Saquinavir Pediatric Index

Medical Advocates
Saquinavir (Fortovase/Invirase)

Pediatric Index

General Reports
Pharmacokinetics
Combination Therapy
US Treatment Guidelines

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Last Update: March 05, 2015
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General Reports

     Conference Reports, Abstracts, and Posters

Barriers to the development of a pediatric formulation of saquinavir
M Bachynsky, MInfeld, W Phuapradit, et al
[8th Int Congress on Drug Therapy in HIV Infection]
Abstract

Pharmacokinetics

Clinical Pharmacology



Pharmacokinetics
    Journal Papers, Abstracts, and Commentaries

Pharmacokinetics and pharmacodynamics of saquinavir in pediatric patients with
human immunodeficiency virus infection.
Grub S, Delora P, Ludin E, et al.
Clin Pharmacol Ther 2002 Mar;71(3):122-30
Abstract

     Conference Reports, Abstracts, and Posters

A Pharmacokinetic Study of Ritonavir-boosted Saquinavir in HIV-infected Children
4 Months to <6 Years Old
J Haznedar, A Zhang, E Labriola-Tompkins
(17th CROI)
Abstract

Pharmacokinetics of saquinavir (SQV) with nelfinavir (NFV) or ritonavir (RTV) in
HIV-infected children.
(8 CROI)
Abstract

Combination Therapy

    Journal Papers, Abstracts, and Commentaries

Double Boosted Protease Inhibitors, Saquinavir, and Lopinavir/Ritonavir, in Nucleoside Pretreated Children
at 48 Weeks.
Kosalaraksa P, Bunupuradah T, Engchanil C, et al
Pediatr Infect Dis J. 2008 May 22.
Abstract

Pharmacokinetics and 24-Week Efficacy/Safety of Dual Boosted Saquinavir/Lopinavir/Ritonavir
in Nucleoside-Pretreated Children.
Ananworanich J, Kosalaraksa P, Hill A, et al
Pediatr Infect Dis J. 2005 Oct;24(10):874-87
Abstract

Combination therapy with saquinavir soft gelatin capsules in children with human
immunodeficiency virus infection.
Kline MW, Brundage RC, Fletcher CV, et al.
Pediatric Infectious Disease Journal 2001; 20:666- 671.
Abstract

Comparison of ritonavir plus saquinavir- and nelfinavir plus saquinavir-containing
regimens as salvage therapy in children with human immunodeficiency virus type 1
infection.
Hoffmann F, Notheis G, Wintergerst U, et al.
Pediatric Infectious Disease Journal 2000; 19:47-51.
Abstract

     Conference Reports, Abstracts, and Posters

Lack of PI resistance in children failing double boosted saquinavir (SQV)/lopinavir/ritonavir
(LPV/r) combination
Bunupuradah T., Kosalaraksa P., Engchanil C., et al
(XVI International AIDS Conference)
Abstract

Efficacy and safety of double boosted saquinavir (SQV)/lopinavir/ritonavir (LPV/r) in nucleoside
pre-treated children at 48 weeks
Kosalaraksa P., Bunupuradah T., Engchanil C., et al
(XVI International AIDS Conference)
Abstract

Pharmacokinetics and 24-Week Efficacy and Safety of Saquinavir/Lopinavir/Ritonavir
in RTI-pre-treated Children
J Ananworanich , P Kosalaraksa, U Siangphoe. et al
(12 CROI)
Abstract

A randomized trial of combination therapy with saquinavir soft gel capsules (SQV) in
HIV-infected children .
(8 CROI)
Abstract

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Saquinavir Pediatric Index