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Disease Index Main New/Newsworthy  Home Page

Last Update:  August 03, 2017  
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New and Noteworthy
     

July 2017
 
 

General Reports
 

     Internet Documents
 
  FULL-TEXT PDF DOCUMENT
What HIV Clinicians Should Know (and Do) About HCV Coinfection
Mascolini, M   RITA Summer 2014

HCV infection remains among the most difficult-to-manage comorbidities in people with HIV. But care for HCV-coinfected people changed dramatically with
the advent of direct-acting antivirals (DAAs), as it has for everyone with HCV. This issue of Research Initiative, Treatment Action (RITA) examines how
DAAs have already transformed treatment of HCV infection and considers how they may continue to do so. A practice-oriented interview with HCV/HIV expert
Douglas Dieterich
offers nuts-and-bolts advice on prescribing DAAs for coinfected people and encourages more involvement by HIV clinicians in HCV management.
A second review article dissects perhaps the most controversial question about HCV/HIV coinfection—does HCV make HIV infection worse? Scores of studies
addressing different aspects of this question are almost evenly split in their conclusions. The RITA article suggests how HIV clinicians with coinfected patients may
work their way out of this data maze.
A final review analyzes sexual HCV transmission among gay and bisexual men. Early research rated sexual HCV
transmission a rare event. But that thinking—still echoed in some online CDC material—stands starkly at odds with an explosive HCV epidemic documented in gays
and bisexuals who do not inject drugs.
Document

    Journal Papers, Abstracts, and Commentaries

 
 
Decreased pro-inflammatory immune responses during recurrent acute HCV infections in HIV co-infected patients.
Hullegie SJ, Arends JEA, Groothuismink ZMA, et al
J Gen Virol. 2017 Jun 8.
Abstract

HCV viremia associates with NK cell activation and dysfunction in anti retroviral HIV/HCV co-infected subjects.
Papasavvas E, Azzoni L, Yin X,  et al

J Viral Hepat
.
2017 Apr 17
Abstract

Update in HIV-hepatitis C virus coinfection in the direct acting antiviral era.
Meissner EG.

Curr Opin Gastroenterol
. 2017 Feb 23.

Abstract

Risk factors for hepatitis C virus reinfection after sustained virologic response in patients co-infected with HIV.
Young J, Rossi C, Gill J,  et al

Clin Infect Dis
. 2017 Feb 12.
Abstract

Dynamic change in the NS3 protease domain in HIV/HCV-coinfected patients naïve to anti-HCV protease inhibitors.
Bagaglio S, Messina E, Hasson H, et al
New Microbiol. 2017 Jan 5;40(1).
Abstract

Hepatitis C virus (HCV) RNA profiles among chronic HIV/HCV-coinfected individuals in ESPRIT; spontaneous HCV RNA clearance observed in nine individuals.
Grint D, Tedaldi E, Peters L, et al
HIV Med. 2016 Oct 26.
Abstract

FULL-TEXT ARTICLE
Recent advances in understanding hepatitis C.
Douam F, Ding Q, Ploss A.
F1000Res
. 2016 Feb 3;5. pii: F1000 Faculty Rev-131
Paper

IL15 polymorphism is associated with advanced fibrosis, inflammation-related biomarkers and virologic response in HIV/HCV coinfection.
Jiménez-Sousa MA, Berenguer J, Rallón N, Pineda-Tenor D, et al

iver Int
. 2016 Feb 2. .
Abstract

Biochemical non-invasive assessment of liver fibrosis cannot replace biopsy in HIV-HCV coinfected patients.
Kliemann DA, Wolff FH, Tovo CV, et al

Ann Hepatol
. 2015 Jan-2016 Feb;15(1):27-32.
Abstract

FULL-TEXT ARTICLE
Identification of Variants of Hepatitis C Virus (HCV) Entry Factors in Patients Highly Exposed to HCV but Remaining Uninfected:
An ANRS Case-Control Study

Fouquet B, Ghosn J, Quertainmont Y,et al  
PLoS One
. 2015 Nov 16;10(11):e0142698.
Paper

FULL-TEXT ARTICLE
Virological Mechanisms in the Coinfection between HIV and HCV.
Liberto MC, Zicca E, Pavia G, et al
Mediators Inflamm
. 2015;2015:320532

