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Efavirenz
/Tenofovir/Emtricitabine (Atripla)
 
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New and Noteworthy
     

March 2016
 

Journal Citations
     

Animal Studies
 
  Pharmacokinetic profiling of efavirenz-emtricitabine-tenofovir fixed dose combination in pregnant and non-pregnant rats.
Nirogi R, Bhyrapuneni G, Kandikere V, et al
Biopharm Drug Dispos
. 2012 May 18.
Abstract

General Reports
 
 

An Investigation of Liquid Chromatography-Mass Spectral Attributes and Analytical Performance Characteristics of Tenofovir, Emtricitabine and Efavirenz in Human Plasma.
Ndolo SM, Sichilongo K, Massele A,  et al
J Anal Toxicol. 2015 Oct 20.
Abstract

\FULL-TEXT ARTICLE
A Randomized Comparative Trial of Continued Abacavir/Lamivudine plus Efavirenz or Replacement with Efavirenz/Emtricitabine/Tenofovir DF in Hypercholesterolemic HIV-1 Infected Individuals.
Moyle GJ, Orkin C, Fisher M,  et al
PLoS One. 2015 Feb 6;10(2):e0116297
.
Paper

FULL-TEXT ARTICLE
Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults

Lamorde M, Byakika-Kibwika P, Tamale WS,  et al
AIDS Res Treat. 2012;2012:105980.
Paper

Budget impact of a set-dose combination of efavirenz-emtricitabine-tenofovir in the treatment of patients infected with HIV-1.
Oyagüez I, Casado MA, Cotarelo M, et al.
Farm Hosp. 2009 Sep 1;33(5):247-56
Abstract

Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet.
[
No authors listed] 
Prescrire Int
. 2009 Jun;18(101):105.
Abstract

FULL-TEXT ARTICLE
Atripla - HIV therapy in one pill.
Julg B, Bogner JR.   
Ther Clin Risk Manag. 2008 Jun;4(3):573-7.
Paper
 

Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients.
Sánchez-de la Rosa R, Herrera L, Moreno S.
Clin Ther. 2008 Feb;30(2):372-81.
Abstract

The first once-daily single-tablet regimen for the treatment of HIV-infected patients.
Killingley B, Pozniak A.  
Drugs Today (Barc).
2007 Jul;43(7):427-42
Abstract

Bioequivalence of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Single-Tablet Regimen.
Mathias AA, Hinkle J, Menning M, et al 
J Acquir Immune Defic Syndr.
2007 Jul 19;
Abstract

Efavirenz/Emtricitabine/Tenofovir disoproxil fumarate: triple combination tablet.
Frampton JE, Croom KF. 
Drugs.
2006;66(11):1501-12
Abstract
 
Tenofovir Disoproxil Fumarate, Emtricitabine, and Efavirenz Versus Fixed-Dose Zidovudine/Lamivudine and Efavirenz in Antiretroviral-Naive Patients: Virologic, Immunologic, and Morphologic Changes: A 96-Week Analysis.
Pozniak AL, Gallant JE, Dejesus E, et al  
J Acquir Immune Defic Syndr. 2006 Oct 12;
Abstract
 

Efficacy
 
 
FULL-TEXT ARTICLE
Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification.
Ananworanich J, Chomont N, Fletcher JL, et al
J Virus Erad
. 2015;1(2):116-122.
Paper

Lipid Changes in Virologically Suppressed HIV-Infected Patients Switching from any Antiretroviral Therapy to the Emtricitabine/Rilpivirine/Tenofovir Single Tablet: GeSida Study 8114.
Palacios R, Mayorga M, Pérez-Hernández IA, Rivero A, et al
J Int Assoc Provid AIDS Care. 2016 Feb 8.
Abstract

Tenofovir DF/emtricitabine and efavirenz combination therapy for HIV infection in patients treated for tuberculosis: the ANRS 129 BKVIR trial.
L
ortholary O, Roussillon C, Boucherie C,  et al
J Antimicrob Chemother. 2015 Dec 17.
Abstract

