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Malaria Drugs

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Amodiaquine
Artemether-Lumefantrine
Artemisinin  
 Atovaquone
Azithromycin
Chloroquine
Cotrimoxazole
Mefloquine
Piperaquine		 Pyrimethamine
Sulfadoxine/Pyrimethamine




 
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Last Update:  July 16, 2017 
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General Reports
 
       Journal Papers, Abstracts, and Commentaries
 
 
Antiretroviral therapy with efavirenz accentuates pregnancy-associated reduction of dihydroartemisinin-piperaquine exposure during malaria chemoprevention.
 Kajubi R, Huang L, Jagannathan P, Chamankhah N, et al
Clin Pharmacol Ther. 2017 Feb 10.
Abstract

FULL-TEXT ARTICLE
 Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial.
 Ndibazza J, Mpairwe H, Webb EL,  et al
 PLoS One. 2012;7(12):e50325
Paper

Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study
McGready R, Lee S, Wiladphaingern J,   et al
Lancet Infect Dis. 2011 Dec 12
 Abstract

Drugs for treating uncomplicated malaria in pregnant women.
 Orton L, Garner P.  
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004912.
 Abstract
 
Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali.
Kayentao K, Kodio M, Newman RD, et al 
J Infect Dis. 2005 Jan 1;191(1):109-16.
 Abstract

Drugs for preventing malaria-related illness in pregnant women and death in the newborn (Cochrane Review).
 Garner P, Gulmezoglu AM.
Cochrane Database Syst Rev 2003;(1):CD000169
 Abstract

Malaria prophylaxis and the reduction of anemia at childbirth.
Geelhoed DW, Visser LE, Addae V,et al  
Int J Gynaecol Obstet 2001 Aug;74(2):133-8
 Abstract
 
Safety, efficacy and determinants of effectiveness of antimalarial drugs during pregnancy: implications for prevention programmes in Plasmodium falciparum-endemic sub-Saharan Africa.
Newman RD, Parise ME, Slutsker L
Trop Med Int Health. 2003 Jun;8(6):488-506.
 Abstract
 
Drugs for preventing malaria-related illness in pregnant women and death in the newborn.
Garner P, Gulmezoglu AM.
Cochrane Database Syst Rev. 2000;(2):CD000169.
 Abstract
Amodiaquine
 
       Journal Papers, Abstracts, and Commentaries
 
  Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy.
Tarning J, Chotsiri P, Jullien V,  et al
Antimicrob Agents Chemother. 2012 Aug 27
 Abstract

FULL-TEXT pDF ARTICLE
Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
 Tarning J, Kloprogge F, Piola P,  et al
Malar J. 2012 Aug 22;11(1):293
 Paper

Can amodiaquine be used safely during pregnancy?
Thomas F, Erhart A, D'Alessandro U.
Lancet Infect Dis. 2004 Apr;4(4):235-9.
Abstract
Artemethe/Lumefantrine
 
        Journal Papers, Abstracts, and Commentaries
 
 
Artemether-Lumefantrine Pharmacokinetics and Clinical Response is Minimally Altered in Ugandan Pregnant Women Treated for Uncomplicated Plasmodium Falciparum Malaria.
Nyunt MM, Nguyen VK, Kajubi R,  et al
Antimicrob Agents Chemother. 2015 Dec 14
 Abstract

Longitudinal Outcomes in a Cohort of Ugandan Children Randomized to Artemether-lumefantrine Versus Dihydroartemisinin-piperaquine for the Treatment of Malaria
 Wanzira H, Kakuru A, Arinaitwe E, et al
Clin Infect Dis. 2014 May 13.
Abstract

FULL-TEXT PDF ARTICLE
 Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial.
 Muehlenbachs A, Nabasumba C, McGready R, et al 
Malar J. 2012 May 3;11(1):150
 Paper
 
Artemisinin/Artesunate
 

        Journal Papers, Abstracts, and Commentaries

 

Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum malaria.
Tietche F, Chelo D, Mina Ntoto NK, et al
Am J Trop Med Hyg. 2010 Jun;82(6):1034-40
 Abstract

FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
FULL-TEXT ARTICLE
The safety of artemisinins during pregnancy: a pressing question.
Dellicour S, Hall S, Chandramohan D, Greenwood B.
Malar J. 2007 Feb 14;6:15.
Paper
 
The safety of the combination artesunate and pyrimethamine-sulfadoxine given during pregnancy. 
Deen JL, von Seidlein L, Pinder M, et al.
Trans R Soc Trop Med Hyg. 2001 Jul-Aug;95(4):424-8.
 Abstract   
 
Atovaquone
 

        Journal Papers, Abstracts, and Commentaries

 
The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.
 Na-Bangchang K, Manyando C, Ruengweerayut R, et al 
Eur J Clin Pharmacol. 2005 Jul 23;
Abstract   
 
The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.
McGready R, Stepniewska K, Edstein MD, et al
Eur J Clin Pharmacol. 2003 Oct;59(7):545-52
 Abstract   
 
Azithromycin
 

        Journal Papers, Abstracts, and Commentaries

 
FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
 Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
Chloroquine
 

        Journal Papers, Abstracts, and Commentaries

 
Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial.
Villegas L, McGready R, Htway M,et al
Trop Med Int Health. 2007 Feb;12(2):209-18.
 Abstract
 
Failure of a Chloroquine Chemoprophylaxis Program to Adequately Prevent Malaria during Pregnancy in Koupela District, Burkina Faso.
 Sirima SB, Sawadogo R, Moran AC, et al.
Clin Infect Dis 2003 Jun 1;36(11):1374-82
 Abstract
 
Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan.
Olayemi O, Fehintola FA, Osungbade A, et al
Obstet Gynaecol. 2003 Sep;23(5):490-5.
Abstract
 
Cotrimoxazole
 
        Journal Papers, Abstracts, and Commentaries
 
 
The Effect of Cotrimoxazole Prophylactic Treatment on Malaria, Birth Outcomes, and Postpartum CD4 Count in HIV-Infected Women.
Dow A, Kayira D, Hudgens MG, et al
Infect Dis Obstet Gynecol. 2013;2013:340702.
 Abstract

Cotrimoxazole prophylaxis versus mefloquine intermittent preventive treatment to prevent malaria in HIV-infected pregnant women: two randomized controlled trials.
Denoeud-Ndam L, Zannou DM, Fourcade C, et al
J Acquir Immune Defic Syndr. 2013 Nov 11.
 Abstract
 
Mefloquine
 

      Journal Papers, Abstracts, and Commentaries

  FULL-TEXT ARTICLE
 Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial.
González R, Desai M, Macete E,  et al
PLoS Med. 2014 Sep 23;11(9):e1001735.
Paper

Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso
 Valea I, Tinto H, Traore/Coulibaly M,  et al.
J Antimicrob Chemother. 2014 Jun
Abstract

Cotrimoxazole prophylaxis versus mefloquine intermittent preventive treatment to prevent malaria in HIV-infected pregnant women: two randomized controlled trials.
 Denoeud-Ndam L, Zannou DM, Fourcade C, et al
J Acquir Immune Defic Syndr. 2013 Nov 11.
 Abstract

Tolerability of mefloquine intermittent preventive treatment for malaria in HIV-infected pregnant women in Benin.
 Denoeud-Ndam L, Clément MC, Briand V,  et al
J Acquir Immune Defic Syndr. 2012 Jun 13.
 Abstract
Piperaquine
 
        Journal Papers, Abstracts, and Commentaries
 
 
The application of physiologically-based pharmacokinetic modelling to assess the impact of antiretroviral-mediated drug-drug interactions on piperaquine antimalarial therapy during pregnancy.
Olafuyi O, Coleman M, Badhan RKS.
Biopharm Drug Dispos. 2017 Jul 14
 Abstract
 