Paper

Evolution and function of the HCV NS3 protease in patients with acute hepatitis C and HIV coinfection.
Dietz J, Lutz T, Knecht G, Gute P,  et al
Virolog
y
. 2015 Aug 18;485:213-222
Abstract

Hepatitis C in human immunodeficiency virus co-infected individuals: Is this still a "special population"?
Karageorgopoulos DE, Allen J, Bhagani S.
World J Hepatol. 2015 Jul 28;7(15):1936-52.
Abstract

Natural history and treatment of Hepatitis C/HIV coinfection: is it time to change paradigms?
Arends JE, Lieveld F, Boeijen LL,, et al

J Hepatol
. 2015 Jul 14.

Abstract

Hepatitis C in Children Coinfected with Human Immunodeficiency Virus: A Systematic Review.
Indolfi G, Bartolini E, Serranti D,  et al
J Pediatr Gastroenterol Nutr
. 2015 Jul 2.
Abstract

HIV Co-infected Have Similar SVR Rates as HCV Mono-infected with DAAs: It's Time to End Segregation and Integrate HIV Patients into HCV Trials.
Shafran SD.
Clin Infect Dis
. 2015 Jun 9..
Abstract

HIV Infection Status as a Predictor of Hepatitis C Virus RNA Testing in Primary Care.
Yartel AK, Morgan RL, Rein DB,  et al

Am J Prev Med
. 2015 Apr 17
Abstract

Effect of eradication of HCV on hepatic venous pressure gradient in HIV-infected patients with compensated HCV-related cirrhosis.
Sánchez-Conde M, Pérez-Latorre L, Rincón D,  et al
J Acquir Immune Defic Syndr. 2015 Apr 8
Abstract

Changes in HIV RNA and CD4 cell count following acute HCV infection in chronically HIV-infected individuals.
Gras L, de Wolf F, Smit C, Prins M,  et al 
J Acquir Immune Defic Syndr
. 2014 Dec 31
Abstract

Perceived Medical Risks of Drinking, Alcohol Consumption, and Hepatitis C Status Among Heavily Drinking HIV Primary Care Patients.
Elliott JC, Aharonovich E, O'Leary A, et al A
lcohol Clin Exp Res
. 2014 Dec;38(12):3052-3059
Abstract

rs7903146 Polymorphism at Transcription Factor 7 Like 2 Gene Is Associated with Total Cholesterol and Lipoprotein Profile in HIV/Hepatitis C Virus-Coinfected Patients.
Pineda-Tenor D, Berenguer J, Jiménez-Sousa MA, et al
AIDS Res Hum Retroviruses. 2014 Oct 29
Abstract

FULL-TEXT ARTICLE
Hepatitis C virus infection in the human immunodeficiency virus infected patient.
Clausen LN, Lundbo LF, Benfield T.
World J Gastroenterol. 2014 Sep 14;20(34):12132-12143. Review.
Paper

FULL-TEXT ARTICLE
Induction of Multiple Immune Regulatory Pathways with Differential Impact in HCV/HIV Coinfection.
Cho H, Kikuchi M, Li Y, Nakamoto N, et al
Front Immunol
. 2014 Jul 8;5:265.
Paper

FULL-TEXT ARTICLE
Occasional spontaneous clearance of chronic hepatitis C virus in HIV infected individuals
Stenkvist J, Nyström J, Falconer K, et al
J Hepatol
. 2014 Jun 18.
Paper

Systemic Cytokine and Interferon Responsiveness Patterns in HIV and HCV Mono and Co-Infections.
Fernandez-Botran R, Joshi-Barve S, et al
J Interferon Cytokine Res
. 2014 Jun 23
Abstract

Occasional spontaneous clearance of chronic hepatitis C virus in HIV infected individuals.
Stenkvist J, Nyström J, Falconer K, et al
J Hepatol
. 2014 Jun 18.
Abstract

Revisiting liver disease progression in HIV/HCV-coinfected patients: The influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3.
Mandorfer M, Payer BA, Schwabl P,  et al 
Liver Int. 2014 Jun 6.
Abstract

HIV virological rebounds but not blips predict liver fibrosis progression in antiretroviral-treated HIV/hepatitis C virus-coinfected patients.
Cooper C, Rollet-Kurhajec K, Young J,  et al

HIV Med
. 2014 May 18
Abstract

High rate of hepatitis C virus (HCV) recurrence in HIV-infected individuals with spontaneous HCV RNA clearance.
Peters L, Mocroft A, Soriano V,  et al
HIV Med. 2014 May 11.
Abstract

FULL-TEXT PDF ARTICLE
HCV core antigen and HCV-RNA in HIV/HCV co-infected patients with different HCV genotypes.

