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Last Update:  March 25, 2018
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New and Noteworthy

March 2018

General Reports

  • Using technology to improve HIV antiretroviral adherence
    by Jessica Haberer, M.D.

      Journal Papers, Abstracts, and Commentaries

Association of Depressive Symptoms with Lapses in Antiretroviral Medication Adherence Among People Living with HIV: A Test of an Indirect Pathway.
Babowitch JD, Sheinfil AZ, Woolf-King SE
 AIDS Behav
. 2018 Mar


Prospective State and Trait Predictors of Daily Medication Adherence Behavior in HIV.
Cook PF, Schmiege SJ, Starr W,, et al
Nurs Res
. 2017 Jul/Aug;66(4):275-285

90-90-90-Plus: Maintaining Adherence to Antiretroviral Therapies.
Corless IB, Hoyt AJ, Tyer-Viola L, et al
AIDS Patient Care STDS
. 2017 May;31(5):227-236

Baseline CD4 Count and Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis.
Bock P, James A, Nikuze A, et al
J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):514-521..

Adherence to Antiretroviral Therapy and Virologic Failure: A Meta-Analysis.
Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM.
Medicine (
. 2016 Apr;95(15):e3361.

Adherence to Antiretroviral Therapy for the Success of Emerging Interventions to Prevent HIV Transmission: A Wake up Call.
Nachega JB, Uthman OA, Mills EJ, Quinn TC.
J AIDS Clin Res. 2013 Oct 22;2012(Suppl 4).

Assessing adherence to antiretroviral therapy in randomized HIV clinical trials: a review of currently used methods.
Marcellin F, Spire B, Carrieri MP, Roux P.
Expert Rev Anti Infect Ther. 2013 Mar;11(3):239-50.

Impact of immune reconstitution inflammatory syndrome on antiretroviral therapy adherence.
Nachega JB, Morroni C, Chaisson RE,  et al
Patient Prefer Adherence
. 2012;6:887-91

Focus on Increasing Treatment Self-Efficacy to Improve Human Immunodeficiency Virus Treatment Adherence.
Nokes K, Johnson MO, Webel A,  et al

J Nurs Scholarsh
. 2012 Nov 1.

Adherence to Antiretroviral Therapy and Its Determinants in HIV/AIDS Patients: A Review.
Emamzadeh-Fard S, Alinaghi SA, Paydary K .
Infect Disord Drug Targets. 2012 Sep 12.

Correlates of Antiretroviral and Antidepressant Adherence Among Depressed HIV-Infected Patients.
Bottonari KA, Tripathi SP, Fortney JC, et al
AIDS Patient Care STDS
. 2012 May;26(5):265-73

The clinical interpretation of viral blips in HIV patients receiving antiviral treatment: are we ready to infer poor adherence?
Chun-Hai Fung I, Gambhir M, van Sighem A,  et al
J Acquir Immune Defic Syndr
. 2012 Jan 19.

Problems taking pills: understanding HIV medication adherence from a new perspective.
Okonsky JG.
. 2011 Jun 28.

Levels of Adherence Required for Virologic Suppression Among Newer Antiretroviral Medications (March).
Kobin AB, Sheth NU.
Ann Pharmacother. 2011 Mar 8


Antiretroviral adherence program in HIV patients: a feasibility study in the Swiss HIV Cohort Study.
Krummenacher I, Cavassini M, Bugnon O,  et al
Pharm World Sci
. 2010 Sep 23

Early Adherence to Antiretroviral Medication as a Predictor of Long-Term HIV Virological Suppression: Five-Year Follow Up of an Observational Cohort.
Ford N, Darder M, Spelman T,  et al
PLoS One
. 2010 May 5;5(5):e10460.

Adherence to Antiretroviral Therapy and HIV Transmission Risks: Implications for Test-and-Treat Approaches to HIV Prevention.
Kalichman SC, Cherry C, Amaral CM, et al
AIDS Patient Care STDS
. 2010 May 3.

Standard Care Impact on Effects of Highly Active Antiretroviral Therapy Adherence Interventions: A Meta-analysis of Randomized Controlled Trials.
de Bruin M, Viechtbauer W, Schaalma HP, et al 
Arch Intern Med
. 2010 Feb 8;

Modelling imperfect adherence to HIV induction therapy
Miran RE.Smith RJ
BMC Infectious Diseases
2010, 10:6

The risk of virologic failure decreases with duration of HIV suppression, at greater than 50% adherence to antiretroviral therapy.
Rosenblum M, Deeks SG, van der Laan M, Bangsberg DR.
PLoS One
. 2009 Sep 29;4(9):e7196

Simplification and First Validation of a Short Battery of Patient Questionnaires for Clinical Management of HIV-Infected Patients: The HIV-SQUAD (Symptom Quality of life Adherence) Questionnaire(R).
Spire, Arnould, Barbier, Durant, Gilquin, Landman, et al
HIV Clin Trials
. 2009 Jul-Aug;10(4):215-32.

