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HAART/ART
/cART
  Cardiovascular Adverse Events
 
General Reports 
Atherosclerosis
Cardiomyopathy 
Carotid Artery Disorders
Cerebrovascular Disorders
Cholesterol levels Increases   
Hypertension
Lipid Disorders

 

 

HAART Adverse Events Main New/Newsworthy  Home Page

Last Update:  February 27, 2018  
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General Reports

                    

          Journal Papers, Abstracts, and Commentaries

 
Diastolic Dysfunction in Individuals with Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Anti-Retroviral Therapy (CHART) Study.
Butler J, Kalogeropoulos AP, Anstrom KJ, Nickens P, et al
J Card Fail
. 2018 Feb 23. pii: S1071-9164(18)30064-2
Abstract

Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV-Positive Participants in the START (Strategic Timing of Antiretroviral Treatment) Trial.
Baker JV, Sharma S, Achhra AC,  et al 
J Am Heart Asso
c
. 2017 May
Abstract

Effects of Antiretroviral Therapy on Immune Function and Arterial Inflammation in Treatment-Naive Patients With Human Immunodeficiency Virus Infection.
Zanni MV, Toribio M, Robbins GK,  et alJ
AMA Card
iol
. 2016 Jul 1;1(4):474-80. .
Abstract

HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.
Lambert CT, Sandesara PB, Hirsh B, et al  

HIV Med
. 2015 Nov 26.
Abstract

FULL-TEXT ARTICLE
Risk Factors of Cardiovascular Diseases in HIV/AIDS Patients on HAART.
Nsagha DS, Assob JC, Njunda AL,  et al
Open AIDS J. 2015 Oct 20;9:51-59

Paper

Risk of Cardiovascular Events Associated with Current Exposure to HIV Antiretroviral Therapies in a US Veteran Population.
Desai M, Joyce V, Bendavid E, Olshen RA,  et al 

Clin Infect Dis
. 2015 Apr 22.
Abstract

Myocardial Infarction, Stroke, and Mortality in cART-Treated HIV Patients on Statins.
Krsak M, Kent DM, Terrin N,  et al

AIDS Patient Care STDS
. 2015 Apr 9.
Abstract

Assessment of arterial elasticity among HIV-positive participants with high CD4 cell counts: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.
Baker J, Engen N, Huppler Hullsiek K, et al
HIV Med
. 2015 Apr;16 Suppl 1:109-18

Abstract

QT Dispersion in HIV-Infected Patients Receiving Combined Antiretroviral Therapy.
Wongcharoen W, Suaklin S, Tantisirivit N, et al

Ann Noninvasive Electrocardiol
. 2014 Apr 21.
Abstract

Perivascular fat, inflammation, and cardiovascular risk in HIV-infected patients on antiretroviral therapy.
Longenecker CT, Jiang Y, Yun CH,  et al
Int J Cardiol. 2013 Jul 22.
Abstract

FULL-TEXT ARTICLE
Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review.
Bavinger C, Bendavid E, Niehaus K, et al

PLoS One
. 2013;8(3):e59551
Paper

Venous and Arterial Thromboembolic Complications Associated with HIV Infection and
Highly Active Antiretroviral Therapy.
Auerbach E, Aboulafia DM.
Semin Thromb Hemost. 2012 Oct 6.
Abstract

HAART to heart: highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected
or exposed children and adults.
Lipshultz SE, Mas CM, Henkel JM,  et al

Expert Rev Anti Infect Ther
. 2012 Jun;10(6):661-74..
Abstract

Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison
between hypertensive and normotensive subjects with and without HIV infection.
Grandi AM, Nicolini E, Giola M, Gianni M, et al

J Hum Hypertens
. 2011 Sep 15

Abstract

Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients:
Effects of Antiretroviral Therapy and Adipose Tissue Distribution.
van Wijk JP, Cabezas MC.
Int J Vasc Med. 2012;2012:201027.
Abstract

