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Potential kidney toxicity from the antiviral drug tenofovir: new
indications, new formulations, and a new prodrug.
Chan L, Asriel B, Eaton EF, Wyatt CM.
Curr Opin Nephrol Hypertens.
2017 Dec 22.
Abstract
Tenofovir-Associated Nephrotoxicity Among a US National Historical Cohort of
HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals.
LaFleur J, Bress AP, Esker S, et al
J Acquir Immune Defic Syndr.
2017 Nov 27.
Abstract
Fatal lactic acidosis in hepatitis B
virus-associated decompensated
cirrhosis treated with tenofovir: A
case report.
Jung
TY, Jun DW, Lee KN,
et al
Medicine (Baltimore).
2017 Jun;96(25):e7133
Abstract
Treatment-limiting
renal tubulopathy in patients
treated with tenofovir disoproxil
fumarate.
Hamzah L, Jose S, Booth JW, et
al
J Infect.
2017 Jan 24.
Abstract
Case of Tenofovir-associated Fanconi Syndrome in Patient
with Chronic Hepatitis B
Kim D, Lee J, Kim DH, Kang K, et al
Korean J Gastroenterol. 2016 Dec
25;68(6):317-320.
Abstract
Tenofovir-induced nephrotoxicity: A retrospective cohort
study.
Koh HM, Suresh K.
Med J Malaysia. 2016
Dec;71(6):308-312.
Abstract
Value of Cystatin C-Based e-GFR Measurements to Predict
Long-Term Tenofovir Nephrotoxicity in Patients With Hepatitis B.
Koksal AR, Alkim H, Boga S,
et al
Am J Ther. 2016
Oct 4
Abstract
Plasma tenofovir trough concentrations are associated
with renal dysfunction in Japanese patients with HIV infection: a
retrospective cohort study.
Kunimoto Y, Ikeda H, Fujii S,
et al
J Pharm Health Care Sci. 2016
Sep 22;2:22
Abstract
Acute kidney injury, risk factors and prognosis in
hospitalized HIV-infected adults in South Africa, compared by Tenofovir
exposure.
Seedat F, Martinson NA, Motlhaoleng K, et al
AIDS Res
Hum Retroviruses. 2016 Aug 1.
Abstract
Tenofovir: Is Tenofovir Alafenamide Safer than Tenofovir
Disoproxil Fumarate for the Kidneys?
Aloy B, Tazi I, Bagnis CI, Gauthier M, et al
AIDS Rev. 2016 Jul
19;18(4).
Abstract
Fanconi syndrome induced by tenofovir: A case report.
Lify B, Dabo G, Nascimento O, Iraqui S
Saudi J Kidney Dis Transpl. 2016
Jul-Aug;27(4):808-11.
Abstract
FULL-TEXT ARTICLE
Tenofovir-associated nephrotoxicity in patients with chronic hepatitis
B: two cases.
Cho H, Cho Y, Cho EJ,
Clin Mol Hepatol.
2016 Jun;22(2):286-91.
Paper
HIV Infection, Tenofovir Disoproxil Fumarate, and Urine
α1-Microglobulin: A Cross-sectional Analysis in the Multicenter AIDS
Cohort Study.
Jotwani V, Scherzer R, Estrella MM,
et al
Am J Kidney Dis.
2016 Jun 7.
Abstract
Cumulative tenofovir disoproxil fumarate exposure is
associated with biomarkers of tubular injury and fibrosis in
HIV-infected men.
Jotwani V, Scherzer R, Estrella MM,
et al
J Acquir Immune Defic Syndr.
2016 Apr 15
Abstract
Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B
monoinfection.
Conti F, Vitale G, Cursaro C, et al
Ann Hepatol. 2016
Mar-Apr;15(2):273-6.
Abstract
Incidence of stage 3 chronic kidney disease and progression on
tenofovir-based regimens: A cohort study in HIV-infected adults in Cape
Town, South Africa.
Zachor H, Machekano R, Estrella MM, et al
AIDS. 2016 Feb 1
Abstract
FULL-TEXT ARTICLE
A Single-Nucleotide Polymorphism in ABCC4 Is Associated with
Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1
Infection.
