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Rilpivirine (Edurant)
 
Journal Abstracts, Papers, and Commentaries|

Animal Studies                     Drug/Drug Interactions
General Reports                    
Therapeutic Strategies         
Pharmacokinetics                  
Prophylaxis
Diagnostics/Monitoring
Viral Dynamics
Resistance
Efficacy

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Last Update:  February 17, 2018
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Animal Studies
 

  Low Frequency of Drug Resistant Variants Selected by Long Acting Rilpivirine (RPV LA) in Macaques Infected with RT-SHIV.
Melody K, McBeth S, Kline C,et al
Antimicrob Agents Chemother. 2015 Oct 5.

Abstract

General Reports
 

 
Penetration and antiviral efficacy of total and unbound maraviroc, raltegravir and rilpivirine in both female and male genital fluids from HIV-positive patients receiving regimens containing these antiretrovirals.
Lę MP, Belarbi L, Chaix ML, Dulioust E, et al
J Antimicrob Chemother. 2017 Sep 8.
Abstract

Factors associated with pre-treatment HIV RNA: application for the use of abacavir and rilpivirine as the first-line regimen for HIV-infected patients in resource-limited settings.
Kiertiburanakul S, Boettiger D, Ng OT, .et al
AIDS Res Ther. 2017 May 5;14:27.
Abstract

Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.
Hohmann N, Reinhard R, Schnaidt S,  et a;
J Antimicrob Chemother. 2016 May 1
Abstract

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus.
Liu N, Wei L, Huang L, et al
J Med Chem. 2016 Apr 28;59(8):3689-704.
Abstract

Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue.
Dezzutti CS, Else LJ, Yandura SE. et al
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2765-70.
Abstract

FULL-TEXT ARTICLE
Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.
Smith SJ, Pauly GT, Akram A,  et a;
Retrovirology. 2016 Feb 16;13:11.
Paper

Distinct pharmacodynamic activity of rilpivirine in ectocervical and colonic explant tissue.
Dezzutti CS, Else LJ, Yandura SE, et al
Antimicrob Agents Chemother
. 2016 Feb 22.
Abstract

FULL-TEXT ARTICLE
Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission.
Kovarova M, Council OD, Date AA,  et al
PLoS Pathog
. 2015 Oct 16;11(10):e1005170

Paper

Deep sequencing analysis of HIV-1 reverse transcriptase at baseline and time of failure in patients receiving rilpivirine in the phase III studies ECHO and THRIVE.
Van Eygen V, Thys K, Van Hove C, et al
J Med Virol
. 2015 Sep 28.
Abstract

Formulation and pharmacology of long-acting rilpivirine.
Williams PE, Crauwels HM, Basstanie ED.
Curr Opin HIV AIDS. 2015 Jul;10(4):233-8
Abstract

Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine.
Theys K, Camacho RJ, Gomes P,  et al
Clin Microbiol Infect. 2015 Feb 19.
Abstract

Recent advances in rilpivirine: new data and promising treatment option.
Casado JL, Bańón S.
AIDS Rev. 2014 Jul-Sep;16(3):172-81
Abstract

Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz.
BBlas-García A, Polo M, Alegre F, et al  
J Antimicrob Chemother
. 2014 Jul 9
Abstract

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: Implications for rilpivirine use in resource-limited settings.
Sluis-Cremer N, Jordan MR, Huber K, et al
Antiviral Res
. 2014 Apr 15

Abstract

Rilpivirine: drug profile of a second-generation non-nucleoside reverse transcriptase HIV-inhibitor.
Ripamonti D, Bombana E, Rizzi M.
Expert Rev Anti Infect Ther
. 2013 Nov 28
Abstract


Effect of food on rilpivirine/emtricitabine/tenofovir disoproxil fumarate, an antiretroviral single-tablet regimen for the treatment of HIV infection.
Custodio JM, Yin X, Hepner M,  et al
J Clin Pharmacol
. 2013 Oct 19

Abstract

An update on clinical utility of rilpivirine in the management of HIV infection in treatment-naďve patients.
Putcharoen O, Kerr SJ, Ruxrungtham K.
HIV AIDS (Auckl)
. 2013 Sep 16;5:231-241.
Abstract

