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Last Update:  March 21, 2018
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General Reports
 

      Videos

 
HIV and Hepatitis C: Treatment
John Scott, MD, MSc
 

HIV and HCV Treatment Case Discussion
 

Practical Approaches of Integrating HCV into HIV Care

      Internet Documents

  FULL-TEXT PDF DOCUMENT
What HIV Clinicians Should Know (and Do) About HCV Coinfection

Mascolini, M   RITA Summer 2014

HCV infection remains among the most difficult-to-manage comorbidities in people with HIV. But care for HCV-coinfected people changed dramatically
with the advent of direct-acting antivirals (DAAs), as it has for everyone with HCV. This issue of Research Initiative, Treatment Action (RITA) examines
how DAAs have already transformed treatment of HCV infection and considers how they may continue to do so. A practice-oriented interview with HCV/HIV
expert Douglas Dieterich offers nuts-and-bolts advice on prescribing DAAs for coinfected people and encourages more involvement by HIV clinicians in HCV
management. A second review article dissects perhaps the most controversial question about HCV/HIV coinfection—does HCV make HIV infection worse?
Scores of studies addressing different aspects of this question are almost evenly split in their conclusions. The RITA article suggests how HIV clinicians with
coinfected patients may work their way out of this data maze.
A final review analyzes sexual HCV transmission among gay and bisexual men. Early research
rated sexual HCV transmission a rare event. But that thinking—still echoed in some online CDC material—stands starkly at odds with an explosive HCV epidemic
documented in gays and bisexuals who do not inject drugs.
Document

     Journal Papers, Abstracts, and Commentaries

 

Effectiveness and security of chronic hepatitis C treatment in coinfected patients in real-world.
Uriarte-Pinto M, Navarro-Aznarez H, et al
Int J Clin Pharm. 2018 Mar 20.
Abstract

Successful treatment of HIV-/HCV-coinfected patients in the era of direct acting antivirals: is advanced liver disease still a limiting factor?
Gonzales Zamora JA.
Infect Dis (Lond). 2017 Nov 12:1
Abstract

Eradication of HCV and non-liver-related non-AIDS-related events in HIV/HCV coinfection.
Berenguer J, Rodríguez-Castellano E, Carrero A, et al
Hepatology. 2017 Jan 21..

Abstract

A molecular transmission network of recent hepatitis C infection in people with and without HIV: Implications for targeted treatment strategies.
Bartlett SR, Wertheim JO, Bull RA, et al
J Viral Hepat
. 2016 Nov 24.
Abstract

Association of serum albumin and AST with 5-year all-cause mortality in HIV/HCV coinfection and HIV monoinfection.
Scherzer R, Heymsfield SB, Rimland D, et al

AIDS
. 2016 Sep 24
Abstract

FULL-TEXT ARTICLE
Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients.
Medrano LM, Rallón N, Berenguer J, et al
J Transl Med. 2016 Sep 2;14(1):257.

Paper

FULL-TEXT ARTICLE
Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy.
Spaan M, Hullegie SJ, Beudeker BJ, Kreefft K, et al
PLoS One
. 2016 Jul 14;11(7):e0159243
Paper

Changes in the response to treatment against chronic hepatitis C between 1999 and 2015: data from a prospective cohort. [Spain]
Mancebo M, Real LM, Mira JA,
et al
Eur J Gastroenterol Hepatol. 2016 Jul 12.

Abstract

Pharmacologic Considerations in the Treatment of Hepatitis C Virus in Persons With HIV.
MacBrayne CE, Kiser JJ.
Clin Infect Dis
. 2016 Jul 15;63 Suppl 1:S12-23.
Abstract

High rates of hepatitis C virus (HCV) cure using direct-acting antivirals in HIV/HCV-coinfected patients: a real-world perspective.
Hawkins C, Grant J, Ammerman LR

J Antimicrob Chemother
.
2016 Jun 20.
Abstract

Double Filtration Plasmapheresis in Treatment of Patients With Co-Infection of Hepatitis C and Human Immunodeficiency Virus.
Mednikov RV, Rabinovich VI, Kizlo SN, et al
Ther Apher Dial
. 2016 Apr 5.
Abstract

Modelling the impact of deferring HCV treatment on liver-related complications in HIV coinfected men who have sex with men.
Zahnd C, Salazar-Vizcaya L, Dufour JF, et al
 
J Hepatol
. 2016 Feb 24. pii: S0168-8278(16)00164-1.
Abstract

Optimum combination therapy regimens for HIV/HCV infection.
Rey D, Muret P, Piroth L.
Expert Rev Anti Infect Ther
. 2016 Jan 28.
Abstract

Current treatment options for hepatitis C patients co-infected with HIV.
Rockstroh JK, Hardy WD.

