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Atazanavir (Reyataz)
 
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Last updated:  April 02, 2018
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General Reports
       

 
Cerebrospinal fluid drug concentrations and viral suppression in HIV-1-infected patients receiving ritonavir-boosted atazanavir plus lamivudine dual antiretroviral therapy (Spanish HIV/AIDS Research Network, PreEC/RIS 39).
Imaz A, Niubó J, Amara A, et al 
J Neurovirol
. 2018 Mar 14

Abstract

FULL-TEXT ARTICLE
Prevalence and correlates of persistent intracellular HIV transcription in individuals on efavirenz versus atazanavir-based regimens: A prospective cohort study.
Pilalas D, Skoura L, Margariti A, et al 
PLoS One
. 2018 Mar 13;13(3):e0194262.
Paper

Durability and tolerability of first-line regimens including two nucleoside reverse transcriptase inhibitors and raltegravir or ritonavir boosted-atazanavir or -darunavir: data from the ICONA Cohort.
d'Arminio Monforte A, Lorenzini P,  et al
HIV Clin Trials. 2018 Mar 1:1-9.

Abstract

Impact of Micellar Surfactant on Supersaturation and Insight into Solubilization Mechanisms in Supersaturated Solutions of Atazanavir.
I
ndulkar AS, Mo H, Gao Y, et al
Pharm Res. 2017 Mar 28.
Abstract

FULL-TEXT ARTICLE
Evolution of blood-associated HIV-1 DNA levels after 48 weeks of switching to atazanavir/ritonavir+lamivudine dual therapy versus continuing triple therapy in the randomized AtLaS-M trial.
Lombardi F, Belmonti S, Quiros-Roldan E,  et al  
J Antimicrob Chemother
. 2017 Mar 10.
Paper

FULL-TEXT ARTICLE
Role of systemic inflammation scores for prediction of clinical outcomes in patients treated with atazanavir not boosted by ritonavir in the Italian MASTER cohort.
Postorino MC, Prosperi M, Focŕ E,  et al 
BMC Infect Dis
. 2017 Mar 15;17(1):212.

Paper

Determination of genotoxic impurity in atazanavir sulphate drug substance by LC-MS.
K GB, K BM, N S, D R, N VV, B HB.
J Pharm Biomed Anal. 2017 Jan 5;132:156-158.

Abstract

Changes in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.
Kelesidis T, Moser C, Stein JH,
J Infect Dis. 2016 Sep 1;214(5):748-52

Abstract

FULL-TEXT ARTICLE
Trace Level Determination of Mesityl Oxide and Diacetone Alcohol in Atazanavir Sulfate Drug Substance by a Gas Chromatography Method.

Raju KV, Pavan Kumar KS,  et al
Sci Pharm. 2016 Apr-Jun;84(2):321-31.

Paper

Factors involved in continuance of atazanavir-based regimens: results from a cohort of HIV1-positive patients.
Giacomelli A, Oreni L, Franzetti M,   et al
Antiviral Res
. 2016 Feb 19. pii: S0166-3542(16)30081-X.

Abstract

Persistence, adherence and all-cause healthcare costs in atazanavir- and darunavir-treated patients with human immunodeficiency virus in a real-world setting.
Farr AM, Johnston SS, Ritchings C,  et al

J Med Econ
. 2015 Dec 7:1-35.

Abstract

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.
Gammal RS, Court MH, Haidar CE,  et al  
Clin Pharmacol Ther
. 2015 Sep 29.

Abstract

Brief Report: Cobicistat Compared With Ritonavir as a Pharmacoenhancer for Atazanavir in Combination With Emtricitabine/Tenofovir Disoproxil Fumarate: Week 144 Results.
Gallant JE, Koenig E, Andrade-Villanueva JF, et al  
J
Acquir Immune Defic Syndr
. 2015 Jul 1;69(3):338-340.

Abstract

Advances and challenges in PBPK modeling - Analysis of factors contributing to the oral absorption of atazanavir, a poorly soluble weak base.
Berlin M, Ruff A, Kesisoglou F, et al
Eur J Pharm Biopharm
. 2015 Apr 11

Abstract

The protease inhibitor atazanavir blocks hERG K(+) channels expressed in HEK293 cells and obstructs hERG protein transport to cell membrane.
Han SN, Sun XY, Zhang Z, Zhang LR.
Acta Pharmacol Sin. 2015 Apr;36(4):454-62.
Abstract

Comparison of the Metabolic Effects of Ritonavir boosted Darunavir or Atazanavir versus Raltegravir, and the Impact of Ritonavir Plasma Exposure: ACTG 5257.
Ofotokun I, Na LH, Landovitz RJ,  et al
Clin Infect Dis
. 2015 Mar 12.
Abstract

Anti-HIV drugs, lopinavir/ritonavir and atazanavir, modulate innate immune response triggered by Leishmania in macrophages:
The role of NFκB and PPARγ
Alves ÉA, de Miranda MG, Borges TK, Magalhăes KG, Muniz-Junqueira MI.
Int Immunopharmacol. 2014 Dec 26
Abstract

FULL-TEXT ARTICLE
Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.
Puligujja P, Balkundi SS, Kendrick LM, et al
Biomaterials
. 2015 Feb;41:141-50.
Paper

Factors involved in treatment durability and immunological recovery in a cohort of HIV-positive patients receiving atazanavir-based regimens.
Giacomelli A, Oreni L, Franzetti M, et al
J Int AIDS Soc
. 2014 Nov 2;17(4(Suppl 3)):19830

Abstract

Disappearance of renal stones in a HIV-1-infected patient after reduction of atazanavir dose.
Lanzafame M, Bonora S, Lattuada E, et al
AIDS Res Hum Retroviruses. 2014 Jul 6.

Abstract

Intracellular accumulation of atazanavir/ritonavir according to plasma concentrations and OATP1B1, ABCB1 and PXR genetic polymorphisms.
D'Avolio A, Carcieri C, Cusato J, et al

J Antimicrob Chemother
. 2014 Jul 4

Abstract

Optimized self-nanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: in vitro/in vivo characterization.
Singh G, Pai RS.
Expert Opin Drug Deliv. 2014 Jul;11(7):1023-32
Abstract

Evaluation of Atazanavir and Darunavir Interactions with Lipids for Developing pH-Responsive Anti-HIV Drug Combination Nanoparticles.
Duan J, Freeling JP, Koehn J,  et al  
J Pharm Sci
. 2014 Jun 19.
Abstract

Optimized self-nanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: in vitro/in vivo characterization.
Singh G, Pai RS.
Expert Opin Drug Deliv
. 2014 May 12:1-10

Abstract

Effect of Protein Binding on Unbound Atazanavir and Darunavir Cerebrospinal Fluid Concentrations.
Delille CA, Pruett ST, Marconi VC,  et al
J Clin Pharmacol
. 2014 Apr 1.

Abstract

Evaluation of Boosted and Unboosted Atazanavir Plasma Concentration in HIV Infected Patients.
Amadasi S, Odolini S, Focŕ E, et alCurr
HIV Res. 2014 Feb 7.

Abstract

Role of P-glycoprotein in the distribution of the HIV-protease inhibitor, atazanavir, in the brain and male genital tract.
Robillard KR, Chan GN, Zhang G,
Antimicrob Agents Chemother. 2013 Dec 30.

Abstract

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir.
Dalla-Vechia L, Reichart B, Glasnov T,  et al

Org Biomol Chem
. 2013 Oct 21;11(39):6806-23.
Abstract

FULL-TEXT PDF ARTICLE (MUST BE DOWNLOADED FROM THE SITE)
Atazanavir-bilirubin interaction: a pharmacokinetic-pharmacodynamic model.
Lozano R, Domeque N, Apesteguia AF.

Clin Pharmacol
. 2013 Sep 27;5:153-159.
Paper

Revealing the metabolic sites of atazanavir in human by parallel administrations of D-atazanavir analogs.
Cheng C, Vedananda S, Wu L, et al

J Mass Spectrom
. 2013 Sep;48(9):1019-31.

Abstract

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir.
Dalla-Vechia L, Reichart B, Glasnov T,  et al
Org Biomol Chem. 2013 Sep 18;11(39):6806-13.
Abstract


Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load.
Luz AJ, Poeta J, Linden R,  et al

Braz J Infect Dis
. 2013 Aug 6.

