MedICAL ADVOCATES
Children
  Malaria Drugs
 
General Reports
 Amodiaquine
Artemotil
Artemethe-/Lumefantrine
Artemisinin
Artesunate
Atovaquone
Azithromycin
 Chloramphenicol
Choroquine
Co-trimoxazole
 		 Diazepam
Dihydroartemisinin
Fosmidomycin
Halofantrine
Lorazepam  
Lopinavir
 Mefloquine
Paracetamol
 Piperaquine
 Quinine
Sulfadoxine
 
Malaria Main Page Pediatric Main Page Home Page
Last Update:  February 10, 2016    
 Documents identified with this icon are in Portable Document Format (PDF) and require the Adobe Acrobat Reader
General Reports
 

          Journal Papers, Abstracts, and Commentaries

 
Prediction of Antimalarial Drug Clearance in Children: A Comparison of Three Different Interspecies Scaling Methods.
 Mahmood I, Cheng A, Brauer E, Humeniuk R.  
 Eur J Drug Metab Pharmacokinet. 2015 Nov 7
 Abstract

A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections.
 Manning L, Rosanas-Urgell A, Laman M, et al
Malar J. 2012 Apr 3;11(1):107
 Abstract

IgG against Plasmodium falciparum variant surface antigens and growth inhibitory antibodies in
Mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine.
Quelhas D, Jiménez A, Quintó L,  et al
Immunobiology. 2010 Dec 25
 Abstract

Effect Of Antiretroviral Therapy On Asymptomatic Malaria Parasitaemia In HIV-1 Infected Children.
Adetifa IM, Akinsulie AO, Temiye EO, et al
Niger Postgrad Med J. 2008 Sep;15(3):141-5.
 Abstract
 
FULL TEXT ARTICLE
A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal
intermittent preventive treatment for malaria in Senegalese children.
 Sokhna C, Cissé B, Bâ el H, et al
PLoS ONE. 2008 Jan 23;3(1):e1471.
 Paper

Comparative efficacy of antimalarial drugs including ACTs in the treatment of
uncomplicated malaria among children under 5 years in Ghana.
Koram KA, Abuaku B, Duah N, Quashie N.
Acta Trop. 2005 Sep;95(3):194-203.
 Abstract

Pediatric Malaria Drugs
Imbert P, Laurent C.
Med Trop (Mars) 2002;62(5):554-60
 Abstract
Amodiaquine
 
         Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated
infections treatedwith amodiaquine.
 Sowunmi A, Balogun ST, Gbotosho GO, Happi CT, et al  
Malar J. 2008 Sep 2;7:169.
Paper
 
Effect of concomitant artesunate administration and CYP2C8 polymorphisms on the pharmacokinetics
of amodiaquine in Ghanaian children with uncomplicated malaria.
 Adjei GO, Kristensen K, Goka BQ, et al  
Antimicrob Agents Chemother. 2008 Sep 8.
 Abstract
 
Combination therapy for uncomplicated falciparum malaria in Ugandan children:
a randomized trial.
Dorsey G, Staedke S, Clark TD, et al
JAMA. 2007 May 23;297(20):2210-9.
 Abstract

Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria
in children in Guinea-Bissau: implications for future treatment recommendations.
Kofoed PE, Ursing J, Poulsen A, et al
Trans R Soc Trop Med Hyg. 2006 Aug 10;
 Abstract

High reinfection rate and treatment failures in children treated with amodiaquine for falciparum
malaria in Muheza villages, Northeastern Tanzania.
Lemnge M, Alifrangis M, Kafuye MY
Am J Trop Med Hyg. 2006 Aug;75(2):188-93
 Abstract
 
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-
pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in
Central African children with noncomplicated malaria
Menard D, Madji N, Manirakiza A, et al
Am J Trop Med Hyg. 2005 May;72(5):581-5
 Abstract
 
Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and
artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm
randomised effectiveness trial.
Mutabingwa TK, Anthony D, Heller A, et al
Lancet. 2005 Apr 23-29;365(9469):1474-80
 Abstract
Artemisinin
 
          Journal Papers, Abstracts, and Commentaries
 
  FULL-TEXT ARTICLE
 Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children.
 Djimde AA, Maiga AW, Ouologuem D, et al
Parasite. 2016;23:3.
Abstract

Efficacy of Artemisinin-Based Combination Treatments of Uncomplicated Falciparum Malaria in Under-Five-Year-Old Nigerian Children.
Oguche S, Okafor HU, Watila I,  et al   
Am J Trop Med Hyg. 2014 Sep 22.
Abstract