Expert Rev Gastroenterol Hepatol
.2016 Jan 22. .

Abstract

Assessing liver disease in HIV-HCV coinfected patients.
Tsochatzis EA, Castera L.
Curr Opin HIV AIDS
. 2014 Jun 30.

Abstract

Treatment of Hepatitis C in HIV-Infected Patients: Moving Towards an Era of All Oral Regimens.
Chen TY, Jain MK.
 
AIDS Patient Care STDS
. 2015 Jun;29(6):329-37.
Abstract

Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals.
Grint D, Peters L, Rockstroh JK,  et al
 
AIDS
. 2015 Apr 13.

Abstract

CROI 2015: Highlights of Viral Hepatitis Therapy.
Luetkemeyer AF, Wyles DL.
Top Antivir Med. 2015 Mar-Apr;23(1):66-76

Abstract

FULL-TEXT ARTICLE
Treatment of chronic hepatitis C in patients with HIV/HCV coinfection.
Coppola N, Martini S, Pisaturo M,  et al
World J Virol
. 2015 Feb 12;4(1):1-12
Paper

Influence of Treatment Complexity on Adherence and Incidence of Blips in HIV/HCV Coinfected Patients.
Calvo-Cidoncha E, González-Bueno J, Almeida-González CV, Morillo-Verdugo R.

J Manag Care Spec Pharm. 2015 Feb;21(2):153-7.

Abstract

Management of hepatitis C virus and human immunodeficiency virus coinfection.
O'neil CR, Coffin CS.
Minerva Gastroenterol Dietol. 2014 Sep;60(3):165-175..
Abstract

Hepatitis C virus NS3 sequence diversity and antiviral resistance-associated variant frequency in HCV/HIV coinfection.
Jabara CB, Hu F, Mollan K,  et al
Antimicrob Agents Chemother
. 2014 Aug 4.
Abstract

PPARγ2 Pro12Ala polymorphism is associated with sustained virological response in HIV/HCV coinfected patients under HCV therapy.
Fernández-Rodríguez A, Berenguer J, Rallón N,  et al
"
J Acquir Immune Defic Syndr
. 2014 Jul 26
.
Abstract

Efficacy of lead-in silibinin and subsequent triple therapy in difficult-to-treat HIV/hepatitis C virus-coinfected patients.
Braun D, Rauch A, Durisch N, et al

HIV Med
. 2014 Jun 4.
Abstract

HIV/hepatitis C virus coinfection management: changing guidelines and changing paradigms.
Cooper C, Klein M.
HIV Med. 2014 May 6..

Abstract

Spontaneous HCV clearance in HIV patients with chronic hepatitis C-bearing IL28B-CC alleles using antiretroviral therapy.
Vispo E, Barreiro P, Plaza Z,  et al

AIDS
. 2014 Mar 15
Abstract

FULL-TEXT ARTICLE
GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C.
Feng Y, Liu L, Feng YM,  et al

Hepat Mon
. 2014 Mar 3;14(3):e14169.
Paper

Using patient-reported outcomes to improve the management of co-infection with HIV and HCV: the ANRS CO13 HEPAVIH cohort.
Marcellin F, Roux P, Winnock M, Lions C,  et al
Expert Rev Gastroenterol Hepatol. 2014 Mar 3..
Abstract

HCV and HIV co-infection: mechanisms and management.
Chen JY, Feeney ER, Chung RT.
Nat Rev Gastroenterol Hepatol. 2014 Feb 18.
Abstract

Treating HCV in HIV 2013: on the cusp of change.
Martel-Laferrière V, Dieterich DT.
Liver Int. 2014 Feb;34 Suppl 1:53-9.

Abstract

Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis.
Grint D, Peters L, Rockstroh JK, et al
AIDS. 2014 Feb 20;28(4):577-87.
Abstract

CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core: Canadian guidelines for management and treatment of HIV/hepatitis C coinfection in adults.
Hull M, Klein M, Shafran S, Tseng A,Can
J Infect Dis Med Microbiol. 2013 Winter;24(4):217-38.
Abstract

Re-treatment of chronic HCV infection in HIV co-infected patients and predictors of sustained viral response.
Krastinova E, Bani-Sadr F, Fromentin D, et a
l
Infect. 2013 Dec 27

Abstract


Strategies for assignment of HIV/HCV genotype 1-coinfected patients to either dual-therapy or direct-acting antiviral agent based triple therapy.
Mandorfer M, Neukam K, Rivero A,  et al
Antivir Ther. 2013 Dec 17.
Abstract