Abstract

Impact of UGT1A1 Gilbert Variant on Discontinuation of Ritonavir-boosted Atazanavir in AIDS Clinical Trials Group
Study A5202.

Ribald HJ, Daar ES, Tierney C,  et al
J Infect Dis. 2012 Nov 12.
Abstract

Economic and Health-related Quality of Life (HRQL) Comparison of Lopinavir/ritonavir (LPV/r) and Atazanavir plus Ritonavir (ATV+RTV) based Regimens for Antiretroviral Therapy (ART)-Naďve and -Experienced United Kingdom (UK) Patients in 2011.
Simpson K, Baran R, Collomb D,  et al

J Med Econ
. 2012 May 7.
Abstract

Ritonavir boosting dose reduction from 100 to 50 mg does not change the atazanavir steady-state exposure in healthy volunteers.
Estévez JA, Moltó J, Tuneu L,  et al

J Antimicrob Chemother
. 2012 May 7.
Abstract

In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials.
Xia X, Zhou C, Ballell L, Garcia-Bennett AE.
ChemMedChem. 2011 Dec 5.
Abstract

Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naďve HIV-1 infected patients.
Röshammar D, Simonsson US, Ekvall H, et al
J Pharmacokinet Pharmacodyn
. 2011 Oct 2.
Abstract

Randomized comparison of metabolic and renal effects of saquinavir/r or atazanavir/r plus tenofovir/emtricitabine in treatment-naďve HIV-1-infected patients.
Vrouenraets S, Wit F, Fernandez Garcia E, et al
HIV Med
. 2011 Aug 7.
Abstract

Atazanavir concentration in hair is the strongest predictor of outcomes on
antiretroviral therapy.
Gandhi M, Ameli N, Bacchetti P, et al
Clin Infect Dis
. 2011 May;52(10):1267-75.
Abstract

HIV-Infected Adolescents: Relationship Between Atazanavir Plasma Levels and Bilirubin Concentrations.
Nso AP, Larru B, Bellón JM,  et al
J Adolesc Health. 2011 Jan;48(1):100-2'

Abstract
 

Atazanavir metabolism according to CYP3A5 status: An in vitro - in vivo assessment.
Wempe MF, Anderson PL.
Drug Metab Dispos. 2010 Dec 9.
Abstract

Comparison of the influence of four classes of HIV antiretrovirals on adipogenic differentiation: the minimal effect of raltegravir and atazanavir.
Minami R, Yamamoto M, Takahama S,  et al  
J Infect Chemother
. 2010 Aug 13.
Abstract

Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-
overexpressing cell lines.
Bierman WF, Scheffer GL, Schoonderwoerd A,  et al
J Antimicrob Chemother
. 2010 Jun 15
Abstract

Differential Effects of Efavirenz, Lopinavir/r, and Atazanavir/r on the Initial Viral Decay Rate in Treatment Naďve HIV-1-Infected Patients.
Edén A, Andersson LM, Andersson O, et al
AIDS Res Hum Retroviruses
. 2010 May 10.
Abstract

The relation between treatment outcome and efavirenz, atazanavir or lopinavir exposure in the NORTHIV trial of treatment-naďve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al 
Eur J Clin Pharmacol
.
2010 Apr;66(4):349-57
Abstract


Effect of ritonavir and atazanavir on human subcutaneous preadipocyte proliferation and differentiation.
Caso G, Mileva I, McNurlan MA, et al
Antiviral Res
. 2010 Feb 10
Abstract

Factors influencing lopinavir and atazanavir plasma concentration.
Stöhr W, Back D, Dunn D, et al
J Antimicrob Chemother
. 2009 Nov 6.
Abstract

Trends in uptake of recently approved antiretrovirals within a national healthcare system.
Belperio P, Mole L, Boothroyd D, Backus L.
HIV Med
. 2009 Oct 23.
Abstract

Changes in Body Composition with Ritonavir-Boosted and Unboosted Atazanavir Treatment in Combination with Lamivudine and Stavudine: A 96-Week Randomized, Controlled Study.
McComsey G, Rightmire A, Wirtz V, et a,
Clin Infect Dis
. 2009 Mar 20.
Abstract
 

Low atazanavir concentrations in cerebrospinal fluid.
Best BM, Letendre SL, Brigid E, et al
AIDS
. 2009 Jan 2;23(1):83-87.
Abstract
 
The effect of atazanavir and atazanavir/ritonavir on UDP-glucuronosyltransferase using lamotrigine as a phenotypic probe.
Burger DM, Huisman A, Van Ewijk N, et al  
Clin Pharmacol Ther
. 2008 Dec;84(6):698-703.
Abstract
 
Atazanavir: its role in HIV treatment.
Wood R.  
Expert Rev Anti Infect Ther
. 2008 Dec;6(6):785-96.
Abstract
 
Comparison of ABC Transporter Modulation by Atazanavir in Lymphocytes and Human Brain Endothelial Cells: ABC Transporters Are Involved in the Atazanavir-Limited Passage across an in Vitro Human Model of the
Blood-Brain Barrier.
Bousquet L, Roucairol C, Hembury A, et al 

AIDS Res Hum Retroviruses.
2008 Aug 26.
Abstract
 
No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial.
Dubé MP, Shen C, Greenwald M, Mather KJ.
Clin Infect Dis.
2008 Aug 15;47(4):567-74.
Abstract
 
Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes.
Jones SP, Waitt C, Sutton R, Back DJ, Pirmohamed M.
AIDS.
2008 Jul 11;22(11):1293-8.
Abstract
 
The Effect of Atazanavir and Atazanavir/Ritonavir on UDP-Glucuronosyltransferase Using Lamotrigine as a Phenotypic Probe.
Burger D, Huisman A, Van Ewijk N, et al 
Clin Pharmacol Ther.
2008 Jun 4.
Abstract
 
Cardiovascular risk score change in HIV-1-infected patients switched to an atazanavir-based combination antiretroviral regimen.
Colafigli M, Di Giambenedetto S, Bracciale L 
HIV Med. 2008 Jan 21
Abstract
 
The Genotypic Inhibitory Quotient: A Predictive Factor of Atazanavir Response in HIV-1-Infected Treatment-Experienced Patients.
Solas C, Colson P, Ravaux I, et al
J Acquir Immune Defic Syndr. 2008 Jan 11
Abstract
 
Evolution of the HIV-1 protease region in heavily pretreated HIV-1 infected patients receiving Atazanavir.
Vergani B, Cicero ML, Vigano' O, et al
J Clin Virol
. 2007 Nov 13;
Abstract
 
HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress.
Pyrko P, Kardosh A, Wang W, et al 
Cancer Res.
2007 Nov 15;67(22):10920-10928

Abstract
 
Atazanavir: simplicity and convenience in different scenarios.
Perez-Elias MJ.
Expert Opin Pharmacother.
2007 Apr;8(5):689-700.
Abstract
 
FULL TEXT PDF ARTICLE
Pharmaceutical Approach to HIV Protease Inhibitor Atazanavir for Bioavailability Enhancement Based on Solid Dispersion System.
Fukushima K, Terasaka S, Haraya K, et al
Biol Pharm Bull.
2007 Apr;30(4):733-8.
Paper
 
Penetration of atazanavir in seminal plasma of men infected with HIV-1.
van Leeuwen E, Ter Heine R, van der Veen F, et al 
Antimicrob Agents Chemother. 2006 Oct 30;
Abstract
 
A prospective evaluation of the effect of atazanavir on the QTc interval and QTc dispersion in HIV-positive patients.
Busti AJ, Tsikouris JP, Peeters MJ, et al 
HIV Med. 2006 Jul;7(5):317-22.
Abstract|
 
Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity: demonstrable  differences in vitro and clinically.
Noor MA, Flint OP, Maa JF, Parker RA.  
AIDS
. 2006 Sep 11;20(14):1813-21.
Abstract
 
Review of atazanavir: a novel HIV protease inhibitor.
Fuster D, Clotet B.
Expert Opin Pharmacother.
2005 Aug;6(9):1565-72.
Abstract
 
Atazanavir for the treatment of human immunodeficiency virus infection.
Busti AJ, Hall RG, Margolis DM.
Pharmacotherapy. 2004 Dec;24(12):1732-47.