Rilpivirine inhibits drug transporters ABCB1, SLC22A1 and SLC22A2 in vitro.
Moss DM, Liptrott NJ, Curley P, et al 
Antimicrob Agents Chemother
. 2013 Sep 3

Abstract

Safety profile of rilpivirine: general and neuropsychiatric tolerability, safety in patients with hepatitis B or C viruses, and lipid profile.
López Cortés LF, Martínez E, von Wichmann MA.
Enferm Infecc Microbiol Clin
. 2013 Jun;31S2:6-11
Abstract

Rilpivirine - a novel HIV-1 non-nucleoside reverse transcriptase inhibitor
Snopková S, Havlíčková K, Polák P, Slesinger P, Husa P.
Klin Mikrobiol Infekc Lek. 2013 Mar;19(1):19-22.
Abstract

The Role of Rilpivirine in Clinical Practice: Strengths and Weaknesses of the New Nonnucleoside Reverse Transcriptase Inhibitor for HIV Therapy.
Imaz A, Podzamczer D.
AIDS Rev. 2012 Oct;14(4):268-78.
Abstract

Absence of a pharmacokinetic interaction of rilpivirine with the P-glycoprotein substrate digoxin in healthy volunteers.
Crauwels H, Deckx H, Enweonye I,  et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18337.
Abstract

Update on rilpivirine: A new potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV replication.
Zaharatos GJ, Wainberg MA.
Ann Med
. 2012 Nov 17.
Abstract

Rilpivirine. First-line treatment of HIV infection: efavirenz is better documented.

[No authors listed]
Prescrire Int. 2012 Nov;21(132):262-5

Abstract

Rilpivirine: a new non-nucleoside reverse transcriptase inhibitor.
Sharma M, Saravolatz LD.
J Antimicrob Chemother
. 2012 Oct 25
Abstract

Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.
Schafer JJ, Short WR.
Antivir Ther. 2012 Jul 25.
Abstract

FULL-TEXT ARTICLE
Rilpivirine: A second-generation nonnucleoside reverse transcriptase inhibitor.
James C, Preininger L, Sweet M.
Am J Health Syst Pharm. 2012 May 15;69(10):857-61.
Paper

Rilpivirine and complera: new first-line treatment options.
O'Neal R.
BETA
. 2011 Fall-Winter;23(4):14-8.
Abstract

Rilpivirine: A second-generation nonnucleoside reverse transcriptase inhibitor.
James C, Preininger L, Sweet M.
Am J Health Syst Pharm
. 2012 May 15;69(10):857-61.
Abstract

Rilpivirine : a next-generation non-nucleoside analogue for the treatment of HIV infection.
Fernández-Montero JV, Vispo E,  et al
Expert Opin Pharmacother. 2012 May;13(7):1007-14
Abstract

Rilpivirine.
Sanford M.
Drugs
. 2012 Mar 5;72(4):525-41
Abstract

Rilpivirine: a new addition to the anti-HIV-1 armamentarium.
Miller CD, Crain J, Tran B, Patel N.
Drugs Today (Barc). 2011 Jan;47(1):5-15
Abstract

Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
Lansdon EB, Brendza KM, Hung M, et al  
J Med Chem
. 2010 May 3
Abstract

Short-term randomized proof-of-principle trial of TMC278 in patients with HIV type-1 who have previously failed antiretroviral therapy.
Arastéh K, Rieger A, Yeni P, et al 
Antivir Ther
. 2009;14(5):713-22
Abstract

Rilpivirine: a novel non-nucleoside reverse transcriptase inhibitor.
Garvey L, Winston A.
Expert Opin Investig Drugs. 2009 Jul;18(7):1035-4
Abstract
 
Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment.
Baert L, van 't Klooster G, Dries W, et al
Eur J Pharm Biopharm
. 2009 Mar 27
Abstract

Etravirine and rilpivirine: nonnucleoside reverse transcriptase inhibitors with activity against human immunodeficiency virus type 1 strains resistant to previous nonnucleoside agents.
Fulco PP, McNicholl IR.
Pharmacotherapy
2009 Mar;29(3):281-94
Abstract


Rilpivirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV infection.
Ripamonti D, Maggiolo F.
Curr Opin Investig Drugs. 2008 Aug;9(8):899-912.
Abstract
 
