Medical Advocates
Kaposi's Sarcoma
  Drugs
 
General Reports 
 Anthracycline
 Daunorubicin
Docetaxel
Doxorubicin
Imatinib
 Imiquimod
Indinavir
 Interferon
 Interleukins
 Irinotecan
 Lenalidomide 		Nicotine                     Antiretrovirals
Paclitaxel
Rapimycin
 Rituximab
 Sirolimus
Sorafenib
Thalidomide
Toremifene  
Vinblastine
Topical Treatments
Valproic Acid
Vinorelbine
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Last Update:  July 11, 2017
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General Reports
         

          Journal Papers, Abstracts, and Commentaries

 
HHV8 and Kaposi's sarcoma: should we really give up protease inhibitors in all HIV-infected patients?
Philibert P, Chiche L, Caillères S, et al
 AIDS. 2017 Jul 7.
Abstract

FULL-TEXT ARTICLE
 Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study.
El-Mallawany NK, Kamiyango W, Slone JS, et al
PLoS One. 2016 Apr 15;11(4):e0153335
 Paper

Investigational agents for treatment of AIDS-related Kaposi's sarcoma.
Konstantinopoulos PA, Sullivan RJ, Karamouzis MV, Dezube BJ.
Expert Opin Investig Drugs. 2007 Apr;16(4):495-504.
 Abstract
 
Timing of highly active antiretroviral therapy and chemotherapy for Kaposi's sarcoma in
patients with HIV infection.
Loke WC, Spittle MF, Mitchell S, Kulasegaram R. 
Int J STD AIDS. 2006 Aug;17(8):565-6.
Abstract
 
Treatments of AIDS-related Kaposi's sarcoma.
Aversa SM, Cattelan AM, Salvagno L, et al
Crit Rev Oncol Hematol. 2005 Mar;53(3):253-65..
 Abstract
 
Novel pharmacological therapies for the treatment of AIDS-related Kaposi's sarcoma.
Cattelan AM, Trevenzoli M, Aversa SM.
Expert Opin Investig Drugs. 2004 May;13(5):501-513.
 Abstract

Therapy of AIDS-associated Kaposi's sarcoma: targeting pathogenetic mechanisms.
Krown SE.
Hematol Oncol Clin North Am. 2003 Jun;17(3):763-83.
Abstract
 
Anthracycline
         
          Journal Papers, Abstracts, and Commentaries
 
  Liposomal anthracycline chemotherapy and the risk of second malignancies in patients with Kaposi's sarcoma (KS).
Bendle M, Pealing J, Papanastasopoulos P, Bower M.?"
Cancer Chemother Pharmacol. 2014 Jul 24
Abstract
Daunorubicin
         
          Journal Papers, Abstracts, and Commentaries
 
  Liposomal daunorubicin as treatment for Kaposi's sarcoma.
Petre CE, Dittmer DP.   
Int J Nanomedicine. 2007;2(3):277-88.
Abstract
Docetaxel
         

          Journal Papers, Abstracts, and Commentaries

 
Docetaxel in anthracycline-pretreated AIDS-related Kaposi's sarcoma: a retrospective study.
Autier J, Picard-Dahan C, Marinho E, et al 
Br J Dermatol. 2005 May;152(5):1026-9
 Abstract
 
Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma.
Lim ST, Tupule A, Espina BM, Levine AM.
Cancer. 2004 Dec 1;
 Abstract
Doxorubicin
         
          Journal Papers, Abstracts, and Commentaries
 
 
Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma: evidence of symptom
palliation from chemotherapy.
Cianfrocca M, Lee S, Von Roenn J, et al
Cancer. 2010 May 24.
Abstract

Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi's sarcoma.
Cainelli F, Vallone A. 
Biologics. 2009;3:385-90.
Abstract

Long-term prognosis of HIV-infected patients with Kaposi sarcoma treated with pegylated liposomal doxorubicin.
Martín-Carbonero L, Palacios R, Valencia E, et al
Clin Infect Dis. 2008 Aug 1;47(3):410-7.
 Abstract
 
Long-Term Prognosis of HIV-Infected Patients with Kaposi Sarcoma Treated with Pegylated Liposomal Doxorubicin.
Martín-Carbonero L, Palacios R, Valencia E, et al
Clin Infect Dis. 2008 Jun 26.
 Abstract
 
Pegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma.
Udhrain A, Skubitz KM, Northfelt DW.
Int J Nanomedicine. 2007;2(3):345-52.
 Abstract
 
Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects.
Garde SV, Forté AJ, Ge M, et al 
Anticancer Drugs. 2007 Nov;18(10):1189-200.
Abstract
 
Phase II study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi's sarcoma.
Little RF, Aleman K, Kumar P, et al
Blood. 2007 Sep 10;
Abstract

FULL TEXT ARTICLE
 A Randomized, Double-Blind Study of Pegylated Liposomal Doxorubicin for the Treatment of AIDS-Related Kaposi's Sarcoma.
Cooley T, Henry D, Tonda M, Sun S,
 Oncologist. 2007 Jan;12(1):114-23.
Paper

Disseminated classic Kaposi's sarcoma. Two cases with excellent response to pegylated
liposomal doxorubicin.Castiñeiras I, Almagro M, Rodríguez-Lozano J, et al
J Dermatolog Treat. 2006;17(6):377-80.
 Abstract
 
Role of pegylated lyposomal doxorubicin (PLD) in systemic Kaposi's sarcoma: a systematic
review.
Di Trolio R, Di Lorenzo G, Delfino M, De Placido S.
Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):253-63.
 Abstract
 
Treatment of HIV-1-associated Kaposi's sarcoma with pegylated liposomal doxorubicin and HAART simultaneously induces effective tumor remission and CD4+ T cell recovery.
Lichterfeld M, Qurishi N, Hoffmann C, et al
Infection. 2005 Jun;33(3):140-7.
Abstract
 
Imatinib
         

          Journal Papers, Abstracts, and Commentaries

 
FULL TEXT ARTICLE
Imatinib for highly chemoresistant Kaposi sarcoma in a patient with long-term HIV control: a case report and literature review.
Cao W, Vyboh K, Routy B,  et al
 Curr Oncol. 2015 Oct;22(5):e395-e399.
 Paper

Imatinib interferes with survival of multi drug resistant Kaposi's sarcoma cells.
Basciani S, Vona R, Matarrese P, et al  
FEBS Lett. 2007 Dec 22;581(30):5897-903.
 Abstract
 
Imatinib-Induced Regression of AIDS-Related Kaposi's Sarcoma.
Koon HB, Bubley GJ, Pantanowitz L, et al
J Clin Oncol. 2004 Nov 30;
 Abstract
Imiquimod
         

          Journal Papers, Abstracts, and Commentaries

 
Topical imiquimod 5% as a treatment for localized genital Kaposi's sarcoma in an HIV-negative man: a case report.
Fairley JL, Denham I, Yoganathan S, Read TR.
Int J STD AIDS. 2012 Dec;23(12):907-
 Abstract

Imiquimod 5% cream for treatment of HIV-negative Kaposi's sarcoma skin lesions:
 A phase I to II,open-label trial in 17 patients.
Célestin Schartz NE, Chevret S, Paz C, et al
 J   Am Acad Dermatol. 2007 Dec 6
Abstract
 
Development of Kaposi's sarcoma under sirolimus-based immunosuppression and
successful treatment with imiquimod.
Babel N, Eibl N, Ulrich C, et al  Transpl Infect Dis. 2007 Apr 11;
Abstract
Indinavir
         

          Journal Papers, Abstracts, and Commentaries

 
Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the
HIV protease inhibitor indinavir.
Monini P, Sgadari C, Grosso MG,  et al
AIDS. 2009 Jan 22
 Abstract
Interferon
         

          Journal Papers, Abstracts, and Commentaries
 
 
Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma.
Qureshi YA, Karp CL, Dubovy SR. 
Cornea. 2009 Sep;28(8):941-3
 Abstract

Treatment of AIDS-related Kaposi's sarcoma with interleukin-12: rationale and preliminary evidence of clinical activity.
Yarchoan R, Pluda JM, Wyvill KM, et al 
Crit Rev Immunol. 2007;27(5):401-14.
 Abstract
 