Abstract
 
Atazanavir
Orrick JJ, Steinhart CR.
Ann Pharmacother. 2004 Sep 7
Abstract

Atazanavir: New Option for Treatment of HIV Infection.
Havlir DV, O'Marro SD.
Clin Infect Dis
. 2004 Jun 1;38(11):1599-604
Abstract


In Vitro Studies
       

 

Atazanavir: Effects on P-gp transport and CYP3A metabolism in vitro.
Perloff ES, Duan SX, Skolnik PR, et al 
Drug Metab Dispos. 2005 Mar 11;

Abstract


Animal Studies
       

  Effects of Obesity Induced by High-Fat Diet on the Pharmacokinetics of Atazanavir in Rats.
Kobuchi S, Fukushima K, Aoyama H,  et al

Drug Metab
Lett
. 2013 Oct 20.

Abstract

Dosage Studies
       

 
Less-drug regimen including atazanavir in maintenance treatment of HIV infection: how, who, when, why?
Calvez V, Hocqueloux L, Meynard JL
J Antimicrob Chemother
. 2016 Sep 21.
Abstract

Mid-dosing interval concentration of atazanavir and virological outcome in patients treated for HIV-1 infection.
Fabbiani M, Di Giambenedetto S, Ragazzoni E, et al
HIV Med
. 2010 Jan 11.
Abstract

Dose-ranging, randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results.
Murphy RL, Sanne I, Cahn P, et al
AIDS
. 2003 Dec 5;17(18):2603-14.
Abstract


Pharmacokinetics
       

 
Potential associations between atazanavir exposure and clinical outcome: a pharmacokinetic sub-study from the MODAt randomized trial.
Colella E, Cattaneo D, Galli L, et al
New Microbiol. 2018 Mar 2;41(1). [
Abstract

Inflammation investigated as a source of pharmacokinetic variability of atazanavir in AIDS Clinical Trials Group protocol A5224s.
Venuto CS, Lim J, Messing S, et al

Antivir Ther
. 2017 Nov 24.
Abstract

The impact of gastrectomy on the pharmacokinetics of atazanavir and tenofovir.
Gervasoni C, Cattaneo D, Resnati C, et al
Eur J Clin Pharmacol. 2017 Mar 6.
Abstract

Population pharmacokinetics and dose optimisation of ritonavir-boosted atazanavir in thai HIV-infected patients.
Punyawudho B, Thammajaruk N, Ruxrungtham K, Avihingsanon A.
Int J Antimicrob Agents. 2017 Jan 18.
Abstract

Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV-Infected Subjects With Aging Biomarker
Dumond JB, Chen J, Cottrell M, et al
CPT Pharmacometrics Syst Pharmacol. 2016 Dec 29.
Abstract

Pharmacokinetics of Unboosted Atazanavir in Treatment-Experienced HIV-infected Children, Adolescents and Young Adults.
Cressey TR, Hazra R, Wiznia A
, P
Pediatr Infect Dis J
. 2016 Aug 31.

Abstract

Comparison of population pharmacokinetics based on steady-state assumption versus electronically monitored adherence to lopinavir, atazanavir, efavirenz, and etravirine: A retrospective study.
Aline F, Aurélie R, Matthias C, et al
Ther Drug Monit. 2016 Mar 1.
Abstract 

Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy.
Neely M, Louie S, Xu J,  et al
J
 Clin Pharmacol
. 2015 Feb 12
Abstract 

Sex differences in atazanavir pharmacokinetics and associations with time to clinical events: AIDS Clinical Trials Group Study A5202.
Venuto CS, Mollan K, Ma Q,  et al

J Antimicrob Chemother
. 2014 Aug 25.
Abstract 

Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202.
Johnson DH, Venuto C, Ritchie MD,  
Pharmacogenet Genomics
. 2014 Feb 19.
Abstract 

Aging Not Gender Is Associated with High Atazanavir Plasma Concentrations in Asian HIV-Infected Patients.
Avihingsanon A, Kerr SJ, Punyawudho B, et al

AIDS Res Hum Retroviruses
. 2013 Oct 2
Abstract

Pharmacokinetics and Pharmacodynamics of Atazanavir-containing Antiretroviral Regimens, with or without Ritonavir, in Patients who are HIV-positive and Treatment-naďve.
Bertz RJ, Persson A, Chung E,  et al
Pharmacotherapy
. 2013 Mar;33(3):284-94
Abstract

Pharmacokinetic Modelling of Efavirenz, Atazanavir, Lamivudine and Tenofovir in the Female Genital Tract of HIV-Infected Pre-Menopausal Women.
Dumond JB, Nicol MR, Kendrick RN, et al
Clin Pharmacokinet
. 2012 Oct 9
Abstract

Effects of hepatitis C virus infection on the pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected patients.
Di Biagio A, Rosso R, Loregian A,  et al

J Infect Chemother
. 2012 Mar 16
Abstract

A population pharmacokinetic-pharmacogenetic analysis of atazanavir.
Kile DA, Mawhinney S, Aquilante C,  et al

AIDS Res Hum Retroviruse
s
. 2012 Mar 6
Abstract

Pharmacokinetics of switching unboosted atazanavir coadministered with tenofovir disoproxil fumarate from 400 mg once daily to 200 mg twice daily in HIV-positive patients.
Bonora S, Gonzalez de Requena D, D'Avolio A,  et al
Antivir Ther
. 2011;16(4):499-504.
Abstract

Population pharmacokinetics of atazanavir/r in HIV-1 infected children and adolescents.
Foissac F, Blanche S, Dollfus C, et al  
Br J Clin Pharmacol
. 2011 Jun 8.
Abstract

Atazanavir and Atazanavir/Ritonavir Pharmacokinetics in HIV-Infected Infants, Children, and Adolescents.
Kiser JJ, Rutstein RM, Samson P, et al
AIDS
. 2011 May 21.
Abstract

Atypical pharmacokinetics of atazanavir in an HIV-1-infected patient.
Cattaneo D, Meraviglia P, Cozzi V,  et al
Fundam Clin Pharmacol
. 2011 Jan 7.
Abstract

Pharmacokinetics and safety of twice-daily atazanavir 300 mg and raltegravir 400 mg in healthy individuals.
Zhu L, Butterton J, Persson A, Stonier M,  et al
Antivir Ther
. 2010;15(8):1107-14
Abstract

Population Pharmacokinetic modelling of the association between 63396C->T Pregnane-X-Receptor (PXR) polymorphism and unboosted atazanavir clearance.
Schipani A, Siccardi M, D'Avoli, et al
Antimicrob Agents Chemother
.
2010 Oct 4.
Abstract

Pharmacokinetics and Pharmacogenomics of Once Daily Raltegravir and Atazanavir in Healthy Volunteers.
Neely M, Decosterd L, Fayet A, et al
Antimicrob Agents Chemother
. 2010 Sep
Abstract

Pharmacokinetics, protein-binding-adjusted inhibitory quotients for atazanavir/ritonavir 300/100 mg in treatment-naďve HIV-infected patients.
Lambert-Niclot S, Machouf N, Peytavin G, et al
HIV Med
. 2010 May 20.
Abstract

Influence of alpha-1 glycoprotein acid concentrations and variants on atazanavir pharmacokinetics in HIV-infected patients included in the ANRS 107 trial.
Barrail-Tran A, Mentré F, Cosson C, et al
Antimicrob Agents Chemother. 2010 Feb;54(2):614-9.
Abstract

Atazanavir pharmacokinetics in genetically determined CYP3A5 expressors versus non-expressors.
Anderson PL, Aquilante CL, Gardner EM, et al 
J Antimicrob Chemother. 2009 Aug
Abstract

FULL-TEXT PDF ARTICLE
Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers.
Dickinson L, Boffito M, Back D, et al
J Antimicrob Chemother
. 2009 Jun;63(6):1233-43.
Paper
 

A Low Dose of Ritonavir-Boosted Atazanavir Provides Adequate Pharmacokinetic Parameters in HIV-1-Infected Thai Adults.
Avihingsanon A, van der Lugt J, Kerr S, et al 
Clin Pharmacol Ther. 2008 Dec 31

Abstract
 
Pharmacokinetics of atazanavir/ritonavir once daily and lopinavir/ritonavir twice and once daily over 72 h following drug cessation.
Boffito M, Else L, Back D,