Patient-reported outcomes in the single-tablet regimen (STaR) trial of rilpivirine/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate in antiretroviral treatment-naive adults infected with HIV-1 through 48 weeks of treatment.
Wilkins EL, Cohen CJ, Trottier B, et al
AIDS Care
. 2015 Oct 21:1-8
Abstract

Comparison of HIV Virologic Failure Rates Between Patients with Variable Adherence to Three Antiretroviral Regimen Types.
Gordon LL, Gharibian D, Chong K, Chun H.
AIDS Patient Care STDS. 2015 Jul;29(7):384-388.
Abstract

Rilpivirine Versus Efavirenz with Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-Naïve HIV-1-Infected Patients with HIV-1 RNA ≤100,000 Copies/mL: Week 96 Pooled ECHO/THRIVE Subanalysis.
Behrens G, Rijnders B, Nelson M,  et al
AIDS Patient Care STDS
. 2014 Apr;28(4):168-75.
Abstract

Week 48 results from a randomized clinical trial of rilpivirine/emtricitabine/tenofovir disoproxil fumarate vs. efavirenz/emtricitabine/tenofovir disoproxil fumarate in treatment-naive HIV-1-infected adults.
Cohen C, Wohl D, Arribas JR, Henry K, et al
AIDS
. 2014 Feb 6
Abstract

A Randomized Double-Blind Comparison of Coformulated Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate Versus Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate for Initial Treatment of HIV-1 Infection: Analysis of Week 96 Results.
Zolopa A, Sax PE, Dejesus E,  et al
J Acquir Immune Defic Syndr
. 2013 May 1;63(1):96-100.
Abstract

A randomized, double-blind comparison of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir DF versus efavirenz/emtricitabine/tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results.
Zolopa A, Sax PE, Dejesus E,  et al
J Acquir Immune Defic Syndr
. 2013 Feb 7.
Abstract
 

A randomized, double-blind comparison of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results.
Rockstroh JK, Dejesus E, Henry K,  et al
J Acquir Immune Defic Synd
r
. 2013 Jan 18
Abstract

Effectiveness and safety of a single-tablet regimen of emtricitabine/efavirenz/tenofovir in HIV-1-infected patients in infectious diseases department.
Xerinda S, Neves N, Santos S,  et al.
J Int AIDS Soc
. 2012 Nov 11;15(6):18383.
Abstract


FULL-TEXT ARTICLE

Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings.
Campbell TB, Smeaton LM, Kumarasamy N,  et al
PLoS Med
. 2012 Aug;9(8):e1001290.
Paper

Discontinuation of Atripla as first-line therapy in HIV-1 infected individuals.
Scourfield A, Zheng J, Chinthapalli S, et al
AIDS
. 2012 Mar 21 
Abstract

Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Single-Tablet Regimen (Atripla®):A Review of its Use in the Management of HIV Infection.
Deeks ED, Perry CM
Drugs
. 2010 Dec 3;70(17):2315-2338.
Abstract

Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet.
[No authors listed] 
Prescrire Int
. 2009 Jun;18(101):105.
Abstract

Simplification of Antiretroviral Therapy to a Single-Tablet Regimen Consisting of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate Versus Unmodified Antiretroviral Therapy in Virologically Suppressed
HIV-1-Infected Patients.
Dejesus E, Young B, Morales-Ramirez JO, et al
J Acquir Immune Defic Syndr
. 2009 Apr 7.

Abstract
 
FULL-TEXT ARTICLE
Effectiveness and safety of generic fixed-dose combination of tenofovir/emtricitabine/efavirenz in HIV-1-infected patients in Western India.
Pujari S, Dravid A, Gupte N, et al 
Medscape J Med.
2008;10(8):196.

Paper
 
Adverse Events
 
  FULL-TEXT ARTICLE
Acute Liver Toxicity due to Efavirenz/Emtricitabine/Tenofovir.