Likanonsakul S, Suntisuklappon B, Nitiyanontakij R, et al
PLoS One. 2016 Jan
25;11(1):e0147724
Paper
Prevalence and significance of proximal renal tubular
abnormalities in HIV-infected patients receiving tenofovir.
Casado JL, Bañón S, Santiuste C,
et al
AIDS. 2016 Jan;30(2):231-9.
Abstract
Tenofovir clearance is reduced in hiv-positive patients
with subclinical tubular impairment.
Calcagno A, Cusato J, Marinaro L, et al
AIDS. 2015 Dec 3.
Abstract
FULL-TEXT ARTICLE
Nephrotoxicity during tenofovir treatment: a three-year follow-up study in a
Brazilian reference clinic.
da Silva Pinto Neto LF, Bassetti BR,
et
al
Braz J Infect Dis. 2015 Nov 20.
pii: S1413-8670(15)00192-0.
Paper
Renal Toxicity of Concomitant Exposure to Tenofovir and
Inhibitors of Tenofovir's Renal Efflux Transporters in HIV-1 Patients.
Rokx C, Alshangi H, Verbon A,
et al
J Infect Dis.
2015 Sep 23.
Abstract
Effects of renal tubular dysfunction on bone in
tenofovir-exposed HIV-positive patients.
Hamzah L, Samarawickrama A, Campbell L,
et al
AIDS. 2015 Sep
10;29(14):1785-92.
Abstract
FULL-TEXT ARTICLE
Low Incidence of Renal Dysfunction among HIV-Infected Patients on a
Tenofovir-Based First Line Antiretroviral Treatment Regimen in Myanmar.
Low Kyaw NT, Harries AD, Chinnakali P, et al
PLoS One. 2015 Aug 24;10(8):e0135188.
Paper
Proximal tubular dysfunction and kidney injury associated with
tenofovir in HIV patients: a case series.
Waheed S, Attia D, Estrella MM,
et al
Clin Kidney J. 2015
Aug;8(4):420-5.
Abstract
FULL-TEXT ARTICLE
Fanconi syndrome and chronic renal failure in a chronic hepatitis B monoinfected
patient treated with tenofovir.
Magalhães-Costa P, Matos L, et al
Rev Esp Enferm Dig. 2015 Jul;107(8):512-514.
Paper
Tenofovir plasma concentrations related to estimated glomerular
filtration rate changes in first-line regimens in African HIV-infected patients:
ANRS 12115 DAYANA substudy.
Lê MP, Landman R, Koulla-Shiro S, et al
J Antimicrob Chemother. 2015 Jan 11.
Abstract
Renal Function Recovery and HIV Viral Suppression Following
Tenofovir Discontinuation for Renal Impairment
Romo FT, Aziz M, Livak B,
J AIDS Clin Res. 2014
Nov;5(11). pii: 379.
Abstract
Tenofovir-induced Fanconi syndrome in chronic hepatitis B monoinfected patients
that reverted after tenofovir withdrawal.
Viganò M, Brocchieri A, Spinetti A, et al.
J Clin Virol.
2014 Oct 5;61(4):600-603.
Abstract
Tenofovir-Related Nephropathies in HIV-Infected Patients.
Lai S, Mariotti A, Lai C, Testorio M, et al
Curr Vasc Pharmacol. 2014
Nov 20
Abstract
Low body weight and tenofovir use are risk factors for renal
dysfunction in Vietnamese HIV-infected patients. A prospective 18-month
observation study.
Mizushima D, Tanuma J, Dung NT,
et al
J Infect Chemother. 2014 Oct 6.
Abstract
Long-term exposure to tenofovir continuously decrease renal function in
HIV-1-infected patients with low body weight: results from 10 years of
follow-up.
Nishijima T, Kawasaki Y, Tanaka N, et al
AIDS.
2014 Aug 24;28(13):1903-1910
Abstract
A chronic kidney disease risk score to determine tenofovir safety
in a prospective cohort of HIV-positive male veterans.
Scherzer R, Gandhi M, Estrella MM, et al
AIDS. 2014 Jun 1;28(9):1289-1295.
Abstract
Renal function of participants in the Bangkok Tenofovir Study,
Thailand, 2005-2012.