FULL-TEXT ARTICLE
Decreased Heart Rate Variability in HIV Positive Patients Receiving Antiretroviral Therapy:
Importance of Blood Glucose and Cholesterol

Askgaard G,  Kristoffersen US. Mehlsen J, et al
PLoS One
.
201131 May 2011
Paper

Reduction in coronary and peripheral vasomotor function in patients with HIV after
initiation of antiretroviral therapy: a longitudinal study with positron emission
tomography and flow-mediated dilation.
Kristoffersen US, Wiinberg N, Petersen CL, et al
Nucl Med Commun
. 2010 Aug 7.
Abstract

Antiretroviral therapy with heart.
Randell P, Moyle G.

Am J Ther
. 2009 Nov-Dec;16(6):579-84.
Abstract

Association of Highly Active Antiretroviral Therapy With Increased Arterial Stiffness
in Patients Infected With Human Immunodeficiency Virus.
Lekakis J, Ikonomidis I, Palios J,et al 

Am J Hypertens
. 2009 Jun 25
Abstract

Human Immunodeficiency Virus and Highly Active Antiretroviral Therapy-Associated Metabolic Disorders
and Risk Factors for Cardiovascular Disease.
Anuurad E, Semrad A, Berglund L.
Metab Syndr Relat Disord. 2009 Apr 8.
Abstract
 

Reduction in circulating markers of endothelial dysfunction in HIV-infected patients during
antiretroviral therapy.

Kristoffersen U, Kofoed K, Kronborg G,
HIV Med. 2009 Feb;10(2):79-87.
Abstract
 
Diabetes Mellitus, Preexisting Coronary Heart Disease, and the Risk of Subsequent Coronary
Heart Disease Events in Patients Infected With Human Immunodeficiency Virus. The Data
Collection on Adverse Events of Anti-HIV Drugs (D:A:D Study).
Worm SW, De Wit S, Weber R, et al
Circulation. 2009 Feb 2.
Abstract
 
Cardiovascular effects of antiretroviral drugs: clinical review.
Filardi PP, Paolillo S, Marciano C, et al 

Cardiovasc Hematol Disord Drug Targets
. 2008 Dec;8(4):238-44.
Abstract
 
Silent cardiac dysfunction and exercise intolerance in HIV+ men receiving combined antiretroviral therapies.
Thöni GJ, Schuster I, Walther G, et al

AIDS.
2008 Nov 30;22(18):2537-2540
Abstract
 
HIV and antiretroviral therapy: lipid abnormalities and associated cardiovascular risk in
HIV-infected patients.
Kotler DP.
J Acquir Immune Defic Syndr. 2008 Sep 1;49 Suppl 2:S79-85.
Abstract
 
Ankle-branch index and HIV: the role of antiretrovirals.
Olalla J, Salas D, Del Arco A, et al
HIV Med. 2008 Sep 14.
Abstract
 
Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and
after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s.
Torriani FJ, Komarow L, Parker RA, et al
J Am Coll Cardiol. 2008 Aug 12;52(7):569-76.
Abstract
 
HIV Therapy, Metabolic Syndrome, and Cardiovascular Risk.
Pao V, Lee GA, Grunfeld C. et al

Curr Atheroscler Rep
. 2008 Feb;10(1):61-70
Abstract
 
Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection
and antiretroviral therapy.

Calza L, Manfredi R, Pocaterra D, Chiodo F.

J Infect. 2008 Mar 19

Abstract
 
Dyslipidemia and Cardiovascular Disease Risk Factor Management in HIV-1-Infected Subjects Treated with HAART in the
Spanish VACH Cohort.

Pere D, Ignacio SL, Ramón T,
Open AIDS J. 2008;2:26-38.
Abstract
 
Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of
antiretroviral therapy in HIV infection.

Wand H, Calmy A, Carey DL, Samaras K, et al 
AIDS. 2007 Nov 30;21(18):2445-2453.

Abstract
 
Autonomic dysfunction in HIV patients on antiretroviral therapy: studies of heart rate
variability.

