HIV Infection/Disease Neorological Disorders

Medical Advocates
HIV Infection/Disease

Progressive Multifocal Leukoencephalopathy

General Reports
Epidemiology
Diagnosis
Clinical Management
Drugs
Case Studies

CNS Main Page

Main New/Newsworthy

Home Page

Last Update: September 06, 2016
Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader

General Reports

Journal Papers, Abstracts, and Commentaries

CNS-Immune Reconstitution Inflammatory Syndrome in the Setting of HIV Infection, Part 1: Overview and Discussion of Progressive Multifocal Leukoencephalopathy-Immune Reconstitution Inflammatory Syndrome and Cryptococcal-Immune Reconstitution Inflammatory Syndrome.
Post MJ, Thurnher MM, Clifford D, et al
AJNR Am J Neuroradiol. 2012 Jul 12
Abstract

Atypical progressive multifocal leukoencephalopathy in HIV with a high CD4 count:
the use of magnetic resonance imaging plus spectrometry studies.
Manfredi R, Piergentili B, Marinacci G, Calza L.
Int J STD AIDS. 2012 Mar;23(3):e35-
Abstract

Progressive multifocal leukoencephalopathy in HIV-1 infection.
Cinque P, Koralnik IJ, Gerevini S, et al
Lancet Infect Dis. 2009 Oct;9(10):625-36.
Abstract

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients
treated with rituximab, natalizumab, and efalizumab: a Review from the Research on
Adverse Drug Events and Reports (RADAR) Project.
Carson KR, Focosi D, Major EO, et al
Lancet Oncol. 2009 Aug;10(8):816-24.
Abstract

Incidence and Outcome of Progressive Multifocal Leukoencephalopathy over 20 Years of the
Swiss HIV Cohort Study.
Khanna N, Elzi L, Mueller NJ, Garzoni C, et al
Clin Infect Dis. 2009 Apr 6.
Abstract

Progressive multifocal leukoencephalopathy following rituximab therapy in HIV negative patients:
a report of 57 cases from the Research on Adverse Drug Event and Reports (RADAR) project.
Carson KR, Evens AM, Richey EA, et al
Blood. 2009 Mar 5.
Abstract

Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated
dendritic cells from patients with progressive multifocal leukoencephalopathy.
Marzocchetti A, Lima M, Tompkins T, et al
Virology. 2008 Dec 4.
Abstract

Immune Reconstitution Associated With Progressive Multifocal Leukoencephalopathy in Human
Immunodeficiency Virus: A Case Discussion and Review of the Literature.
Travis J, Varma A, Duplessis D,
Neurologist. 2008 Sep;14(5):321-326.
Abstract

Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired
immunodeficiency syndrome patient
Bernal-Cano F, Joseph JT, Koralnik IJ.
J Neurovirol. 2007 Sep;13(5):474-476.
Abstract

Longitudinal study of two cases of progressive multifocal leukoencephalopathy with a clinical
benign evolution.
Delbue S, Marchioni E, Sotgiu G, et al
J Neurovirol. 2007 Jun;13(3):268-73.
Abstract

Progressive multifocal leukoencephalopathy--epidemiology, clinical pictures, diagnosis
and therapy
Kishida S.
Brain Nerve. 2007 Feb;59(2):125-37.
Abstract

Frequency and phenotype of JC Virus-specific CD8+ T lymphocytes in the peripheral blood
of patients with Progressive Multifocal Leukoencephalopathy.
Lima MA, Marzocchetti A, Autissier P, et al
J Virol. 2007 Jan 17;
Abstract

New trends in progressive multifocal leukoencephalopathy.
Gasnault J, Taoufik Y .
Rev Neurol (Paris). 2006 Jan;162(1):43-56
Abstract

Changes in the natural history of progressive multifocal leukoencephalopathy in HIV-negative
lymphoproliferative disorders: Impact of novel therapies.
Garcia-Suarez J, de Miguel D, Krsnik I, Banas H,
Am J Hematol. 2005 Nov 28;80(4):271-281
Abstract

Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune
restoration in AIDS-related progressive multifocal leukoencephalopathy.
Vendrely A, Bienvenu B, Gasnault J, et al
Acta Neuropathol (Berl). 2005 Mar 1;
Abstract

Progressive Multifocal Leukencephalopathy in Patients on Highly Active Antiretroviral
Therapy: Survival and Risk Factors of Death.
Wyen C, Hoffmann C, Schmeier N
J Acquir Immune Defic Syndr. 2004 Oct 1;37(2):1263-1268.
Abstract

New insights into progressive multifocal leukoencephalopathy.
Koralnik IJ
Curr Opin Neurol. 2004 Jun;17(3):365-70.
Abstract

