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Tenofovir Disoproxil Fumarate
(Viread)
   
Journal HIV Efficacy/Non-Efficacy Citations

Prophylaxis
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Last Update:  April 24, 2018
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Prophylaxis
 

 

MTN-017: A Rectal Phase 2 Extended Safety and Acceptability Study of Tenofovir Reduced-Glycerin 1% Gel.
Cranston RD, Lama JR, Richardson BA, Carballo-Diéguez , et al
Clin Infect Dis. 2016 Dec 16.
Abstract

Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports.
Fox J, Brady M, Alexander H, et a
l
Infect Dis Ther
. 2016 Jan 9.
Abstract

Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir Gel.
Herold BC, Chen BA, Salata RA, et al

Clin Infect Dis
. 2015 Oct 27
Abstract

Concentrations of TFV-DP/FTC-TP in dried blood spots and TFV/FTC in hair are strongly correlated in iPrEx OLE: Implications for PrEP adherence monitoring.
Gandhi M, Glidden DV, Liu A,  et al
J Infect Dis
. 2015 Apr 20.

Abstract

Mucosal effects of tenofovir 1% gel. Downlink full-text article)
Hladik F, Burgener A, Ballweber L,  et al

Elife
. 2015 Feb 3;4.
Abstract

Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Marrazzo JM, Ramjee G, Richardson BA,  et al
 
N Engl J Med
. 2015 Feb 5;372(6):509-18.
Abstract

Risk of Drug Resistance Among Persons Acquiring HIV Within a Randomized Clinical Trial of Single- or Dual-Agent Preexposure Prophylaxis.
Lehman DA, Baeten JM, McCoy CO,  et al  

J Infect Dis
.
2015 Jan 13. pii: jiu677
.
Abstract

FULL-TEXT ARTICLE
Strong Relationship between Oral Dose and Tenofovir Hair Levels in a Randomized Trial: Hair as a Potential Adherence Measure for Pre-Exposure Prophylaxis (PrEP).
Liu AY, Yang Q, Huang Y, Bacchetti P,. et al
PLoS One. 2014 Jan 8;9(1):e83736.
Paper

Impact of Tenofovir gel as a PrEP on HIV infection: A mathematical model.
Ashrafur Rahman SM, Vaidya NK, Zou X.
J Theor Biol. 2013 Dec 28.
Abstract

Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.
Baeten JM, Donnell D, Mugo NR, et al

Lancet Infect Dis
. 2014 Oct 8
Abstract

FULL-TEXT ARTICLE
Multicompartmental pharmacokinetic model of tenofovir delivery by a vaginal gel.
Gao Y, Katz DF.
PLoS One
. 2013 Sep 11;8(9):e74404
Paper

FEM-PrEP: Adherence Patterns and Factors Associated With Adherence to a Daily Oral Study Product for Pre-exposure Prophylaxis.
Corneli AL, Deese J, Wang M,  et al
J Acquir Immune Defic Syndr. 2014 Jul 1;66(3):324-331.
Abstract


FULL-TEXT ARTICLE

A Phase 1 Randomized, Double Blind, Placebo Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel (MTN-007)
McGowan I, Hoesley C, Cranston RD,  et al
PLoS One. 2013;8(4):e60147.
Paper

Preformulation and development of a once-daily sustained-release tenofovir vaginal tablet tablet containing a single excipient.
McConville C, Friend DR, Clark MR, Malcolm K.
J
Pharm Sci. 2013 Apr 9.
Abstract

Rectal microbicide development.
McGowan I.
Curr Opin HIV AIDS. 2012 Oct 1.
Abstract

Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and
sexual behavior in the CAPRISA 004 tenofovir gel trial.
Abdool Karim Q, Kharsany AB, Frohlich JA,  et al
Trials
. 2011 Mar 7;12(1):67.
Abstract

FULL-TEXT ARTICLE
A Randomized Trial to Assess Anti-HIV Activity in Female Genital Tract Secretions and Soluble Mucosal Immunity Following Application of 1% Tenofovir Gel
M Keller MJ,  Madan RP Torres NM, et al
PLoS ONE 6(1): e16475
Paper

Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection.
Anderson PL, Kiser JJ, Gardner EM, et al
J Antimicrob Chemother
. 2010 Nov 30.|
Abstract

