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Efavirenz
(Sustiva/Strocrin)
 
Journal Citations: Adult/Adolescent Treatment

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Dosage
Quality of Life
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Last Update:  March 10, 2018
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General Reports
           

 

IAssociation of CYP2B6 Single-Nucleotide Polymorphisms Altering Efavirenz Metabolism With Hepatitis C Virus (HCV) Treatment Relapse Among Human Immunodeficiency Virus/HCV-Coinfected African Americans Receiving Ledipasvir/Sofosbuvir in the ION-4 Trial.
Kleinstein SE, Shea PR, Stamm LM, et al 
Clin Infect Dis
. 2018 Mar 7.
Abstract

Efavirenz is related to neuropsychiatric symptoms among adults, but not among adolescents living with HIV in Kilimanjaro, Tanzania.
Boer MS, Schellekens A, Duinmaijer A, et alT
r
op Med Int Health
. 2017 Dec 8
Abstract

Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults.
Marzolini C, Sabin C, Raffi F,  et al
AIDS. 2014 Nov 25
Abstract

FULL-TEXT ARTICLE
Single tablet regimens are associated with reduced Efavirenz withdrawal in antiretroviral therapy naive or switching for simplification HIV-infected patients.

Fabbiani M, Zaccarelli M, Grima P,
BMC Infect Dis. 2014 Jan 13;14(1):26
Paper

Plasma concentrations of efavirenz with a 600 mg standard dose in Cambodian HIV-infected adults treated for tuberculosis with a body weight above 50 kg.
Borand L, Laureillard D, Madec Y,  et al
Antivir Ther
. 2012 Dec 12.
Abstract

The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study.
The HIV-CAUSAL Collaboration.
AIDS
. 2012 Apr 26.
Abstract

FULL-TEXT PDF ARTICLE
Effects of vitamin D supplementation on the bone specific biomarkers in HIV infected individuals under treatment with efavirenz.
Etminani-Esfahani M, Khalili H, Jafari S,  et al
BMC Res Notes
. 2012 Apr 26;5(1):204
Paper"

FULL-TEXT ARTICLE

Effects of Maraviroc and Efavirenz on Markers of Immune Activation and Inflammation and Associations with CD4 Cell Rises in HIV-Infected Patients.
Funderburg N, Kalinowska M, Eason J, et al
 
PLoS One
. 2010 Oct 6;5(10). pii: e13188.
Paper

Change in High-Sensitivity C-Reactive Protein (hsCRP) Levels following Initiation of Efavirenz-Based Antiretroviral Regimens in HIV-infected Individuals.
Shikuma C, Ribaudo HJ, Zheng Y, et al
AIDS Res Hum Retroviruses
. 2010 Sep 23.
Abstract

Quantifying the risks and benefits of efavirenz use in HIV-infected women of childbearing age in the USA.
Hsu H, Rydzak C, Cotich K,  et al;
HIV Med
. 2010 Jun 17.
Abstract

The relation between treatment outcome and efavirenz, atazanavir or lopinavir exposure in the NORTHIV trial of treatment-naïve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al 
Eur J Clin Pharmacol
.
2010 Apr;66(4):349-57
Abstract


Dosage
           

 
Antiretroviral dose optimization: the future of efavirenz 400 mg dosing.
Boffito M, Lamorde M, Watkins M, Pozniak A.
Curr Opin HIV AIDS
. 2017 Jul;12(4):339-342.
Abstract

Pharmacokinetic and Pharmacodynamic Comparison of Once Daily Efavirenz (400mg Versus 600mg) in Treatment-Naïve HIV-Infected Patients: Results of the ENCORE1 Study.
Dickinson L, Amin J, Else L, et al
Clin Pharmacol Ther
. 2015 Jun 5.
Abstract


Quality of Life Studies
           

 
Virologic Suppression, Treatment Adherence, and Improved Quality of Life on a Once-Daily Efavirenz-Based Regimen in Treatment-Naïve HIV-1-Infected Patients Over 96 Weeks.
J
ayaweera D, Dejesus E, Nguyen KL, et al 
HIV Clin Trials
. 2009 Nov-Dec;10(6):375-84
Abstract

Central Nervous System Benefits
 

  Cerebrospinal-fluid exposure of efavirenz and its major metabolites when dosed at 400 and 600 mg once daily; a randomised controlled trial.
Winston A, Amin J, Clarke A. et al
Clin Infect Dis
. 2014 Dec 11. pii: ciu976.
Abstract

Neuropsychometric Correlates of Efavirenz Pharmacokinetics and Pharmacogenetics Following a Single Oral Dose.
Johnson DH, Gebretsadik T, Shintani A,  et alr
J Clin Pharmacol
. 2012 Sep 7
Abstract