Antivir Ther
. 2008;13(7):901-7.
Abstract
 
Population Pharmacokinetics of Atazanavir in Human Immunodeficiency Virus-Infected Patients.
Solas C, Gagnieu MC, Ravaux I, Drogoul MP, et al 
Ther Drug Monit.
2008 Sep 16
.
Abstract
 
The steady-state pharmacokinetics of atazanavir/ritonavir in HIV-1-infected adult outpatients is not affected by gender-related co-factors.
von Hentig N, Babacan E, Lennemann T, et al
J Antimicrob Chemother. 2008 May 13
Abstract
 
Effects of Acid-reducing agents on the pharmacokinetics of lopinavir/ritonavir and ritonavir-boosted atazanavir.
Klein CE, Chiu YL, Cai Y, et al
Clin Pharmacol. 2008 May;48(5):553-62.
Abstract
 
Factors associated with altered pharmacokinetics in substance users and non-substance users receiving lopinavir and atazanavir.
Higgins N, Zingman BS, Slish J, et al
Am J Addict.
2007 Nov-Dec;16(6):488-94
.
Abstract
 

Pharmacokinetics of Antiretroviral Regimens Containing Tenofovir Disoproxil Fumarate and Atazanavir/Ritonavir in Adolescents and Young Adults with HIV Infection - Study ATN056.
Kiser JJ, Fletcher CV, Flynn PM, et al 
Antimicrob Agents Chemothe
r. 2007 Nov 19;
Abstract
 
Beneficial Pharmacokinetic Interaction Between Atazanavir and Lopinavir/Ritonavir.
Pham PA, Flexner CW, Parsons T, et al 
J Acquir Immune Defic Syndr.
2007 Mar 29;
Abstract

Population pharmacokinetics of atazanavir in patients with human immunodeficiency
virus infection.
Colombo S, Buclin T, Cavassini M, et al 
Antimicrob Agents Chemother.
2006 Aug 28;
Abstract
 
Virological responses to atazanavir-ritonavir-based regimens: resistance-substitutions score and pharmacokinetic parameters (Reyaphar study).
Pellegrin I, Breilh D, Ragnaud JM, et al  
Antivir The
r. 2006;11(4):421-9
Abstract
 
Influence of tenofovir, nevirapine and efavirenz on ritonavir-boosted atazanavir pharmacokineticsin HIV-infected patients.
Dailly E, Tribut O, Tattevin P, et  al
Eur J Clin Pharmacol.
2006 Jun 9;
Abstract
 
Steady-state pharmacokinetics of atazanavir given alone or in combination with saquinavir hard-gel capsules or amprenavir in HIV-1-infected patients.
Seminari E, Guffanti M, Villani P, et al 
Eur J Clin Pharmacol. 2005 Jul 23;
Abstract
 
Atazanavir trough plasma concentration monitoring in a cohort of HIV-1-positive individuals receiving highly active antiretroviral therapy.
Winston A, Bloch M, Carr A,  et al  
J Antimicrob Chemother.
2005 Jul 4
Abstract

The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults.
Noor MA, Parker RA, O'mara E, et al 
AIDS.
2004 Nov 5;18(16):2137-2144.

Abstract


Resistance
       

 
Characterization of associations and development of atazanavir resistance after unplanned treatment interruptions.
Tinago W, O'Halloran J, O'Halloran R, et al

HIV Med
. 2014 Apr;15(4):224-32.

Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study.
Dolling DI, Dunn DT, Sutherland KA,  et al
J Antimicrob Chemother
. 2013 May 27.
Abstract

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.
Cavaco-Silva J, Aleixo MJ, Van Laethem K, et al
J Antimicrob Chemother. 2012 Sep 13
Abstract

Two Different Patterns of Mutations are Involved in the Genotypic Resistance Score for Atazanavir Boosted Versus Unboosted by Ritonavir in Multiple Failing Patients.
Santoro MM, Bertoli A, Lorenzini P, et al 
Infection. 2009 Jan 23.
Abstract
 

The HIV-1 protease resistance mutation I50L is associated with resistance to atazanavir and susceptibility to other protease inhibitorsin multiple mutational contexts.
Sista P, Wasikowski B, Lecocq P, et al 
J Clin Virol.
2008 May 9
Abstract
 
The Genotypic Inhibitory Quotient: A Predictive Factor of Atazanavir Response in HIV-1-Infected Treatment-Experienced Patients.
Solas C, Colson P, Ravaux I, et al
J Acquir Immune Defic Syndr. 2008 Jan 11
Abstract
 
Virological failure and subsequent resistance profiles in individuals exposed to atazanavir.
Stebbing J, Nathan B, Jones R, et al  
AIDS.
2007 Aug 20;21(13):1826-8.
Abstract
 
Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV.
Ma Q, Brazeau D, Zingman BS, et al  
Pharmacogenomics.
2007 Mar;8(3):227-235.
Abstract
 
Virological responses to atazanavir-ritonavir-based regimens: resistance-substitutions score and pharmacokinetic parameters (Reyaphar study).
Pellegrin I, Breilh D, Ragnaud JM, et al  
Antivir The
r. 2006;11(4):421-9
Abstract
 
Clinical validation of atazanavir/ritonavir genotypic resistance score in protease inhibitor-experienced patients.
Vora S, Marcelin AG, Gunthard HF, Flandre P, et al  
AIDS.
2006 Jan 2;20(1):35-40
Abstract
 
Atazanavir Signature I50L Resistance Substitution Accounts for Unique Phenotype of Increased Susceptibility to Other Protease Inhibitors in a Variety of Human
Immunodeficiency Virus Type 1 Genetic Backbones.

Weinheimer S, Discotto L, Friborg J, et al
Antimicrob Agents Chemother.
2005 Sep;49(9):3816-24.
Abstract

Identification of I50L as the Signature Atazanavir (ATV)-Resistance Mutation in Treatment-Naive HIV-1-Infected Patients Receiving ATV-Containing Regimens.
C
olonno R, Rose R, McLaren C, et al 
J Infect Dis.
2004 May 15;189(10):1802-10.
Abstract


Cross Resistance
       

Protease Inhibitors
 
 
Molecular Basis for Increased Susceptibility of Isolates with Atazanavir Resistance-Conferring Substitution I50L to Other Protease Inhibitors.
Yanchunas J Jr, Langley DR, et al   
Antimicrob Agents Chemother.
2005 Sep;49(9):3825-32.

Abstract

Viral Dynamics
       

 
Defining a cut-off for atazanavir in hair samples associated with virological failure among adolescents failing second-line antiretroviral treatment
Chawana TD, Gandhi M, Nathoo K, et al  
J Acquir Immune Defic Syndr. 2017 May 17.
Abstract

FULL-TeXT ARTICLE
Baseline Natural Killer and T Cell Populations Correlation with Virologic Outcome after Regimen Simplification to Atazanavir/Ritonavir Alone (ACTG 5201).
McKinnon JE, Mailliard RB, Swindells S, et al

PLoS One
. 2014 May 6;9(5):
Paper

HIV-1 Amino Acid Changes Among Participants With Virologic Failure: Associations With First-line Efavirenz or Atazanavir Plus Ritonavir and Disease Status.
Mollan K, Daar ES, Sax PE,  et al  
J Infect Dis
. 2012 Nov 12.
Abstract

A Nucleoside- and Ritonavir-Sparing Regimen Containing Atazanavir Plus Raltegravir in Antiretroviral Treatment-Naďve HIV-Infected Patients: SPARTAN Study Results.
Kozal MJ, Lupo S, Dejesus E, Molina JM,  et al
HIV Clin Trials
. 2012 May-Jun;13(3):119-30
Abstract

Differential Effects of Efavirenz, Lopinavir/r, and Atazanavir/r on the Initial Viral Decay Rate in Treatment Naďve HIV-1-Infected Patients.
Edén A, Andersson LM, Andersson O, et al A
IDS Res Hum Retroviruses
. 2010 May 10.
Abstract

Mid-dosing interval concentration of atazanavir and virological outcome
in patients treated for HIV-1 infection.
Fabbiani M, Di Giambenedetto S, Ragazzoni E, et al
HIV Med
. 2010 Jan 11.
Abstract

Time to virological failure with atazanavir/ritonavir and lopinavir/ritonavir, with or without an H2-receptor blocker, not significantly different in HIV observational database study.
Keiser PH, Nassar N.
Int J STD AIDS. 2008 Aug;19(8):561-2
Abstract
 