Powder for reconstitution of the anti-HIV-1 drug TMC278 - Formulation development, stability and animal studies.
Van Gyseghem E, Pendela M, Baert L, et al
Eur J Pharm Biopharm. 2008 Jul 9.
Abstract
 
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.
Das K, Bauman JD, Clark AD Jr,
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71.
Paper
 
FULL-TEXT PDF ARTICLE
Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase.
Fang C, Bauman JD, Das K, et al
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1472-7.
Paper
 
Short-term antiviral activity of TMC278--a novel NNRTI--in treatment-naive HIV-1-infected subjects.
Goebel F, Yakovlev A, Pozniak AL, et al
AIDS. 2006 Aug 22;20(13):1721-6.
Abstract

 
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile  (R278474, rilpivirine).
Janssen PA, Lewi PJ, Arnold E, et al
J Med Chem. 2005 Mar 24;48(6):1901-9.
Abstract


Pharmacokinetics
 

  Pharmacokinetics of rilpivirine and 24-week outcomes after switching from efavirenz in virologically-suppressed HIV-1-infected adolescents.
Jantarabenjakul W, Anugulruengkitt S, Kasipong N, et al  
Antivir Ther
. 2017 Oct 10.
Abstract

Rilpivirine Pharmacokinetics Without and With Darunavir/ritonavir once daily in Adolescents and Young Adults.
Foca M, Yogev R, Wiznia A,
Pediatr Infect Dis J. 2016 May 16.
Abstract

Rilpivirine Pharmacokinetics in 3 HIV-Positive Patients With Liver Cirrhosis Concomitantly Receiving Pantoprazole.
Calcagno A, Trentalange A, Simiele M,  et al
Ther Drug Monit. 2015 Oct;37(5):695-6.
Abstract

Steady-state pharmacokinetics of rilpivirine under different meal conditions in HIV-1-infected Ugandan adults.
Lamorde M, Walimbwa S, Byakika-Kibwika P, et al
J Antimicrob Chemother
. 2015 Feb 3. |
Abstract

Mechanism of action and pharmacokinetics of rilpivirine.
Portilla J, Estrada V.
Enferm Infecc Microbiol Clin. 2013 Jun;31S2:2-5.
Abstract

Effect of food on the pharmacokinetics of emtricitabine/rilpivirine/tenofovir disoproxil fumarate single-tablet regimen.
Ramanathan S, Custodio J, Yin X, Hepner M,  et al  
J Int AIDS Soc
. 2012 Nov 11;15(6):18333.
Abstract

FULL-TEXT ARTICLE
Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation.
van 't Klooster G, Hoeben E, Borghys H,
Antimicrob Agents Chemother
. 2010 May;54(5):2042-50.
Paper


Diagnostics/Monitoring
 

 
UPLC-MS/MS method for the simultaneous quantification of three new antiretroviral drugs, dolutegravir, elvitegravir and rilpivirine, and other thirteen antiretroviral agents plus cobicistat and ritonavir boosters in human plasma.
Simiele M, Ariaudo A, De Nicolň A, et aL
J Pharm Biomed Anal
. 2017 Feb 3;138:223-230.
Abstract

Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study.
Prathipati PK, Mandal S, Destache CJ.
J Pharm Biomed Anal. 2016 Jul 26;129:473-481
Abstract

Development And Validation Of A Chromatographic Uv Method For The Simultaneous Quantification Of Dolutegravir And Rilpivirine In Human Plasma.
Cozzi V, Charbe N, Baldelli S,  et al  
Ther Drug Monit
. 2016 Feb 16
Abstract

A liquid chromatography-tandem mass spectrometry assay for quantification of rilpivirine and dolutegravir in human plasma.
Grégoire M, Deslandes G, Renaud C,  et al
J Chromatogr B Analyt Technol Biomed Life Sci
. 2014 Sep 16;971C:1-9
Abstract

A validated assay by liquid chromatography-tandem mass spectrometry for the simultaneous quantification of elvitegravir and rilpivirine in HIV positive patients.
Aouri M, Calmy A, Hirschel B,  et al 
J Mass Spectrom
. 2013 May;48(5):616-625.
Abstract

A validated assay by liquid chromatography-tandem mass spectrometry for the simultaneous quantification of elvitegravir and rilpivirine in HIV positive patients.
Aouri M, Calmy A, Hirschel B,  et al 
J Mass Spectrom. 2013 May;48(5):616-625.