Pyrimethamine
 

          Journal Papers, Abstracts, and Commentaries 

  FULL-TEXT PDF ARTICLE
 Plasmodium falciparum dihydrofolate reductase alleles and pyrimethamine use in pregnant Ghanaian women.
Mockenhaupt FP, Eggelte TA, Bohme T, et al
Am J Trop Med Hyg 2001 Jul;65(1):21-6
 Paper		  
Quinine
 

          Journal Papers, Abstracts, and Commentaries 

  Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection.
Kayentao K, Guirou EA, Doumbo OK, et al
Am J Trop Med Hyg. 2014 Jan 13
 Abstract
Sulfadoxine -Pyrimethamine
 

          Journal Papers, Abstracts, and Commentaries 

 
FULL TEXT ARTICLE
 Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia.
 Tan KR, Katalenich BL, Mace KE, et al
Malar J. 2014 Jun 9;13(1):227
 Paper

FULL-TEXT ARTICLE
Intermittent preventive therapy with sulfadoxine-pyrimethamine for malaria in pregnancy: a cross-sectional study from Torero, Uganda.
 Arinaitwe E, Ades V, Walakira A,  et al
PLoS One. 2013 Sep 4;8(9):e73073.
Paper

The effect of antenatal monthly sulphadoxine-pyrimethamine, alone or with azithromycin, on foetal and neonatal growth faltering in Malawi: a randomised controlled trial.
Luntamo M, Kulmala T, Cheung YB, et al
Trop Med Int Health. 2013 Apr;18(4):386-97.
 Abstract

The impact of intermittent preventive treatment with sulphadoxine-pyrimethamine on the prevalence of malaria parasitaemia in pregnancy.
Umeh UA, Obi SN, Onah HE,  et al
Trop Doct. 2012 Mar 7.
 Abstract

FULL-TEXT ARTICLE
A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women.
Kalilani L, Mofolo I, Chaponda M,et al
PLoS ONE. 2007 Nov 14;2(11):e1166.
Paper
 
Two-Dose versus Monthly Intermittent Preventive Treatment of Malaria with Sulfadoxine-Pyrimethamine in HIV-Seropositive Pregnant Zambian Women.
 Hamer DH, Mwanakasale V, Macleod WB, et al 
J Infect Dis. 2007 Dec 1;196(11):1585-1594
 Abstract
 
Inferiority of Single-Dose Sulfadoxine-Pyrimethamine Intermittent Preventive Therapy for Malaria during Pregnancy among HIV-Positive Zambian Women.
 Gill CJ, Macleod WB, Mwanakasale V, et al 
J Infect Dis. 2007 Dec 1;196(11):1577-1584.
 Abstract
 
Pharmacokinetics of Sulfadoxine-Pyrimethamine in HIV-Infected and Uninfected Pregnant Women in Western Kenya.
 Green MD, van Eijk AM, van Ter Kuile FO, et al 
J Infect Dis. 2007 Nov 1;196(9):1403-8
 Abstract
 
Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review.
 ter Kuile FO, van Eijk AM, Filler SJ. 
JAMA. 2007 Jun 20;297(23):2603-16.
 Abstract
 
Randomized Trial of 2-Dose versus Monthly Sulfadoxine-Pyrimethamine Intermittent Preventive Treatment for Malaria in HIV-Positive and HIV-Negative Pregnant Women in Malawi.
Filler SJ, Kazembe P, Thigpen M 
J Infect Dis. 2006 Aug 1;194(3):286-93.
Abstract

Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum malaria.
 Staalsoe T, Shulman CE, Dorman EK ,et al
 Infect Immun. 2004 Sep;72(9):5027-30
 Abstract
 
  Implementation of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in Kisumu, western Kenya.
 Eijk AM, Ayisi JG, Kuile FO, et al
Trop Med Int Health. 2004 May;9(5):630-7.
 Abstract
 
Effectiveness of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in western Kenya: a hospital-based study.
van Eijk AM, Ayisi JG, ter Kuile FO
 Trop Med Int Health. 2004 Mar;9(3):351-60.
 Abstract

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