Virological failure and subsequent resistance profiles in individuals exposed to atazanavir.
Stebbing J, Nathan B, Jones R, et al  
AIDS.
2007 Aug 20;21(13):1826-8.
Abstract
 
Virological responses to atazanavir-ritonavir-based regimens: resistance-substitutions score and pharmacokinetic parameters (Reyaphar study).
Pellegrin I, Breilh D, Ragnaud JM, et al  
Antivir The
r. 2006;11(4):421-9
Abstract

Effect of baseline protease genotype and phenotype on HIV response to atazanavir/ritonavir in treatment-experienced patients.
Naeger LK, Struble KA.
AIDS
. 2006 Apr 4;20(6):847-53
Abstract


Drug Comparison Studies
       

Miscellaneous Combinations
 
  Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study.
Orrell C, Hagins DP, Belonosova E, et al
Lancet HIV. 2017 Jul 17.
Abstract

Brief Report: Cobicistat Compared With Ritonavir as a Pharmacoenhancer for Atazanavir in Combination With Emtricitabine/Tenofovir Disoproxil Fumarate: Week 144 Results.
Gallant JE, Koenig E, Andrade-Villanueva JF, et al
 J
Acquir Immune Defic Syndr
. 2015 Jul 1;69(3):338-340.
Abstract

Dual treatment with atazanavir-ritonavir plus lamivudine versus triple treatment with atazanavir-ritonavir plus two nucleos(t)ides in virologically stable patients with HIV-1 (SALT): 48 week results from a randomised, open-label, non-inferiority trial.
Perez-Molina JA, Rubio R, Rivero A,  et al
Lancet Infect Dis. 2015 Jun 5
Abstract

Atazanavir vs Darunavir

 
  FULL-TEXT ARTICLE
Comparison of atazanavir/ritonavir and darunavir/ritonavir based antiretroviral therapy for antiretroviral naďve patients
Antoniou T, Szadkowski L, Walmsley S,  et al  
BMC Infect Dis. 2017 Apr 11;17(1):266.
Paper

Early lipid changes with atazanavir/ritonavir or darunavir/ritonavir.
Martinez E, Gonzalez-Cordon A, Ferrer E, Domingo P,  et al
HIV Med
. 2014 Jan 12.
Abstract

Atazanavir vs Efavirenz
 

  Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: A prospective study of HIV-positive individuals.
Cain LE, Caniglia EC, Phillips A,  et al 
Medicine (Baltimore)
. 2016 Oct;95(41):e5133.
Abstract

Relationship between plasma bilirubin level and oxidative stress markers in HIV-infected patients on atazanavir- vs. efavirenz-based antiretroviral therapy.
Estrada V, Monge S, Gómez-Garre MD,  et al

HIV Med
. 2016 Mar 3.
Abstract

Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing ritonavir-boosted atazanavir to efavirenz with fixed-dose abacavir and Lamivudine.
Honda M, Ishisaka M, Ishizuka N,  et al
Intern Med. 2011;50(7):699-705.
Abstract

Comparison of Once-Daily Atazanavir With Efavirenz, Each in Combination With Fixed-Dose Zidovudine and Lamivudine, As Initial Therapy for Patients Infected With HIV.
Squires K, Lazzarin A, Gatell JM 
J Acquir Immune Defic Syndr. 2004 Aug 15;36(5):1011-1019
Abstract
 

Atazanavir vs Fosamprenavir
 
  FULL TEXT PDF ARTICLE
Fosamprenavir or atazanavir once daily boosted with ritonavir 100mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT
Smith KY, Weinberg WG, Dejesus E, et aL
AIDS Res Ther. 2008 Mar 28;5(1):5
Paper

 
Atazanavir vs Indinavir
 
  FULL-TeXT ARTICLE
Indinavir and atazanavir; comparison of predicted property by chemoinformatics technique and implication on renal problem in HIV infected patients.
Joob B, Wiwanitkit V.
J Nephropharmacol
. 2016 Jan 21;6(1):21-22.

Paper

Atazanavir vs Lopinavir/Ritonavir
 

 
Boosted lopinavir vs. boosted atazanavir-containing regimens and immunologic, virologic and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries.
Cain LE, Hernán MA; The HIV-CAUSAL Collaboration.

Clin Infect Dis
. 2015 Jan 6. pii: ciu1167
Abstract

Comparison of Body Composition Changes Between Atazanavir/Ritonavir and Lopinavir/Ritonavir Each in Combination with Tenofovir/Emtricitabine in Antiretroviral-Naďve Patients with HIV-1 Infection.
Moyle GJ, Hardy H, Farajallah A, et al
Clin Drug Investig
. 2014 Apr;34(4):287-96.
Abstract

Economic and Health-related Quality of Life (HRQL) Comparison of Lopinavir/ritonavir (LPV/r) and Atazanavir plus Ritonavir (ATV+RTV) based Regimens for Antiretroviral Therapy (ART)-Naďve and -
Experienced United Kingdom (UK) Patients in 2011.
Simpson K, Baran R, Collomb D,  et al 
J Med Econ
. 2012 May 7.
Abstract

Pharmacokinetics and inhibitory quotient of atazanavir/ritonavir versus lopinavir/ritonavir in HIV-infected, treatment-naive patients who participated in the CASTLE Study.
Zhu L, Liao S, Child M, Zhang J,  et al

J Antimicrob Chemother
. 2011 Nov 25.
Abstract

Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic interaction and predictors of drug exposure.
Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.
Abstract
 

96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures.
Johnson M, Grinsztejn B, Rodriguez C, et al 
AIDS. 2006 Mar 21;20(5):711-718.
Abstract
 
Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial.
Cohen C, Nieto-Cisneros L, Zala C, et al   
Curr Med Res Opin. 2005 Oct;21(10):1683-92.
Abstract
 
Atazanavir/RTV vs Nevirapine
 
  Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviral-naive HIV-1 patients: the ARTEN Trial.
Soriano V, Arastéh K, Migrone H,  et al
Antivir Ther
. 2011;16(3):339-48.
Abstract

Atazanavir/RTV/Emtricitabine/Tenofovir vs Elvitegravir/Cobicistat/Emtricitabine/Tenofovir
 

  A randomized, double-blind comparison of single tablet regimen elvitegravir/cobicistat/emtricitabine/tenofovir DF versus ritonavir-boosted atazanavir plus emtricitabine/tenofovir DF
for initial treatment of HIV-1 infection: analysis of week 144 results.
Clumeck N, Molina JM, Henry K. et al
J Acquir Immune Defic Syndr. 2013 Dec 16.
Abstract

Diagnostics/Monitoring
       

 
Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Phung N, Kuncze K, Okochi H, et al

Rapid Commun Mass Spectrom
. 2018 Jan 9.
Abstract

Is the unbound concentration of Atazanavir of interest in Therapeutic Drug Monitoring?
Metsu D, Seraissol P, Delobel P, et al
Fundam Clin Pharmacol. 2016 Sep 24.

Abstract

Cerebrospinal fluid analysis for HIV replication and biomarkers of immune activation and neurodegeneration in long-term atazanavir/ritonavir monotherapy treated patients.
Ferretti F, Bigoloni A, Passeri L, et al
Medicine
(Baltimore)
. 2016 Jul;95(28):e4144.
Abstract

Quantitative determination of free/bound atazanavir via high-throughput equilibrium dialysis and LC-MS/MS, and the application in ex vivo samples.
Xu XS, Rose A, Demers R, et al 

Bioanalysis
. 2014 Dec;6(23):3169-82.
Abstract

Quantification of cell-associated atazanavir, darunavir, lopinavir, ritonavir, and efavirenz concentrations in human mononuclear cell extracts.
Podany AT, Winchester LC, Robbins BL, Fletcher CV.