Abstract

Determination of rilpivirine (TMC-278) plasma concentrations by the conventional LC-MS method.
Shibata M, Takahashi M, Kuwahara T, et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18361
Abstract

Liquid chromatography-tandem mass spectrometric assay for the non-nucleoside reverse transcriptase inhibitor rilpivirine in human plasma.
Burugula L, Pilli NR, Makula A,  et al
Biomed Chromatogr
. 2012 Jun 22.
.
Abstract


Viral Dynamics
 

  Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis.
Rimsky L, Vingerhoets J, Van Eygen V, et al
J Acquir Immune Defic Syndr
. 2011 Nov 7.
Abstract

Resistance
 

 

In Vitro Cross-Resistance Profiles of Rilpivirine, Dapivirine and MIV-150: NNRTI Microbicides in Clinical Development for the Prevention of HIV-1 Infection.
Giacobbi NS, Sluis-Cremer N.
Antimicrob Agents Chemother. 2017 May 15.
Abstract

Rilpivirine and Doravirine have complementary efficacies against NNRTI-Resistant HIV-1 mutants.
Smith SJ, Pauly GT, Akram A,
J Acquir Immune Defic Syndr. 2016 Apr 23
Abstract

Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance.
Gray WT, Frey KM, Laskey SB,
ACS Med Chem Lett. 2015 Aug 31;6
Abstract

Transmitted drug resistance to rilpivirine in newly diagnosed antiretroviral naive adults.
Alvarez M, Monge S, Chueca N,  et al
Clin Microbiol Infect
. 2015 Jan;21(1):104.e1-5.
Abstract

Real-life rilpivirine resistance and potential emergence of an E138A-positive HIV strain in north-eastern France.
Jeulin H, Foissac M, Boyer L, et al  
J Antimicrob Chemother
. 2014 Jul 8.
Abstract

Rilpivirine resistance and the dangerous liaisons with substitutions at position 184 among patients infected with HIV-1: Analysis from a national drug-resistance database (ARCA).
Rossotti R, Fonte L, Meini G,  et al
J Med Virol. 2014 May 17.
Abstract

Transmitted drug resistance to rilpivirine among antiretroviral-naďve patients living with HIV from northern Poland.
Parczewski M, Urbańska A, Maciejewska K, et al
J Int AIDS Soc. 2014 Apr 17;17(1):18929.

Abstract

Prevalence in the USA of rilpivirine resistance-associated mutations in clinical samples and effects on phenotypic susceptibility to rilpivirine and etravirine.
Picchio GR, Rimsky LT, Van Eygen V,
Antivir Ther. 2014 Apr 4
Abstract

Rilpivirine, emtricitabine and tenofovir resistance in HIV-1-infected rilpivirine-naive patients failing antiretroviral therapy.
Lambert-Niclot S, Charpentier C, Storto A, et al
J Antimicrob Chemother
. 2013 Dec 2
Abstract

The Connection Domain Mutation N348I in HIV-1 Reverse Transcriptase Enhances Resistance to Etravirine and Rilpivirine but Restricts the Emergence of the E138K Resistance Mutation by Diminishing Viral Replication Capacity.
Xu HT, Colby-Germinario SP, Oliveira M,  et al
J Virol
. 2013 Nov 13.
Abstract

Genetic barrier to the development of resistance to rilpivirine and etravirine between HIV-1 subtypes CRF02_AG and B.
Fofana DB, Soulie C, Maiga AI, et al
J Antimicrob Chemother. 2013 Jul 5.
Abstract

Resistance profile of rilpivirine.
Imaz A, García F, di Yacovo S, Llibre JM.
Enferm Infecc Microbiol Clin. 2013 Jun;31S2:36-43
Abstract

The Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and their Interactions with the M184I Mutation in Defining Patterns of Resistance to the Non-Nucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine.
Xu HT, Colby-Germinario SP, Asahchop EL, et al 
Antimicrob Agents Chemother
. 2013 Apr 22.
Abstract

Prevalence of pre-existing resistance-associated mutations to rilpivirine, emtricitabine and tenofovir in antiretroviral-naive patients infected with B and non-B subtype HIV-1 viruses.
Lambert-Niclot S, Charpentier C, Storto A,  et al
J Antimicrob Chemother
. 2013 Jan 29.
Abstract