 

Efficacy
General Studies                    HIV/TB

General  HIV Studies

 
Virologic suppression and CD4 cell count recovery after initiation of raltegravir- or efavirenz- containing HIV treatment regimens.
Edwards JK, Cole SR, Hall HI, et al
AIDS. 2017 Nov 2
Abstract

HIV Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Reduces Neural Stem Cell Proliferation in Vitro and in Vivo.
Jin J, Grimmig B, Izzo J, Brown LAM,  et al
Cell Transplant. 2016 Nov;25(11):
Abstract


HIV Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Reduces Neural Stem Cell Proliferation in Vitro and in Vivo.
Jin J, Grimmig B, Izzo J, Brown LAM,  et al
Cell Transplant. 2016 Nov;25(11)
:
Abstract

Efavirenz or nevirapine in three-drug combination therapy with two nucleoside or nucleotide-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-naïve individuals.
Mbuagbaw L, Mursleen S, Irlam JH, et al
Cochrane Database Syst Rev
. 2016 Dec 10;12:CD004246
Abstract

Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients.
Bouazza N, Cressey TR, Foissac F,  et al 
J Antimicrob Chemother
. 2016 Oct 24.
Abstract

Different impact of raltegravir versus efavirenz on CD4/CD8 ratio recovery in HIV-infected patients.
Serrano-Villar S, Zhou Y, Rodgers AJ, Moreno S.
J Antimicrob Chemother. 2016 Sep 21
Abstract

FULL-TEXT ARTICLE
Complete dataset for 2-treatment, 2-sequence, 2-period efavirenz bioequivalence study conducted with nightly dosing.
Ibarra M, Magallanes L, Lorier M, et al
Data Brief
. 2016 Mar 15;7:751-4.
Paper

FULL-TEXT ARTICLE
Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial.
Serrano-Villar S, Sainz T, Ma ZM,  et al
PLoS Pathog
. 2016 Jan 21;12(1):e1005381|
Paper

Efavirenz (EFV) but not Atazanavir/ritonavir (ATV/r) Significantly Reduces Atovaquone Concentrations in HIV-infected Subjects.
Calderón MM, Penzak SR, Pau AK,,et a
lClin Infect Dis. 2016 Jan 20.
Abstract

FULL-TEXT ARTICLE
Efavirenz-Based Regimens in Antiretroviral-Naive HIV-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Kryst J, Kawalec P, Pilc A. et al 
PLoS On
e
. 2015 May 1;10(5):e0124279
Paper

FULL-TEXT ARTICLE
Prospective Immune Dynamics during the First 24 Weeks of Efavirenz Based-Antiretroviral Therapy in HIV-1-Infected Subjects, According to CD4+ T-Cell Counts at Presentation: The IMMUNEF Clinical Trial.
Soria A, Trabattoni D, Squillace N,  et al
PLoS One
. 2015 Feb 11;10(2):e0117118.
Paper

Use of efavirenz or atazanavir/ritonavir is associated with better clinical outcomes of HAART compared to other protease inhibitors: routine evidence from the Italian MASTER Cohort.
Postorino MC, Prosperi M, Quiros-Roldan E, et al
Clin Microbiol Infect. 2014 Nov 11. pii: S1198-743X(14)00088-3.
Abstract

Week 48 results of a Phase IV trial of etravirine with antiretrovirals other than darunavir/ritonavir in HIV-1-infected treatment-experienced adults.
Arathoon E, Bhorat A, Silaghi R,  et al  
J Int AIDS Soc
. 2014 Nov 2;17(4 Suppl 3):19783
Abstract

Virologic and immunologic responses in treatment-naive patients to ritonavir-boosted atazanavir or efavirenz with a common backbone.
Wang Q, Young J, Bernasconi E, Vernazza P, et al
HIV Clin Trials
. 2014 May-Jun;15(3):92-103.
Abstract

Comparing the efficacy of efavirenz and boosted lopinavir using viremia copy-years.
Lima VD, Sierra-Madero J, Wu Z,  et a;
J Int AIDS So
c
. 2014 May 6;17(1):18617.
Abstract

Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial.
ENCORE1 Study Group.
Lancet. 2014 Feb 7. pii: S0140-6736(13)62187-X.
Abstract

Outcomes In Older Versus Younger Patients Over 96 Weeks In Hiv-1-Infected Patients Treated With Rilpivirine Or Efavirenz In Echo And Thrive
Ryan R, Dayaram YK, Schaible D,  et al
Curr HIV Res
. 2014 Jan 28
Abstract

