Medical Advocates
Atazanavir (Reyataz)
   
Journal Citations: Drug/Drug/Substance Interactions
ATZ/Acid Reducing AgentsATZ/Bilirubin
 ATZ/Boceprevir
 ATZ/Buprenorphine
ATZ/Chinese Herbs
 ATZ/CEP 1347
 ATZ/Disulfiram
ATZ/Lansoprazole
ATZ/Lopinavir
ATZ/NVP
 ATZ/Methadone
 ATZ/Raltegravir
 ATZ/Rifampin		 ATZ/RTV                           
ATZ/RTV/Efavirenz           
ATZ/RTV/Methadone  
ATZ/RTV/Minocycline
 ATZ/RTV/Norethindrone
ATZ/RTV/Omeprazole
ATZ/RTV/Quetiapine
ATZ/RTV/Rifampin
ATZ/RTV/Rosuvastatin
 ATZ/Sutherlandia frutescens  
ATZ/Tacrolimus
ATZ/Tenofovir
 		 ATZ/RTV/Tenofovir
ATZ/RTV/Valproic Acid
ATZ/Voriconazole






 
 
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Last updated:  December 20, 2016
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Atazanavir/Bilirubin
       
 
FULL-TEXT ARTICLE
Atazanavir–bilirubin interaction: a pharmacokinetic–pharmacodynamic model
Roberto Lozano, Nieves Domeque, Alberto-Fermin Apesteguia
Clin Pharmacol. 2013; 5: 153–159.
Paper
Correction in:
Clin Pharmacol. 2013; 5: 175.
Atazanavir/Boceprevir
       
  Pharmacokinetic Interactions Between the HCV Protease Inhibitor Boceprevir and Ritonavir-Boosted HIV-1 Protease Inhibitors Atazanavir, Darunavir, and Lopinavir.
 Hulskotte EG, Feng HP, Xuan F, et al
Clin Infect Dis. 2012 Dec 14.
 Abstract
Atazanavir/Buprenorphine
       
  Interaction between buprenorphine and atazanavir or atazanavir/ritonavir.
 McCance-Katz EF, Moody DE  
 Drug Alcohol Depend. 2007 Jul 20
 Abstract
Atazanavir/CEP-1347
       
  Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.
Ma Q, Gelbard HA, Maggirwar SB,  et al
J Neurovirol. 2013 Jun 5
 Abstract
Atazanavir/Chinese Herbs
       
  Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo.
Cheng BH, Zhou X, Wang Y, et al
J Ethnopharmacol. 2015 Mar 13;162:369-76.
Abstract
Atazanavir/Disulfiram
       
  Interaction of disulfiram with antiretroviral medications: Efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism.
McCance-Katz EF, Gruber VA, Beatty G,  et al
Am J Addict. 2013 Oct 11.
Abstract
Atazanavir/Lansoprazole
       
  Inhibition of atazanavir oral absorption by lansoprazole gastric Acid suppression in |
healthy volunteers.
 Tomilo DL, Smith PF, Ogundele AB, et al 
Pharmacotherapy. 2006 Mar;26(3):341-6.
 Abstract
Atazanavir/Lopinavir
       
 
The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients.
 Chetchotisakd P. 
Expert Rev Anti Infect Ther. 2009 Sep;7(7):801-5.
 Abstract

Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic
interaction and predictors of drug exposure.
Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.
Abstract
Atazanavir/Methadone
       
 

Atazanavir plasma concentrations are impaired in HIV-1-infected adults simultaneously
taking a methadone oral solution in a once-daily observed therapy setting.
 Haberl A, Moesch M, Nisius G, et al  
Eur J Clin Pharmacol. 2010 Apr;66(4):375-81
 Abstract

Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports.
 Gallagher DP, Kieran J, Sheehan G, et al
 Clin Infect Dis. 2008 Jun 17.
 Abstract

Lack of an effect of atazanavir on steady-state pharmacokinetics of methadone in patients
chronically treated for opiate addiction.
 Friedland G, Andrews L, Schreibman T, et al 
AIDS. 2005 Oct 14;19(15):1635-1641.
Abstract
Atazanavir/Nevirapine
       
  Effect of nevirapine on the steady-state trough concentrations of atazanavir in
HIV-infected patients receiving atazanavir/ritonavir.
 Moltó J, Deig E, Valle M,  et al 
Ther Drug Monit. 2010 Feb;32(1):93-6.
 Abstract
Atazanavir/Raltegravir
       
  Atazanavir increases the plasma concentrations of 1200 mg raltegravir dose.
Krishna R, East L, Larson P,  et al
Biopharm Drug Dispos. 2016 Dec;37(9):533-541
 Abstract

Brief Report: Switch to Ritonavir-Boosted Atazanavir Plus Raltegravir in Virologically Suppressed Patients With HIV-1 Infection: A Randomized Pilot Study.
van Lunzen J, Pozniak A, Gatell JM, et al
J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):538-43
 Abstract

Atazanavir Modestly Increases Plasma Levels of Raltegravir in Healthy Subjects.
 Iwamoto M, Wenning LA, Mistry GC, et al
Clin Infect Dis. 2008 May 30.
Abstract
Atazanavir/Rifampin
       
  Effect of Concomitant Rifampin on the Pharmacokinetics and Safety of Twice-Daily Atazanavir:
ACTG Protocol A5213.
 Acosta EP, Kendall MA, Gerber JG, et al
Antimicrob Agents Chemother. 2007 Jun 18;
Abstract
Atazanavir/Ritonavir
       
 

 