Lebech AM, Kristoffersen US, Mehlsen J, et al
 
Clin Physiol Funct Imaging
. 2007 Nov;27(6):363-7.
Abstract

Highly active antiretroviral therapy-associated metabolic syndrome: pathogenesis and
cardiovascular risk
Barbaro G.
Am J Ther. 2006 May-Jun;13(3):248-60.

Abstract

Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome and Cardiovascular Risk.
Barbaro G, Barbarini G.
Chemotherapy. 2006 May 2;52(4):161-165
Abstract
 
HAART to Heart: HIV-related Cardiomyopathy and Other Cardiovascular Complications.
Dakin CL, O'connor CA, Patsdaughter CA. 
AACN Clin Issues. 2006 January/March;17(1):18-29.
Abstract
 
Age and sex modulate metabolic and cardiovascular risk markers of patients after 1 year of
highly active antiretroviral therapy (HAART).
Leitner JM, Pernerstorfer-Schoen H,
Atherosclerosis. 2005 Oct 1;
Abstract
 
Reviewing the Cardiovascular Complications of HIV Infection After the Introduction of
Highly Active Antiretroviral Therapy.
Barbaro G.

Curr Drug Targets Cardiovasc Haematol Disord. 2005 Aug;5(4):337-43.
Abstract
 
Coronary Artery Calcium in HIV-infected Men Treated With Highly Active Antiretroviral Therapy.
Robinson FP, Hoff JA, Kondos GT. 

J Cardiovasc Nurs.
2005 May/June;20(3):149-154.
Abstract
 
Antiretroviral therapy and cardiovascular risk.
Vandhuick O, Guias B, De Saint Martin L, Bressollette L.
J Mal Vasc.
2004 Oct;29(4):192-199
Abstract
 
Risks of cardiovascular disease in patients receiving antiretroviral therapy for
HIV infection: implications for treatment.
Steinhart CR, Emons MF

AIDS Read.
2004 Feb;14(2):86-90, 93-5
Abstract

Combination antiretroviral therapy and the risk of myocardial infarction.
Friis-Moller N, Sabin CA, Weber R, et al
N Engl J Med. 2003 Nov 20;349(21):1993-2003.
Abstract"
 

       Conference Reports, Abstracts, and Posters
 
 
Impact of short-term change in body mass index (BMI) after antiretroviral therapy (ART) initiation on subsequent risk of cardiovascular disease (CVD) and diabetes in HIV-positive individuals: the D:A:D study
A.C. Achhra, A. Mocroft, P. Reiss, et al

(XX International AIDS Conference)
Abstract

Atherosclerosis

                    

          Journal Papers, Abstracts, and Commentaries
 
 
Associations between antiretroviral use and subclinical coronary atherosclerosis.
Thomas GP, Li X, Post WS, et al  
AIDS
. 2016 Aug 3.
Abstract

Plasma Klotho Levels Were Inversely Associated with Subclinical Carotid Atherosclerosis in HIV-infected Patients Receiving Combined Antiretroviral Therapy.
Jeong SJ, Song JE, Kim SB, et al

AIDS Res Hum Retroviruses
. 2013 Aug 13..
Abstract

Pharmacogenetics of the Metabolic Disturbances and Atherosclerosis Associated with
Antiretroviral Therapy in HIV-Infected Patients.

Veloso S, Peraire J, Viladés C,  et al
Curr Pharm Des
. 2010 Aug 5

Abstract

Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection
and antiretroviral therapy.

Calza L, Manfredi R, Pocaterra D, Chiodo F.