Garbuglia AR, Monachetti A, Galli C, et al
BMC Infect Dis. 2014 Apr 23;14(1):222
Paper

Hepatitis C virus NS3/4A quasispecies diversity in acute hepatitis C infection in HIV-1 co-infected patients.
Nevot M, Boesecke C, Parera M,  et al
J Viral Hepat
. 2014 Mar 27.
Abstract

Towards hepatitis C eradication from the HIV-infected population.
Barreiro P, Fernandez-Montero JV, de Mendoza C,  et al
Antiviral Res
. 2014 Feb 14
Abstract

Transmission and evolution of hepatitis C virus in HCV seroconverters in HIV infected subjects.
Shen C, Gupta P, Xu X,  et al

Virology
. 2014 Jan 20;449:339-49.
Abstract

Intra-host evolution of multiple genotypes of hepatitis C virus in a chronically infected patient with HIV along a 13-year follow-up period.
Culasso AC, Baré P, Aloisi N, et al

Virology
. 2014 Jan 20;449:317-27.
Abstract

Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients.
Guzmán-Fulgencio M, García-Álvarez M, Berenguer J,  et al

J Infect
. 2013 Oct 31.
Abstract

FULL-TEXT ARTICLE
Marijuana Smoking Does Not Accelerate Progression of Liver Disease in HIV-Hepatitis C Coinfection: A Longitudinal Cohort Analysis.
Brunet L, Moodie EE, Rollet K,et al
Clin Infect Dis. 2013 Sep;57(5):663-70.
Paper

Association between elevated coffee consumption and daily chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the
ANRS CO13 HEPAVIH cohort study.

Patrizia Carrieri M, Lions C, Sogni P,  et al
J Hepatol. 2013 Aug 23
Abstract

Extent of HCV NS3 protease variability and resistance-associated mutations assessed by next generation sequencing in HCV monoinfected and HIV/HCV coinfected patients.
Bartolini B, Giombini E, Zaccaro P, et al
Virus Res
. 2013 Aug 13
Abstract

Immune activation in HIV/HCV-infected patients is associated with low-level expression of liver expressed antimicrobial peptide-2 (LEAP-2).
Shata MT, Abdel-Hameed EA, Hetta HF, Sherman KE.

J Clin Pathol
. 2013 Aug 12
Abstract

Update on HIV/HCV Coinfection.
Soriano V, Vispo E, Fernandez-Montero JV,  et al
Curr HIV/AIDS Rep. 2013 Jul 7.

Abstract

Progression of liver fibrosis in monoinfected patients by hepatitis C virus and coinfected by HCV and human immunodeficiency virus.
Tovo CV, Becker SC, Almeida PR, Galperim B, Chaves S.
Arq Gastroenterol. 2013 Mar;50(1):19-22.
Abstract

FULL-TEXT ARTICLE
Immune Biomarker Differences and Changes Comparing HCV Mono-Infected, HIV/HCV Co-Infected, and HCV Spontaneously Cleared Patients.
Kushner LE, Wendelboe AM, Lazzeroni LC,  et al

PLoS One
. 2013 Apr 4;8(4):e60387.
Paper

FULL-TEXT ARTICLE
Complementary Role of HCV and HIV in T-Cell Activation and Exhaustion in HIV/HCV Coinfection.
Feuth T, Arends JE, Fransen JH, et al

PLoS One
. 2013;8(3):e59302
.
Paper

FULL-TEXT ARTICLE
Monocyte Activation in HIV/HCV Coinfection Correlates with Cognitive Impairment.
Rempel H, Sun B, Calosing C, et al

PLoS One
. 2013;8(2):e55776.
Paper

Syphilis negatively influences the response to hepatitis C virus treatment in an HIV-infected patient.
Nagami EH, Kim AY, Baden RP, McGovern BH.
Top Antivir Med. 2012 Oct;20(4):134-8.
Abstract