An alternative methodology for the prediction of adherence to anti HIV treatment.
Thompson IR, Bidgood P, Petroczi A, et al 
AIDS Res Ther
. 2009 Jun 1;6(1):9.

Development and Efficacy of an Intervention to Enhance Readiness for Adherence among Adults Who Had Previously Failed HIV Treatment.
Enriquez M, Cheng AL, McKinsey DS, Stanford J.
AIDS Patient Care STDS
. 2009 Feb 3.

Relationship between Adherence Level, Type of the Antiretroviral Regimen, and Plasma HIV Type 1 RNA Viral Load: A Prospective Cohort Study.
Martin M, Del Cacho E, Codina C, et al
AIDS Res Hum Retroviruses. 2008 Oct 6.

Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on antiretroviral therapy.
Bisson GP, Gross R, Bellamy S, et al
PLoS Med. 2008 May 20;5(5):e109.
Self-Reported Sexual Dysfunction Is Frequent Among HIV-Infected Persons and Is Associated with Suboptimal Adherence to Antiretrovirals.
Trotta MP, Ammassari A, Murri R, et al

AIDS Patient Care STDS.
2008 Apr;22(4):291-299.
Differential adherence to combination antiretroviral therapy is associated with virological failure with resistance.
Gardner EM, Sharma S, Peng G, et al
AIDS. 2008 Jan 2;22(1):75-82
Experiences and perceptions of patients with 100% adherence to highly active antiretroviral therapy: a qualitative study.
Sidat M, Fairley C, Grierson J
AIDS Patient Care STDS. 2007
The Role of Adherence to Antiretroviral Therapy in the Management of HIV Infection.
Conway B.
J Acquir Immune Defic Syndr.
2007 Jun 1;45 Suppl 1:S14-8.
Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic

Nachega JB, Hislop M, Dowdy DW, et al
Ann Intern Med
. 2007 Apr 17;146(8):564-73
74 Abstract
Adherence and plasma drug concentrations are predictors of confirmed virologic response after
24-week salvage highly active antiretroviral therapy.

Quiros-Roldan E, Torti C, et al
AIDS Patient Care STDS. 2007 Feb;21(2):92-9.
Outcomes of a Multifaceted Medication Adherence Intervention for HIV-Positive Patients.
Dieckhaus KD, Odesina V
AIDS Patient Care STDS. 2007 Feb;21(2):81-91.
Optimal drug treatment regimens for HIV depend on adherence.
Krakovska O, Wahl LM.
J Theor Biol. 2007 Jan 23;
Medication Adherence and Sexual Risk Behavior among HIV-Infected Adults: Implications for Transmission of Resistant Virus.
Remien RH, Exner TM, Morin SF, et al 
AIDS Behav
. 2007 Jan 23;
The Elusive Gold Standard: Future Perspectives for HIV Adherence Assessment and
Chesney MA.  
J Acquir Immune Defic Syndr.
2006 Dec;43 Suppl 1:S149-55.
Moving From Theory to Research to Practice: Implementing an Effective Dyadic Intervention to Improve Antiretroviral Adherence for Clinic Patients.
Remien RH, Stirratt MJ, Dognin J, et al
J Acquir Immune Defic Syndr
. 2006 Dec 1;43 Suppl 1:S69-S78
Self-Report Measures of Antiretroviral Therapy Adherence: A Review with Recommendations for HIV Research and Clinical Management.
Simoni JM, Kurth AE, Pearson CR, et al 
AIDS Behav.
2006 Jun 3;
Becoming a "Treatment Success": What Helps and What Hinders Patients from Achieving and Sustaining Undetectable Viral Loads.
Alfonso V, Geller J, Bermbach N, et al
AIDS Patient Care STDS
. 2006 May;20(5):326-334.