Distinct resistance patterns to etravirine and rilpivirine in viruses containing nnrti mutations at baseline.
Asahchop EL, Wainberg MA, Oliveira M, et al
AIDS. 2012 Dec 19.
Abstract

Preexisting mutations in the rilpivirine Phase III trials ECHO and THRIVE: prevalence and impact on virologic response.
Vingerhoets J, Rimsky L, Van Eygen V,  et al
Antivir Ther
. 2012 Sep 6.
Abstract

FULL-TEXT PDF ARTICLE
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine.
Singh K, Marchand B, Rai DK,  et al
J Biol Chem. 2012 Sep 6
Paper

Rilpivirine Resistance Mutations in HIV Patients Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Therapies.
Anta L, Llibre JM, Poveda E,  et al
AIDS
. 2012 Aug 7.
Abstract

Panel of prototypical recombinant infectious molecular clones resistant to nevirapine, efavirenz, etravirine, and rilpivirine.
Balamane M, Varghese V, Melikian GL, et al
Antimicrob Agents Chemother. 2012 Aug;56(8):4522-4
Paper
 

Minority variants associated with resistance to HIV-1 nonnucleoside reverse transcriptase inhibitors during primary infection.
Nicot F, Saliou A, Raymond S, et al  J
Clin Virol
. 2012 Jul 19.
Abstract

E138K and M184I mutations in HIV-1 reverse transcriptase co-emerge as a result of APOBEC3 editing in the absence of drug exposure.
Fourati S, Malet I, Lambert S,  et al
AIDS. 2012 Jun 12
Abstract

Panel of Prototypical Recombinant Infectious Molecular Clones Resistant to Nevirapine, Efavirenz, Etravirine, and Rilpivirine.
Balamane M, Varghese V, Melikian GL,  et al
Antimicrob Agents Chemother
. 2012 Jun 4.
Abstract

Prevalence of TMC278 (rilpivirine) associated mutations in the Frankfurt Resistance Database.
Reinheimer C, Doerr HW, Stürmer M. et al
J Clin Virol
. 2011 Dec 30.
Abstract

   
  Etravirine and rilpivirine resistance in HIV-1 subtype CRF01_AE-infected adults failing non-nucleoside reverse transcriptase inhibitor-based regimens.
Bunupuradah T, Ananworanich J, Chetchotisakd P,  et al
Antivir Ther. 2011;16(7):1113-21
Abstract

Efficacy
 

 
FULL-TEXT ARTICLE
Long-term efficacy and safety of rilpivirine plus abacavir and lamivudine in HIV-1 infected patients with undetectable viral load.
Galizzi N, Galli L, Poli A, Gianotti N,  et a
lPLoS One. 2018 Feb 16;13(2):e0191300
Paper

Efficacy and safety of dolutegravir and rilpivirine dual therapy as a simplification strategy: a cohort study.
Gantner P, Cuzin L, Allavena C, et al
HIV Med
. 2017 Apr 26.
Abstract

Rilpivirine as a Treatment for HIV-infected Antiretroviral-naďve Adolescents: Week 48 Safety, Efficacy, Virology and Pharmacokinetics.
Lombaard J, Bunupuradah T, Flynn PM, et al
Pediatr Infect Dis J. 2016 Nov;35(11):1215-1221.
Abstract

Rilpivirine, emtricitabine and tenofovir alafenamide: single-tablet combination for the treatment of HIV-1 infection in selected patients.
Ogbuagu O.
Expert Rev Anti Infect Ther. 2016 Oct 31
Abstract

Rilpivirine as a Treatment for HIV-infected Antiretroviral-Naďve Adolescents: Week 48 Safety, Efficacy, Virology and Pharmacokinetics
Lombaard J, Bunupuradah T, Flynn PM,
Pediatr Infect Dis J. 2016 Jun 10.
Abstract

FULL-TEXT ARTICLE
Role of Rilpivirine and Etravirine in Efavirenz and Nevirapine-Based Regimens Failure in a Resource-Limited Country: A Cross- Sectional Study
Teeranaipong P, Sirivichayakul S, Mekprasan S,
PLoS One. 2016 Apr 27;11(4):e0154221.
Paper