The evolving face of human immunodeficiency virus-related progressive
multifocal leukoencephalopathy: Defining a consensus terminology.
Cinque P, Koralnik IJ, Clifford DB.
J Neurovirol 2003 Apr;9 Suppl 1:88-92
Abstract

Unusual viral infections (progressive multifocal leukoencephalopathy and
cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell
rescue and peritransplantation rituximab.
Goldberg SL, Pecora AL, Alter RS , et al.
Blood 2002 Feb 15;99(4):1486-8
Abstract

Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy
patients with a CTL responsespecific for a commonly recognized JC virus epitope
Koralnik IJ, Du Pasquier RA, Kuroda MJ
J Immunol 2002 Jan 1;168(1):499-504
Abstract

JCV-specific cellular immune response correlates with a favorable clinical outcome in
HIV-infected individuals with progressive multifocal leukoencephalopathy.
Du Pasquier RA, Clark KW, Smith PS et al.
J Neurovirol 2001 Aug;7(4):318-22
Abstract

Epidemiology

Journal Papers, Abstracts, and Commentaries

Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome:
Explaining the high incidence and disproportionate frequency of the illness relative to other
immunosuppressive conditions.
Berger JR.
Neurovirol 2003 Apr;9 Suppl 1:38-41
Abstract

Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era
of highly active antiretroviral therapy:Data from the Italian Registry Investigative Neuro AIDS
(IRINA).
Antinori A, Cingolani A, Lorenzini P, et al.
J Neurovirol 2003 Apr;9 Suppl 1:47-53
Abstract

Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: Is
there a biological explanation?
Shankar S, Satishchandra P, Mahadevan A et al J
Neurovirol 2003 Apr;9(Supplement 1):59-67
Abstract

Diagnosis

Journal Papers, Abstracts, and Commentaries

Use of Diffusion-Weighted Imaging to Evaluate the Initial Response of Progressive
Multifocal Leukoencephalopathy to Highly Active Antiretroviral Therapy:
Early Experience.
Buckle C, Castillo M.
AJNR Am J Neuroradiol. 2010 Apr 1
Abstract

Improved detection of JC virus in AIDS patients with progressive multifocal leukoencephalopathy
by T-antigen specific fluorescence resonance energy transfer hybridization probe real-time PCR
Evidence of diverse JC virus genotypes associated with progressive multifocal leukoencephalopathy
in Southern Africa.
Glass AJ, Venter M.
J Med Virol. 2009 Sep 22;81(11):1929-1937
Abstract

Effective use of JC virus PCR for diagnosis of progressive multifocal leukoencephalopathy.
Wang Y, Kirby JE, Qian Q.J
Med Microbiol. 2009 Feb;58(Pt 2):253-5.
Abstract

Clinical Management

Journal Papers, Abstracts, and Commentaries

Treatment options for AIDS patients with progressive multifocal leukoencephalopathy.
Hern�ndez B, Dronda F, Moreno S.
Expert Opin Pharmacother. 2009 Feb;10(3):403-16.
Abstract

PML-IRIS in patients with HIV infection. Clinical manifestations and treatment with steroids.
Tan K, Roda R, Ostrow L, McArthur J, Nath A.
Neurology. 2009 Jan 7.
Abstract

Incidence, Clinical Presentation, and Outcome of Progressive Multifocal Leukoencephalopathy in
HIV-Infected Patients during the Highly Active Antiretroviral Therapy Era: A Nationwide Cohort Study.
Engsig FN, Hansen AB, Omland LH,et al
J Infect Dis. 2008 Nov 13.
Abstract

Remission of progressive multifocal leukoencephalopathy and primary central nervous system
lymphoma in an HIV-infected patient.
Lima MA, Katz-Brull R, Lenkinski RE, et al
Eur J Neurol. 2007 Jun;14(6):598-602.
Abstract

AIDS-Related Progressive Multifocal Leukoencephalopathy in the Era of HAART:
Report of Two Cases and Review of the Literature.
Wyen C, Lehmann C, Fatkenheuer G, Hoffmann C.
AIDS Patient Care STDS. 2005 Aug;19(8):486-94.
Abstract

The effect of highly active antiretroviral therapy-induced immune reconstitution on
development and outcome of progressive multifocal leukoencephalopathy: Study of 43
cases with review of the literature.
Cinque P, Bossolasco S, Brambilla AM, et al
J Neurovirol 2003 Apr;9 Suppl 1:73-80
Abstract

Inflammatory reaction in progressive multifocal leukoencephalopathy:Harmful or
beneficial?
Pasquier RA, Koralnik IJ.
J Neurovirol 2003 Apr;9 Suppl 1:25-31
Abstract

