MAC

Medical Advocates
Mycobacterium avium complex

Drugs

General Reports
Clarithromycin
Ethambutol
Infliximab.
Interferon
Mefloquine/Moxifloxacin/Ethambutol
Picolinic Acid/Quinacrine
Rifabutin

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Last Update: March 18, 2017
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General Reports

Journal Papers, Abstracts, and Commentaries

The Microbiological and Clinical Effects of Combined Therapy according to Guidelines on the
Treatment of Pulmonary Mycobacterium avium Complex Disease in Japan - Including a
Follow-Up Study.
Kobashi Y, Matsushima T.
Respiration. 2006 Sep 5;
Abstract

Combined effects of ATP on the therapeutic efficacy of antimicrobial drug regimens against
Mycobacterium avium complex infection in mice and roles of cytosolic phospholipase A2-
dependent mechanisms in the ATP-mediated potentiation of antimycobacterial host resistance.
Tomioka H, Sano C, Sato K, et al
J Immunol. 2005 Nov 15;175(10):6741-9.
Abstract

Clarithromycin

Journal Papers, Abstracts, and Commentaries

Clinical comparison of male and female patients with pulmonary disease caused by Mycobacterium
avium complex (P-MAC)
Morimoto K, Ishikawa R, Moriya A, et al
Kekkaku. 2008 Nov;83(11):711-5
Abstract

Concentrations of clarithromycin and active metabolite in the epithelial lining fluid of patients with
Mycobacterium avium complex pulmonary disease.
Hasegawa N, Nishimura T, Watabnabe M, et al
Pulm Pharmacol Ther. 2008 Nov 21.
Abstract

Clinical features and treatment history of clarithromycin resistance in M. avium-intracellulare
complex pulmonary disease patients
Kuwabara K, Tsuchiya T Nihon Kokyuki
Gakkai Zasshi. 2007 Aug;45(8):587-92
Abstract

Efficacy and outcomes of clarithromycin treatment for pulmonary MAC disease.
Fujikane T, Fujiuchi S, Yamazaki Y, et al
Int J Tuberc Lung Dis. 2005 Nov;9(11):1281-7.
Abstract

Prophylactic clarithromycin to treat mycobacterium avium in HIV patients receiving
zidovudine may significantly increase mortality by suppressing lymphopoiesis and
hematopoiesis.
Freund YR, Dousman L, Mohagheghpour N. et al .
Int Immunopharmacol 2002 Sep;2(10):1465-75
Abstract

Ethambutol

Journal Papers, Abstracts, and Commentaries
	Ethambutol Ocular Toxicity in Treatment Regimens for Mycobacterium avium Complex Lung Disease. Griffith DE, Brown-Elliott BA, et al Am J Respir Crit Care Med. 2005 Apr 28; Abstract

Infliximab

Journal Papers, Abstracts, and Commentaries
	Mycobacterium Avium Complex Septic Arthritis in a Patient Treated by Infliximab. Chalhoub N, Georgescu C, Altorok N. Am J Ther. 2015 Aug 11. Abstract

Interferon

Journal Papers, Abstracts, and Commentaries
	Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS. Sekiguchi Y, Yasui K, Yamazaki T, et al Clin Infect Dis. 2005 Dec 1;41(11):e104-6. Abstract

Mefloquine/Moxifloxacin/Ethambutol

Journal Papers, Abstracts, and Commentaries

Mefloquine, moxifloxacin, and ethambutol are a triple-drug alternative to
macrolide-containing regimens for treatment of Mycobacterium avium disease.
Bermudez LE, Kolonoski P, Petrofsky M, et al
J Infect Dis. 2003 Jun 15;187(12):1977-80.
Abstract

Picolinic Acid/Quinacrine

Journal Papers, Abstracts, and Commentaries
	Activity of picolinic acid in combination with the antiprotozoal drug quinacrine against Mycobacterium avium complex. Shimizu T, Tomioka H. Antimicrob Agents Chemother. 2006 Sep;50(9):3186-8. Abstract

Rifabutin

Journal Papers, Abstracts, and Commentaries

Effect of a 150 mg dose of rifabutin on serum itraconazole levels in patients with coexisting chronic pulmonary aspergillosis and Mycobacterium avium complex lung disease.
Moon SM, Jhun BW, Lee H,et al
J Infect Chemother. 2017 Mar 8.
Abstract

Rifabutin corneal deposits in a patient with acquired immunodeficiency syndrome:
in vivo confocal microscopy investigation.
Mazzotta C, Traversi C, Nuti E, et al
Eur J Ophthalmol. 2009 May-June;19(3):481-483.
Abstract

Rifabutin-induced Hypopyon Uveitis in Patients with Acquired Immunodeficiency Syndrome
Infected with Mycobacterium avium Complex.
Wang HH, Chung YM, Lin YC, et al
J Chin Med Assoc. 2007 Mar;70(3):136-9.
Abstract

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Mycobacterium avium Complex Drugs