Martin M, Vanichseni S, Suntharasamai P, et al
Clin Infect Dis. 2014 May
14
Abstract
ABCC2*1C and plasma tenofovir concentration are correlated to decreased
glomerular filtration rate in patients receiving a tenofovir-containing
antiretroviral regimen.
Manosuthi W, Sukasem C, Thongyen S,
et al
J Antimicrob Chemother. 2014 Apr
30.
Abstract
FULL-TEXT ARTICLE
Fanconi
Syndrome Accompanied by Renal Function Decline with Tenofovir Disoproxil
Fumarate: A Prospective, Case-Control Study of Predictors and Resolution
in HIV-Infected Patients.
Gupta SK, Anderson AM, Ebrahimi R, et al
PLoS One. 2014 Mar
20;9(3):e92717
Paper
The rate of recovery in renal function when patients with
HIV infection discontinue treatment with tenofovir.
Young J, Wang Q, Fux C, et al
HIV Med. 2014 Mar 18.
Abstract
Long-term treatment with tenofovir: prevalence of kidney
tubular dysfunction and its association with tenofovir plasma
concentration.
Ezinga M, Wetzels
JF, Bosch ME, et al
Antivir Ther. 2014 Feb 2
Abstract
Common clinical conditions - age, low BMI, ritonavir use, mild
renal impairment - affect tenofovir pharmacokinetics
in a large cohort of HIV-infected women.
Baxi SM, Greenblatt RM, Bacchetti P,
et al
AIDS. 2013
Nov 23.
Abstract
FULL-TEXT
ARTICLE
WHO Antiretroviral Therapy Guidelines 2010 and Impact of
Tenofovir on Chronic Kidney Disease in Vietnamese HIV-Infected
Patients.
Mizushima D, Tanuma J, Kanaya F,
et al
PLoS One.
2013 Nov 6;8(11):e79885.
Paper
An investigation of the pattern of kidney injury in HIV-positive
persons exposed to tenofovir disoproxil fumarate: An examination
of a large population database (MHRA database).
Danjuma MI, Mohamad-Fadzillah NH,
Khoo S.
Int J STD AIDS.
2013 Sep 24.
Abstract
Tenofovir Effect on the Kidneys of HIV-Infected Patients: A
Double-Edged Sword?
Tourret J, Deray G, Isnard-Bagnis C.
J Am Soc Nephrol.
2013 Sep 19.
Abstract
Evaluation of Renal Adverse Effects of Combination Anti-retroviral
Therapy including Tenofovir in HIV-infected Patients.
Tanaka H, Arai M, Tomoda Y,
et al
J Pharm Pharm Sci.
2013;16(3):405-13.
Abstract
Preclinical efficacy of melatonin in the amelioration of
tenofovir nephrotoxicity by the attenuation of oxidative stress, nitrosative
stress, and inflammation in rats.
Ramamoorthy H, Abraham P, Isaac B.
J Basic Clin Physiol Pharmacol. 2014 Jan
27:1-13
Abstract
Tenofovir-related nephrotoxicity: An ongoing clinical challenge.
Foisy MM, Hughes C, Hills- et al
Am J Health Syst Pharm. 2013 Aug 1;70(15):1272-4
Abstract
FULL-TEXT PDF
ARTICLE
Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted
protease inhibitor-based regimen on renal function in HIV-infected
individuals: a prospective, multicenter study.
Cao Y, Han Y, Xie J, et al
BMC Infect Dis. 2013
Jul 1;13(1):301.
Abstract
Tenofovir-related Fanconi's syndrome and
osteomalacia in a teenager with HIV.
Lucey JM, Hsu P, Ziegler JB.
BMJ Case Rep. 2013 Jul 9;2013(jul08_2).
Abstract |
Tenofovir-associated Fanconi Syndrome in patients with chronic
hepatitis B monoinfection.
Gracey DM, Snelling P, McKenzie P, Strasser SI.
Antivi Ther.
2013 Jul 10.
Abstract
Tenofovir Treatment Duration Predicts Proteinuria in a
Multi-Ethnic United States Cohort of Children and Adolescents with Perinatal
HIV-1 Infection.