 Population Pharmacokinetic Modeling of the Changes in Atazanavir Plasma Clearance Caused by Ritonavir Plasma Concentrations in HIV-1 Infected Patients.
Moltó J, Estévez JA, Miranda C, et al
Br J Clin Pharmacol. 2016 Jul 22.
Abstract

Role of ritonavir in the drug interactions between telaprevir and ritonavir-boosted atazanavir.
Gutierrez-Valencia A, Ruiz-Valderas R, Torres-Cornejo A,  et al
Clin Infect Dis. 2013 Oct 21.
 Abstract
Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic
interaction and predictors of drug exposure.
 Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.
 Abstract
Atazanavir/Ritonavir/Efavirenz
       
 

 

 Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV-1-infected patients starting efavirenz, lopinavir-ritonavir, or atazanavir-ritonavir plus tenofovir/emtricitabine: Final 48-week results (the Advanz-3 trial).
 Miro JM, Manzardo C, Ferrer E, et al
 J Acquir Immune Defic Syndr. 2015 Feb 17.
Abstract
Atazanavir/Tenofovir
       
  Coadministration of tenofovir decreased atazanavir plasma concentration after unilateral nephrectomy.
 Kunimoto Y, Yasui H, Touda N,  et al
J Infect Chemother. 2012 Oct 5
 Abstract
Atazanavir/Ritonavir/Methadone
       
  Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports.
 Gallagher DP, Kieran J, Sheehan G, et al
 Clin Infect Dis. 2008 Jun 17.
 Abstract
Atazanavir/Ritonavir/Norethindrone
       
  Increased exposure of norethindrone in HIV+ women treated with ritonavir-boosted atazanavir therapy.
DuBois BN, Atrio J, Stanczyk FZ, Cherala G.
Contraception. 2014 Aug 30.
 Abstract
Atazanavir/Ritonavir/Omeprazole
       
  Effect of Low-Dose Omeprazole (20 mg Daily) on the Pharmacokinetics of Multiple-Dose
Atazanavir With Ritonavir in Healthy Subjects.
 Zhu L, Persson A, Mahnke L, et al
J Clin Pharmacol. 2010 May 10.
 Abstract
Atazanavir/Ritonavir/Quetiapine
       
  Clinically Significant Adverse Events from a Drug Interaction Between Quetiapine and
Atazanavir-Ritonavir in Two Patients
Pollack TM, McCoy C, Stead W.
Pharmacotherapy. 2009 Nov;29(11):1386-1391
 Abstract
Atazanavir/Ritonavir/Minocycline
       
  Effects of Minocycline and Valproic acid Coadministration on Atazanavir Plasma Concentrations in HIV-infected Adults Receiving Atazanavir/Ritonavir.
 Dicenzo R, Peterson DR, Cruttenden K, et al 
Antimicrob Agents Chemother. 2008 Jun 23.
 Abstract
Atazanavir/Ritonavir/Rifampin
       
 
Pharmacokinetic interaction between rifampicin and ritonavir-boosted atazanavir in
HIV-infected patients.
Mallolas J, Sarasa M, Nomdedeu M, et al
HIV Med. 2007 Mar;8(2):131-4.
 Abstract

Effect of rifampin on steady-state pharmacokinetics of atazanavir with ritonavir in healthy
volunteers.
 Burger DM, Agarwala S, Child M, et al 
Antimicrob Agents Chemother. 2006 Oct;50(10):3336-42.
Abstract
Atazanavir/Ritonavir/Rosuvastatin
       
  Effects of Atazanavir/Ritonavir or Fosamprenavir/Ritonavir on the Pharmacokinetics of Rosuvastatin.
 Busti AJ, Bain AM, Hall RG 2nd, et al  
J Cardiovasc Pharmacol. 2008 May 29.
 Abstract
 
Atazanavir/Ritonavir/Tacrolimus
       
  Interactions between Atazanavir-Ritonavir and Tenofovir in Heavily Pretreated Human
Immunodeficiency Virus-Infected Patients.
 Taburet AM, Piketty C, Chazallon C,et al 
Antimicrob Agents Chemother. 2004 Jun;48(6):2091-6.
Abstract
Atazanavir/Ritonavir/Tenofovir
       
  Interactions between Atazanavir-Ritonavir and Tenofovir in Heavily Pretreated Human
Immunodeficiency Virus-Infected Patients.
 Taburet AM, Piketty C, Chazallon C,et al 
Antimicrob Agents Chemother. 2004 Jun;48(6):2091-6.
Abstract
Atazanavir/Ritonavir/Valproic Acid
       
  Effects of Minocycline and Valproic acid Coadministration on Atazanavir Plasma Concentrations in HIV-infected Adults
Receiving Atazanavir/Ritonavir.
 Dicenzo R, Peterson DR, Cruttenden K, et al 
Antimicrob Agents Chemother. 2008 Jun 23.
 Abstract
Atazanavir/Voriconazole
       
  Voriconazole and atazanavir: a CYP2C19-dependent manageable drug-drug interaction.
Calcagno A, Baietto L, Pagani N,  et al
Pharmacogenomics. 2014 Jul;15(10):1281-6.
Abstract
Atazanavir/Sutherlandia frutescens
       
  Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir.
Müller AC, Skinner MF, Kanfer I.
 Evid Based Complement Alternat Med. 2013;2013:324618.
 Abstract
Atazanavir/Acid Reducing Agents
       
  In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents
Kis O, Walmsley SL, Bendayan R.
Pharm Res. 2014 Mar 5.
 Abstract

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Atazanavir Journal Citations
Drug/Drug/Substance Interactions