HIV-HCV co-infection: epidemiology, pathogenesis and therapeutic implications.
Andreoni M, Giacometti A, Maida I,| et al

Eur Rev Med Pharmacol
Sci
. 2012 Nov;16(11):1473-83.
Abstract

HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection.
Neukam K, García-Rey S, et al

Antiviral Res
. 2012 Sep;95(3):212-5.
Abstract

FULL-TEXT ARTICLE

Hepatitis B and C Co-Infection Are Independent Predictors of Progressive Kidney Disease in HIV-Positive, Antiretroviral-Treated Adults.
Mocroft A, Neuhaus J, Peters L,  et al
PLoS One
. 2012;7(7):e40245.

Paper

HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection.
Neukam K, García-Rey S, Cifuentes C,  et al
Antiviral Res. 2012 Jun 29.
Abstract

Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis.
Resino S, Sánchez-Conde M, Berenguer J.
Curr Opin Infect Dis. 2012 Jun 28.
Abstract

HIV Coinfection With Hepatitis C Virus: Evolving Epidemiology and Treatment Paradigms.
Taylor LE, Swan T, Mayer KH.

Clin Infect Dis
. 2012 Jul;55 Suppl 1:S33-42..
Abstract

Hepatitis C viral load, genotype 3 and IL28B CC genotype predict mortality in HIV and hepatitis C coinfected individuals.
Clausen LN, Astvad K, Ladelund S,  et al;

AIDS
. 2012 May 2.
Abstract

FULL-TEXT PDF ARTICLE

Crosstalk between HIV and Hepatitis C Virus during co-Infection.
Rider PJ, Liu F.
BMC Med
. 2012 Apr 3;10(1):32.
Paper

     Conference Reports, Abstracts, and Posters 
 

 
Differences in CD4+ T cell immune activation in HIV, hepatitis C (HCV) and HIV/HCV co-infection are influenced by HIV and HCV infection status
A. Hodowanec, K.E. Brady, W. Gao, et al
(XIX International AIDS Conference)
Abstract

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?
P. Vickerman , N. Martin , A. Roy, et al
(XIX International AIDS Conference)
Abstract

Videos

 
David Wong: Hepatitis C & HIV (ACT Community Forum)
Ontario HIV Treatment Network (OHTN)
 

Pathogenesis
 

     Journal Papers, Abstracts, and Commentaries
 
  Pathogenesis of Hepatitis C Virus Coinfection in the Brains of Patients Infected with HIV.
Letendre S, Paulino AD, Rockenstein E, et al
J Infect Dis. 2007 Aug 1;196(3):361-70.

Abstract

Natural History/Disease Progression
 

     Journal Papers, Abstracts, and Commentaries

 
Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis.
Thein HH, Yi Q, Dore GJ, Krahn MD. 
AIDS. 2008 Oct 1;22(15):1979-1991.
Abstract
 
  

Screening

 

     

     Journal Papers, Abstracts, and Commentaries

 
  FULL-TEXT ARTICLE
Will a quadruple multiplexed point-of-care screening strategy for HIV-related co-infections be feasible and impact detection of new co-infections in at-risk populations? Results from cross-sectional studies.
Pai NP, Dhurat R, Potter M,  et al

BMJ Open
. 2014 Dec 15;4(12):e005040. .
Paper

Oncology

 

     

     Journal Papers, Abstracts, and Commentaries

  Association between chronic hepatitis C and hepatitis C/HIV co-infection and the development of colorectal adenomas.
Hurtado-Cordovi J, Davis-Yadley AH, Lipka S, V et al
J Gastrointest Oncol. 2016 Aug;7(4):609-14.
Abstract

The Effect of HIV Viral Control on the Incidence of Hepatocellular Carcinoma in Veterans with Hepatitis C and HIV Coinfection
Kramer JR, Kowalkowski MA, Duan Z, Chiao EY.
J Acquir Immune Defic Syndr. 2014 Dec 31.
Abstract

Plasmablastic lymphoma of the retroperitoneum in an HIV- and HCV-positive patient: hard to diagnose
and harder to treat.
Dholaria B, Alapat D, Pandey T, Agarwal A.
Med Oncol
. 2012 May 6.
.
Abstract

High Levels of HCV core+1 Antibodies in HCV Patients with Hepatocellular Carcinoma.
Dalagiorgou G, Vassilaki N, Foka P, et al
J Gen Virol
. 2011 Feb 9.

