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Last Update: April 21, 2018
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New and Noteworthy

April 2018

March 2018


General Reports

           Journal Papers, Abstracts, and Commentaries 

Gender differences in the use of cardiovascular interventions in HIV-positive persons; the D:A:D Study.
Hatleberg CI, Ryom L, El-Sadr W,  et azl
 J Int AIDS Soc
. 2018 Mar;21(3

Cardiovascular disease (CVD) and chronic kidney disease (CKD) event rates in HIV-positive persons at high predicted CVD and CKD risk: A prospective analysis of the D:A:D observational study
Boyd MA, Mocroft A, Ryom L, et al
PLoS Med. 2017 Nov 7;14(11

HIV-related cardiovascular disease: closing the gap in mortality.
Holloway CJ, Boccara F.
Curr Opin HIV AIDS. 2017 Nov;12(6):509-512.

Current assessment of heart rate variability and QTc interval length in HIV/AIDS.
McIntosh RC, Lobo JD, Hurwitz BE.
Curr Opin HIV AIDS. 2017 Nov;12(6):528-533

Projecting 10-yr, 20-yr and Lifetime Risks of Cardiovascular Disease in Persons Living with HIV in the US.
Losina E, Hyle EP, Borre ED, et al

Clin Infect Dis
. 2017 Jun 12.

Cardiovascular health in an aging HIV population.
Boccara F.
AIDS. 2017 Jun 1;31 Suppl 2:S157-S163

HIV status and type of coronary stent placed in patients presenting with ST-elevation myocardial infarction.
Albaeni A, Harris C, Eid SM,  et  al

Coron Artery Dis
. 2017 Mar 10.

Contribution of common infections to cardiovascular risk in HIV positive individuals.
Berquist V, Hoy JF, Trevillyan JM.

. 2017 Feb 9;19(2). .


Impact of pharmaceutical care on cardiovascular risk among older HIV patients on antiretroviral therapy.
Domingues EA, Ferrit-Martín M, Calleja-Hernández MÁ.

 Int J Clin Pharm
2016 Nov 18

Screening and management of risk factors for cardiovascular disease in HIV-positive patients attending an Australian urban sexual health clinic.
Kakar S, Drak D, Amin T,  et al

Sex Health
. 2016 Nov 11. '

Cardiorespiratory fitness levels and moderators in people with HIV: A systematic review and meta-analysis.
Vancampfort D, Mugisha J, Rosenbaum S, et al

Prev Med
. 2016 Oct 3;93:106-114

Cardiovascular Complications of HIV in Endemic Countries.
Feinstein MJ, Bogorodskaya M, Bloomfield GS,
Curr Cardiol Rep. 2016 Nov;18(11):113

Prediction of hard cardiovascular events in HIV patients.
Raggi P, De Francesco D, Manicardi M, Zona S,  et al

J Antimicrob Chemother
. 2016 Sep 2

Screening and risk assessment for coronary artery disease in HIV infection: an unmet need.
Nadel J, Holloway CJ
HIV Med. 2016 Aug 24.

Trends in cardiovascular disease mortality among persons with HIV in New York City, 2001-2012.
Hanna DB, Ramaswamy C, Kaplan RC, et al

Clin Infect Dis
. 2016 Jul 20.

Cardiovascular disease risk scores' relationship to subclinical cardiovascular disease among HIV-infected and-uninfected men.
Monroe AK, Haberlen SA, Post WS, et al
AIDS. 2016 May 19.

What happens to cardiovascular system behind the undetectable level of HIV viremia?
d'Ettorre G, Ceccarelli G, Pavone P, et al

AIDS Res Ther
. 2016 Apr 27;13:

Delivery of health care for cardiovascular and metabolic diseases among people living with HIV/AIDS in African countries: a systematic review protocol.
Watkins DA, Tulloch NL, Anderson ME, et al
Syst Rev. 2016 Apr 16;5(1):63.

Randomized trial of a multidisciplinary lifestyle intervention in HIV-infected patients with moderate-high cardiovascular risk.
Saumoy M, Alonso-Villaverde C, et al

. 2016 Jan 11;246:301

The Chronicity of HIV Infection Should Drive the Research Strategy of NeuroHIV Treatment Studies: A Critical Review.
Gates TM, Cysique LA.