FULL-TEXT ARTICLE
In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide
Rohan LC, Moncla BJ, Kunjara Na,
  et al
PLoS One
. 2010 Feb 19;5(2):e9310
Paper

Tolerability of HIV postexposure prophylaxis with tenofovir/emtricitabine and lopinavir/ritonavir tablet formulation.
Tosini W, Muller P, Prazuck T,  et al
AIDS
. 2010 Aug 19
Abstract

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women.
Karim QA, Karim SS, Frohlich JA,  et al |
Science
. 2010 Jul 19
Abstract

Tenofovir DF Plus Lamivudine or Emtricitabine for Nonoccupational Postexposure Prophylaxis (NPEP) in a Boston Community Health Center.
Mayer KH, Mimiaga MJ, Cohen D,et al 

J Acquir Immune Defic Syndr
. 2007 Dec 20
Abstract
 

FULL-TEXT ARTICLE
The Abandoned Trials of Pre-Exposure Prophylaxis for HIV: What Went Wrong?
Singh J,  Mills EJ 
PLOS Medicine Vol2 Issue 9 Sep 2005
Paper
 
FULL-TEXT PDF ARTICLE
Media reporting of tenofovir trials in Cambodia and Cameroon
Mills EJ, Rachlis B, Wu P, et al
BMC International Health and Human Rights
2005, 5:6 doi:10.1186/1472-698X-5-6
Paper
 
The use of a triple nucleoside-nucleotide regimen for nonoccupational HIV post-exposure prophylaxis.
Winston A, McAllister J, Amin J, et al 
HIV Med
. 2005 May;6(3):191-197
Abstract
 

Treatment
 

 
Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety?
Hill A, Hughes SL, Gotham D, Pozniak AL.
 
J Virus Erad
. 2018 Apr 1;4(2):72-79.

Abstract

Immunological outcomes of Tenofovir versus Zidovudine-based regimens among people living with HIV/AIDS: a two years retrospective cohort study.
Ayele T, Jarso H, Mamo G.
AIDS Res Ther
. 2017 Feb 1;14(1):5.
Abstract
 

Lipid-lowering effect and changes in estimated cardiovascular risk after switching to a tenofovir-containing regimen for the treatment of HIV-infected patients.
Gagliardini R, Fabbiani M, Colafigli M, et al
J Chemother. 2016 Dec 26:1
Abstract

Lipid-lowering effect and changes in estimated cardiovascular risk after switching to a tenofovir-containing regimen for the treatment of HIV-infected patients.
Gagliardini R, Fabbiani M, Colafigli M, et al

J Chemother
. 2016 Dec 26

Abstract

Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis.
Ewald H, Santini-Oliveira M, Bühler JE,  et al
HIV Clin Trials. 2016 Dec 13:1-11.
Abstract

FULL-TEXT ARTICLE
The efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in antiretroviral regimens for HIV-1 therapy: Meta-analysis.
Wang H, Lu X, Yang X,et al.
Medicine (Baltimore). 2016 Oct;95(41):e5146.
Paper

FULL-TEXT ARTICLE
Long-Term Durability of Tenofovir-Based Antiretroviral Therapy in Relation to the Co-Administration of Other Drug Classes in Routine Clinical Practice.
Costarelli S, Cozzi-Lepri A, Lapadula G, et al
PLoS One. 2016 Oct 7;11(10):e0160761.
Paper

The effect of Tenofovir on renal function among Ugandan adults on long-term antiretroviral therapy: a cross-sectional enrolment analysis.
Salome T, Kasamba I, Mayanja BN,
AIDS Res Ther. 2016 Aug 30;13(1):28.
Abstract

Renal outcomes after up to eight years of tenofovir exposure in HIV-HBV-coinfected patients.
Boyd A, Miailhes P, Lascoux-Combe C,

Antivir Ther
. 2016 Aug 24.
Abstract

FULL-TEXT ARTICLE
Is There a Need for Viral Load Testing to Assess Treatment Failure in HIV-Infected Patients Who Are about to Change to Tenofovir-Based First-Line Antiretroviral Therapy? Programmatic Findings from Myanmar.
Thiha N, Chinnakali P, Harries AD,  et al