Abstract


Quality of Life

 

     

     Journal Papers, Abstracts, and Commentaries

 
Hepatitis C virus infection is associated with painful symptoms in HIV-infected adults.
Tsui JI, Cheng DM, Libman H, et al 
AIDS Care. 2012 Jan 24.
Abstracts

Health-Related Quality of Life of Patients with HIV Disease: Impact of Hepatitis C Coinfection.
Fleming CA, Christiansen D, Nunes D, et al
Clin Infect Dis. 2004 Feb 15;38(4):572-578.
Abstract


Reproduction
 

     Journal Papers, Abstracts, and Commentaries

 
Assessing the reproductive performance of men co-infected with HIV-1 and hepatitis C undergoing assisted reproduction.
Chu MC, Pena JE, Nakhuda GS, et al 
Ar
ch Gynecol Obstet. 2006 Jun;274(3):155-9
Abstract

Provider Challenges
 

     Journal Papers, Abstracts, and Commentaries

 
Provider and Patient Correlates of Provider Decisions to Recommend HCV Treatment to HIV Co-Infected Patients.
Wagner G, Osilla KC, Garnett J,et al

J Int Assoc Physicians AIDS Care (Chic)
. 2012 May 7.

Abstract

Hepatitis C virus infection is associated with painful symptoms in HIV-infected adults.
Tsui JI, Cheng DM, Libman H, et al 
AIDS Care
. 2012 Jan 24.
Abstract

Challenges Facing Providers Caring for HIV/HCV-Coinfected Patients.
Lekas HM, Siegel K, Leider J.
Qual Health Res
. 2011 Aug .

Abstract

Patient and Provider Characteristics Associated with the Decision of HIV Coinfected Patients to Start Hepatitis C Treatment.
Osilla KC, Wagner G, Garnett J, et al
AIDS Patient Care STDS. 2011 Aug 8
Abstract


Patient Perspectives
 

     Journal Papers, Abstracts, and Commentaries

 
No significant effect of cannabis use on the count and percentage of circulating CD4 T-cells in HIV-HCV co-infected patients (ANRS CO13-HEPAVIH French cohort).
Marcellin F, Lions C, Rosenthal E,  et al
Drug Alcohol Rev. 2016 Apr 13

Abstract

FULL-TEXT ARTICLE
Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients.
Wagner G, Chan Osilla K, Garnett J, et al
AIDS Res Treat
. 2011;2011:903480.

Paper

Patient and Provider Characteristics Associated with the Decision of HIV Coinfected
Patients to Start Hepatitis C Treatment.
Osilla KC, Wagner G, Garnett J, et al
AIDS Patient Care STDS
. 2011 Aug 8
Abstract


HIV/HCV/HBV Tri-infection
 

     Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
Reactivation of occult HBV infection in an HIV/HCV Co-infected patient successfully treated with sofosbuvir/ledipasvir: a case report and review of the literature.
Fabbri G, Mastrorosa I, Vergori A, et al
BMC Infect Dis
. 2017 Mar 1;17(1):182.
Paper

T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use.
Kallas E, Huik K, Türk S, et al
Viral Immunol. 2016 Aug 26
Abstract

Hepatic Decompensation in HIV/HBV/HCV Patients Compared to HIV/HCV Patients and the Impact of Anti-HBV Nucleos(t)ide Therapy.
Lo Re V, Wang L, Devine S,  et al
Clin Infect Dis
. 2014 Jun 18
Abstract

FULL TEXT ARTICLE
Inferior epigastric artery pseudoaneurysm in a kidney transplant recipient.
Tozzi M, Molteni B, Franchin M,et al
Case Rep Transplant. 2013;2013:459320.
Paper

Serious neuropsychiatric adverse effects in a hepatitis C virus/hepatitis B virus/HIV-coinfected patient receiving bosentan and telaprevir.
L
ê MP, Gervais A, Le Beller C, et al
J Antimicrob Chemother. 2013 Jan 20.
Abstract
 

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HIV/HCV Coinfection