FULL TEXT ARTICLE
A Head-to-Head Comparison of Four Artemisinin-Based Combinations for Treating Uncomplicated Malaria
in African Children A Randomized Trial.
The Four Artemisinin-Based Combinations (4ABC) Study Group.
PLoS Med. 2011 Nov;8(11):e1001119.
Paper

Therapeutic Efficacies of Artemisinin-Based Combination Therapies in Nigerian Children with
Uncomplicated Falciparum Malaria during Five Years of Adoption as First-Line Treatments.
Gbotosho GO, Sowunmi A, Happi CT, Okuboyejo TM.
Am J Trop Med Hyg. 2011 Jun;84(6):936-43.
 Abstract

Effect of nutritional status on response to treatment with artemisinin-based combination
therapy in young Ugandan children with malaria.
Verret WJ, Arinaitwe E, Wanzira H,  et al
Antimicrob Agents Chemother. 2011 Mar 7.
Abstract

Artemotil
 

          Journal Papers, Abstracts, and Commentaries

  A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral
malaria.
Thuma PE, Bhat GJ, Mabeza GF, et al.
Am J Trop Med Hyg 2000 Apr;62(4):524-9
Abstract		  
Artemether-Lumefantrine
 

          Journal Papers, Abstracts, and Commentaries

 
FULL TEXT PDF ARTICLE
 Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
 Adjei GO, Oduro-Boatey C, Rodrigues OP,  et al
Malar J. 2012 Dec 17;11(1):420. [
 Paper

FULL-TEXT PDF ARTICLE
 Surveillance of the efficacy of artemetherlumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009.
 Dorkenoo MA, Barrette A, Agbo YM, et al
Malar J. 2012 Oct 8;11(1):338
 Paper

Efficacy of artemether-lumefantrine in the treatment of uncomplicated malaria in children living in a
rural area of Burkina Faso in 2009.
Siribié M, Diarra A, Tiono AB,  et al
Bull Soc Pathol Exot. 2012 Feb 9.
 Abstract

Adherence to artemether/lumefantrine treatment in children under real-life situations in rural Tanzania.
Simba DO, Kakoko D, Tomson G,  et al
Trans R Soc Trop Med Hyg. 2011 Nov 16
 Abstract

FULL-TEXT ARTICLE
 The Impact of Retail-Sector Delivery of Artemether-Lumefantrine on Malaria Treatment of Children under
Five in Kenya: A Cluster Randomized Controlled Trial.
 Kangwana BP, Kedenge SV, Noor AM, et al
PLoS Med. 2011 May;8(5):e1000437.
Paper

Therapeutic Efficacy and Effects of Artemether-Lumefantrine and Artesunate-Amodiaquine Coformulated
or Copackaged on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum
Malaria in Southwest Nigeria.
Gbotosho GO, Sowunmi A, Okuboyejo TM,  et al
Am J Trop Med Hyg. 2011 May;84(5):813-9.
 Abstract

Home management of malaria with artemether-lumefantrine compared with standard care in urban
Ugandan children: a randomised controlled trial.
Staedke SG, Mwebaza N, Kamya MR,
Lancet. 2009 Apr 9.
Abstract

A randomized, open-label, comparative efficacy trial of artemether-lumefantrine suspension versus
artemether-lumefantrine tablets for treatment of uncomplicated Plasmodium falciparum malaria in
children in western Kenya.
Juma EA, Obonyo CO, Akhwale WS, Ogutu BR.  
Malar J. 2008 Dec 22;7(1):262.
 Abstract
 
FULL-TEXT ARTICLE
Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat
cross-sectional study.
Zurovac D, Ndhlovu M, Sipilanyambe N, et al
Malar J. 2007 Mar 16;6:31.
Paper

FULL-TEXT ARTICLE
Assessment of the therapeutic efficacy of a paediatric formulation of  artemether-lumefantrine
(Coartesiane) for the treatment of uncomplicated Plasmodium falciparum in children in Zambia.
Chanda P, Hawela M, Kango M, Sipilanyambe N.
Malar J. 2006 Aug 28;5:75.
Paper 

Feasibility and acceptability of the use of artemether-lumefantrine in the home management
of uncomplicated malaria in children 6-59 months old in Ghana.
Chinbuah AM, Gyapong JO, Pagnoni F, et al
Trop Med Int Health. 2006 Jul;11(7):1003-16.
Abstract
 