PLoS One
. 2016 Aug 9;11(8):e0160616.
Paper

Optimizing the virological success of tenofovir DF/FTC/rilpivirine in HIV-infected naive and virologically suppressed patients through strict clinical and virological selection.
Bernaud C, Khatchatourian L, Rodallec A,

Infect D Infect Dis (Lond)
.
2016 Oct;48(10):754-9(Lond). 2016 Oct;48(10):754-9.
Abstract

Prevalence and significance of proximal renal tubular abnormalities in HIV-infected patients receiving tenofovir.
Casado JL, Bañón S, Santiuste C, et al

AIDS
. 2016 Jan;30(2):231-9. '
Abstract

Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing.
Casadellà M, Noguera-Julian M, Sunpath H,  et al

AIDS
. 2016 Jan 23
Abstract

Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).
Reinheimer C, Wesner A, Keppler OT, et al

Med Microbiol Immunol
. 2016 Jan 8.
Abstract

Tenofovir monotherapy after achieving complete viral suppression on entecavir plus tenofovir combination therapy.
Kim LH, Chaung KT, Ha NB,  et al

Eur J Gastroenterol Hepatol
. 2015 Apr 21.
Abstract

FULL-TEXT ARTICLE
Week 120 Efficacy of Tenofovir, Lamivudine and Lopinavir/r-Based Second-Line Antiretroviral Therapy in Treatment-Experienced HIV Patients.
Han Y, Li Y, Xie J, er al

PLoS One
. 2015 Mar 30;10(3):e0120705.
Paper

Is Zidovudine 1st line therapy virologically comparable to Tenofovir in resource-limited settings?
Labhardt ND, Bader J, Lejone TI, et al

Trop Med Int Health
. 2015 Mar 1

Abstract

FULL-TEXT ARTICLE
The Impact of Choice of NNRTI on Short-Term Treatment Outcomes among HIV-Infected Patients Prescribed Tenofovir and Lamivudine in Johannesburg, South Africa.
Shearer K, Fox MP, Maskew M,  et al
PLoS One. 2013 Aug 7;8(8):e71719.
Paper

FULL-TEXT PDF ARTICLE
Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted protease inhibitor-based regimen on renal function in HIV-infected individuals: a prospective, multicenter study.
Cao Y, Han Y, Xie J, et al
BMC Infect Dis. 2013 Jul 1;13(1):301.
Paper

Tenofovir use and urinary biomarkers among HIV-infected women in the Women's Interagency HIV Study (WIHS).
Oboho I, Abraham A, Benning L, et a;
J Acquir Immune Defic Syndr. 2012 Dec 18.
Abstract

Efficacy and tolerance of tenofovir-lamivudine-efavirenz combination in HIV-1 patients in Fann Teaching Hospital in Dakar.]
Diop SA, Fortes-Déguénonvo L, Seydi M,  et al
Bull Soc Pathol Exot
. 2012 Dec 17.
Abstract

Effectiveness and safety of a single-tablet regimen of emtricitabine/efavirenz/tenofovir in HIV-1-infected patients in infectious diseases department.
X
erinda S, Neves N, Santos S, et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18383
Abstract

Safety and efficacy of once-daily single generic fixed-drug combination tablet of tenofovir, lamivudine and efavirenz among HIV-infected Thais.
Maek-A-Nantawat W, Avihingsanon A, Thainsanguankul W, et al
J Int AIDS Soc. 2012 Nov 11;15(6):18285.
Abstract

Tenofovir in second-line ART in Zambia and South Africa: Collaborative analysis of cohort studies.
Wandeler G, Keiser O, Mulenga L,  et al
J Acquir Immune Defic Syndr
. 2012 Jun 27.
Abstract

Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era.
De Clercq E.
Biochem Pharmacol. 2012 Apr 5.
Abstract

FULL-TEXT ARTICLE
Comparison of Bone and Renal Effects In HIV-infected Adults Switching to Abacavir or Tenofovir Based Therapy in a Randomized Trial.
Rasmussen TA, Jensen D, Tolstrup M, et al
PLoS One
. 2012;7(3):e32445.
Paper

A Review of the Virological Efficacy of the 4 World Health Organization-Recommended Tenofovir-Containing Regimens for Initial HIV Therapy.
Tang MW, Kanki PJ, Shafer RW.
Clin Infect Dis. 2012 Mar;54(6):862-75.
Abstract