AIDS-associated Kaposi's sarcoma: Is there still a role for interferon alfa?
Krown SE. 
Cytokine Growth Factor Rev. 2007 Jul 24;
 Abstract
 
Interferon-alpha2b With Protease Inhibitor-Based Antiretroviral Therapy in Patients With AIDS-Associated Kaposi Sarcoma: An AIDS Malignancy Consortium Phase I Trial.
Krown SE, Lee JY, Lin L, et al  
J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):149-153.
 Abstract

Management of Kaposi sarcoma: the role of interferon and thalidomide.
 Krown SE.
 Curr Opin Oncol 2001 Sep;13(5):374-81
 Abstract
Irinotecan
         

          Journal Papers, Abstracts, and Commentaries

 
Evidence of activity of Irinotecan in patients with advanced AIDS-related Kaposi's sarcoma.
Vaccher E, di Gennaro G, Simonelli C, et al 
AIDS. 2005 Nov 4;19(16):1915-6.
Abstract
Interleukins
         

IL-12

          Journal Papers, Abstracts, and Commentaries

 
Activity of subcutaneous interleukin-12 in AIDS-related Kaposi's sarcoma.
Little RF, Pluda JM, Wyvill KM
 Blood. 2006 Feb 28;
 Abstract
Lenalidomide
 

          Journal Papers, Abstracts, and Commentaries

  Clinical Activity of Lenalidomide in Visceral Human Immunodeficiency Virus-Related Kaposi Sarcoma.
Steff M, Joly V, Di Lucca J, Feldman J,  et al
JAMA Dermatol. 2013 Oct 2.
Abstract
Nicotine
 

          Journal Papers, Abstracts, and Commentaries

  Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial.
Goedert JJ, Scoppio BM, Pfeiffer R, et al
 J Eur Acad Dermatol Venereol. 2008 Apr 1
 Abstract
Paclitaxel
 

          Journal Papers, Abstracts, and Commentaries

 
Efficacy of paclitaxel in the treatment of Kaposi sarcoma.
Ercolak V, Sahin B, Gunaldi M, Duman BB, Afsar CU.
 Eur Rev Med Pharmacol Sci. 2015 Nov;19(21):4095-100.
 Abstract

Pemphigus vulgaris-associated Kaposi's sarcoma: response to paclitaxel and review of the literature.
Balighi K, Daneshpazhooh M, Aghazadeh N, et al
J Eur Acad Dermatol Venereol. 2013 Ded
 Abstract

Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated Kaposi's sarcoma: an Eastern Cooperative
Oncology Group (ECOG)and AIDS Malignancy Consortium (AMC) trial.
Cianfrocca M, Lee S, Von Roenn J,  et al
Cancer Chemother Pharmacol. 2011 Jan 5
 Abstract

Randomized trial of paclitaxel versus pegylated liposomal doxorubicin for advanced human immunodeficiency virus-associated Kaposi sarcoma: evidence of symptom
palliation from chemotherapy.
Cianfrocca M, Lee S, Von Roenn J, et al
Cancer. 2010 May 24.
Abstract

Kaposi's sarcoma in an HIV-positive person successfully treated with paclitaxel.
Dongre A, Montaldo C 
Indian J Dermatol Venereol Leprol. 2009 May-Jun;75(3):290-2.
 Abstract

Successful treatment with three-weekly paclitaxel of an anthracycline-refractory classical
Kaposi's sarcoma.Silvestris N, Galetta D, Colucci G.
 Anticancer Res. 2009 Feb;29(2):675-6.
 Abstract
 
Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells.
Cai J, Zheng T, Masood R, et al 
Sarcoma. 2000;4(1-2):37-45.
 Abstract
 
Weekly paclitaxel for advanced aggressive classic Kaposi sarcoma: experience in 17 cases.
Brambilla L, Romanelli A, Bellinvia M, et al
Br J Dermatol. 2008 Mar 20
Abstract
 

Potential drug interaction with paclitaxel and highly active antiretroviral therapy in two patients with AIDS-associated Kaposi sarcoma.
Bundow D, Aboulafia DM.
Am J Clin Oncol. 2004 Feb;27(1):81-4.
 Abstract
 
FULL-TEXT ARTICLE
Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells.
 Cai J, Zheng T, Masood R, et al
 Sarcoma. 2000;4(1-2):37-45.
 Paper