Rilpivirine vs. efavirenz-based single-tablet regimens in treatment-naive adults: week 96 efficacy and safety from a randomized phase 3b study.|
van Lunzen J, Antinori A, Cohen CJ, et al
AIDS. 2016 Jan;30(2):251-9.
Abstract

Efficacy and safety of a switch to rilpivirine-based regimens in treatment-experienced HIV-1-infected patients: a cohort study.
Gazaignes S, Resche-Rigon M, Gatey C,  et al
Antivir Ther
. 2015 Nov 13.
Abstract

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.
Neogi U, Häggblom A, Singh K,  et al
J Antimicrob Chemother
. 2015 Oct 30.

Abstract

Patient-reported outcomes in the single-tablet regimen (STaR) trial of rilpivirine/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate in antiretroviral treatment-naive adults infected with HIV-1 through 48 weeks of treatment.
Wilkins EL, Cohen CJ, Trottier B, et al
AIDS Care
. 2015 Oct 21:1-8

Abstract

Effectiveness and Safety of Rilpivirine, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Treatment-Naive Adults Infected with HIV-1: A Meta-analysis.
Li SL, Xu P, Zhang L, et al
HIV Clin Trials
. 2014 Nov-Dec;15(6):261-8.
Abstract

Efficacy and safety of rilpivirine-based regimens in treatment-experienced HIV-1 infected patients: a prospective cohort study.
Gazaignes S, Resche-Rigon M, Yang C, et al
J Int AIDS Soc
. 2014 Nov 2;17(4(Suppl 3)):19796
Abstract

Lipid changes in HIV-patients switching to the coformulated single tablet FTC/RPV/TDF (Eviplera®). Efficacy and safety analysis. GeSida Study 8114.
Pérez-Hernández IA, Palacios R, Mayorga M, et al
J Int AIDS Soc
. 2014 Nov 2;17(4(Suppl 3)):19795.
Abstract

The Efficacy, Pharmacokinetics and Safety of a Nevirapine to Rilpivirine Switch in Virologically Suppressed HIV-1 Infected Patients.
Rokx C, Blonk M, Verbon A,  et al
J Acquir Immune Defic Syndr. 2014 Sep 22.
Abstract

Initiation of rilpivirine, tenofovir and emtricitabine (RPV/TDF/FTC) regimen in 363 patients with virological vigilance assessment in 'real life'
Amiel C, Schneider V, Guessant S,  et al
J Antimicrob Chemother. 2014 Aug 11.
Abstract

Rilpivirine Versus Efavirenz with Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment-Naďve HIV-1-Infected Patients with HIV-1 RNA ≤100,000 Copies/mL: Week 96 Pooled ECHO/THRIVE Subanalysis.
Behrens G, Rijnders B, Nelson M,  et al  
AIDS Patient Care STDS
. 2014 Mar 24.
Abstract

Outcomes In Older Versus Younger Patients Over 96 Weeks In Hiv-1-Infected Patients Treated With Rilpivirine Or Efavirenz In Echo And Thrive
Ryan R, Dayaram YK, Schaible D,  et al
Curr HIV Res
. 2014 Jan 28
Abstract

Data on rilpivirine in treatment-naďve patients. Lessons from ECHO, THRIVE and STaR.
Domingo P, Ribera E.
Enferm Infecc Microbiol Clin. 2013 Jun;31S2:20-29.
Abstract

Rilpivirine Versus Efavirenz in HIV-1-Infected Subjects Receiving Emtricitabine/Tenofovir DF: Pooled 96-Week Data from ECHO and THRIVE Studies.
Nelson MR, Elion RA, Cohen CJm et al
HIV Clin Trials. 2013 May-Jun;14(3):81-91.
Abstract

96-week resistance analyses of rilpivirine in treatment-naive, HIV-1-infected adults from the ECHO and THRIVE Phase III trials.
Rimsky L, Van Eygen V, Hoogstoel A,  et al
Antivir Ther. 2013 May 28
Abstract

 Rilpivirine : a next-generation non-nucleoside analogue for the treatment of HIV infection.
Fernández-Montero JV, Vispo E,  et al
Expert Opin Pharmacother
. 2012 May;13(7):1007-14
Abstract

Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir.
Wainberg MA.HIV AIDS (Auckl). 2013;5:41-9.
Abstract

Rilpivirine versus efavirenz in HIV-1 patients with baseline viral load ≤100 000 copies/ml: week 48 Phase III analysis.
Molina JM, Clumeck N, Redant K,  et al
AIDS
. 2012 Dec 31.
Abstract

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Johnson BC, Pauly GT, Rai G, et al
Retrovirology
. 2012 Dec 5;9(1):99.
Abstract

Week 96 efficacy and safety of rilpivirine in treatment-naďve, HIV-1 patients in two Phase III randomised trials.
Cohen CJ, Molina JM, Cassetti I, et al
AIDS
. 2012 Dec 3.
Abstract

Rilpivirine. First-line treatment of HIV infection: efavirenz is better documented.
[No authors listed]
Prescrire Int. 2012 Nov;21(132):262-5
Abstract

Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era.
De Clercq E.
Biochem Pharmacol
. 2012 Apr 5.
Abstract

Efficacy and safety of rilpivirine in treatment-naive, HIV-1-infected patients with hepatitis B virus/hepatitis C virus coinfection enrolled in the Phase III randomized, double-blind ECHO and THRIVE trials.
Nelson M, Amaya G, Clumeck N, et al
J Antimicrob Chemother
. 2012 Apr 24.
Abstract

Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naďve, HIV-1-infected patients: Pooled results from the phase 3 double-blind, randomized ECHO and THRIVE trials.
Cohen C, Molina J, Cahn P, et al
J Acquir Immune Defic Syndr
. 2012 Feb 16
Abstract

   
  Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial.
Molina JM, Cahn P, Grinsztejn B. et al
Lancet. 2011 Jul 16;378(9787):238-46.
Abstract
   
  Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial.
Cohen CJ, Andrade-Villanueva J, Clotet B, et al 
Lancet
. 2011 Jul 16;378(9787):229-37.
Abstract
 
  New antiretroviral drugs: a review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir.
Hughes CA, Robinson L, Tseng A, Macarthur RD.
Expert Opin Pharmacother
. 2009 Aug 13.
Abstract

Adverse Events
 

  A randomized, controlled trial of the effect of rilpivirine versus efavirenz on cardiovascular risk in healthy volunteers.
Gupta SK, Slaven JE, Kamendulis LM, Liu Z.
J Antimicrob Chemother
. 2015 Jul 131

Abstract

Analysis of Lipid Levels and Changes in Body Fat Distribution in Treatment-Naive, HIV-1-Infected Adults Treated with Rilpivirine or Efavirenz Over 96 Weeks in the ECHO and THRIVE Trials.
Tebas P, Sension M, Arribas J,  et al
Clin Infect Dis
. 2014 Apr 11.
Abstract

Change in vitamin D levels and risk of severe vitamin D deficiency over 48 weeks among HIV-1-infected, treatment-naive adults receiving rilpivirine or efavirenz in a Phase III trial (ECHO).
Wohl DA, Orkin C, Doroana M,  et al
Antivir Ther. 2014 Jan 16.
Abstract

Liver Toxicity in HIV-Infected Patients Receiving Novel Second-Generation Nonnucleoside Reverse Transcriptase Inhibitors Etravirine and Rilpivirine.
Casado JL. 
AIDS Rev. 2013 Jul-Sep;15(3):139-45.
Abstract


Drug/Drug Interactions
 

 
MDR1 and BCRP transporter-mediated drug-drug interaction between rilpivirine and abacavir; effect on intestinal absorption.
Reznicek J, Ceckova M, Ptackova Z, et al
Antimicrob Agents Chemother. 2017 Jul 10.
Abstract

Evaluation of Drug-Drug Interactions between Direct-Acting Anti-Hepatitis C Virus Combination Regimens and the HIV-1 Antiretroviral Agents Raltegravir, Tenofovir, Emtricitabine, Efavirenz, and Rilpivirine.
Khatri A, Dutta S, Dunbar M, et al
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2965-71.
Abstract

Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial.
Kakuda TN, Leopold L, Nijs S,  et al
J Clin Pharmacol
. 2014 May;54(5):563-73.
Abstract

The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers.
Crauwels HM, van Heeswijk RP, Vandevoorde A,  
J Clin Pharmaco
l
. 2013 Nov 6.
Abstract

Lack of an effect of rilpivirine on the pharmacokinetics of ethinylestradiol and norethindrone in healthy volunteers.
Crauwels HM, van Heeswijk RP, Buelens A,  et al
Int J Clin Pharmacol Ther
. 2013 Oct 28.
Abstract

Lack of Pharmacokinetic Interaction Between Rilpivirine and Integrase Inhibitors Dolutegravir and GSK1265744.
Ford SL, Gould E, Chen S, et al 
Antimicrob Agents Chemother
. 2013 Aug 26.