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the
treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Martensson A, Stromberg J, Sisowath C, et al
Clin Infect Dis. 2005 Oct 15;41(8):1079-86.
 Abstract
 
Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and
artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm
randomised effectiveness trial.
Mutabingwa TK, Anthony D, Heller A, et al
Lancet. 2005 Apr 23-29;365(9469):1474-80
 Abstract
 
Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African
infants and children with acute, uncomplicated falciparum malaria.
Falade C, Makanga M, Premji Z, et al
Trans R Soc Trop Med Hyg. 2005 Jun;99(6):459-67.
 Abstract
 
Artesunate
 

          Journal Papers, Abstracts, and Commentaries

 
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children:
a randomised controlled trial in Burkina Faso.
 Coulibaly B, Pritsch M, Bountogo M, et al
J Infect Dis. 2014 Sep 28
 Abstract

FULL TEXT PDF ARTICLE
 Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
 Adjei GO, Oduro-Boatey C, Rodrigues OP,  et al
Malar J. 2012 Dec 17;11(1):420. [
 Paper

FULL-TEXT PDF ARTICLE
 Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial.
 Kayentao K, Doumbo OK, Pénali LK,  et al
Malar J. 2012 Oct 31;11(1):364.
 Paper

FULL-TEXT PDF ARTICLE
 Surveillance of the efficacy of artemetherlumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009.
 Dorkenoo MA, Barrette A, Agbo YM, et al
Malar J. 2012 Oct 8;11(1):338
 Paper

Oral Artesunate-Amodiaquine and Artemether-Lumefantrine in the Treatment of Uncomplicated
Hyperparasitaemic Plasmodium falciparum Malaria in Children.
 Gbotosho GO, Sowunmi A, Okuboyejo TM, Happi CT.
J Trop Pediatr. 2011 May 26
Abstract

Assessing the cost-effectiveness of prereferral rectal artesunate for treatment of severe childhood malaria.
Conteh L, Yeung S.
Expert Rev Pharmacoecon Outcomes Res. 2011 Apr;11(2):141-5.
 Abstract

FULL-TEXT ARTICLE
An open randomized clinical trial in comparing two artesunate-based combination treatments on
Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine
(fixed dose over
24 hours) versus artesnate/amodiaquine (fixed dose over 48 hours).
Ayede IA, Falade AG, Sowunmi A, Jansen FH.
Malar J. 2010 Dec 31;9:378.
 Paper

Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effectiveness analysis.
Tozan Y, Klein EY, Darley S,  et al
Lancet. 2010 Dec 4;376(9756):1910-5.
Abstract

FULL TEXT PDF ARTICLE
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in
children with uncomplicated falciparum malaria on the coast of Benin, West Africa
Nahum A, Erhart A, D Gazard D, et al  
Malaria Journal 2007, 6:170
Paper

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated
falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
Grandesso F, Hagerman A, Kamara S, et al
 Trop Med Int Health. 2006 Jul;11(7):1017-21.
Abstract

Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-
sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in
Nigerian children.
Sowunmi A, Fehintola FA, Adedeji AA, et al
Trop Med Int Health. 2005 Nov;10(11):1161-70.
 Abstract
 
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the
treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.
Martensson A, Stromberg J, Sisowath C, et al
Clin Infect Dis. 2005 Oct 15;41(8):1079-86.
 Abstract
 
FULL-TEXT  ARTICLE
5-day nonobserved artesunate monotherapy for treating uncomplicated Falciparum malaria
in young Gabonese children.
Schwarz NG, Oyakhirome S, Potschke M, et al
Am J Trop Med Hyg. 2005 Oct;73(4):705-9.
 Paper
 
Life-saving rectal artesunate for complicated malaria in children.
Pengsaa K, Sirivichayakul C, Na-Bangchang K, et al
Southeast Asian J Trop Med Public Health. 2005 May;36(3):597-601.
 Abstract
 
 
          Conference Reports, Abstracts, and Posters 
 
  CONFERENCE PDF POSTER
 High Risk of Neutropenia in HIV-infected Children following Treatment with Artesunate +
Amodiaquine for Uncomplicated Malaria in Uganda
 M Kamya, A Gasasira, J Achan, et al
 (15th CROI)
 PDF Poster     Abstract
Atovaquone
 

