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Dapivirine (TMC 120)

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Last Update: May 26, 2017
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New and Noteworthy

May 2017

Dapivirine vaginal ring use does not diminish the effectiveness of hormonal contraception.
Balkus JE, Palanee-Phillips T, Reddy K, et al J Acquir Immune Defic Syndr. 2017 May 23.

In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine and MIV-150: NNRTI Microbicides in Clinical Development for the Prevention of HIV-1 Infection.
Giacobbi NS, Sluis-Cremer N .Antimicrob Agents Chemother. 2017 May 15.

Journal Abstracts, Papers, and Commentaries

Dapivirine vaginal ring use does not diminish the effectiveness of hormonal contraception.
Balkus JE, Palanee-Phillips T, Reddy K, et al J Acquir Immune Defic Syndr. 2017 May 23.

In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine and MIV-150: NNRTI Microbicides in Clinical Development for the Prevention of HIV-1 Infection.
Giacobbi NS, Sluis-Cremer N .Antimicrob Agents Chemother. 2017 May 15.
Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ring.
McCoy CF, Murphy DJ, Boyd P, J
Pharm Sci. 2017 Apr 26
Abstract

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women.
Nel A, van Niekerk N, Kapiga S, et al
N Engl J Med. 2016 Dec;375(22):2133-2143.
Abstract

Pharmacokinetic Modeling of a Gel-Delivered Dapivirine Microbicide in Humans.
Halwes ME, Steinbach-Rankins JM, Frieboes HB.
Eur J Pharm Sci. 2016 Aug 21
Abstract

FULL-TEXT ARTICLE
Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial.
Dezzutti CS, Richardson-Harman N, Rohan LC, et al
Medicine (Baltimore). 2016 Jul;95(28):e4174.
Paper
Dezzutti CS, Richardson-Harman N, Rohan LC, et al
Medicine (Baltimore).(Baltimore). 2016 Jul;95(28):e4174.
Abstract

FULL TEXT ARTICLE
Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa
Nel A, Bekker LG, Bukusi E, et al
PLoS One. 2016 Mar 10;11(3):e0147743
Paper
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
Baeten JM, Palanee-Phillips T, Brown ER, et al N Engl J Med. 2016 Feb 22
A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film.
Bunge KE, Dezzutti CS, Rohan LC,et al
J Acquir Immune Defic Syndr. 2015 Nov 11
Abstract

Pharmacodynamic Activity of Dapivirine and Maraviroc Single Entity and Combination Topical Gels for HIV-1 Prevention.
Dezzutti CS, Yandura S, Wang L, et al
Pharm Res. 2015 Jun 16.
Abstract

Protection against re in macaques by rectal specific-gel formulations of maraviroc and tenofovir.ctal SHIV transmission
Dobard CW, Taylor A, Sharma S, et al
J Infect Dis. 2015 Jun 12|
Abstract

FULL TEXT ARTICLE
Characteristics of Women Enrolled into a Randomized Clinical Trial of Dapivirine Vaginal Ring for HIV-1 Prevention.
Palanee-Phillips T, Schwartz K, Brown ER, et al
PLoS One. 2015 Jun 10;10(6):e0128857.
Paper
A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women.
Nel A, Haazen W, Nuttall J, Romano J, et al
AIDS. 2014 Jun 19;28(10):1479-87.
Abstract

FULL TEXT ARTICLE
Increased Dapivirine tissue accumulation through vaginal film codelivery of dapivirine and Tenofovir.
Akil A, Devlin B, Cost M, Rohan LC.
Mol Pharm. 2014 May 5;11(5):1533-41
Paper
Dual quantification of dapivirine and maraviroc in cervicovaginal secretions from ophthalmic tear strips and polyester-based swabs via liquid chromatographic-tandem mass spectrometric (LC-MS/MS) analysis.
Parsons TL, Emory JF, Seserko LA, et al
J Pharm Biomed Anal. 2014 Sep;98:407-16.
Abstract

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.
Murphy DJ, Desjardins D, Dereuddre-Bosquet N, et al
J Antimicrob Chemother. 2014 May 26.
Abstract

Development of dapivirine vaginal ring for HIV prevention.
Devlin B, Nuttall J, Wilder S, et al
Antiviral Res. 2013 Oct 24.
Abstract

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Dapivirine (TMC 120)