J Infect. 2008 Mar 19
Abstract

Premature atherosclerosis in HIV positive patients and cumulated time of exposure
to antiretroviral therapy (SHIVA study).
Martin LD, Vandhuick O, Guillo P, et al 

Atherosclerosis.
2005 Aug 29;
Abstract

Comparison of the risks of atherosclerotic events versus death from other causes associated
with antiretroviral use.
Kwong GP, Ghani AC, Rode RA, et al
AIDS. 2006 Oct 3;20(15):1941-1950.
Abstract

Cardiomyopathy

                    

          Journal Papers, Abstracts, and Commentaries

 
HAART to Heart: HIV-related Cardiomyopathy and Other Cardiovascular Complications.
Dakin CL, O'connor CA, Patsdaughter CA. 
AACN Clin Issues. 2006 January/March;17(1):18-29.
Abstract

Dilated Cardiomyopathy in Two Adult Human Immunodeficiency Positive (HIV+) Patients Possibly
Related to Highly Active Antiretroviral Therapy (HAART).
Breuckmann F, Neumann T, Kondratieva J, et al 
Eur J Med Res
. 2005 Sep 12;10(9):395-9.
Abstract


Carotid Artery Disorders

                    

          Journal Papers, Abstracts, and Commentaries
 
 
Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study.
LaBounty TM, Hardy WD, Fan Z,  et al
HIV Med
. 2015 Dec 3.
Abstract

Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients.
Zhu H, Yuan J, Wang Y, et al
Braz J Infect Dis
. 2014 May 9.
Abstract

Plasma Klotho Levels Were Inversely Associated with Subclinical Carotid Atherosclerosis in HIV-infected Patients Receiving Combined Antiretroviral Therapy.
Jeong SJ, Song JE, Kim SB, et al
AIDS Res Hum Retroviruses
. 2013 Aug 13.
Abstract

Associations of antiretroviral drug use and HIV-specific risk factors with
carotid intima-media thickness.
Delaney JA, Scherzer R, Biggs ML,et al

AIDS
. 2010 Jul 27.
Abstract

Increase in Carotid Artery Intima-Media Thickness and Arterial Stiffness but Improvement in Several
Markers of Endothelial Function after Initiation of Antiretroviral Therapy.
van Vonderen MG, Hassink EA, van Agtmael MA, et al
J Infect Dis. 2009 Mar 10.
Abstract


Cerebrovascular Disorders
                    

          Journal Papers, Abstracts, and Commentaries

  Cerebrovascular Ischemic Events in HIV-1-Infected Patients Receiving Highly Active Antiretroviral
Therapy: Incidence and Risk Factors.
Corral I, Quereda C, Moreno A, et al

Cerebrovasc Dis
. 2009 Apr 24;27(6):559-563.
Abstract

Cholesterol Levels Increases

                    

          Journal Papers, Abstracts, and Commentaries

  Increased lipoprotein remnant cholesterol levels in HIV-positive patients during antiretroviral
therapy.

Anuurad E, Thomas-Geevarghese A, Devaraj S, et al
Atherosclerosis. 2007 Nov 8
Abstract

Hypertension
                    

          Journal Papers, Abstracts, and Commentaries
 

 
Evidence of increased blood pressure and hypertension risk among people living with HIV on antiretroviral therapy: a systematic review with meta-analysis.
Nduka CU, Stranges S, Sarki AM, et al

J Hum Hypertens
. 2015 Oct 8
Abstract

Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison
between hypertensive and normotensive subjects with and without HIV infection.
Grandi AM, Nicolini E, Giola M, Gianni M, et al

J Hum Hypertens
. 2011 Sep 15
Abstract

Impact of highly active antiretroviral therapy on blood pressure in HIV-infected patients.
A prospective study in a cohort of naive patients.
Palacios R, Santos J, Garcia A, et al 
HIV Med. 2006 Jan;7(1):10-5.
Abstract
 

Association between highly active antiretroviral therapy and hypertension in a large
cohort of men followed from 1984 to 2003.
Seaberg EC, Munoz A, Lu M, et al 

AIDS. 2005 Jun 10;19(9):953-960.

Abstract

Regression of HIV-associated pulmonary arterial hypertension and
long-term survival during antiretroviral therapy.
Speich R, Jenni R, Opravil M, Jaccard R.
Swiss Med Wkly 2001 Dec 1;131(45-46):663-5
Abstract

 
 


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