          Journal Papers, Abstracts, and Commentaries

  Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the
immunogenicity of live oral typhoid and cholera vaccines.
Faucher JF, Binder R, Missinou MA, et al.
Clin Infect Dis 2002 Nov 15;35(10):1147-54
Abstract
 
Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of
acute Plasmodium falciparum malaria in children.
Anabwani G, Canfield CJ, Hutchinson DB. et al
Pediatr Infect Dis J. 1999 May;18(5):456-61
Abstract
 
Azithromycin
 

          Journal Papers, Abstracts, and Commentaries

  Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplicated malaria i
n Tanzanian children: a randomized, controlled trial.
Sykes A, Hendriksen I, Mtove G,  et al
Clin Infect Dis. 2009 Oct 15;49(8):1195-201.
 Abstract
Chloramphenicol
 

          Journal Papers, Abstracts, and Commentaries

  Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplicated malaria i
n Tanzanian children: a randomized, controlled trial.
Sykes A, Hendriksen I, Mtove G,  et al
Clin Infect Dis. 2009 Oct 15;49(8):1195-201.
 Abstract
 
Chloramphenicol pharmacokinetics in African children with severe malaria.
Kokwaro GO, Muchohi SN, Ogutu BR, Newton CR.
J Trop Pediatr. 2006 Aug;52(4):239-43.
 Abstract
Choroquine
 

          Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT  ARTICLE
Use of pre-packaged chloroquine for the home management of presumed malaria in Malagasy
children.
Ratsimbasoa A, Randrianarivelojosia M, Millet P, et al
Malar J. 2006 Sep 14;5:79
Paper
 
Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria
 in children in Guinea-Bissau: implications for future treatment recommendations.
Kofoed PE, Ursing J, Poulsen A, et al
Trans R Soc Trop Med Hyg. 2006 Aug 10;
 Abstract
 
FULL-TEXT ARTICLE
 Randomised Trial of Chloroquine/Sulphadoxine-Pyrimethamine in Gambian Children with
Malaria: Impact against Multidrug-Resistant P. falciparum.
Dunyo S, Ord R, Hallett R, Jawara M, et al
PLoS Clin Trials. 2006 Jul 21;1(3):e14
Paper
 
FULL-TEXT ARTICLE
Chloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission
to Mosquitoes of Multidrug-Resistant Plasmodium falciparum.
Hallett RL, Dunyo S, Ord R, et al
PLoS Clin Trials. 2006 Jul 21;1(3):e15
 Paper
 
Pre-treatment with chloroquine and parasite chloroquine resistance in Ghanaian children
with severe malaria.
Evans JA, May J, Tominski D, et al
QJM. 2005 Nov;98(11):789-96.
 Abstract
 
Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons:
gametocyte carriage and response to oral chloroquine.
Adedeji AA, Fehintola FA, Fateye BA, et al
J Trop Pediatr. 2005 Oct;51(5):288-94.
 Abstract
 
Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-
pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in
Central African children with noncomplicated malaria
Menard D, Madji N, Manirakiza A, et al
Am J Trop Med Hyg. 2005 May;72(5):581-5
 Abstract
 
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of
uncomplicated falciparum malaria in young African children: double-blind randomised
controlled trial.
Alloueche A, Bailey W, Barton S,et al
Lancet. 2004 Jun 5;363(9424):1843-8
 Abstract

FULL-TEXT PDF ARTICLE
 Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in
southern, central Vietnam using an extended 28-day in vivo test and polymerase chain
reaction genotyping.
Taylor WR, Doan HN, Nguyen DT 
Am J Trop Med Hyg. 2000 Jun;62(6):693-7.
Paper
Co-trimoxazole
 

          Journal Papers, Abstracts, and Commentaries

  Impact of daily cotrimoxazole on clinical malaria and asymptomatic parasitemias in HIV-exposed uninfected infants.
 Davis NL, Barnett EJ, Miller WC, et al
Clin Infect Dis. 2015 Apr 21
 Abstract

FULL-TEXT ARTICLE
Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial.
Sandison TG, Homsy J, Arinaitwe E,  et al
BMJ. 2011 Mar 31;342:d1617.
 Paper

Effects of antifolates--co-trimoxazole and pyrimethamine-sulfadoxine--on gametocytes
in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria.
Sowunmi A, Fateye BA, Adedeji AA
 Mem Inst Oswaldo Cruz. 2005 Jul;100(4):451-5.
 Abstract
Diazepam
 