Purswani M, Patel K, Kopp JB, et al
Pediatr Infect Dis J. 2012 Dec 17
Abstract
The Frequency of Adjusted Renal Dosing of Tenofovir DF and Its
Effects on Patient Outcomes.
Langness JA, Hindman JT, Johnson SC,
Kiser JJ.
J Pharm
Pract. 2012 Dec 2.
Abstract
Recovery of eGFR in patients who develop renal complications on
tenofovir.
Jose S, Hamzah L,
Campbell L, Sabin C, Post F; for the UK CHIC study.
J Int AIDS Soc. 2012 Nov
11;15(6):18137
Abstract
Tenofovir-induced acute kidney injury in HIV-infected patients in western
India: a resource limited setting perspective.
Sadre A, Munshi N, Dhande S, Dravid A.
J Int AIDS Soc.
2012 Nov 11;15(6):18308.
Abstract
Renal impairment in patients receiving a tenofovir-cART regimen:
Impact of tenofovir trough concentration.
Poizot-Martin I, Solas C, Allemand J, et al
J Acquir Immune Defic Syndr.
2012 Nov 28
Abstract
Association Between Tenofovir Exposure and Reduced Kidney Function
in a Cohort of HIV-Positive Patients: Results from 10 Years of
Follow-up.
Laprise
C, Baril JG, Dufresne
S, Trottier H.
Clin Infect Dis.
2012 Nov 9.
Abstract
Increased Time Exposure to Tenofovir Is Associated with a Greater
Decrease in Estimated Glomerular Filtration Rate in HIV Patients
with Kidney Function of Less than 60 ml/min/1.73 m.
Fafin C, Pugliese P, Durant J, et al
Nephron Clin Pract.
2012 Sep 29;120(4):c205-c214
Abstract
Drug-Induced Acute Interstitial Nephritis Mimicking Acute
Tubular Necrosis after Initiation of Tenofovir-Containing
Antiretroviral
Therapy in Patient with HIV-1 Infection.
Nishijima T, Yazaki H,
Hinoshita F, et al
Intern Med. 2012;51(17):2469-71.
Abstract |
Update on tenofovir toxicity in the kidney.
Hall AM.
Pediatr Nephrol. 2012 Aug 10.
Abstract |
High rate of reversibility of renal damage in a cohort of
HIV-infected patients receiving tenofovir-containing antiretroviral therapy.
Bonjoch A, Echeverría P,
Perez-Alvarez N, et al
Antiviral Res.
2012 Aug 6.
Abstract
Tenofovir associated proteinuria.
Kelly MD, Gibson A, Bartlett H, et
al
AIDS. 2012 Aug 7.
Abstract
Lamivudine or emtricitabine (XTC)/protease inhibitor dual
therapy as a harm-reduction strategy in patients with tenofovir-related renal
toxicity: A case-control study.
Rossotti R, Moioli MC, Chianura L, et
al
Scand J Infect Dis. 2012 Jul 17.
Abstract
Diffuse Tubulointerstitial Nephritis Accompanied by Renal Crystal Formation in
an HIV-infected Patient
Undergoing Highly Active Antiretroviral Therapy.
Kanzaki G, Tsuboi N, Miyazaki Y,
et al
Intern Med.
2012;51(12):1543-8.
Abstract |
FULL-TEXT PDF
ARTICLE
Renal
safety of tenofovir containing antiretroviral regimen in a Singapore cohort.
Chua AC, Llorin RM, Lai K, et al
AIDS Res Ther. 2012 Jun 15;9(1):19.
Paper |
Renal Toxicity of Long-Term Therapy With Tenofovir in
HIV-Infected Patients.
Monteagudo-Chu MO, Chang MH,
et al
J Pharm Pract. 2012 May 2.
Abstract
Similar Risk of Renal Events Among Patients Treated with
Tenofovir or Entecavir for Chronic Hepatitis B.
Gish RG, Clark MD, Kane SD,
et al
Clin Gastroenterol Hepatol. 2012 Apr 13.
Abstract
FULL-TEXT ARTICLE
Comparison of Bone and Renal Effects In HIV-infected Adults Switching to
Abacavir or Tenofovir Based Therapy
in a Randomized Trial.