Patil R, Ona MA, Papafragkakis H,  et al
Case Reports Hepatol. 2015;2015:280353
Paper

Cutaneous Adverse Reactions to Highly Antiretroviral Therapy in HIV-Positive Patients.
Pistone G, Pistone A, Sorbello D, et al
Case Rep Dermatol
. 2014 May 17;6(2):145-9. 
Abstract

EFV/FTC/TDF-Associated Hepatotoxicity: A Case Report and Review.
Echenique IA, Rich JD.
AIDS Patient Care STDS
. 2013 Aug 12.
Abstract


Patient-Reported Symptoms on the Antiretroviral Regimen Efavirenz/Emtricitabine/Tenofovir.
Edelman EJ, Gordon K, Rodriguez-Barradas MC
AIDS Patient Care STDS
. 2012 May 21.
Abstract
 

Resistance
 

FULL-TEXT ARTICLE
Emergent HIV-1 Drug Resistance Mutations Were Not Present at Low-Frequency at Baseline in Non-Nucleoside Reverse Transcriptase Inhibitor-Treated Subjects in the STaR Study
Porter DP, Daeumer M, Thielen A, et al
Viruses
. 2015 Dec 7;7(12):6360-70.
Paper

Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir + emtricitabine/lamivudine + efavirenz administered on a multiple tablet therapy.
Blanco JL, Montaner JS, Marconi VC, et al
AIDS
. 2014 Nov 13;28(17):2531-9.
Abstract

Week 144 resistance analysis of elvitegravir/cobicistat/emtricitabine/tenofovir DF versus efavirenz/emtricitabine/tenofovir DF in antiretroviral-naive patients.
White KL, Kulkarni R, McColl DJ,  et al
Antivir Ther. 2014 Oct 16
Abstract
 

 

Characterization of HIV-1 Drug Resistance Development Through Week 48 in Antiretroviral Naive Subjects on Rilpivirine/Emtricitabine/Tenofovir DF or Efavirenz/Emtricitabine/Tenofovir DF in the STaR Study (GS-US-264-0110).
Porter DP, Kulkarni R, Fralich T, et al
J Acquir Immune Defic Syn
dr
. 2014 Mar 1;65(3):318-26
Abstract

The emergence of drug resistant HIV variants at virological failure of HAART combinations containing efavirenz, tenofovir and lamivudine or emtricitabine within the UK Collaborative HIV Cohort.
Bulteel N, Bansi-Matharu L, Churchill D, et al
J Infect
. 2013 Sep 19.
 
Abstract

 
Virologival Fail
 
   

Economics

 
  Cost-effectiveness of the once-daily efavirenz/emtricitabine/tenofovir tablet compared with the once-daily elvitegravir/cobicistat/emtricitabine/tenofovir tablet as first-line antiretroviral therapy in HIV-infected adults in the US.
Juday T, Correll T, Anene A, Broder MS,  et al
Clinicoecon Outcomes Res
. 2013 Sep 2;5:437-45.
Abstract

Antiretroviral therapy in HIV-infected patients: a proposal to assess the economic value of the single-tablet regimen.
Colombo GL, Di Matteo S, Maggiolo F.
Clinicoecon Outcomes Res
. 2013;5:59-68
Abstract


Perinatal Updates
 

Journal Citations

  Reassuring Birth Outcomes with Tenofovir/Emtricitabine/Efavirenz used for Prevention of Mother to Child Transmission of HIV in Botswana.
Zash R, Souda S, Chen JY,  et al
J Acquir Immune Defic Syndr
. 2015 Sep 12
Abstract

A Quantitative Study of Factors Influencing Quality of Life in Rural Mexican Women Diagnosed With HIV.
Holtz C, Sowell R, Vanbrackle L, et al
J
Assoc Nurses AIDS
Care
. 2014 Apr 20.

Abstract


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Efavirenz/Emtricitabine/Tenofovir (Atripla)