

Prevalence of hepatitis C in Swedish diabetics is low and comparable to that in health care workers.
Sjöberg K, Widell A, Verbaan H.
Eur J Gastroenterol Hepatol. 2008 Feb;20(2):135-8
Abstract

High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for
chronic hepatitis C virus infection.
Schreuder TC, Gelderblom HC, Weegink CJ, et al
Liver Int. 2008 Jan;28(1):39-46.
Abstract

Hpatitis C is associated with type 2 diabetes mellitus in HIV-infected persons without
traditional risk factors.
Jain M, Aragaki C, Fischbach L, et al
HIV Med. 2007 Nov;8(8):491-7.
Abstract

Hypercholesterolemia

Journal Papers, Abstracts, and Commentaries

Association of hypercholesterolemia with hepatitis C virus infection in HIV-infected people.
Polgreen P, Fultz S, Justice A, et al
HIV Med. 2004 May;5(3):144-15
Abstract

Hyperglycemia

Journal Papers, Abstracts, and Commentaries

Hyperglycemia among persons with hepatitis C: Not the classical diabetic phenotype.
Behrendt CE, Ruiz RB.
Diabetes Res Clin Pract. 2006 Jan;71(1):68-74.
Abstract

Hyperuricemia

Journal Papers, Abstracts, and Commentaries

Hyperuricaemia: another metabolic feature affecting the severity of chronic hepatitis because of HCV infection.
Petta S, Macaluso FS, Cammà C, et al
Liver Int. 2012 Jul 5.
Abstract

Hyperlipidemia

Journal Papers, Abstracts, and Commentaries

Prevalence and treatment of hyperlipidemia in patients with chronic hepatitis C infection.
Murthy GD, Vu K, Venugopal S.
Eur J Gastroenterol Hepatol. 2009 Apr 24
Abstract

Insulin Resistance

Journal Papers, Abstracts, and Commentaries

FULL-TEXT ARTICLE
Verification of B-lymphocyte activating factor's involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease.
Himoto T, Fujita K, Nomura T, Tani J, et al
Diabetol Metab Syndr. 2017 Jun 13;9:45.
Paper

Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults.
Reid M, Ma Y, Scherzer R, Price JC, et al
AIDS. 2017 Jan 28;31(3):385-393
Abstract

Insulin Resistance is Associated With Significant Liver Fibrosis in Chronic Hepatitis C Patients: A Systemic Review and Meta-Analysis.
Patel S, Jinjuvadia R, Patel R, Liangpunsakul S.
J Clin Gastroenterol. 2015 Aug 19|
Abstract

Exacerbation of Insulin Resistance and Hepatic Steatosis Deriving from Zinc Deficiency in Patients with HCV-Related Chronic Liver Disease.
Himoto T, Nomura T, Tani J
Biol Trace Elem Res. 2014 Nov 21
Abstract

FULL-TEXT ARTICLE
Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3.
Abenavoli L, Masarone M, Peta V, et al
World J Gastroenterol. 2014 Nov 7;20(41):15233-15240
Paper

Hepatitis C virus infection and insulin resistance.
Bose SK, Ray R.
World J Diabetes. 2014 Feb 15;5(1):52-58. Review
Abstract

Prevalence of insulin resistance in chronic hepatitis C genotype 1 and 3 patients.
Péres DP, Cheinquer H, Wolf FH, et al
Ann Hepatol. 2013 Nov-Dec 2013;12(6):871-875.
Abstract

A sustained virological response prevents development of insulin resistance in chronic hepatitis C patients.
Aghemo A, Prati GM, Rumi MG, et al
Hepatology. 2012 May 22
Abstract

HCV synergizes with body weight in the promotion of insulin resistance.
Delgado-Borrego A, Kamegaya Y, Jordan SH, et al
Viral Hepat. 2010 May 20.
Abstract

Reduction of Insulin Resistance with Effective Clearance of Hepatitis C Infection:
Results from the Halt-C Trial.
Delgado-Borrego A, Jordan SH, et al
Clin Gastroenterol Hepatol. 2010 Feb 12
Abstract

Insulin resistance and not steatosis is associated with modifications in oxidative
stress markers in chronic hepatitis C, non-3 genotype.
Oliveira AC, Parise ER, Catarino RM, et al
Free Radic Res. 2009 Dec;43(12):1187-94.
Abstract

The Change of Insulin Sensitivity in Hepatitis C Patients with Normal Insulin Sensitivity;
A 5-year prospective follow-up study.
Park SK, Cho YK, Park JH, et al
Intern Med J. 2009 Aug 27.
Abstract

Insulin Resistance and Geographical Origin: Major Predictors of Liver Fibrosis
and Response to Peginterferon and Ribavirin in HCV-4.
Moucari R, Ripault MP, Martinot-Peignoux M, et al
Gut. 2009 Aug 10.
Abstract

Insulin Resistance Is Common in Patients with Predominantly Genotype 3
Chronic Hepatitis C.
Duseja A, Dhiman RK, Chawla Y, et al
Dig Dis Sci. 2009 Jun 10.
Abstract

FULL-TEXT ARTICLE
Insulin resistance and hepatitis C.
Romero-Gomez M.
World J Gastroenterol. 2006 Nov 28;12(44):7075-80
Paper

Metabolic Syndrome

Journal Papers, Abstracts, and Commentaries

Metabolic syndrome is associated with poor treatment response to antiviral therapy in chronic hepatitis C genotype 3 patients.
Aziz H, Gill U, Raza A, Gill ML.
Eur J Gastroenterol Hepatol. 2014 May;26(5):538-43.
Abstract

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HCV Metabolic Disorders