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Lopinavir/Ritonavir (Kaletra/Aluvia)
 
Journal Citations: Resistance

General Reports                               
Cross Resistance      




 


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Last Update: June 28, 2016
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Resistance: General Reports

 

 
Random lopinavir concentrations predict resistance on lopinavir-based antiretroviral therapy.
Court R, Gordon M, Cohen K, Stewart A,  et al
Int J Antimicrob Agents. 2016 Jun 9.
Abstract

Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks.
Raposo LM, Arruda MB, de Brindeiro RM, Nobre FF.
J Med Syst. 2016 Mar;40(3):69.
Abstract

FULL-TEXT ARTICLE
Comparable Long-Term Efficacy of Lopinavir/Ritonavir and Similar Drug-Resistance Profiles in Different HIV-1 Subtypes.
Grossman Z, Schapiro JM, Levy I, Elbirt D,  et al
PLoS One. 2014 Jan 27;9(1):e86239.
Paper

Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen.
Alteri C, Artese A, Beheydt G,  et al
J Antimicrob Chemother
. 2013 May 17
Abstract

Impact of lopinavir/ritonavir use on antiretroviral resistance in recent clinical practice.
Lambert-Niclot S, Masquelier B, Cohen Codar I, et al
J Antimicrob Chemother
. 2012 Jun 25.
Abstract

Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with
lopinavir/ritonavir as their first protease inhibitor.
Barber TJ, Harrison L, Asboe D, et al
J Antimicrob Chemother. 2012 Jan 17
Abstract

FULL-TEXT ARTICLE
Can Linear Regression Modeling Help Clinicians in the Interpretation of Genotypic Resistance Data? An Application to Derive a Lopinavir-Score.
Cozzi-Lepri A, Prosperi MC, Kjær J, et al
PLoS One
. 2011;6(11):e25665.
Paper

Lopinavir/ritonavir resistance in patients infected with HIV-1: two divergent resistance pathways?
Champenois K, Baras A, Choisy P, et al
J Med Virol
. 2011 Jul 13.
Abstract

Genotypic Resistance at Viral Rebound among Patients Who Received Lopinavir/ritonavir-
or Efavirenz-Based First Antiretroviral Therapy in South Africa.
Dlamini JN, Hu Z, Ledwaba J, Morris L
J Acquir Immune Defic Syndr. 2011 Jun 18.
Abstract

Protease Inhibitors Resistance Analysis in the MONARK Trial Comparing First Line Lopinavir/ritonavir
Monotherapy to Lopinavir/ritonavir plus Zidovudine and Lamivudine triple therapy.
Delaugerre C, Flandre P, Chaix ML, et a
Antimicrob Agents Chemother. 2009 May 18
Abstract

Lopinavir/ritonavir monotherapy for the treatment of HIV-1 infection: the emergence of resistance
Delgado R.
Enferm Infecc Microbiol Clin. 2008 Dec;26 Suppl 16:34-40.
Abstract

Enzymatic and Structural Analysis of the I47A Mutation Contributing to the Reduced Susceptibility
to HIV Protease Inhibitor Lopinavir.
Grantz Saskova K, Kozisek M, et al 
Protein Sci. 2008 Jun 17.
Abstract
 

Prevalence and impact of HIV-1 protease mutation L76V on lopinavir resistance.
de Mendoza C, Garrido C, Corral A, et al  
AIDS.
2008 Jan 11;22(2):311-3.
Abstract
 
Prevalence and impact of HIV-1 protease mutation L76V on lopinavir resistance.
de Mendoza C, Garrido C, Corral A  
AIDS.
2008 Jan 11;22(2):311-3.
Abstract
 
Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir
in patients with HIV

Ma Q, Brazeau D, Zingman BS, et al  
Pharmacogenomics.
2007 Mar;8(3):227-235.
Abstract
 
The use of drug resistance algorithms and genotypic inhibitory quotient in prediction of
lopinavir-ritonavir treatment response in human immunodeficiency virus type 1 protease
inhibitor-experienced patients.