Antimicrob Agents Chemother
. 2014 May;58(5):2866-70
Abstract

Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS.
Mishra T, Shrivastav PS.
ScientificWorldJournal. 2014 Jan 23;2014:482693.
Abstract

Atazanavir-Induced Urine Crystals Demonstrated by Infrared Spectroscopic Analysis.
Inagaki I, Adachi M, Ito H, et al
Urol Int. 2013 Dec 5
Abstract

External Validation of the Bilirubin-Atazanavir Nomogram for Assessment of Atazanavir Plasma Exposure in HIV-1-Infected Patients.
Rekić D, Röshammar D, Bergstrand M, et al
AAPS J. 2012 Dec 7.
Abstract

Comparison of extraction procedures for assessment of matrix effect for selective and reliable determination of atazanavir in human plasma by LC-ESI-MS/MS.
Yadav M, Trivedi V, Upadhyay V,
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Jan 9.
Abstract

Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients.
Cattaneo D, Ripamonti D, Baldelli

Fundam Clin Pharmacol
. 2011 Nov 2. .
Abstract

UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues.
Huang J, Gautam N, Bathena SP 
JChromatogr B Analyt Technol Biomed Life Sci
. 2011 Jul 1
Abstract

Therapeutic Monitoring and Variability of Atazanavir in HIV-Infected Patients, With and Without HCV Coinfection, Receiving Boosted or Unboosted Regimens.
Regazzi M, Villani P, Gulminetti R, et al
Ther Drug Monit
.
2011 May 4.
Abstract

Use of serum bilirubin levels as surrogate marker of early virological response to atazanavir-based
antiretroviral therapy.
Morello J, Alvarez E, Cuenca L, et al
AIDS Res Hum Retroviruses
. 2011 Feb 25.
Abstract

Clinical Evaluation of a Dried Blood Spot Assay for Atazanavir
Van Schooneveld T, Swindells S, Nelson SR, et al
Antimicrob Agents Chemother
. 2010 Jul 26.
Abstract

The relation between treatment outcome and efavirenz, atazanavir or lopinavir exposure in the NORTHIV trial of treatment-naďve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al
Eur J Clin Pharmacol
. 2009 Dec 5.
Abstract

Baseline lipid levels rather than the presence of reported body shape changes determine the degree of improvement in lipid levels after switching to atazanavir.
van Vonderen, Gras, Wit, Brinkman, et al
HIV Clin Trials
. 2009 May-Jun;10(3):168-80.

Abstract
 

HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients.
D'Avolio A, Siccardi M, Sciandra M, et al
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 7;
Abstract
 
Monitoring Atazanavir Concentrations With Boosted or Unboosted Regimens in HIV-Infected Patients in Routine Clinical Practice.
Moltó J, Santos JR, Valle M, et al  
Ther Drug Monit.
2007 Oct;29(5):648-651.
Abstract
 
Assessing the Impact of Substance use and Hepatitis Coinfection on Atazanavir and Lopinavir Trough Concentrations in HIV-Infected Patients During Therapeutic Drug Monitoring.
Slish J, Ma Q, Zingman BS, et al 
Ther Drug Monit.
2007 Oct;29(5):560-565.
Abstract
 
Therapeutic drug monitoring of the HIV protease inhibitor atazanavir in clinical practice.
Cleijsen RM, van de Ende ME, Kroon FP, et al
J Antimicrob Chemother. 2007 Aug 17;
Abstract
 
Integration of Atazanavir into an Existing Liquid Chromatography UV Method for Protease Inhibitors: Validation and Application.
Keil K, Hochreitter J, Difrancesco R, et al
Ther Drug Monit.
2007 Feb;29(1):103-109.
Abstract
 
A quantitative immunoassay for plasma and intracellular atazanavir: studies of drug
accumulation in cultured T-cells.
Roucairol C, Azoulay S, Nevers MC, et al 
Antimicrob Agents Chemother
. 2006 Nov 20;
Abstract
 
Full Validation of an Analytical Method for the HIV-Protease Inhibitor Atazanavir in Combination With 8 Other Antiretroviral Agents and its Applicability to Therapeutic Drug Monitoring.
Rezk NL, Crutchley RD, Yeh RF, Kashuba AD.
Ther Drug Monit. 2006 Aug;28(4):517-25.
Abstract
 
Simple determination of the HIV protease inhibitor atazanavir in human plasma by high-performance liquid chromatography with UV detection.
Loregian A, Pagni S, Ballarin E, et al
J Pharm Biomed Anal. 2006 Jun 7;

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma.
Sparidans RW, Dost F, Crommentuyn KM, et al  
Biomed Chromatogr.
2005 Jun 14;
Abstract
 
Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction.
Colombo S, Guignard N, Marzolini C, et al  
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Oct 15;810(1):25-34.
Abstract
 
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray
ionization tandem mass spectrometry.

Crommentuyn KM, Rosing H, Hillebrand MJ, et al
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 May 25;804(2):359-67
Abstract
 
Liquid chromatography-tandem mass spectrometric quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human peripheral blood mononuclear cells
(PBMC): practical approaches to PBMC preparation and PBMC assay design for high-
throughput analysis.
Jemal M, Rao S, Gatz M, Whigan D. 
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct 5;795(2):273-89
Abstract
 
Quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human plasma by liquid chromatography-tandem mass spectrometry following automated solid-phase
extraction.

Schuster A, Burzawa S, Jemal M, et al.

C
hromatogr B Analyt Technol Biomed Life Sci 2003 May25;788(2):377-86
Abstract
 

Adverse Events
       

 
Long-term oral atazanavir attenuates myocardial infarction-induced cardiac fibrosis.
Zhang G, Zhang X, Li D, Tian J, Jiang W.

Eur J Pharmacol
. 2018 Mar 29
Abstract

Inflammation investigated as a source of pharmacokinetic variability of atazanavir in AIDS Clinical Trials Group protocol A5224s.
Venuto CS, Lim J, Messing S,  et al

Antivir Ther
. 2017 Nov 24.
Abstract

Ureteral Obstruction Due to Radiolucent Atazanavir Ureteral Stones.
Grant MT, Eisner BH, Bechis SK.

J Endourol Case Rep
. 2017 Oct 1;3(1):152
Abstract

Atazanavir-Associated Crystalline Nephropathy.
Santoriello D, Al-Nabulsi M, Reddy A, et al 
Am J Kidney Dis. 2017 Jun 2
Abstract

Drug- and Drug Abuse-Associated Hyperbilirubinemia: Experience With Atazanavir.
Roy-Chowdhury J, Roy-Chowdhury N, et al
Clin Pharmacol Drug Dev. 2017 Mar;6(2):140-146
Abstract

Psychiatric Symptoms in Patients Receiving Dolutegravir.
Fettiplace A, Stainsby C, Winston A, et al
J Acquir Immune Defic Syndr. 2016 Dec 7.
Abstract

Acute intermittent porphyria precipitated by atazanavir/ritonavir.
Bharti S, Malhotra P, Hirsch B.
Int J STD AIDS. 2016 Nov;27(13):1234-1235.
Abstract

FULL-TEXT ARTICLE
Risk of cardiovascular events among patients with HIV treated with atazanavir-containing regimens: a retrospective cohort study.
Rosenblatt L, Farr AM, Nkhoma ET, Nelson JK, et al

BMC Infect Dis
. 2016 Sep 19;16(1):492.
Paper

Frequency of atazanavir-associated leukocyturia development and renal function decline.
Dbeibo L, Arif S, He F, Gupta SK.

AIDS
. 2016 Jun 1;30(9):1488-9.
Abstract

Severe hyperbilirubinemia in an HIV-HCV coinfected patient starting the 3D regimen that resolved after TDM-guided atazanavir dose reduction.
Cattaneo D, Riva A, Clementi E, et al

Ther Drug Monit
. 2016 Feb 25.
Abstract

Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.
Chow D, Kohorn L, Souza S, Ndhlovu L,
AIDS. 2016 Feb 20;30(4):672-4
Abstract

Acute intermittent porphyria precipitated by atazanavir/ritonavir.
Bharti S, Malhotra P, Hirsch B.
Int J STD AIDS. 2016 Feb 11. pii: 0956462416633981
Abstract

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.
Gammal RS, Court MH, Haidar CE,  et al  
Clin Pharmacol Ther
. 2015 Sep 29.