Abstract

Pharmacokinetic interactions
Arazo Garcés P, Los Santos Gil ID.
Enferm Infecc Microbiol Clin. 2013 Jun;31S2:12-19
Abstract

Clinical Perspective on Drug‑Drug Interactions with the Non-nucleoside Reverse Transcriptase Inhibitor Rilpivirine.
Crauwels H, van Heeswijk RP, Stevens M,  et al 
AIDS Rev
. 2013 May 17;15(2):87-101.

Abstract


Therapeutic Strategies
 

 

Switch from unboosted protease inhibitor to a single-tablet regimen containing rilpivirine improves cholesterol and triglycerides.
Di Biagio A, Riccardi N, Taramasso L,  et al
I
nt J Antimicrob Agents
. 2016 Nov;48(5):551-554.
Abstract

Efficacy and safety of dolutegravir and rilpivirine dual therapy as a simplification strategy: a cohort study.
Gantner P, Cuzin L, Allavena C, et al
HIV Med. 2017 Apr 26.
Abstract

Enteral Administration of Twice-Daily Dolutegravir and Rilpivirine as a Part of a Triple-Therapy Regimen in a Critically Ill Patient with HIV.
Turley SL, Fulco PP.
J Int Assoc Provid AIDS
Care
. 2017
Abstract

Clinical Outcomes of Virologically-Suppressed Patients with Pre-existing HIV-1 Drug Resistance Mutations Switching to Rilpivirine/Emtricitabine/Tenofovir Disoproxil Fumarate in the SPIRIT Study.
Porter DP, Toma J, Tan Y,
HIV Clin Trials. 2016 Feb;17(1):29-37.
Abstract

Improvement of lipid profiles when switching from efavirenz to rilpivirine in HIV-infected patients with dyslipidemia.
Thamrongwonglert P, Chetchotisakd P, Anunnatsiri S, Mootsikapun P.
 HIV Clin Trials
. 2016 Jan 7:1-5.
Abstract

Association of dolutegravir and rilpivirine, enhanced by foscarnet induction, in effective salvage antiretroviral therapy.
Leporrier J, Etienne M, Chapuzet C, et al
J Clin Virol
. 2014 Aug;60(4):428-30

Abstract

Successful switch to rilpivirine/tenofovir/emtricitabine in HIV-1-infected patients with an isolated K103N mutation acquired during prior nonnucleoside reverse transcriptase inhibitor therapy.
Rokx C, Verbon A, Rijnders B.
HIV Med. 2014 Apr 16.
Abstract

Efficacy and safety 48 weeks after switching from efavirenz to rilpivirine using emtricitabine/tenofovir disoproxil fumarate-based single-tablet regimens.
Mills AM, Cohen C, Dejesus E ,et al
HIV Clin Trials. 2013 Sep-Oct;14(5):216-33.
Abstract

Potential role of rilpivirine in simplification regimens.
Casado JL, Moreno S.
Enferm Infecc Microbiol Clin. 2013 Jun;31S2:30-35.
Abstract

 

Prophylaxis
 

 

FULL-TEXT ARTICLE
Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission.
Kovarova M, Council OD, Date AA,  et a
PLoS Pathog
. 2015 Aug 13;11(8):e1005075.

Paper

Long-acting rilpivirine for HIV prevention.
Jackson A, McGowan I.
Curr Opin HIV AIDS
. 2015 Jul;10(4):253-7.
Abstract

A compartmental pharmacokinetic evaluation of long-acting rilpivirine in HIV negative volunteers for pre-exposure prophylaxis (PrEP).
Jackson AG, Else LJ, Mesquita PM,  et al
Clin Pharmacol Ther. 2014 May 26

Abstract

 


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