Rapimycin
 

          Journal Papers, Abstracts, and Commentaries

  Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma.
Di Paolo S, Teutonico A, Ranieri E, et al 
Am J Kidney Dis. 2007 Mar;49(3):462-70.
 Abstract
Rituximab
 

          Journal Papers, Abstracts, and Commentaries

  FULL-TEXT ARTICLE
Pathology of rituximab-induced Kaposi sarcoma flare.
Pantanowitz L, Früh K, Marconi M, et al
BMC Clin Pathol. 2008 Jul 23;8:7.
Paper
Sorafenib
 

          Journal Papers, Abstracts, and Commentaries

  FULL-TEXT ARTICLE
A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma.
Uldrick TS, Gonçalves PH, Wyvill KM, et al 
Oncologist. 2017 May;22(5):505-e49.
 Paper
Sirolimus
 

          Journal Papers, Abstracts, and Commentaries

 
The use of sirolimus to treat Kaposi's sarcoma in an HIV-negative rheumatoid arthritis patient on disease-modifying drug therapies.
Wu W, Li C, Lee RA, Hata T. I
nt J Dermatol. 2014 Jul 11.
Abstract

Kaposi's sarcoma resolves after sirolimus therapy in a patient with pemphigus vulgaris.
Saggar S, Zeichner JA, Brown TT, et al  
Arch Dermatol. 2008 May;144(5):654-7.
 Abstract

Sirolimus for visceral and cutaneous Kaposi's sarcoma in a renal-transplant recipient.
Gheith O, Bakr A, Wafa E, et al
Clin Exp Nephrol. 2007 Sep;11(3):251-4.
Abstract
Thalidomide
 

          Journal Papers, Abstracts, and Commentaries

  Management of Kaposi sarcoma: the role of interferon and thalidomide.
 Krown SE.
 Curr Opin Oncol 2001 Sep;13(5):374-81
 Abstract
   
  Clinical aspects and management of AIDS-related Kaposi's sarcoma.
 Levine AM, Tulpule A.
 Eur J Cancer 2001 Jul;37(10):1288-95
 Abstract
   
  Activity of thalidomide in AIDS-related Kaposi's sarcoma.
 Little RF, Wyvill KM, Pluda JM, et al.
 J Clin Oncol 2000 Jul;18(13):2593-602
 Abstract
Toremifene
 

         Journal Papers, Abstracts, and Commentaries

  Antiproliferative Properties of Toremifene on AIDS-Related Kaposi's Sarcoma Cells.
Hong A, Leigh BR.  
Chemotherapy 2002 Dec;48(5):238-243
 Abstract		  
Vinblastine
 

          Journal Papers, Abstracts, and Commentaries

  Chemotherapy of disseminated cutaneous classic Kaposi's sarcoma with vinblastine.
Turk HM, Buyukberber S, Canci C, et al.
J Dermatol 2002 Oct;29(10):657-60
 Abstract		  
Topical Treatments
 
          Journal Papers, Abstracts, and Commentaries
 
 

Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma.
Miles SA, Dezube BJ, Lee JY, et al. 
AIDS 2002 Feb 15;16(3):421-429
 Abstract

Phase III vehicle-controlled, multi-centered study of topical alitretinoin gel  0.1% in cutaneous AIDS-related Kaposi's sarcoma.
Bodsworth NJ, Bloch M, Bower M, et al.
Am J Clin Dermatol 2001;2(2):77-87
 Abstract

  
Valproic Acid
 
          Journal Papers, Abstracts, and Commentaries
 
  Molecular and clinical assessment in the treatmnt of AIDS Kaposi sarcoma with valproic Acid.
Lechowicz M, Dittmer DP, Lee JY, et al 
Clin Infect Dis. 2009 Dec 15;49(12):1946-9.
 Abstract		  
Vinorelbine
 
          Journal Papers, Abstracts, and Commentaries
 
  Vinorelbine therapy in classic Kaposi's sarcoma: a retrospective study of 20 patients.
Brambilla L, Recalcati S, Tourlaki A.|
 Eur J Dermatol. 2015 Nov 6
 Abstract		  

 

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