Paradoxical Effects of Clinician Emphasis on Adherence to Combination Antiretroviral Therapy for HIV/AIDS.
Tugenberg T, Ware NC, Wyatt MA. 
AIDS Patient Care
STDS. 2006 Apr;20(4):269-74
Adherence to Antiretroviral Therapy: Merging the Clinical and Social Course of AIDS

Castro A 
PLoS Medicine  Vol 2, Issue 11,Nov 2005 
Modelling the association between adherence and viral load in HIV-infected patients.
Vrijens B, Goetghebeur E, de Klerk E, et al 
Stat Med.
2005 Aug 24;24(17):2719-2731

Similar adherence rates favor different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors.
Maggiolo F, Ravasio L, Ripamonti D, et al 
Clin Infect Dis. 2005 Jan 1;40(1):158-63.
British HIV Association (BHIVA)/British Association for Sexual Health and HIV (BASHH) guidelines on provision of adherence support to individuals receiving antiretroviral therapy
Poppa A, Davidson O, Deutsch J, et al 
HIV Med. 2004 Jul;5 Suppl 2:46-60
Perspectives on Adherence and Simplicity for HIV-Infected Patients on Antiretroviral Therapy: Self-Report of the Relative Importance of Multiple Attributes of Highly Active Antiretroviral Therapy (HAART) Regimens in Predicting Adherence.
Stone VE, Jordan J, Tolson J, Miller R, Pilon T.

J Acquir Immune Defic Syndr.
2004 Jul 1;36(3):808-816.
The Impact of Adherence on CD4 Cell Count Responses Among HIV-Infected Patients.
Wood E, Hogg RS, Yip B, et al 
J Acquir Immune Defic Syndr.
2004 Apr 12;35(3):261-268.
No Evidence of an Association between Transient HIV Viremia ("Blips") and Lower Adherence  to the Antiretroviral Medication Regimen.
Miller LG, Golin CE, Liu H, et al 
Infect Dis. 2004 Apr 15;189(8):1487-96.
Effect of Medication Adherence on Survival of HIV-Infected Adults Who Start Highly Active Antiretroviral Therapy When the CD4+ Cell Count Is 0.200 to 0.350 x 109 cells/L.
Wood E, Hogg RS, Yip B, Harrigan PR, et al 
Ann Intern Med.
2003 Nov 18;139(10):810-6.

Adherence to Antiretroviral Therapy and Persistence of HIV RNA in Semen.
Barroso PF, Schechter M, Gupta P, et al.
J Acquir Immune Defic Syndr 2003 Apr 1;32(4):435-40

HIV/AIDS medication adherence factors: inner-city clinic patient's self-reports.
Graney MJ, Bunting SM, Russell CK.
Tenn Med 2003 Feb;96(2):73-8


Chronic disease self-management and adherence to HIV medications.
Gifford AL, Groessl EJ.
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S163-6
Adherence to antiretroviral therapy among patients with HIV: a critical link between behavioral and biomedical sciences.
Ickovics JR, Meade CS.
J Acquir Immune Defic Syndr 2002 Dec 15;31 Suppl 3:S98-102
Adherence, resistance, and timing: current issues in the use of new therapies.
Volberding P.
AIDS Read 2002 Aug;12(8):349-50, 356-7, 368
Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: from a predictive to a dynamic approach.
Spire B, Duran S, Souville M, et al.
Soc Sci Med 2002 May;54(10):1481-96
Impact of adherence on duration of virological suppression among patients receiving combination antiretroviral therapy.
Raboud JM, Harris M, Rae S, Montaner JS.
HIV Med 2002 Apr;3(2):118-24
Adherence to antiretroviral therapy by human immunodeficiency virus-infected patients.
Turner BJ.
J Infect Dis 2002 May 15;185 Suppl 2:S143-51
Nonadherence to highly active antiretroviral therapy: clinically relevant patient categorization based on electronic event monitoring.
Van Wijngaerden E, De Saar V, De Graeve V, et al
AIDS Res Hum Retroviruses 2002 Mar 20;18(5):327-30
Patient adherence to HIV medication regimens: a review of published and abstract reports.
Fogarty L, Roter D, Larson S, et al
Patient Educ Couns 2002 Feb;46(2):93-108
Correlates of adherence to combination antiretroviral therapy among members of HIV-positive mixed status couples.
Wagner GJ, Remien RH, Carballo-Dieguez A, Dolezal C.
AIDS Care 2002 Feb;14(1):105-9


Measuring Adherence

          Journal Papers, Abstracts, and Commentaries
  Practical and conceptual challenges in measuring antiretroviral adherence.
Berg KM, Arnsten JH.  
J Acquir Immune Defic Syndr.
2006 Dec;43 Suppl 1:S79-87.

A Practical Method to Calibrate Self-Reported Adherence to Antiretroviral Therapy.
Liu H, Miller LG, Hays RD. et al  
J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S104-S112.