A Randomized Study of Tenofovir Disoproxil Fumarate in Treatment-Experienced Human Immunodeficiency Virus-1 Infected Adolescents.
Negra MD, de Carvalho AP, de Aquino MZ, et al
Pediatr Infect Dis J
. 2012 Feb 1.
Abstract

Topical Tenofovir, a Microbicide Effective against HIV, Inhibits Herpes Simplex Virus-2 Replication.
Andrei G, Lisco A, Vanpouille C,  et al
Cell Host Microbe
. 2011 Oct 4;10(4):379-89.
Abstract

Comparative outcomes of tenofovir- and zidovudine-based antiretroviral therapy regimens in Lusaka, Zambia.
Moyo C, Schuttner L, Mulenga LB, et al
J Acquir Immune Defic Syndr
. 2011 Aug 18
Abstract

Treatment Durability, Effectiveness, and Safety with Atazanavir/Ritonavir-Based HAART Regimen
in Treatment-Naïve HIV-lnfected Patients.
Tremblay C, Trottier B, Rachlis A, et al
HIV Clin Trials. 2011 May-Jun;12(3):151-60
Abstract

Long-Term Renal Safety of Tenofovir Disoproxil Fumarate in Vertically HIV-Infected Children, Adolescents and Young Adults: A 60-Month Follow-Up Study.
Viganò A, Bedogni G, Manfredini V,  et al 
Clin Drug Investig
. 2011;31(6):407-15
Abstract

Lipid-lowering effect of tenofovir in HIV-infected patients.
Fabbiani M, Bracciale L, Doino M, et al

J Antimicrob Chemother
. 2010 Dec 5
Abstract

Comparison of Antiviral Activity of Regimens Containing Nucleos(t)ide (NUC) Pairs in HIV-Infected Patients Initiating REScue Therapy (The NUCREST Study).|
Pérez-Molina JA, Serrano O, Milinkovic A, et al

HIV Clin Trials
. 2010 Sep-Oct;11(5):294-302.
Abstract

A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206.
Tungsiripat M, Kitch D, Glesby MJ,  et al
AIDS
. 2010 Jul 17;24(11):1781-4.
Abstract

Lower arterial stiffness and Framingham score after switching abacavir to tenofovir in men at high cardiovascular risk.
Sinn K, Richardson R, Carr A.
AIDS
. 2010 Jul 19
Abstract

Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data.
Nelson M, Girard PM, Demasi R, et al  
J Antimicrob Chemother
. 2010 May 24
Abstract

A Randomized Comparative Trial of Continued Zidovudine/Lamivudine or Replacement With Tenofovir Disoproxil Fumarate/Emtricitabine in Efavirenz-Treated HIV-1-Infected Individuals.
Fisher M, Moyle GJ, Shahmanesh M et al
J Acquir Immune Defic Syndr. 2009 Jun 25
Abstract

Renal Function in Patients with Preexisting Renal Disease Receiving Tenofovir-Containing Highly Active Antiretroviral Therapy in the HIV Outpatient Study.
Young B, Buchacz K, Moorman A, et al 

AIDS Patient Care STDS
. 2009 Jul 10.
Abstract

The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
Feng JY, Ly JK, Myrick F, Goodman D, et al
Retrovirology. 2009 May 13;6(1):44
Abstract

Johann Wolfgang Goethe-University Hospital, HIV Treatment and Clinical Research Unit, Medical Department II, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Stephan C, Dauer B, Khaykin P, et al
Curr HIV Res. 2009 May;7(3):320-6
Abstract

A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients.
Girard PM, Cabié A, Michelet C, et al
 
J Antimicrob Chemother
. 2009 Apr 29
Abstract

High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients.
Rey D, Hoen B, Chavanet P,  et al  
J Antimicrob Chemother
. 2008 Nov 2
Abstract

 

Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine --a Staccato trial substudy.
Ananworanich J, Nuesch R, Côté HC, et al
 
J Antimicrob Chemother
. 2008 Mar 12
Abstract
 

The Safety and Efficacy of Switching Stavudine to Tenofovir DF in Combination with Lamivudine and Efavirenz in HIV-1-Infected Patients: Three-Year Follow-up After
Switching Therapy.
Valdez JR, Cassetti I, Suleiman JM, et al 