Effectiveness of efavirenz compared with ritonavir-boosted protease inhibitor-based regimens as initial therapy for patients with plasma HIV-1 RNA above 100,000 copies/ml.
Imaz A, Llibre JM, Navarro J,  et al
Antivir Ther
. 2014 Jan 23.
Abstract

FULL=TEXT ARTICLE
Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations.
Ngaimisi E, Habtewold A, Minzi O,  et al
PLoS One
. 2013 Jul 5;8(7):e67946.
Paper

Efavirenz Outperforms Boosted Atazanavir among Treatment-Naive HIV-1-Infected Persons in Routine Clinical Care.
Taniguchi T, Grubb JR, Nurutdinova D, et al
J Int Assoc Physicians AIDS Care (Chic). 2012
Abstract

Rilpivirine. First-line treatment of HIV infection: efavirenz is better documented.
[No authors listed]
Prescrire Int. 2012 Nov;21(132):262-5
Abstract

FULL-TEXT ARTICLE
Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings.
Campbell TB, Smeaton LM, Kumarasamy N,  et al
PLoS Med
. 2012 Aug;9(8):e1001290.
Paper

Long term outcomes of nevirapine containing antiretroviral therapy at a center in Thailand.
Htun WL, Bowonwatanuwong C, Phonrat B, Pitisuttithum P.
Southeast Asian J Trop Med Public Health
. 2012 Jul;43(4):860-70.
Abstract

FULL-TEXT ARTICLE
Efavirenz conceptions and regimen management in a prospective cohort of women on antiretroviral therapy.
Schwartz S, Taha TE, Venter WD, et al
Infect Dis Obstet Gynecol
. 2012;2012:723096.
Paper

Comparative Effectiveness of Initial Antiretroviral Therapy Regimens: ACTG 5095 and 5142 Clinical Trials Relative to ART-CC Cohort Study.
Mugavero MJ, May M, Ribaudo HJ, et al
J Acquir Immune Defic Syndr
. 2011 Aug 18

Abstract

Failure of Initial Therapy With Two Nucleosides and Efavirenz Is Not Associated With Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase.
Brehm JH, Lalama CM, Hughes MD, et al
J Acquir Immune Defic Syndr. 2011 Apr;56(4):344-348.
Abstract

Minimum effective plasma concentration of efavirenz in treatment-naive Chinese HIV-infected patients.
Sun J, Chen J, Yao Y, et al
Int J STD AIDS. 2010 Dec;21(12):810-3.
Abstract

Maraviroc versus Efavirenz, Both in Combination with Zidovudine-Lamivudine, for the Treatment of Antiretroviral-Naive
Subjects with CCR5-Tropic HIV-1 Infection.
Cooper DA, Heera J, Goodrich J,  et al
J Infect Dis
. 2010 Feb 12.
Abstract

Prospective, Randomized, Open Label Trial of Efavirenz vs Lopinavir/Ritonavir in HIV+ Treatment-Naive Subjects With CD4+<200 cell/mm3 in Mexico.
Sierra-Madero J, Villasis-Keever A, Méndez P,et al
J Acquir Immune Defic
Syndr
. 2010 Jan 20
Abstract

Efavirenz in the therapy of HIV infection.
Rakhmanina NY, van den Anker JN.
Expert Opin Drug Metab Toxicol
. 2010 Jan;6(1):95-103
Abstract

 

 
HIV/HCV Studies
 
  Long-term safety and tolerability of nevirapine and efavirenz-containing regimens in HIV/HCV-coinfected patients.
Mauelshagen A, Horst H, Stellbrink H, Hoffmann C.
J Int AIDS Soc. 2012 Nov 11;15(6):18416.
Abstract


 

HIV/TB Studies
 
 
FULL-TEXT ARTICLE
Plasma Concentrations, Efficacy and Safety of Efavirenz in HIV-Infected Adults Treated for Tuberculosis in Cambodia (ANRS 1295-CIPRA KH001 CAMELIA Trial).
Borand L, Madec Y, Laureillard D, et al
PLoS One. 2014 Mar 7
Paper 

CYP2B6 G516T and ABCB-1 C3435T polymorphisms: implications for efavirenz-associated liver toxicity in HIV/tuberculosis co-infected Thai adults.
Uttayamakul S, Manosuthi W, Likanonsakul S,  et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18409.
Abstract

Impact of pharmacogenetic markers of CYP2B6 and clinical factors on plasma efavirenz level in HIV/tuberculosis co-infected Thai patients.
Manosuthi W, Sukasem C, Lueangniyomkul A, et al 
J Int AIDS Soc
. 2012 Nov 11;15(6):18410

Abstract


Drug Failure
       

 
CYP2B6 516G&gt;T Minor Allele Protective of Late Virologic Failure in Efavirenz-treated HIV-Infected Patients in Botswana.
Vujkovic M, Bellamy SL, Zuppa AF,  et al
J Acquir Immune Defic Syndr
. 2017 May 5
Abstract