Hepatitis C Virus Management of HIV-infected Patients in the era of Directly Acting Antivirals (DAAs).
Zeremski M, Martinez AD, Talal AH.
Clin Infect Dis
. 2013 Dec 13..
Abstract

Treatment of Genotype 1 HCV Infection in the HIV Coinfected Patient in 2014.
Chastain CA, Naggie S.
Curr HIV/AIDS
Rep
. 2013 Nov 24
Abstract

Treatment of Genotype 2 and Genotype 3 Hepatitis C Virus (HCV) Infection in Human Immunodeficiency Virus Positive Patients.
Brown K, Labrie M, Coffin CS.
Curr HIV/AIDS Rep. 2013 Nov 21
Abstract

FULL-TEXT ARTICLE
Managing HIV/hepatitis C co-infection in the era of direct acting antivirals.
Rockstroh JR, Bhagani S
BMC Med
. 2013 Nov 1;11:234
.
Paper

Optimizing treatment in HIV/HCV coinfection.
Puoti M, Rossotti R, Travi G, Panzeri C, et al
Dig Liver Dis. 2013 Sep 30;45S5:S355-S362.

Abstract

Changes in biomarkers of liver disease during successful combination antiretroviral therapy in HIV/HCV-coinfected individuals.
Rohrbach J, Stickel F, Schmid P, et al
Antivir Ther. 2013 Sep 13. .
Abstract

Effect of hepatitis C virus on immunological and virological responses in HIV-infected patients initiating highly active antiretroviral therapy: a meta-analysis.
Tsiara CG, Nikolopoulos GK, Dimou NL, et al

J Viral Hepa
t
. 2013 Oct;20(10):715-24
Abstract

Therapy of chronic hepatitis C virus infection in the era of direct-acting and host-targeting antiviral agents.
Conteduca V, Sansonno D, Russi S, et al
J Infect. 2013 Sep 3.
Abstract

Viral hepatitis and HIV: update and management.
Núñez M, Mendes-Correa MC.
Antivir Ther
.
2013;18(3 Pt B):451-
Abstract

Current Management of Hepatitis C Virus Infection in Patients With HIV Co-infection.
Sulkowski MS.

J Infect Dis
. 2013 Mar;207 Suppl 1:S26-32.
Abstract

FULL-TEXT ARTICLE
Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected with HIV: A Systematic Review and Meta-Analysis of Observational Cohorts.
Davies A, Singh KP, Shubbe
r Z,  et al
PLoS One
. 2013;8(2):e55373.
Paper

Acute Hepatitis C in an HIV-Infected patient: A Case Report and Review of Literature.
Driver TH, Terrault N, Saxena V.
J Gen Intern Med. 2012 Nov 14.
Abstract

FULL-TEXT ARTICLE
Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants.
Vidal F, López-Dupla M, Laguno M,  et al

PLoS One
. 2012;7(11):e47725. .
Paper

Treatment of hepatitis C in patients infected with human immunodeficiency virus in the direct-acting antiviral era.
Soriano V, Labarga P, Vispo E,  et al
Infect Dis Clin North Am. 2012 Dec;26(4):931-48.
Abstract

Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients.
Lo Re V 3rd, Teal V, Localio AR,  et al

AIDS Behav
. 2012 Aug 21..
Abstract

Effect of hepatitis C treatment on CD4 cell counts and the risk of death in HIV-hepatitis C co-infected patients; COHERE collaboration.
The HCV working group of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord.
Antivir Ther. 2012 Jul 24
Abstract

Spontaneous clearance of chronic hepatitis C infection in a patient with a 20-year-old HIV-hepatitis C co-infection and chronic active hepatitis.
Manfredi R, Dentale N, Calza L.
Int J STD AIDS. 2012 Mar;23(3):e48-50.
Abstract

Recent advances in the treatment of HIV/HBV and HIV/HCV co-infection.
Masgala A, Bonovas S, Nikolopoulos GK.
Mini Rev Med Chem
. 2012 Apr 25..
Abstract

Mortality in HCV-infected Patients with a Diagnosis of AIDS in the Era of Combination Anti-retroviral Therapy.
Branch AD, Van Natta ML, Vachon ML,  et al
Clin Infect Dis
. 2012 Apr 24. .
Abstract

Accumulation of drug resistance and loss of therapeutic options precede commonly used criteria for treatment failure in HIV-1 subtype-C-infected patients.
Barth RE, Aitken SC, Tempelman H, et al

Antivir Ther
. 2011 Dec 2.
Abstract

HIV and hepatitis C co-infection: acute HCV therapy.
Boesecke C, Vogel M.
Curr Opin HIV AIDS. 2011 Nov;6(6):459-64.
Abstract

Successful treatment of acute hepatitis C virus in HIV positive patients using the European
AIDS Treatment Network guidelines for treatment duration.
Dorward J, Garrett N, Scott D, et al
J Clin Virol
. 2011 Sep 14.
Abstract

Hepatitis C virus infection and coinfection with human immunodeficiency virus:
challenges and advancements in management.

