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Abacavir (Ziagen)
 
Pediatric Index

Pharmacokinetics
 Viral Dynamics
 Efficacy
Adverse Events
 Adherence
 Salvage Therapy
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Last Update:  February 02, 2018
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Pharmacokinetics
 

    Journal Papers, Abstracts, and Commentaries

 
Population pharmacokinetics of abacavir in infants, toddlers and children.
Zhao W, Piana C, Danhof M,  et al
Br J Clin Pharmacol. 2012 Nov 5.
 Abstract

Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir:
application of individualized therapy in HIV infected infants and toddlers.
Zhao W, Cella M, Della Pasqua O, et al
Br J Clin Pharmacol. 2011 Oct 11.
 Abstract

Abacavir and Metabolite Pharmacokinetics in HIV-1-Infected Children and Adolescents.
 Cross SJ, Rodman JH, Lindsey JC, et al
J Acquir Immune Defic Syndr. 2009 Mar 11
 Abstract

Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age
from 1 month to 16 years: a population analysis.
 Jullien V, Urien S, Chappuy H, et al  
J Clin Pharmacol. 2005 Mar;45(3):257-64.
Abstract
Viral Dynamics
 

    Journal Papers, Abstracts, and Commentaries
 
  Virologic Response in Children Treated with Abacavir Compared with Stavudine-Based Antiretroviral Treatment - A South African Multi-Cohort Analysis.
Technau KG, Schomaker M, Kuhn L, et al
Pediatr Infect Dis J. 2013 Dec 30.
 Abstract
Efficacy Data
 

    Journal Papers, Abstracts, and Commentaries

 

FULL-TEXT ARTICLE
 Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial.
 Mulenga V, Musiime V, Kekitiinwa A,  et al
Lancet Infect Dis. 2015 Oct 5
 Paper

FULL-TEXT ARTICLE
 Efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV infected children and adolescents: a systematic review and meta-analysis.
 Adetokunboh OO, Schoonees A, Balogun TA, Wiysonge CS.
BMC Infect Dis. 2015 Oct 26;15(1):469.
Paper

FULL-TEXT PDF ARTICLE
 Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol.
 Adetokunboh OO, Schoonees A, Wiysonge CS.
Syst Rev. 2014 Aug 12;3(1):87.
 Paper

Poor Early Virologic Performance and Durability of Abacavir-based First-line Regimens for HIV-infected Children.
Technau KG, Lazarus E, Kuhn L, et al
Pediatr Infect Dis J. 2013 Aug;32(8):851-855
 Abstract

A phase I study of abacavir (1592U89) alone and in combination with other antiretroviral
agents in infants and children with human immunodeficiency virus infection. AIDS Clinical
Trials Group 330 Team.
Kline MW, Blanchard S, Fletcher CV et al.
Pediatrics 1999; 103(4): e47.
Abstract

     Conference Reports, Abstracts and Posters

 

24-month treatment outcomes amongst HIV-positive children and adolescent patients prescribed stavudine vs. abacavir
A.T. Brennan, M. Maskew, L. Long
(XX International AIDS Conference)
 Abstract
Highly active antiretroviral therapy including high dose abacavir reduces cerebrospinal fluid human
immunodeficiency virus (HIV) RNA and soluble tumor necrosis factor II receptor in children with HIV
encephalopathy
Saavedra-Lozano, S Madison, et al
(14IAC)
 Abstract

Antiretroviral efficacy and tolerability of Abacavir (ABC) based regimens in a clinical cohort
of HIV-infected children
F Hoffmann, T Niehues, B Buchholz, et al
 (14IAC)
Abstract
Adherence
 

     Conference Reports, Abstracts and Posters

  Adherence and acceptability of once daily lamivudine and abacavir in HIV-1
infected children.
LeProvost M., Flynn J., Green H., Gibb D.M., et al
 (3rd IAS)
 Abstract
Adverse Events
 

    Journal Papers, Abstracts, and Commentaries

  HLA- B*5701 Allele in HIV-infected Indian Children and its Association with Abacavir Hypersensitivity.
Manglani MV, Gabhale YR, Lala MM, Sekhar R, More D.
 Indian Pediatr. 2017 Dec 14.
Abstract

Adverse events associated with abacavir use in HIV-infected children and adolescents: a systematic review and meta-analysis.
Jesson J, Dahourou DL, Renaud F, et al
Lancet HIV. 2016 Feb;3(2):e64-75
 Abstract
Salvage Therapy
 

    Journal Papers, Abstracts, and Commentaries
 
  Salvage Therapy With Abacavir and Other Reverse Transcriptase Inhibitors for Human
Immunodeficiency-Associated Encephalopathy.
 Saavedra-Lozano J, Ramos JT, Navarro ML, et al 
Pediatr Infect Dis J. 2006 Dec;25(12):1142-1152.
Abstract
 
Drug Failure
 

    Journal Papers, Abstracts, and Commentaries

  High Prevalence of Abacavir-Associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy.
Dziuban EJ, DeVos J, Ngeno B,  et al  
Pediatr Infect Dis J. 2017 Apr 5.
 Abstract

 

High Prevalence of Abacavir-Associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy.
Dziuban EJ, DeVos J, Ngeno B,  et al  Pediatr Infect Dis J. 2017 Apr 5.

 

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