FULL-TEXT PDF ARTICLE
Plasma Concentrations of Efavirenz and Nevirapine among HIV-Infected Patients with Immunological Failure Attending a Tertiary Hospital in North-Western Tanzania.
Gunda DW, Kasang C, Kidenya BR,  et al
PLoS One. 2013 Sep 10;8(9):e75118
Paper

Discontinuation of efavirenz therapy in HIV patients due to neuropsychiatric adverse effects.
Leutscher PD, Stecher C, Storgaard M, Larsen CS.
Scand J Infect Dis. 2013 Feb 21.
Abstract

Virological failure of staggered and simultaneous treatment interruption in HIV patients who began Efavirenz-based regimens after allergic reactions to nevirapine.
Siripassorn K, Manosuthi W, Pakdee A,  et al
AIDS Res Ther. 2013 Jan 25;10(1):4.
Abstract

Prevalence of etravirine resistance associated mutations in HIV-1 strains isolated from infected individuals failing efavirenz: comparison between subtype B and non-B genetic variants.
Pereira-Vaz J, Duque V, Pereira B, et al
J Med Virol
. 2012 Apr;84(4):551-4.
Abstract

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.
Wyen C, Hendra H, Siccardi M, et al
J Antimicrob Chemother. 2011 
2011 Jun 29.
Abstract


Drug Comparison Studies
       

 
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: A prospective study of HIV-positive individuals.
Cain LE, Caniglia EC, Phillips A,  et al
Medicine (Baltimore)
. 2016 Oct;95(41):e5133.
Abstract

Rilpivirine vs. efavirenz-based single-tablet regimens in treatment-naive adults: week 96 efficacy and safety from a randomized phase 3b study.|
van Lunzen J, Antinori A, Cohen CJ, et al
AIDS
. 2016 Jan;30(2):251-9.
Abstract

Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women.
Cohan D, Natureeba P, Koss CA, et al
AIDS
. 2014 Nov 25.
Abstract

Use of efavirenz or atazanavir/ritonavir is associated with better clinical outcomes of HAART compared to other protease inhibitors: routine evidence from the Italian MASTER Cohort.
Postorino MC, Prosperi M, Quiros-Roldan E, et al
Clin Microbiol Infect. 2014 Nov 11

Abstract

The relation between efavirenz versus nevirapine and virologic failure in Johannesburg, South Africa.
Shearer K, Brennan AT, Maskew M,  et al
J Int AIDS Soc
. 2014 Oct 22;17(1):19065.
Abstract

Interpreting the reasons for the choice and changing of two drug regimens in an observational cohort: comparison of a ritonavir-boosted protease inhibitor-based versus a nonnucleoside reverse transcripase inhibitor-based first-line regimen.
Jarrin I, Hernández-Novoa B, Alejos B, et al
HIV Med. 2014 Mar 24.

Abstract

FULL-TEXT ARTICLE

Outcomes for Efavirenz versus Nevirapine-Containing Regimens for Treatment of HIV-1 Infection: A Systematic Review and Meta-Analysis.
Pillay P, Ford N, Shubber Z, Ferrand RA.
PLoS One
. 2013 Jul 22;8(7):e68995.
Paper

Lipid profiles for etravirine versus efavirenz in treatment-naive patients in the randomized, double-blind SENSE trial.
Fätkenheuer G, Duvivier C, Rieger A,  et al

J Antimicrob Chemother
. 2011 Dec 29.
Abstract

Long-term Treatment With Raltegravir or Efavirenz Combined With Tenofovir/Emtricitabine for Treatment-Naive Human Immunodeficiency Virus-1-Infected Patients: 156-Week Results From STARTMRK.
Rockstroh JK, Lennox JL, Dejesus E,  et al
Clin Infect Dis
. 2011 Oct;53(8):807-816.
Abstract

A randomized cross-over study to compare raltegravir and efavirenz (SWITCH-ER study).
Nguyen A, Calmy A, Delhumeau C, et al
AIDS
. 2011 May 17
Abstract

A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study.
Reekie J, Reiss P, Ledergerber B, Sedlacek D, et al
HIV Med
. 2010 Aug 31
Abstract

Raltegravir Versus Efavirenz Regimens in Treatment-Naive HIV-1-Infected Patients: 96-Week Efficacy, Durability, Subgroup, Safety, and Metabolic Analyses.
Lennox JL, Dejesus E, Berger DS,  et al
J Acquir Immune Defic Syndr. 2010 Apr 15
Abstract


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Efavirenz Journal Citations: Adult/Adolescent Treatment