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New and Noteworthy
       

March 2015

Journal Papers, Abstracts, and Commentaries
General Reports Pharmacokinetics Resistance Adverse Events Efficacy

General Reports
 
  Vibrational and thermal analyses of multicomponent crystal forms of the anti-HIV drugs lamivudine and zalcitabine.
Martins FT, Guimar„es FF, Honorato SB,  et al
J Pharm Biomed Anal
.
2015 Mar 11;110:76-82.

Abstract

Pharmacokinetics
 

  FULL-TEXT ARTICLE
Pharmacokinetics and Distribution over the Blood-Brain Barrier of Zalcitabine (2',3'-ideoxycytidine)
and BEA005 (2',3'-Dideoxy-3'-Hydroxymethylcytidine) in Rats, Studied by Microdialysis .
Borg N, Stahle L.
Antimicrob Agents Chemother
1998 Sep;42(9):2174-2177
Paper
   
  FULL-TEXT ARTICLE
Zalcitabine Population Pharmacokinetics: Application of Radioimmunoassay.

Adams JM, Shelton MJ, Hewitt RG,  et al  
Antimicrob Agents Chemother 1998 Feb;42(2):409-413
Paper

Viral Dynamics

Resistance

  FULL-TEXT ARTICLE
Early Virological Failure in Naive Human Immunodeficiency Virus Patients Receiving Saquinavir
(Soft Gel Capsule)-Stavudine-Zalcitabine (MIKADO Trial) Is Not Associated with Mutations Conferring
Viral Resistance.

Mouroux M, Yvon-Groussin A, Peytavin G, et al.
J
Clin Microbiol 2000 Jul;38(7):2726-2730
Paper

Adverse Events

  Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or
zalcitabine
.
Walker UA, Bauerle J, Laguno M, et al.  
Hepatology. 2004 Feb;39(2):311-7.
Abstract

Efficacy

  Management of HIV infection in Nigeria with zalcitabine in combination with saquinavir mesylate:
preliminary findings.
Akinsete I, Njoku OS, Okanny CC,et al. 
West Afr J Med 2000 Oct;19(4):265-268
Abstract
   
  FULL-TEXT ARTICLE
Early Virological Failure in Naive Human Immunodeficiency Virus Patients Receiving Saquinavir
(Soft Gel Capsule)-Stavudine-Zalcitabine (MIKADO Trial) Is Not Associated with Mutations
Conferring Viral Resistance.
Mouroux M, Yvon-Groussin A, Peytavin G, et al.
J
Clin Microbiol 2000 Jul;38(7):2726-2730
Paper

Conference Reports, Abstracts, and Posters
         

15th CROI
 

Perinatal
Guidelines        

United States

     Internet Documents

  FULL TEXT PDF DOCUMENT
Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs
in Pregnant HIV-Infected Women for Maternal Health and Interventions to Reduce
Perinatal HIV  Transmission in the United States.
Perinatal HIV Guidelines Working Group.
November 2, 2007

Guidelines

 
  FULL TEXT PDF DOCUMENT
Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy
Perinatal HIV Guidelines Working Group.
November 2, 2007
Guidelines

Pediatric Data
Guidelines Monotherapy      

Prevention/Treatment Guidelines and Recommendations

US Treatment Guidelines

Monotherapy

    Journal Papers, Abstracts, and Commentaries

  Dideoxycytidine alone and in an alternating schedule with zidovudine (AZT) in children with
symptomatic human immunodeficiency virus infection.
Pizzo PA, Butler K, Balis F et al.

Journal of Pediatrics
1990; 117: 799-808.
Abstract
   
  Phase I evaluation of zalcitabine administered to human immunodeficiency virus-infected
children. Chadwick EG, Nazareno LA, Nieuwenhuis TJ et al.
Journal of Infectious Disease 1995; 172(6): 1475- 1479.
Abstract
   
  Comparative trial of two dosages of zalcitabine in zidovudine- experienced children with advanced
human immunodeficiency virus disease.
Spector SA, Blanchard S, Wara DW et al. Pediatric AIDS Clinical Trials Group.

Pediatric Infectious Disease Journal
1997; 16(6): 623-626.
Abstract


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