Fatal immune restoration disease in human immunodeficiency virus type1-infected
patients with progressive multifocal leukoencephalopathy: impact of antiretroviral
therapy-associated immune reconstitution.
Safdar A, Rubocki RJ, Horvath JA, et al
Clin Infect Dis 2002 Nov 15;35(10):1250-7
Abstract

Conference Reports, Abstracts, and Posters

Progressive multifocal leukoencephalopathy (PML) in AIDS patients receiving
potent antiretroviral therapies: changes in clinical presentation, diagnosis, and
prognosis
I. Corra, J.L. Casado, J. Garcia, et al
(5th IAS Conference)
Abstract

Drugs

Cidofovir

Journal Papers, Abstracts, and Commentaries

A WEEK-IN-REVIEW FEATURED REPORT
Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal
leukoencephalopathy.
Kraemer C, Evers S, Nolting T, et al
J Neurol. 2008 Jan 18
Abstract

Prolonged survival in AIDS-related progressive multifocal leukoencephalopathy following
anti-retroviral therapy and cidofovir.
Roberts MT, Carmichael A, Lever AM.
Int J Antimicrob Agents 2003 Apr;21(4):347-9
Abstract

A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS.
Marra CM, Rajicic N, Barker DE, et al.
AIDS 2002 Sep 6;16(13):1791-1797
Abstract

Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: A monocenter
observational study with clinical and JC virus load monitoring.
Gasnault J, Kousignian P, Kahrama et al.
J Neurovirol 2001 Aug;7(4):375-81
Abstract

Efalizumab
Journal Papers, Abstracts, and Commentaries
	Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Carson KR, Focosi D, Major EO, et al Lancet Oncol. 2009 Aug;10(8):816-24. Abstract

Mefloquine

Journal Papers, Abstracts, and Commentaries

A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes.
Clifford DB, Nath A, Cinque P, et al
J Neurovirol. 2013 Jun 4
Abstract

Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient.
Adachi E, Koibuchi T, Imai K, et al
Int J STD AIDS. 2012 Aug;23(8):603-
Abstract

Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient
nfected with human immunodeficiency virus.
Moenster RP, Jett RA.
Am J Health Syst Pharm. 2012 Mar 15;69(6):496-8.
Abstract

Maraviroc

Journal Papers, Abstracts, and Commentaries

Clinical and immunologic effects of maraviroc in progressive multifocal leukoencephalopathy.
Middel A, Arends JE, van Lelyveld SF, et al
Neurology. 2015 Jun 3
Abstract

Mirtazapine

Journal Papers, Abstracts, and Commentaries

Mirtazapine in an HIV-1 infected patient with progressive multifocal leukoencephalopathy.
Lanzafame M, Ferrari S, Lattuada E, et al
Infez Med. 2009 Mar;17(1):35-7.
Abstract

Mirtazapine Use in Human Immunodeficiency Virus-Infected Patients With Progressive Multifocal
Leukoencephalopathy.
Cettomai D, McArthur JC.
Arch Neurol. 2009 Feb;66(2):255-258
Abstract

Natalizumab
Journal Papers, Abstracts, and Commentaries
	Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Carson KR, Focosi D, Major EO, et al Lancet Oncol. 2009 Aug;10(8):816-24. Abstract

Rituximab
Journal Papers, Abstracts, and Commentaries
	Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Carson KR, Focosi D, Major EO, et al Lancet Oncol. 2009 Aug;10(8):816-24. Abstract

Topotecan

Journal Papers, Abstracts, and Commentaries

Topotecan in the Treatment of Acquired Immunodeficiency Syndrome-Related
Progressive Multifocal Leukoencephalopathy.
Royal III W, Dupont B, McGuire D, et al
J Neurovirol 2003;9(3):411-419
Abstract

Case Reports/Literature Reviews

Journal Papers, Abstracts, and Commentaries

Unmasking of progressive multifocal leukoencephalopathy in a patient with HIV-2.
Toby M, Siddiqui A, Kulasegaram R.
Int J STD AIDS. 2012 Nov;23(11):827-9..
Abstract

FULL-TEXT ARTICLE
Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy
in a man with AIDS.
Yoganathan K, Brown D, Yoganathan K.
Int J Gen Med. 2012;5:331-4.
Paper

Progressive multifocal leukoencephalopathy in an HIV patient receiving successful
long-term HAART.
Mascarello M, Lanzafame M, Lattuada E, Concia E, Ferrari S.
J Neurovirol. 2011 Mar 29.
Abstract

Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable
disorder
Martinez JV, Mazziotti JV, Efron ED. et al
Neurology. 2006 Nov 14;67(9):1692-4
Abstract

CNS Main Page

Main New/Newsworthy

Home Page

HIV -Associated Progressive Multifocal Leukoencephalopathy