• Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse
  transcriptase inhibitor.
  Boojamra CG, Mackman RL, Markevitch DY,  et al
  Bioorg Med Chem Lett. 2008 Feb 1;18(3):1120-3.
  Abstract
• Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.Lansdon EB, Samuel D, Lagpacan L,  et al
  J Mol Biol. 2010 Apr 9;397(4):967-78.
  Abstract
• Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase
  inhibitors.
  Boojamra CG, Parrish JP, Sperandio D,  et al
  Bioorg Med Chem. 2009 Feb 15;17(4):1739-46.
  Abstract
• FULL-TEXT ARTICLE
  Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low
  nephrotoxic potential: characterization of renal transport and accumulation.
  Cihlar T, Laflamme G, Fisher R,  et al Antimicrob Agents Chemother. 2009 Jan;53(1):150-6
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• Mechanism of resistance to GS-9148 by the Q151L mutation in HIV-1 Reverse Transcriptase.
  Scarth BJ, White KL, Chen JM,  et al
  Antimicrob Agents Chemother. 2011 Mar 14
  Abstract
• Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
  Mackman RL, Lin KY, Boojamra CG. et al
  Bioorg Med Chem Lett. 2008 Feb 1;18(3):1116-9
  Abstract
• FULL-TEXT ARTICLE
  Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human
  immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
  Cihlar T, Ray AS, Boojamra CG,  et al
  Paper

GS-9148