CNS Drugs
. 2016 Jan 9

Patterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013.
Feinstein MJ, Bahiru E, Achenbach C, et al

Am J Cardiol
. 2015 Nov 6.

HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.
Lambert CT, Sandesara PB, Hirsh B, et al  

. 2015 Nov 26.

The effect of physical activity on cardiometabolic health and inflammation in treated HIV infection.
Dirajlal-Fargo S, Webel AR, Longenecker CT,  et al

Antivir Ther
. 2015 Oct 12.

Management of cardiovascular conditions in a cohort of patients with HIV: experience from a joint HIV/cardiology clinic.
Koganti S, Kinloch-de Loes S, Hutchinson S, et al
Clin Med. 2015 Oct 5;15(5):442-6.

Cardiovascular Disease-Risk Markers in HIV Patients.
Asztalos BF, Matera R, Horvath KV, et al

JAIDS Clin Res
. 2014 Jun 12;5(7). pii: 317.

Cardiovascular disease in human immunodeficiency virus-infection as a cause of hospitalization: a case-series in a General Hospital in Peru.
Valenzuela-Rodríguez G, Mezones-Holguín E, et al
Braz J Infect Dis
. 2015 Apr 16

Stimulating High Impact HIV-Related Cardiovascular Research: Recommendations From a Multidisciplinary NHLBI Working Group on HIV-Related Heart, Lung, and Blood Disease.
Shah MR, Cook N, Wong R,  et al

J Am Coll Cardiol
. 2015 Feb 24;65(7):738-744.

Cardiovascular Disease in HIV: Traditional and Nontraditional Risk Factors.
Grinspoon SK.

Top Antivir Med
. 2014 September/October;22(4):676-679.

2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque.
Zanni MV, Fitch KV, Feldpausch M, .et al
AIDS. 2014 Sep 10;28(14):2061-70

Cardiovascular disease associated with the human immunodeficiency virus: an update.
S Metkus T Jr, Brown TT, S Post W.

Curr Treat Options Cardiovasc Med
. 2014 Nov;16(11):346

Consensus statement on metabolic disorders and cardiovascular risks in patients with human immunodeficiency virus.
Grupo de expertos del Grupo de Estudio sobre Alteraciones Metabólicas (GEAM), de la Secretaría del Plan Nacional sobre el Sida (SPNS) y del Grupo de Estudio de Sida (GeSIDA

Enferm Infecc Microbiol Clin
. 2014 Aug 27

Pharmacological management of cardiovascular conditions and diabetes in older adults with HIV infection.
Gedela K, Vibhuti M, Pozniak A, et al

. 2014 May;15(5):257-68.

Cardiovascular disease in patients with chronic human immunodeficiency virus infection.
Escárcega RO, Franco JJ, Mani BC,

nt J Cardiol. 2014 Apr 21.

Pharmacological management of cardiovascular conditions and diabetes in older adults with HIV infection.
Gedela K, Vibhuti M, Pozniak A, et al

. 2014 May;15(5):257-68.

Cardiovascular Risk-Factor Knowledge and Risk Perception Among HIV-Infected Adults.
Cioe PA, Crawford SL, Stein MD.

J Assoc Nurses AIDS
. 2013 Sep 24.


Plasma MCP-1 and TNF-α Levels Predict the Presence of Coronary Artery Calcium in HIV-infected Individuals Independent of Traditional Cardiovascular Risk Factors.
Shikuma C, Barbour J, Ndhlovu L, et al

AIDS Res Hum Retroviruses
. 2013 Aug 28

Cardiovascular involvements in HIV infected patients.
Alharethi R.

Expert Rev Cardiovasc Ther
. 2013 Aug 23..


Associations between immune depression and cardiovascular events in hiv infection.
Sabin CA, Ryom L, De Wit S,, et al
AIDS. 2013 Jul 9.

Pointers on cardiovascular disease risk, screening, and management in patients w
Numerous studies show that adults and children with HIV infection face about a 50% higher risk of cardiovascular disease than the general population. But few areas of HIV research have produced more seemingly contradictory results on cardiovascular risk factors, the (negative and positive) impact of antiretroviral therapy, and the role of HIV itself.

This issue of Research Initiative, Treatment Action (RITA) carefully examines evidence from well over 100 studies on cardiovascular risk factors and the impact of individual and combined antiretrovirals on the heart and its vascular tributaries.