          Journal Papers, Abstracts, and Commentaries

  Response to diazepam in children with malaria induced seizures.
 Ikumi ML, Muchohi SN, Ohuma EO, et al  
Epilepsy Res. 2008 Sep 18.
Abstract
Dihydroartemisinin
 

          Journal Papers, Abstracts, and Commentaries

  Dihydroartemisinin suppository in moderately severe malaria: comparative efficacy of
dihydroartemisinin suppository versus intramuscular artemeter followed by oral
sulfadoxine-pyrimethamine in the management of moderately severe malaria in nigerian children.
 Falade CO, Fadero FF, Happi CT, et al  
Am J Trop Med Hyg. 2007 Jan;76(1):1-6.
Abstract
Fosmidomycin
 

          Journal Papers, Abstracts, and Commentaries

  Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with
Plasmodium falciparum malaria.
Borrmann S, Lundgren I, Oyakhirome S, ET AL
 Antimicrob Agents Chemother. 2006 Aug;50(8):2713-8.
 Abstract
Halofantrine
 

          Journal Papers, Abstracts, and Commentaries

 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M, et al
 Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71
Abstract
 
Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M,et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71.
 Abstract
 
Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum
malaria Infection.
Hau I, Seringe S, Aberrane S, De La Rocque F
Eur J Pediatr. 2003 Nov 28
 Abstract
 
FULL-TEXT PDF ARTICLE
Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern,
central Vietnam using an extended 28-day in vivo test and polymerase chain reaction
genotyping.
Taylor WR, Doan HN, Nguyen DT 
Am J Trop Med Hyg. 2000 Jun;62(6):693-7.
Paper
 
Mechanism of cardiotoxicity of halofantrine.
Wesche DL, Schuster BG, Wang WX, Woosley RL.
Clin Pharmacol Ther. 2000 May;67(5):521-9.
Abstract
 
Lorazepam
 

          Journal Papers, Abstracts, and Commentaries

  Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and
convulsions.
Muchohi SN, Obiero K, Newton CR, et al
 Br J Clin Pharmacol. 2007 Jul 17;
Abstract
Lopinavir
 
            Conference Reports, Abstracts, and Posters 
 
  Significant Reduction in Risk of Malaria among HIV+ Children Receiving Lopinavir/ritonavir-based ART Compared to
NNRTI-based ART, a Randomized Open-label Trial
 J Achan, A Kahuru, G Ikilezi, et al
 (19th CROI)
 Abstract
Mefloquine
 

          Journal Papers, Abstracts, and Commentaries

 
Mefloquine for Uncomplicated Plasmodium falciparum Malaria in Children.
Minodier P, Noël G, Tall M,  et al
Pediatr Infect Dis J. 2011 May 18.
Abstract

Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M, et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71
 Abstract

Mefloquine versus halofantrine in children suffering from acute uncomplicated
falciparum malaria
Minodier P, Noel G, Salles M,et al
Arch Pediatr. 2005 Apr;12 Suppl 1:S67-71.
 Abstract

Pedatric Malaria Drugs
Imbert P, Laurent C.
 Med Trop (Mars) 2002;62(5):554-60
 Abstract

  
Paracetamol
 

          Journal Papers, Abstracts, and Commentaries

  Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau:
a randomized controlled trial.
 Kofoed PE, Ursing J, Rodrigues A, Rombo L.
Malar J. 2011 Jun 1;10(1):148. [
 Abstract
Phenobarbital
 

          Journal Papers, Abstracts, and Commentaries

  Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum
malaria and convulsions.
Kokwaro GO, Ogutu BR, Muchohi SN, et al
Br J Clin Pharmacol. 2003 Oct;56(4):453-457
 Abstract
Piperaquine
 

          Journal Papers, Abstracts, and Commentaries

  FULL-TEXT ARTICLE
Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria
intermittent preventive treatment in children.
Cisse B, Cairns M, Faye E, et al 
PLoS One. 2009 Sep 28;4(9):e7164.
Paper
Quinine
 

          Journal Papers, Abstracts, and Commentaries

 
Ventricular fibrillation in a 5-year-old child on therapeutic dose of quinine dihydrochloride infusion
for acute malaria.
 Busari O, Busari O. 
J Natl Med Assoc. 2008 Aug;100(8):945-7.
 Abstract
 
Changes in laboratory features of 192 children with imported falciparum malaria
treated with quinine.
Ladhani S, Patel VS, El Bashir H, Shingadia D.
Pediatr Infect Dis J. 2005 Nov;24(11):1017-20.
Abstract
 