Abstract

FULL-TEXT ARTICLE
Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis
Marinescu CI, Leyes M, Ribas MA,  et al
AIDS Res Treat
. 2015;2015:

Paper
 

FULL-TEXT ARTiCLE
Metabolic and Kidney Disorders Correlate with High Atazanavir Concentrations in HIV-Infected Patients: Is It Time to Revise Atazanavir Dosages?
Gervasoni C, Meraviglia P, Minisci D, et al
PLoS One
. 2015 Apr 15;10(4):e0123670.
Paper
 

FULL-TEXT ARTiCLE
Atazanavir nephrotoxicity.
Hara M, Suganuma A, Yanagisawa N, et al

Clin Kidney J
. 2015 Apr;8(2):137-42.
Paper

 

Changes in kidney function in patients with suppressed HIV RNA who substitute their protease inhibitor with atazanavir/ritonavir.
Hamzah L, Campbell L, Wandolo E, et al
AIDS. 2015 Jan 28;29(3):392-4.
Abstract

 

Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV-1-infected patients starting efavirenz, lopinavir-ritonavir, or atazanavir-ritonavir plus tenofovir/emtricitabine: Final 48-week results (the Advanz-3 trial).
Miro JM, Manzardo C, Ferrer E, et al
J Acquir Immune Defic Syndr. 2015 Feb 17.
Abstract

 

Iatrogenic Cushing's syndrome after triamcinolone plus ritonavir-boosted atazanavir.

Jakeman B, Conklin J, Bouchonville M, Thornton K.

J Am Pharm Assoc (2003). 2015 Feb 6:e87-e

Abstract

Pharmacogenetic testing can identify patients taking atazanavir at risk for hyperbilirubinaemia.
Avihingsanon A, Tongkobpetch S, Kerr SJ,  et al

J Acquir Immune Defic Syndr
. 2015 Jan 23.
Abstract

Atherogenic properties of lipoproteins in HIV patients starting atazanavir/ritonavir or darunavir/ritonavir: a substudy of the ATADAR randomized study.
Saumoy M, Ordóńez-Llanos J, Martínez E,  et al

J Antimicrob Chemothe
r
. 2014 Dec 2
3.
Abstract

FULL-TEXT ARTICLE
Clinical Features and Risk Factors for Atazanavir (ATV)-Associated Urolithiasis: A Case-Control Study
Lafaurie M, De Sousa B, Ponscarme D, et al
PLoS One. 2014 Nov 19;9(11):e112836.
Paper

Changes in bone mineral density after 96 weeks of treatment with atazanavir/ritonavir or lopinavir/ritonavir plus tenofovir DF/emtricitabine in treatment-naďve patients with HIV-1 infection: The CASTLE body composition substudy.
Moyle G, Hardy H, Farajallah A,  et al

J Acquir Immune Defic Synd
r
. 2014 Oct 7

A
bstract

Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study.
Nishijima T, Tsuchiya K, Tanaka N, et al

J Antimicrob Chemother
. 2014 Aug 23.
Abstract

Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202.
Johnson DH, Venuto C, Ritchie MD,
 
Pharmacogenet Genomics
. 2014 Feb 19.
Abstract

Investigation on the mechanism for the binding and drug resistance of wild type and mutations of G86 residue in HIV-1 protease complexed with Darunavir by molecular dynamic simulation and free energy calculation.
Li D, Zhang Y, Zhao RN,  et al

J Mol Model
. 2014 Feb;20(2):2122.
Abstract

Impact of darunavir, atazanavir and lopinavir boosted with ritonavir on cultured human endothelial cells: beneficial effect of pravastatin.
Auclair M, Afonso P, Capel E, et al

Antivir Ther
. 2014 Feb 17
Abstract

Early lipid changes with atazanavir/ritonavir or darunavir/ritonavir.
Martinez E, Gonzalez-Cordon A, Ferrer E, Domingo P,  et al
HIV Med. 2014 Jan 12.
Abstract

Recurrent nephrolithiasis associated with atazanavir use.
Wang LC, Osterberg EC, David SG, Rosoff JS.

BMJ Case Rep
.
2014 Jan 8;2014.
Abstract

Cumulative exposure to ritonavir-boosted atazanavir is associated with cholelithiasis in patients with HIV-1 infection.
Nishijima T, Shimbo T, Komatsu H, et al

J Antimicrob Chemother
. 2013 Dec 29
Abstract

Atazanavir-Induced Urine Crystals Demonstrated by Infrared Spectroscopic Analysis.
Inagaki I, Adachi M, Ito H, et al
Urol Int
. 2013 Dec 5
Abstract

Atazanavir and chest pain.
Phillips M, Saxon C, Lee V.
Int J STD AIDS. 2013 Oct 9.
Abstract

FULL-TEXT ARTICLE
Is ritonavir-boosted atazanavir a risk for cholelithiasis compared to other protease inhibitors?

Hamada Y, Nishijima T, Komatsu H,  et al
PLoS One. 2013 Jul 16;8(7):e69845
Paper

Atazanavir and Other Determinants of Hyperbilirubinemia in a Cohort of 1150 HIV-Positive Patients: Results from 9 Years of Follow-Up.
Laprise C, Baril JG, Dufresne S, Trottier H.

AIDS Patient Care STD
S
. 2013 Jul;27(7):378-86.
Abstract

Co-administration of atazanavir/ritonavir and zinc sulphate: impact on hyperbilirubinemia and pharmacokinetics.
Moyle G, Else L, Jackson A, et al
Antimicrob Agents Chemother. 2013 May 20.
Abstract

Atazanavir induced first degree atrioventricular block and ventricular tachycardia: a case report.
Santimaleeworagun W, Pattharachayakul S, Chusri S, Chayagul P.
J Med Assoc Thai. 2013 Apr;96(4):501-3
Abstract

Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir.
Cotter AG, Brown A, Sheehan G,  et al

AIDS Res Ther
. 2013 May 16;10(1):13.
Abstract

Effect of the UGT1A1*28 Allele on Unconjugated Hyperbilirubinemia in HIV-Positive Patients Receiving Atazanavir: A Systematic Review (April).
Culley CL, Kiang TK, Gilchrist SE, Ensom MH.

Ann Pharmacother
. 2013 Apr 2. [
Abstract

Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events.
Monforte AD, Reiss P, Ryom L,  et al

AIDS
. 2013 Jan 28;27(3):407-415.
Abstract

Role of Drug Efflux and Uptake Transporters in Atazanavir Intestinal Permeability and Drug-Drug Interactions.
Kis O, Zastre JA, Hoque MT,  et al
Pharm Res
. 2012 Dec 7.
Abstract

High incidence of renal stones in HIV-infected patients on ritonavir-boosted atazanavir than in those on other protease inhibitors-containing antiretroviral therapy.
Hamada Y, Nishijima T, Watanabe K, Komatsu H,  et al
Clin Infect Dis
. 2012 Jul 19.
Abstract

Complicated Atazanavir-associated Cholelithiasis: a Report of 14 Cases.
Rakotondravelo S, Poinsignon Y, Borsa-Lebas F,  et al 
Clin Infect Dis
. 2012 Jul 19

Abstract

Diffuse Tubulointerstitial Nephritis Accompanied by Renal Crystal Formation in an HIV-infected Patient Undergoing Highly Active Antiretroviral Therapy.
Kanzaki G, Tsuboi N, Miyazaki Y,  et al
Intern Med
. 2012;51(12):1543-8.
Abstract

Clinical Significance of Hyperbilirubinemia Among HIV-1-Infected Patients Treated with Atazanavir/Ritonavir Through 96 Weeks in the CASTLE Study.
McDonald C, Uy J, Hu W,  et al

AIDS Patient Care STDS
. 2012 Mar 9.
Abstract

Symptomatic Hyperbilirubinemia Secondary to Dapsone Induced Hemolysis and Atazanavir Therapy.
East J, Blanton LS.

Antimicrob Agents Chemother
. 2011 Nov 28.
Abstract

UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil.
Turatti L, Sprinz E, Lazzaretti RK, et al
AIDS Res Hum Retroviruses. 2011 Nov 4
Abstract

Unexpected atazanavir-associated biliary lithiasis in an HIV-infected patient.
Courbon E, Laylavoix F, Soulié C, et al
J Antimicrob Chemother. 2011 Oct 23.
Abstract

Short communication: use of serum bilirubin levels as surrogate marker of early virological response to atazanavir-based antiretroviral therapy.
Morello J, Alvarez E, Cuenca L, et al
AIDS Res Hum Retroviruses
. 2011 Oct;27(10):1043-5.
Abstract

Atazanavir/r exposure is associated with an increased rate of renal stones compared with efavirenz, lopinavir/r and darunavir/r.
Rockwood N, Mandalia S, Bower M, et al
AIDS
. 2011 Jun 29.
Abstract

Development of Buffalo Hump in the course of antiretroviral therapy including raltegravir and unboosted atazanavir: a case report and review of the literature.
Ceccarelli G, d'Ettorre G, Marchetti F, et al 
J Med Case Reports. 2011 Feb 17;5(1):70
Abstract

Chronic interstitial nephritis in an HIV type-1-infected patient receiving ritonavir-boosted atazanavir.
Viglietti D, Verine J, De Castro N,  et a
l
Antivir Ther
. 2011;16(1):119-21.
Abstract

Impact of atazanavir-based HAART regimen on the carotid intima-media thickness of HIV-infected persons: a comparative prospective cohort.
de Saint-Martin L, Bressollette L, Perfezou P, et al
AIDS. 2010 Nov 27;24(18):2797-801.
Abstract

FULL-TEXT ARTICLE
Incidence of Atazanavir-associated Hyperbilirubinemia in Korean HIV Patients: 30 Months Follow-up Results in a Population with Low UDP-glucuronosyltransferase1A1*28 Allele
Frequency.