Rasmussen TA, Jensen D, Tolstrup M, et al
PLoS One.
2012;7(3):e32445.
Paper
Renal function in patients with HIV starting therapy with tenofovir and either
efavirenz, lopinavir or atazanavir.
Young J, Schäfer J, Fux CA,
et al
AIDS. 2012 Mar
13;26(5):567-575
Abstract |
Association of tenofovir exposure with kidney disease risk in HIV infection.
Scherzer R, Estrella M, Li Y,
et al
AIDS. 2012 Feb 4
Abstract |
FULL-TEXT PDF ARTICLE
Renal function in HIV-infected children and adolescents treated with tenofovir
disoproxil fumarate
and
protease inhibitors.
Pontrelli G, Cotugno N, Amodio D,
et al
BMC Infect Dis.
2012 Jan 23;12(1):18.
Paper |
FULL-TEXT ARTICLE
Renal Function Declines More in Tenofovir- than Abacavir-Based
Antiretroviral Therapy in Low-Body
Weight Treatment-Naïve Patients with HIV Infection.
Nishijima T, Gatanaga H, Komatsu H, et al
PLoS One.
2012;7(1):e29977.
Paper |
Early Markers of Tubular Dysfunction in Antiretroviral-Experienced
HIV-Infected Patients Treated with Tenofovir Versus Abacavir.
Maggi P, Montinaro V, Bellacosa C, et al
AIDS Patient Care STDS.
2012 Jan;26(1):5-11.
Abstract
Fanconi syndrome-like tubular acidosis associated with a
tenofovir-containing antiretroviral regimen in a
human immunodeficiency virus-1-infected Asian woman.
Kiyasu Y,
Koganemaru H, Hitomi S.
J Infect Chemother. 2011 Sep 15
Abstract
Persistent decline in estimated but not measured glomerular filtration
rate on tenofovir may reflect tubular
rather than glomerular toxicity.
Vrouenraets SM, Fux CA, Wit
FW, et al
AIDS.
2011 Aug 19
Abstract
FULL-TEXT ARTICLE
Impact
of Small Body Weight on Tenofovir-Associated Renal Dysfunction in
HIV-Infected Patients:
A Retrospective Cohort Study of Japanese Patients.
Nishijima T, Komatsu H, Gatanaga
H, et al
PLoS One. 2011;6(7):e22661.
Paper
Severe Acute Renal Failure in an HIV-Infected Patient
After Only 2 Weeks of Tenofovir-Based Antiretroviral Therapy.
Pavie J, Scemla A,
Bouldouyre MA,
et al
AIDS Patient Care STDS. 2011 Jul 13.
Abstract
A comparison of tenofovir-associated renal function changes in
HIV-infected African Americans vs
Caucasians.
Lao CK, Gruta C, John MD, Cocohoba J.
J Natl Med Assoc.
2011 Jun;103(6):518-22.
Abstract
Subcellular renal proximal tubular mitochondrial
toxicity with tenofovir treatment.
Kohler JJ, Hosseini SH.
Methods Mol Biol.
2011;755:267-77.
Abstract
Tenofovir nephrotoxicity: 2011 update.
Fernandez-Fernandez B, Montoya-Ferrer A, Sanz AB,
et al
AIDS Res Treat.
2011;2011:354908.
Abstract
Tenofovir-induced Fanconi syndrome and osteomalacia in two
HIV-infected patients:
Role of intracellular tenofovir diphosphate levels and review of the
literature.
Haverkort ME, van der Spek
BW, Lips P,
et al
Scand J Infect Dis.
2011 May 12
Abstract
Tenofovir-induced renal toxicity in 324 HIV-infected,
antiretroviral-naïve patients.
Calza L,
Trapani F, Tedeschi S,
et al
Scand J Infect Dis. 2011
Apr 1
Abstract
Tenofovir-Associated Kidney Toxicity in HIV-Infected
Patients: A Review of the Evidence.
Hall AM,
Hendry BM, Nitsch D, Connolly JO.
Am J Kidney Dis.
2011 Mar 22
Abstract
FULL-TEXT ARTICLE
Renal safety of a tenofovir-containing first line regimen: experience
from an antiretroviral cohort
in rural Lesotho.