Hadigan C, Kottilil S.
JAMA. 2011 Jul 20;306(3):294-301..
Abstract

Antiretroviral treatment interruption leads to progression of liver fibrosis in
HIV-hepatitis C virus co-infection.
Thorpe J, Saeed S, Moodie EE., et al
AIDS
. 2011 Feb 16.
Abstract

Acute hepatitis C in HIV-infected individuals - recommendations from the NEAT
consensus conference.
Rockstroh JK; EATC Acute Hepatitis C Infection Consensus Panel.
AIDS
. 2010 Dec 6
Abstract

Hepatitis C treatment among racial and ethnic groups in the IDEAL trial.
Muir AJ, Hu KQ, Gordon SC,et al
J Viral Hepat
. 2010 Nov 25.
Abstract

Treatment of acute hepatitis C in human immunodeficiency virus-infected patients:
The HEPAIG study.
Piroth L, Larsen C, Binquet C, et al
Hepatology. 2010 Sep 7:1916-1923
Abstract

Management of HIV and hepatitis virus coinfection.
Mendes-Corrêa M, Núñez M.
Expert Opin Pharmacother. 2010 Jul 14.
Abstract

New Frontiers of HCV Therapy in HIV/HCV Co-infection.
Amorosa VK.
Curr HIV/AIDS Rep
. 2010 Jun 20
Abstract

Hepatitis C virus (HCV) treatment uptake and changes in the prevalence of HCV genotypes in HIV/HCV-coinfected patients.
Medrano J, Resino S, Vispo E,  et al
J Viral Hepat
. 2010 Apr 27.
Abstract

Treatment of acute HCV infection in HIV-positive patients: experience from a multicentre European cohort.
Vogel M, Dominguez S, Bhagani S, et al  et al 
Antivir Ther
. 2010;15(2):267-7
Abstract

Treatment of hepatitis C virus (HCV) infection in patients coinfected with HIV in the HIV Outpatient Study (HOPS), 1999-2007.
Vellozzi C, Buchacz K, Baker R, et al
J Viral Hepat
. 2010 Mar 29.
Abstract

Recommendations of Gesida/PNS/AEEH for the management and treatment of the adult co-infected patient with hiv and hepatitis A, B and C virus.
Panel de expertos de Gesida, Secretaría del Plan Nacional sobre el Sida
(SPNS) y Asociación Española para el Estudio del Hígado (AEEH).

Enferm Infecc Microbiol Clin
. 2010 Jan;28(1):31.e1-31.e31
Abstract

Rate and Predictors of Success in the Retreatment of Chronic Hepatitis C Virus in HIV/HCV-Coinfected Patients With Prior Nonresponse or Relapse.
Labarga P, Vispo E, Barreiro P, et al
J Acquir Immune Defic Syndr
. 2010 Jan 23.
Abstract
 

 

     Conference Reports, Abstracts, and Posters

 

Knowledge and awareness of current hepatitis C treatment strategies among nurses who care for persons living with HIV in the United States: a call for provider education
J. Kwong, S. Willard, R. Carroll, et al
(XIX International AIDS Conference)
Abstract

Significant variation in recommendations for management of HIV-hepatitis B and C (HIV-HBV and HIV-HCV) co-infection: a survey of national guidelines from resource-limited settings (RLS)
R.C. Heenan, S.T. Wiersma, M. Vitoria, et al

(XIX International AIDS Conference)
Abstract

 

     Videos

 
Cervical Cancer Screening and HIV
Hillary Liss, MD

Management of HIV/HCV Coinfection Sequelae

Anemia


Anemia

     Journal Papers, Abstracts, and Commentaries
 

  Treatment of hepatitis C and anemia in human immunodeficiency virus-infected
patients.
Dieterich DT.
J Infect Dis 2002 May 15;185 Suppl 2:S128-37
Abstract
 

Adverse Events
 

     Journal Papers, Abstracts, and Commentaries

 
Transient liver injury associated with the early recovery of HCV-specific T cell responses and HCV rebound in HIV-1/HCV co-infected patients undergoing highly active antiretroviral therapy.
Fubiao K, Weiwei C, Xinwei Z, et al 
J Acquir Immune Defic Syndr
. 2012 Oct 15
Abstract


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