Choe PG, Park WB, Song JS, et al
J Korean Med Sci
. 2010 Oct;25(10):1427-30.
Paper

Lipid profiles in HIV-infected adults receiving atazanavir and atazanavir/ritonavir: systematic review and meta-analysis of randomized controlled trials.
Carey D, Amin J, Boyd M, Petoumenos K, Emery S.
J Antimicrob Chemother. 2010 Jun 16
Abstract

Adverse Reactions of Atazanavir, Fosamprenavir and Tipranavir in "Real Life"
Balayssac E, Autret-Leca E, Jonville-Béra AP, et al
Therapie. 2010 3-4;65(2):121-128.
Abstract

Renal toxicity associated with tenofovir use.
Rodriguez-Nóvoa S, Alvarez E, Labarga P, Soriano V.
Expert Opin Drug Saf
. 2010 Apr 13.
Abstract

Impact of Ritonavir, Atazanavir and their Combination on the CYP3A4 Induction Potential
of Efavirenz in Primary Human Hepatocytes.
Mugundu GM, Hariparsad N, Desai PB. 
Drug Metab Lett
. 2010 Mar 4.
Abstract

Atazanavir-Associated Choledocholithiasis Leading to Acute Hepatitis in an
HIV-Infected Adult
Jacques AC, Gigučre P, Zhang G,
Ann Pharmacother
. 2009 Dec 2
Abstract

Hyperbilirubinemia during Atazanavir Treatment in 2,404 Patients in the Italian Atazanavir Expanded Access Program and MASTER Cohorts.
Torti C, Lapadula G, Antinori A, et al
Infection. 2009 May 26.
Abstract

Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone.
Collet-Gaudillat C, Roussin-Bretagne S, Desforges-Bullet V, et al 
Ann Endocrino
l (Paris)
. 2009 May 4.
Abstract
 

Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endothelial function in HIV-infected persons: Randomized controlled trial.
Flammer AJ, T T Vo N, Ledergerber B, et al
Heart. 2008 Jul 24.
Abstract
 
Case presentation: nephrolithiasis in a patient treated with atazanavir.
Savini C, James C, Wilson S, et al 
J Assoc Nurses AIDS Care. 2008 May-Jun;19(3):225-7."
Abstract
 
Liver toxicity of antiretroviral combinations including atazanavir/ritonavir in patients co-infected with HIV and hepatitis viruses: impact of pre-existing liver fibrosis.
Pineda JA, Santos J, Rivero A, et al 
J Antimicrob Chemother.
2008 Feb 14

Abstract
 
Urolithiasis in HIV-positive patients treated with atazanavir
Couzigou C, Daudon M, Meynard JL,  
Clin Infect Dis.
2007 Oct 15;45(8):e105-8
Abstract
 
Insulin resistance in HIV-infected patients receiving long-term therapy with efavirenz, lopinavir/ritonavir and atazanavir.
Bernal E, Masiá M, Padilla S, et al
Med Clin (Barc). 2007 Jul 14;129(7):252-4.
Abstract
 
Cushing Syndrome and Severe Adrenal Suppression Caused by Fluticasone and Protease Inhibitor Combination in an HIV-Infected Adolescent.
St Germain RM, Yigit S, Wells L, et al 
AIDS Patient Care STDS
. 2007 Jun;21(6):373-7.
Abstract
 
Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype.
Lankisch TO, Moebius U, Wehmeier M, et al 
Hepatology.
2006 Nov;44(5):1324-32.
Abstract
 
(Renal failure in a patient treated with atazanavir}
Moddel M, Pfammatter R, Varga Z, Keusch G. 
Schweiz Rundsch Med Prax
. 2006 Jun 7;95(23):949-51.
Abstract

Body Fat and Other Metabolic Effects of Atazanavir and Efavirenz, Each Administered in Combination with Zidovudine plus Lamivudine, in Antiretroviral-Naive HIV-Infected Patients.
Jemsek JG, Arathoon E, Arlotti M, et al
Clin Infect Dis. 2006 Jan 15;42(2):273-80.
Abstract
 

Can boosted atazanavir induce hyperlipotrophy?
Dellamonica P.  
J Infect.
2005 Oct 17;
Abstract
 
Acute interstitial nephritis associated with atazanavir, a new protease inhibitor.
Brewster UC, Perazella MA. 
Am J Kidney Dis.
2004 Nov;44(5):e81-4
Abstract

Does atazanavir cause lipodystrophy?
Gazzard BG, Moyle G.
J HIV Ther. 2004 May;9(2):41-4
Abstract


Adherence
       

 
Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy: the ANRS 134-COPHAR 3 trial.
Parienti JJ, Barrail-Tran A, Duval X,  et al

Antimicrob Agents Chemother
. 2013 Mar 4
Abstract

Effect of Adherence as Measured by MEMS, Ritonavir Boosting, and CYP3A5 Genotype on Atazanavir Pharmacokinetics in Treatment-Naive HIV-Infected Patients.
Savic RM, Barrail-Tran A, Duval X,  et al
Clin Pharmacol Ther. 2012 Oct 3
Abstract

Use of bilirubin as a marker of adherence to atazanavir-based antiretroviral therapy.
Petersen K, Riddle MS, Jones LE, et al  
AIDS. 2005 Oct 14;19(15):1700-2.
Abstract


Economics
       

 
Budget impact analysis of the simplification to atazanavir + ritonavir + lamivudine dual therapy of HIV-positive patients receiving atazanavir-based triple therapies in Italy starting from data of the Atlas-M trial.
Restelli U, Fabbiani M, Di Giambenedetto S, et al
Clinicoecon Outcomes Res. 2017 Mar 1;9:173-179
Abstract

Cost-effectiveness of atazanavir+ritonavir (ATV+RTV) vs. lopinavir/ritonavir (LPV/r) in women of childbearing age in the United Kingdom.
Simpson K, Kirbach S, Van de Steen O, Gooch K. J
 Int AIDS Soc
. 2012 Nov 11;15(6):18385
Abstract

Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naive human immunodeficiency virus-infected patients in the United States.
Broder MS, Chang EY, Bentley TG, Juday T, Uy J.
J Med Econ
. 2011 Feb 2.
Abstract

Cost-effectiveness of atazanavir/ritonavir compared with lopinavir/ritonavir in treatment-naďve human immunodeficiency virus-1 patients in Sweden.
Thuresson PO, Heeg B, Lescrauwaet B,  et al
Scand J Infect Dis. 2011 Jan 13

Abstract


Pharmacogenetics
       

 
Inflammation investigated as a source of pharmacokinetic variability of atazanavir in AIDS Clinical Trials Group protocol A5224s.
Venuto CS, Lim J, Messing S,  et al
Antivir Ther
. 2017 Nov 24.

Abstract

Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation.
Leger P, Chirwa S, Nwogu JN, et al
;
Pharmacogenet Genomics
. 2017 Nov 6

Abstract


Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342).
Castillo-Mancilla JR, Aquilante CL, Wempe MF, et al

J Antimicrob Chemother
. 2016 Feb 17.

Abstract

Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study.
Nishijima T, Tsuchiya K, Tanaka N, et al

J Antimicrob Chemother
. 2014 Aug 23.
Abstract

A population pharmacokinetic-pharmacogenetic analysis of atazanavir.
Kile DA, Mawhinney S, Aquilante C,  et a

AIDS Res Hum Retroviruses. 2012 Mar 6
Abstract

 


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