Bygrave H, Kranzer K, Hilderbrand K,
et al
PLoS One. 2011 Mar
2;6(3):e17609.
Paper
Tenofovir renal proximal tubular toxicity is regulated
By OAT1 and MRP4 transporters.
Kohler JJ, Hosseini SH, Green E. et al
Lab Invest.
2011 Mar 14
Abstract
Low incidence of renal impairment observed in
tenofovir-treated patients.
O'Donnell EP, Scarsi KK, Darin KM
J
Antimicrob Chemother. 2011 Feb 17.
Abstract
Tenofovir-induced kidney disease: an acquired renal
tubular mitochondriopathy.
Perazella MA.
Kidney Int. 2010
Dec;78(11):1060-3.
Abstract
|
Two cases of Fanconi's syndrome induced by tenofovir in
the Ivory Coast.
Ondounda M, Tanon A,
Ehui E, et al
Med Mal Infect. 2010
Sep 8
Abstract |
Tenofovir nephrotoxicity: acute tubular necrosis with
distinctive clinical, pathological, and
mitochondrial abnormalities.
Herlitz LC, Mohan S, Stokes MB, et al
Kidney Int.
2010 Sep 1
Abstract |
Systematic review and meta-analysis: renal safety of tenofovir disoproxil
fumarate in
HIV-infected patients.
Cooper RD, Wiebe N,
Smith N, et al
Clin Infect Dis.
2010 Sep 1;51(5):496-505.
Abstract |
Renal toxicity associated with tenofovir use.
Rodriguez-Nóvoa S,
Alvarez E, Labarga P, Soriano V.
Expert Opin Drug Saf.
2010 Jul;9(4):545-59
Abstract |
Randomized Comparison of Renal Effects, Efficacy, and Safety With
Once-Daily
Abacavir/Lamivudine Versus Tenofovir/Emtricitabine, Administered With
Efavirenz, in Antiretroviral-Naive, HIV-1-Infected Adults: 48-Week Results From
the ASSERT Study.
Post FA, Moyle GJ, Stellbrink HJ, et al
J Acquir Immune Defic Syndr. 2010 Apr 24
Abstract |
Impairment in kidney tubular function in patients receiving tenofovir
is associated
with higher tenofovir plasma concentrations.
Rodríguez-Nóvoa S, Labarga P, Davolio A, et al
AIDS. 2010
Mar 17
Abstract |
Incomplete Reversibility of Tenofovir-Related Renal Toxicity in
HIV-Infected Men.
Wever K, van Agtmael MA, Carr A.
J Acquir Immune Defic Syndr. 2010 Feb
19.
Abstract |
Acute renal failure and hypercalcemia in an AIDS patient on tenofovir and
low-dose
vitamin d therapy with immune reconstitution inflammatory syndrome.
Lavae-Mokhtari M, Mohammad-Khani S, Schmidt RE, Stoll M.
Med Klin (Munich). 2009 Oct
15;104(10):810-3
Abstract |
Impact of Tenofovir on Renal Function in HIV-Infected
Antiretroviral Naïve Patients.
Horberg M, Tang B, Towner W, et al
J Acquir Immune Defic Syndr.
2009 Oct 15
Abstract |
Tenofovir-associated renal and bone toxicity.
Woodward CL, Hall AM, Williams IG,
HIV Med.
2009 May 6.
Abstract |
Predictors of Kidney Tubular Dysfunction in HIV-Infected Patients Treated with
Tenofovir:
A Pharmacogenetic Study.
Rodríguez-Nóvoa S, Labarga P, Soriano V, et al
Clin Infect Dis. 2009 Apr
28
.
Abstract |
Progressive renal tubular dysfunction associated with long-term
use of tenofovir DF.
Kinai E, Hanabusa H.
AIDS Res Hum Retroviruses. 2009
Apr;25(4):387-94.
Abstract |
Proximal tubular dysfunction associated with tenofovir and didanosine causing
Fanconi syndrome and
diabetes insipidus: a report of 3 cases.
Irizarry-Alvarado JM, Dwyer JP,
et sl
AIDS Read. 2009
Mar;19(3):114-2
Abstract
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