FULL-TEXT ARTICLE
Quinine pharmacokinetics and pharmacodynamics in children with malaria caused by
Plasmodium falciparum.
Le Jouan M, Jullien V, Tetanye E, et al
Antimicrob Agents Chemother. 2005 Sep;49(9):3658-62.
 Papers

The effect of quinine on the electroretinograms of children with pediatric cerebral malaria.
Lochhead J, Movaffaghy A, Falsini B,  et al.
J Infect Dis 2003 Apr 15;187(8):1342-5
 Abstract

Tolerance of quinine administered as an intrarectal solution in children in French-
speaking Africa.
Barennes H, Mahaman Sani A, Kahia Tani F, et al.
Med Trop (Mars) 1999;59(4):383-8
Abstract

  
Sulfadoxine
 

          Journal Papers, Abstracts, and Commentaries

 
FULL TEXT PDF ARTICLE
High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine
treatment failures in vivo in Gabonese children.
Mombo-Ngoma G, Oyakhirome S,  et al
Malar J. 2011 May 14;10(1):123.
Paper

Population pharmacokinetics of sulfadoxine and pyrimethamine in malawian children with malaria.
Bell DJ, Nyirongo SK, Mukaka M, Molyneux ME, et al
Clin Pharmacol Ther. 2011 Feb;89(2):268-75.
 Abstract

FULL-TEXT ARTICLE
Protective Efficacy of Intermittent Preventive Treatment of Malaria in Infants (IPTi)
Using Sulfadoxine-Pyrimethamine and Parasite Resistance  
Griffi JT, Cairns M, Ghani AC, et al 
PLoS One. 2010 Sep 07
Paper

FULL TEXT PDF ARTICLE
Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in
children with uncomplicated falciparum malaria on the coast of Benin, West Africa
Nahum A, Erhart A, D Gazard D, et al  
Malaria Journal 2007, 6:170
Paper
 
FULL TEXT PDF ARTICLE
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar
trials: public health implications.
 Menendez C, Schellenberg D, Macete E, et al  
Malar J. 2007 Sep 26;6(1):132
 Paper
 
Intermittent preventive treatment in infants as a means of malaria control: a randomized,
double-blind, placebo-controlled trial in northern ghana.
Mockenhaupt FP, Reither K, Zanger P, et al 
Antimicrob Agents Chemother. 2007 Sep;51(9):3273-81
 Abstract
 
A randomized controlled trial of extended intermittent preventive antimalarial treatment in
infants.
Kobbe R, Kreuzberg C, Adjei S, et al
Clin Infect Dis. 2007 Jul 1;45(1):26-8.
Abstract
 
Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications.
Barnes KI, Little F, Smith PJ
Clin Pharmacol Ther. 2006 Dec;80(6):582-96
 Abstract
.
FULL-TEXT ARTICLE
Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with
uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.
Lemnge MM, Ali AS, Malecela EK, et al
Am J Trop Med Hyg. 2005 Oct;73(4):681-5.
Paper
 
FULL-TEXT ARTICLE
Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-
pyrimethamine in Malawian children.
pyrimethamine in Malawian children.
Dzinjalamala FK, Macheso A, Kublin JG, et al
Antimicrob Agents Chemother. 2005 Sep;49(9):3601-6
 Paper
 
Effects of antifolates--co-trimoxazole and pyrimethamine-sulfadoxine--on gametocytes
in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria.
Sowunmi A, Fateye BA, Adedeji AA
 Mem Inst Oswaldo Cruz. 2005 Jul;100(4):451-5.
 Abstract
 
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum
malaria: a randomized, multisite trial to guide national policy in Uganda.
Bakyaita N, Dorsey G, Yeka A, et al
Am J Trop Med Hyg. 2005 May;72(5):573-80.
 Abstract
 
The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the
treatment of severe falciparum malaria in children.
Ogutu BR, Nzila AM, Ochong E,
Trop Med Int Health. 2005 May;10(5):484-8.
 Abstract

Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the
treatment of uncomplicated falciparum malaria in young African children: double-blind
randomised controlled trial.
Alloueche A, Bailey W, Barton S,et al
Lancet. 2004 Jun 5;363(9424):1843-8
 Abstract

 
Malaria Main Page Pediatric Main Page Home Page

Photo by Caroline Jacoby Courtesy of M/MC Photoshare at www.jhuccp.org/mmc  and is protected by current copyright law 
Pediatric Internet Resource Center
Malaria Drugs