This RITA also features an interview with the University of Wisconsin’s James Stein, perhaps the leading authority on cardiovascular disease in people with HIV. Stein offers frank and insightful answers to questions on cardiovascular risk, screening adults and children, the Framingham score, lipid targets, aspirin prophylaxis, and smoking

Recent advances in HIV-associated cardiovascular diseases in Africa.
Syed FF, Sani MU.
Heart. 2013 May 16.

HIV-related mechanisms in atherosclerosis and cardiovascular diseases.
Gibellini D, Borderi M, Clò A,  et al

J Cardiovasc Med
. 2013 May 7.

Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals: The D: A: D Study.
Sabin CA, Ryom L, Kovari H,  et al

J Acquir Immune Defic Syndr

Provider Compliance With Guidelines for Management of Cardiovascular Risk in HIV-Infected Patients.
Lichtenstein KA, Armon C, Buchacz K,  et al
Prev Chronic Dis. 2013 Jan;10

Serum Albumin and Short-Term Risk for Mortality and Cardiovascular Disease among HIV-Infected Veterans.
Lang J, Scherzer R, Weekley CC,  et al
AIDS. 2013 Jan 22. 

The challenge of cardiovascular diseases in HIV-positive patients: it's time for redrawing the maps of cardiovascular risk?
Ceccarelli G, d'Ettorre G, Vullo V.
Int J Clin Pract. 2013 Jan;67(1):1-3.

Cardiovascular Complications of HIV Infection and Treatment.
Garg H, Joshi A, Mukherjee D.

Cardiovasc Hematol Agents Med Chem
. 2012 Aug 30.

Cardiovascular Risk Estimation in 2012: Lessons Learned and Applicability to the HIV Population.
D'Agostino RB Sr
J Infect Dis. 2012 Jun;205 Suppl 3:S362-7.

Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults.
Hsue PY, Deeks SG, Hunt PW

J Infect Di
. 2012 Jun;205 Suppl 3:S375-82.

Ectopic Fat is Linked to Prior Cardiovascular Events in Men With HIV.
Gabriella O, Giovanni G, Stefano Z, et al

J Acquir Immune Defic Syndr
. 2012 Apr 15;59(5):494-7

Low free testosterone in HIV-infected men is not associated with subclinical cardiovascular disease.
Monroe A, Dobs A, Xu X, Palella F
HIV Med. 2012 Feb 2

HIV infection, aging and cardiovascular disease: epidemiology and prevention.
Petoumenos K, Worm SW.

Sex Health
. 2011 Nov;8(4):465-73.



           Conference Reports, Abstracts, and Posters


HIV patient care expertise - an aging population necessitates new skill sets: managing CVD risk
N.L. Okeke, T. Chin, M.E. Clement, C.B. Hicks
 International AIDS Conference)

Impact of short-term change in body mass index (BMI) after antiretroviral therapy (ART) initiation on subsequent risk of cardiovascular disease (CVD) and diabetes in HIV-positive individuals: the D:A:D study
A.C. Achhra, A. Mocroft, P. Reiss, et al

(XX International AIDS Conference)



       Journal Papers, Abstracts, and Commentaries 
  Pathogenesis of cardiovascular disease in HIV infection.
Carr A. 
Curr Opin HIV AIDS. 2008 May;3(3):234-9.


       Journal Papers, Abstracts, and Commentaries 

Left ventricle thrombus after tranexamic acid for spine surgery in an HIV positive patient.
Gerstein NS, Brierley JK, Culling MD.

Spine J
2015 Oct 30.

HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study.
Rasmussen LD, Dybdal M, Gerstoft J, et al

. 2010 Aug 18

The Hemostatic Balance in HIV-Infected Patients with and without Antiretroviral Therapy: Partial Restoration with Antiretroviral Therapy.
Jong E, Louw S, Meijers JC, et al

AIDS Patient Care STD
. 2009 Nov 22.

Thromboses among HIV-Infected Patients during the Highly Active Antiretroviral Therapy Era.
Crum-Cianflone NF, Weekes J, Bavaro M.

AIDS Patient Care STDS
. 2008 Sep 10.