Adherence and Drug Resistance

           Journal Papers, Abstracts, and Commentaries
Adherence as a Predictor of the Development of Class-Specific Resistance Mutations: The Swiss HIV Cohort Study
Wyl V, Klimkait T, Yerly S,  et al
PLoS One
. 2013 Oct 16;8(10):e77691

Effect of Adherence to HAART on Virologic Outcome and on the Selection of Resistance-Conferring Mutations in NNRTI- or PI-Treated Patients.
Maggiolo F, Airoldi M, Kleinloog HD, et al
HIV Clin Trials.
2007 Sep-Oct;8(5):282-92

Adherence to antiretroviral HIV drugs: how many doses can you miss before resistance emerges?
Smith RJ. 
Proc Biol Sci.
2006 Mar 7;273(1586):617-24.
Adherence and resistance
Klimkait T, Vernazza P.
Ther Umsch. 2004 Oct;61(10):631-4
Resistance profiles and adherence at primary virological failure in three different highlyactive antiretroviral therapy regimens: analysis of failure rates in a randomized study.
Roge B, Barfod T, Kirk O, et al
HIV Med. 2004 Sep;5(5):344-351.
Paradoxes of adherence and drug resistance to HIV antiretroviral therapy.
Bangsberg DR, Moss AR, Deeks SG
J Antimicrob Chemother. 2004 May;53(5):696-9
Association between Adherence to Antiretroviral Therapy and Human Immunodeficiency
Virus Drug Resistance.
Sethi AK, Celentano DD, Gange SJ ,et al
Clin Infect Dis. 2003 Oct 15;37(8):1112-1118.
High levels of adherence do not prevent accumulation of HIV drug resistance mutations.
Bangsberg DR, Charlebois ED, Grant RM 

2003 Sep 5;17(13):1925-32.

Therapeutic Drug Monitoring

          Journal Papers, Abstracts, and Commentaries
Preventing HIV antiretroviral resistance through better monitoring of treatment adherence.
Bangsberg DR.

J Infect Dis. 2008
May 15;197 Suppl

Therapeutic drug monitoring of indinavir and nelfinavir to assess adherence to therapy in human immunodeficiency virus-infected children.
van Rossum AM, Bergshoeff AS, Fraaij PL, et al.

Pediatr Infect Dis J 2002 Aug;21(8):743-7


Provider Challenges

         Journal Papers, Abstracts, and Commentaries
Virtual Intervention to Support Self-Management of Antiretroviral Therapy Among People Living With HIV.
Côté J, Godin G, Ramirez-Garcia P,  et al
J Med Internet Res. 2015 Jan 6;17(1):e6.

The impact of HIV clinical pharmacists on HIV treatment outcomes: a systematic review.
Saberi P, Dong BJ, Johnson MO, et al
Patient Prefer Adherence
. 2012;6:297-322.

The importance of the patient-clinician relationship in adherence to antiretroviral medication.
Molassiotis A, Morris K, Trueman

Int J Nurs Pract. 2007 Dec;13(6):370-6.

Is the quality of the patient-provider relationship associated with better adherence and health outcomes for patients with HIV?
Beach MC, Keruly J, Moore RD.
J Gen Intern Med. 2006 J

Better Physician-Patient Relationships Are Associated with Higher Reported Adherence to Antiretroviral Therapy in Patients with HIV Infection.
Schneider J, Kaplan SH, Greenfield S, et al 
J Gen Intern Med.
2004 Nov;19(11):1096-0

Patient-reported and Physician-estimated Adherence to HAART.
Murri R, Ammassari A, Trotta MP, et al  
J Gen Intern Med
. 2004 Nov;19(11):1104-10.
The patient-provider relationship and adherence to highly active antiretroviral therapy.
Russell J, Krantz S, Neville S. et al

Provider inaccuracy in assessing adherence and outcomes with newly initiated antiretroviral therapy.
Gross R, Bilker WB, Friedman HM, et al.
AIDS 2002 Sep 6;16(13):1835-7

How well do clinicians estimate patients' adherence to combination antiretroviral therapy?
Miller LG, Liu H, Hays RD, et al
J Gen Intern Med 2002 Jan;17(1):1-11

Physician-patient relationships, patient satisfaction, and antiretroviral medication Adherence among HIV-infected adults attending a public health clinic.
Roberts KJ.
AIDS Patient Care STDS 2002 Jan;16(1):43-50


Economic Studies

          Journal Papers, Abstracts, and Commentaries
Cost-Effectiveness of an Intervention to Improve Adherence to Antiretroviral Therapy in HIV-Infected Patients.
Freedberg KA, Hirschhorn LR, Schackman BR, et al  
J Acquir Immune Defic Synd
r. 2006 Dec 1;43 Suppl 1:S113-S118

Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection.
Goldie SJ, Paltiel AD, Weinstein MC  
Am J Med. 2003 Dec 1;115(8):632-41.

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