A supplement to the Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (treatment guidelines) was added on April 30, 2007, discussing use of Entecavir in Hepatitis B/HIV Co-infected patients. 

Based on preliminary findings from a recent case series of three patients, the Treatment Guidelines Panel now recommends that: For HBV/HIV co-infected patients, entecavir should not be used for the treatment of HBV infection without concomitant treatment for HIV.

The supplement is available from AIDSinfo at http://www.aidsinfo.nih.gov/contentfiles/EntecavirInHIV.pdf   

The complete Adult and Adolescent Guidelines can be found on the AIDSinfo web site at http://www.aidsinfo.nih.gov/Guidelines/GuidelineDetail.aspx?MenuItem=Guidelines&Search=Off&GuidelineID=7&ClassID=1

Richard Klein
Office of Special Health Issues
Food and Drug Administration

Kimberly Struble
Division of Antiviral Drug Products
Food and Drug Administration