Maillard A, Chapplain JM, Tribut O, et al 

J Clin Virol.
2007 Jan 3;
Abstract
 
Ability of different lopinavir genotypic inhibitory quotients to predict 48-week
virological response in highly treatment-experienced HIV-infected patients
receiving lopinavir/ritonavir.

Gianotti N, Galli L, Danise A, et al 
J Med Virol. 2006 Oct 24;78(12):1537-1541
Abstract
 
Prevalence of the HIV-1 protease mutation I47A in clinical practice and association
with lopinavir resistance.

de Mendoza C, Valer L, Bacheler L, et al 

AIDS
. 2006 Apr 24;20(7):1071-4.
Abstract
 
Relationship between Adherence and the Development of Resistance in
Antiretroviral-Naive, HIV-1-Infected Patients Receiving Lopinavir/Ritonavir or
Nelfinavir.

King MS, Brun SC, Kempf DJ.
Infect Dis. 2005 Jun 15;191(12):2046-52.
Abstract
 
Selection of resistance in protease inhibitor-experienced, human
immunodeficiency virus type 1infected subjects failing lopinavir- and
ritonavir-based therapy: mutation patterns and baseline correlates.

Mo H , King MS, King K, Molla A, et al  

J Virol
. 2005 Mar;79(6):3329-38.
Abstract
 
Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-
based regimen.

Friend J, Parkin N, Liegle T, et al
AIDS. 18(14):1965-1966, September 24, 2004.
Letter

Safety, Efficacy and Development of Resistance under the New Protease Inhibitor
Lopinavir/Ritonavir: 48-Week Results.

Voigt E, Wasmuth JC, Vogel M, et al 
Infection. 2004 Apr;32(2):82-8.
Abstract

 
Incidence of Resistance in a Double-Blind Study Comparing Lopinavir/Ritonavir
Plus Stavudine and Lamivudine to Nelfinavir plus Stavudine and Lamivudine.

Kempf DJ, King MS, Bernstein B, et al
J Infect Di
s. 2004 Jan 1;189(1):51-60
Abstract

Characterization of resistant HIV variants generated by in vitro passage with
lopinavir/ritonavir.

Mo H, Lu L, Dekhtyar T, Stewart KD, et al
Antiviral Res. 2003 Aug;59(3):173-80
Abstract

FULL-TEXT  ARTICLE
The Irresistible Dale Kempf Discusses Kaletra Resistance

Hawes J
Thoughtleaders
2003 Apr
Paper

 
Accumulation of lopinavir resistance-associated mutations over 3 years follow-up of
patients on highly active antiretroviral therapy: implication in salvage therapy.

Tsuchiya K, Matsuoka S, Hachiya A, et al
AIDS. 15(9):1183-1184, June 15, 2001.
Letter

Cross Resistance

 

  New patterns of HIV-1 resistance during HAART.
Fumero E, Podzamczer D. 

Clin Microbiol Infect.
2003 Nov;9(11):1077-84.
Abstract

FULL-TEXT ARTICLE
Improving lopinavir genotype algorithm through phenotype correlations:
novel mutation patterns and amprenavir cross-resistance.

Parkin NT, Chappey C, Petropoulos CJ

AIDS 2003 May 2;17(7):955-61
Paper

FULL-TEXT ARTICLE
Distinct cross-resistance profiles of the new protease inhibitors amprenavir, lopinavir,
and atazanavir in a panel of clinical samples.

Schnell, Tanja; Schmidt, Barbara; Moschik, et al
AIDS. 17(8):1258-1261, May 23, 2003.
Paper

Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced
replication capacity.

Prado JG, Wrin T, Beauchaine J, et al.

AIDS
2002 May 3;16(7):1009-17
Abstract

Genotypic and phenotypic cross-resistance patterns to lopinavir and
amprenavir in protease inhibitor-experienced patients with HIV viremia.

Paulsen D, Liao Q, Fusco G, St Clair M, et al.
AIDS Res Hum Retroviruses 2002 Sep 20;18(14):1011-9
Abstract

 


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Lopinavir/Ritonavir
Journal Papers/Abstracts/Commentaries: Resistance