HIV Clin Trials
. 2007 Nov-Dec;8(6):381-90.
Abstract
 
Randomized Controlled Trial of Once-Daily Tenofovir, Lamivudine, and Lopinavir/Ritonavir Versus Remaining on the Same Regimen in Virologically Suppressed HIV-Infected Patients on Their First PI-Containing HAART Regimen.
Loutfy MR, Ackad N, Antoniou T, et al
 
HIV Clin Trials.
2007 Sep-Oct;8(5):259-68
Abstract
 
Effectiveness and Safety of Simplification Therapy with Once-Daily Tenofovir, Lamivudine, and Efavirenz in HIV-1-Infected Patients with Undetectable Plasma Viral Load on HAART.
Arrizabalaga J, Arazo P, Aguirrebengoa K, et al
HIV Clin Trials. 2007 Sep-Oct;8(5):328-36.
Abstract
 
The Safety and Efficacy of Tenofovir DF in Combination with Lamivudine and Efavirenz Through 6 Years in Antiretroviral-Naïve HIV-1-Infected Patients.
Cassetti I, Madruga JV, Suleiman JM, et al

HIV Clin Trials.
2007 May-Jun;8(3):164-72.
Abstract
 
No response to first-line tenofovir+lamivudine+efavirenz despite optimization according to baseline resistance testing: Impact of resistant minority variants on efficacy of low genetic barrier drugs.
Van Laethem K, De Munter P, Schrooten Y, et al 
J Clin Virol. 2007 Mar 16;
Abstract
 
Efficacy and safety of tenofovir double-dose in treatment-experienced HIV-infected patients: The tenoplus study.
Dominguez S, Ghosn J, Peytavin G, et al
J Med Virol. 2006 Dec 19;79(2):105-110
Abstract
 
Immunological effectiveness of the nucleoside/nucleotide analog combinations, tenofovir + lamivudine, didanosine + lamivudine and tenofovir + didanosine, in patients with HIV infection and sustained viral suppression.
Cervero M, Torres R, Jusdado JJ, Rodriguez-Rosado R. et al
Enferm Infecc Microbiol Clin. 2006 Aug-Sep;24(7):426-30.
Abstract
 
Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients.
Benhamou Y, Fleury H, Trimoulet P, et al 
Hepatology. 2006 Feb 22;43(3):548-555
Abstract
 
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.
Gallant JE, DeJesus E, Arribas JR, et al 

N Engl J Med.
2006 Jan 19;354(3):251-60.
Abstract
 

Improved Lipid Profiles and Maintenance of Virologic Control in Heavily Pretreated HIV-Infected Patients Who Switched from Stavudine to Tenofovir Treatment.
Schewe CK, Maserati R, Wassmer G, et al 

Clin Infect Dis. 2
006 Jan 1;42(1):145-7.
Abstract
 
Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir.
Karrer U, Ledergerber B, Furrer H, et al

AIDS.
2005 Nov 18;19(17):1987-1994.
Abstract
 
High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir.
Leon A, Mallolas J, Martinez E, Lazzari ED, et al 
AIDS. 2005 Oct 14;19(15):1695-7.
Abstract
 
Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies.
Negredo E, Bonjoch A, Paredes R, et al
Clin Infect Dis. 2005 Sep 15;41(6):901-5.
Abstract
 
High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.
Perez-Elias MJ, Moreno S, Gutierrez C, et al 

AIDS.
2005 Apr 29;19(7):695-8
Abstract
 
Paradoxical CD4+ T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosine.
Barrios A, Rendon A, Negredo E,  
AIDS. 2005 Apr 8;19(6):569-575.
Abstract
 
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial.
Gallant JE, Staszewski S, Pozniak AL,et al

JAMA.
2004 Jul 14;292(2):191-201.
Abstract

Tenofovir Disoproxil Fumarate in Nucleoside-Resistant HIV-1 Infection: A Randomized Trial.
Squires K, Pozniak AL, Pierone G Jr, et al
Ann Intern Med. 2003 Sep 2;139(5 Pt 1):313-20
Abstract

 

Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection.
Antoniou T, Park-Wyllie LY, Tseng AL.
Pharmacotherapy 2003 Jan;23(1):29-43
Abstract
 
Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study.
Schooley RT, Ruane P, Myers RA, et al
AIDS 2002 Jun 14;16(9):1257-1263
Abstract
 


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