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Darunavir (Prezista/TMC-114)
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Protease Inhibitors: General Data
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Pediatric Data
Perinatal  Data

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Last Update:  March 02, 2018

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New and Noteworthy

March 2018

February 2018



Pediatric Data

Journal  Abstracts, Papers and Commentaries
Pharmacokinetics, Short Term Safety and Efficacy of the Approved Once-Daily Darunavir/r Dosing Regimen in HIV-Infected Children.
Bastiaans DET, Geelen SPM, Visser EG, et al
Pediatr Infect Dis J
. 2018 Feb 22

Characteristics and early outcomes of children and adolescents treated with darunavir/ritonavir-, raltegravir- or etravirine-containing antiretroviral therapy in the Western Cape Province of South Africa.
Nuttall J, Pillay V.

S Afr Med J
. 2018 Feb 1;

Pharmacokinetics of Once-Daily Darunavir/Ritonavir With and Without Etravirine in Human Immunodeficiency Virus-Infected Children, Adolescents, and Young Adults.
Larson KB, Cressey TR, Yogev R,  et al

Pediatric Infect Dis Soc
. 2016 Jun;5(2):131

Safety of darunavir and atazanavir in HIV-infected children in Europe and Thailand.
European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord.
Antivir Ther
. 2015 Nov 12.

Darunavir: A Review in Pediatric HIV-1 Infection.
Keating GM.
Paediatr Drugs. 2015 Sep 1.

Model-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations in Pediatric HIV-1-Infected Patients Aged 3 to 12 Years
Brochot A, Kakuda TN, Van De Casteele T,
CPT Pharmacometrics Syst Pharmacol. 2015 Jul;4(7):406-414.

Desensitization to darunavir in a pediatric patient
Cambray-Gutiérrez JC, López-Pérez P, Chávez-García AA,
Rev Alerg Mex
. 2015 Jul-Sep;62(3):251-254

Safety and Efficacy of Darunavir/Ritonavir in Treatment-experienced Pediatric Patients: Week 48 Results of the ARIEL Trial.
Violari A, Bologna R, Kumarasamy N, et al
Pediatr Infect Dis J. 2015 Feb 21.

Pharmacokinetics and efficacy of darunavir/ritonavir once daily in virologically suppressed, treatment-experienced HIV-infected children.
Chokephaibulkit K, Rungmaitree S, Phongsamart W,  et al
HIV Med. 2014 Sep;15(8):511-2.

Early Outcomes of Darunavir- and/or Raltegravir-based Antiretroviral Therapy in Children with Multidrug-Resistant HIV at a Pediatric Center in Botswana.
Kirk BL, Gomila A, Matshaba M,   et al

J Int Assoc Physicians AIDS Care (Chic)
. 2013 Jan 11

Profile of darunavir in the treatment of HIV-infected pediatric and adolescent patients.
Dobroszycki J, Abadi J, Wiznia AA, Rosenberg MG.
Adolesc Health Med Ther
. 2011 Sep 14;2:85-93

The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK.
Donegan KL, Walker AS, Dunn D,
Antivir Ther. 2011 Dec 15.

Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced
children and adolescents
Blanche S, Bologna R, Cahn P, et al 
AIDS. 2009 Aug 30

Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.
Neely M, Kovacs A.
Ther Clin Risk Manag. 2009 Jun;5(3):595-615.

Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.
Neely M, Kovacs A.
Ther Clin Risk Manag. 2009 Jun;5(3):595-615

Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child
with vertically acquired multidrug-resistant HIV-1.
Viganò A, Meroni L, Marchetti G, et al

Antivir Ther. 2008;13(6):839-43.


Perinatal Data

          Journal  Abstracts, Papers and Commentaries
  Pharmacokinetics of Once versus Twice Daily Darunavir In Pregnant HIV-Infected Women.
Stek A, Best BM, Wang J,  et al
J Acquir Immune Defic Syndr. 2015 May 6

Pharmacokinetics of total and unbound darunavir in HIV-1-infected pregnant women.
Colbers A, Moltó J, Ivanovic J, et al 

J Antimicrob Chemother
. 2014 Oct 17

Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily.
Zorrilla C, Wright R, Osiyemi O, et al
HIV Med. 2013 Jun 3.

Total and unbound darunavir (DRV) pharmacokinetics (PK) in HIV-1-infected pregnant women.
Zorrilla C, Wright R, Osiyemi O,  et al

J Int AIDS Soc
. 2012 Nov 11;15(6):18340

Use of darunavir and enfuvirtide in a pregnant woman.
Sued O, Lattner J, Gun A, et al
. 2008 Dec;19(12):866-7.

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Darunavir (Prezista/TMC114)