Venous Thromboembolism in Patients With HIV/AIDS: A Case-Control Study.
Ahonkhai AA, Gebo KA, Streiff MB, et al

J Acquir Immune Defic Syndr
. 2008 Jan 11
Human Immunodeficiency Virus Infection and Acute Deep Vein Thromboses.
Louw S, Jacobson BF, Büller H.
Clin Appl Thromb Hemost. 2007 Sep 25;
HIV Disease in Thrombocardiology.
Ener RA, Palermo J, O'murchu B, et al
J Invasive Cardiol. 2007 May;19(5):235-9.
Venous and arterial thrombosis in patients with HIV infection.
Micieli E, Dentali F, Giola M, et al

Blood Coagul Fibrinolysis
. 2007 Apr;18(3):259-63.
Pulmonary thromboembolism in HIV infected admitted patients under 50 years old.
Clemente S, Mineiro A, Diniz A.
Rev Port Pneumol. 2006 Dec;12(6 Suppl 1):61.
Portal vein thrombosis in a patient with HIV treated with a protease inhibitor-containing regimen.
Soentjens P, Ostyn B, Van Outryve S, et al
Acta Clin Belg. 2006 Jan-Feb;61(1):24-9.
Portal vein thrombosis in HIV-infected patients: report of four cases.
Ramanampamonjy RM, Ramarozatovo LS, Bonnet F, et al 

Rev Med Interne
. 2005 Jul;26(7):545-548.
Thrombectomy in HIV Related Peripheral Arterial Thrombosis: A Preliminary Report.
Mulaudzi TV, Robbs JV, Pillay W 

Eur J Vasc Endovasc Surg
. 2005 Jul;30(1):102-6
Portal vein thrombosis in HIV-infected patients: report of four cases.
Ramanampamonjy RM, Ramarozatovo LS, Bonnet F 

Rev Med Interne.
2005 May 27
Is chronic HIV infection associated with venous thrombotic disease? A systematic review.
Klein SK, Slim EJ, de Kruif MD, et al.

Neth J Med.
2005 Apr;63(4):129-36.
Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series.
Jacobson MC, Dezube BJ, Aboulafia al
Clin Infect Dis.
2004 Oct 15;39(8):1214-22.
Thrombosis and a Hypercoagulable State in HIV-Infected Patients.
Shen YM, Frenkel EP.
Clin Appl Thromb Hemost. 2004 Jul;10(3):277-80.
Antiphospholipid antibody syndrome manifesting as a deep venous thrombosis and pulmonary embolism in a patient with HIV.
Shahnaz S, Parikh G, Opran A.
Am J Med Sci. 2004 Apr;327(4):231-2.
Mixed arterial and venous thromboembolism in a person with HIV infection.
Callens S, Florence E, Philippe M, et al
Scand J Infect Dis. 2003;35(11-12):907-8.

Spontaneous arterial thrombosis in a patient with human immunodeficiency virus infection: successful treatment with pharmacomechanical thrombectomy.
Bush RL, Bianco CC, Bixler TJ, et al.

J Vasc Surg. 2003 Aug;38(2):392-5.

AIDS and thrombosis: retrospective study of 131 HIV-infected patients.
Saif MW, Bona R, Greenberg B.
AIDS Patient Care STDS. 2001 Jun;15(6):311-20.
HIV and thrombosis: a review.
Saif MW, Greenberg B.
AIDS Patient Care STDS. 2001 Jan;15(1):15-24.

Endothelial Function


       Journal Papers, Abstracts, and Commentaries 
Cardiovascular disease prevention policy in HIV: recommendations from a modelling study.
Smit M, van Zoest RA, Nichols BE, et al

Clin Infect Dis
. 2017 Oct 6.

Use of statins and aspirin to prevent cardiovascular disease among HIV-positive patients. A survey among Italian HIV physicians.
Maggi P, De Socio GV, Cicalini S,  et al
New Microbiol. 2017 Jan 10;40(1). [

HIV Infection and Primary Prevention of Cardiovascular Disease: Lights and Shadows in the HAART Era.
Ballocca F, Gili S, D'Ascenzo F, et al
Prog Cardiovasc Dis. 2016 Mar 1. pii: S0033-0620(16)30017-2.

Underutilization of Aspirin for Primary Prevention of Cardiovascular Disease among HIV-Infected Patients.
Burkholder GA, Tamhane AR, Salinas JL, et al

Clin Infect Dis
. 2012 Aug 31.

Cardiovascular prevention in HIV patients: Results from a successful intervention program.
Lima EM, Gualandro DM, Yu PC,et al  

s. 2008 Aug 28.

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HIV-Related Cardiovascular Disorders