Medical Advocates

Atazanavir (Reyataz)
 
Journal Citations Therapeutic Strategies
 
First Line Therapy
Boosting Therapy 
Simplification Therapy
Maintenance Therapy
Salvage Therapy

Multiple Virological Failures
Metabolic Disorders
HIV/HBV Coinfection
HIV/HCV Coinfection
HIV/TB Coinfection
HIV/Malaria Coinfection
Liver Disease

Switching Therapies
PEP
 

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Last updated:  April 19, 2018
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First Line Therapy
       

  Atazanavir: a new protease inhibitor to treat HIV infection.
Musial BL, Chojnacki JK, Coleman CI. 
Am J Health Syst Pharm. 2004 Jul 1;61(13):1365-74.
Abstract
 
Boosting Therapy
       

 

 

Low-dose versus standard-dose ritonavir-boosted atazanavir in virologically suppressed Thai adults with HIV (LASA): a randomised, open-label, non-inferiority trial.
Bunupuradah T, Kiertiburanakul S, Avihingsanon A, et al
Lancet HIV. 2016 Aug;3(8):e343-50.
Abstract

FULL-TEXT ARTICLE
Pharmacologic Boosting of Atazanavir in Maintenance HIV-1 Therapy: The COREYA Propensity-Score Adjusted Study.
Hocqueloux L, Choisy P, Le Moal G, et al
PLoS One. 2012;7(11):e49289.

Paper


Simplification Therapy
       

 

Simplification to dual-therapy containing lamivudine and darunavir/ritonavir or atazanavir/ritonavir in HIV-infected patients on virologically suppressive antiretroviral therapy.
Calza L, Cafaggi M, Colangeli V,et al
Infect Dis (Lond). 2017 Dec 6:1-9.
Abstract

Efficacy and safety of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients with virological suppression: 144 week follow-up of the AtLaS pilot study.
Mondi A, Fabbiani M, Ciccarelli N,  et al
J Antimicrob Chemother. 2015 Feb 26.
Abstract

Simplification to atazanavir/ritonavir+lamivudine in virologically suppressed HIV-infected patients: 24-weeks interim analysis from ATLAS-M trial.
Fabbiani M, Di Giambenedetto S, Quiros-Roldan E,
J Int AIDS Soc. 2014 Nov 2;17(4(Suppl 3)):19808.
Abstract

Simplification to atazanavir/ritonavir monotherapy for HIV-1 treated individuals on virological suppression: the MODAt trial.
Castagna A, Spagnuolo V, Galli L, et al

AIDS
. 2014 Jul 23
Abstract

FULL-TeXT ARTICLE
Baseline Natural Killer and T Cell Populations Correlation with Virologic Outcome after Regimen Simplification to Atazanavir/Ritonavir Alone (ACTG 5201).
McKinnon JE, Mailliard RB, Swindells S, et al
PLoS One. 2014 May 6;9(5):
Paper

Safety and feasibility of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors + atazanavir/ritonavir with virological suppression (Atazanavir and Lamivudine for treatment Simplification, AtLaS pilot study).
Di Giambenedetto S, Fabbiani M, Colafigli M, et al
J Antimicrob Chemother. 2013 Jan 30.
Abstract

 
Maintenance Therapy
       

  Atazanavir/ritonavir with lamivudine as maintenance therapy in virologically suppressed HIV-infected patients: 96 week outcomes of a randomized trial.
Fabbiani M, Gagliardini R, Ciccarelli N, et al 
J Antimicrob Chemother. 2018 Apr 12
Abstract

Atazanavir/ritonavir monotherapy as maintenance strategy in HIV-1 treated subjects with viral suppression: 96-week analysis results of the MODAT study.
Spagnuolo V, Galli L, Bigoloni A,  et al

J Int AIDS Soc
. 2014 Nov 2;17(4(Suppl 3)):19806.
Abstract

A meta-analysis of the efficacy and safety of unboosted atazanavir compared with ritonavir-boosted protease inhibitor maintenance therapy in HIV-infected adults with established virological suppression after induction.
Baril J, Conway B, Giguère P, et al
HIV Med. 2014 May;15(5):301-10.
Abstract


Salvage Therapy
       

 
Efficacy and safety of "unboosting" atazanavir in a randomized controlled trial among HIV-infected patients receiving tenofovir DF.
Harris M, Ganase B, Watson B, et al
HIV Clin Trials. 2017 Jan 9:1-9.
Abstract

FULL-TEXT PDF ARTICLE
Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and
lopinavir/ritonavir combination therapy.
Choi H, Jeong SJ, Lee HS, et al
 
J Korean Med Sci.
2008 Aug;23(4):737-9
Paper

Decrease of atazanavir and lopinavir plasma concentrations in a boosted double HIV-protease
inhibitor salvage regimen.

von Hentig N, Kaykhin P, Stephan C, et al
Antimicrob Agents Chemother. 2008 Apr 14
Abstract

Salvage therapy with atazanavir/ritonavir combined to tenofovir in HIV-infected patients
with multiple treatment failures: randomized ANRS 107 trial.
Piketty C, Gerard L, Chazallon C, et al 
Antivir Ther.
2006;11(2):213-21.
Abstract


Multiple Virologic Failures
       

  Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing
multiple virological failures.
Johnson M, Grinsztejn B, Rodriguez C,
AIDS.
2005 Apr 29;19(7):685-694.
Abstract

Metabolic Disorders
       

 
Metabolic effects of atazanavir/ritonavir vs darunavir/ritonavir in combination with tenofovir/emtricitabine in antiretroviral-naïve patients (ATADAR Study).
Martinez E, González-Cordón A, Podzamczer D, Domingo P,  et al
J Int AIDS Soc. 2012 Nov 11;15(6):18202.
Abstract

A randomized comparative 96-week trial of boosted atazanavir versus continued boosted
protease inhibitor in HIV-1 patients with abdominal adiposity.
Moyle GJ, Andrade-Villanueva J, et al

Antivir Ther
. 2012 Mar 2.
Abstract

Effects of switching from lopinavir/ritonavir to atazanavir/ritonavir on muscle glucose uptake and visceral fat
in HIV-infected patients.
Stanley TL, Joy T, Hadigan CM, et al.
AIDS
. 2009 May 25.
Abstract

Improvement in Lipid Profiles in Antiretroviral-Experienced HIV-Positive Patients With Hyperlipidemia
After a Switch to Unboosted Atazanavir.
Sension M, Neto JL, Grinsztejn B, et al
J Acquir Immune Defic Syndr. 2009 Apr 2.
Abstract
 

Improvement in Insulin Sensitivity and Dyslipidemia in Protease Inhibitor-Treated Adult Male
Patients After Switch to Atazanavir/Ritonavir.

Busti AJ, Bedimo R, Margolis DM, Hardin DS.
J Investig
Med. 2008 Feb;56(2):539-544.
Abstract
 
Lipid-lowering efficacy and safety after switching to atazanavir-ritonavir-based highly active
antiretroviral therapy in patients with human immunodeficiency virus.

Nguyen ST, Eaton SA, Bain AM, et al
Pharmacotherapy.
2008 Mar;28(3):323-30.
Abstract
 
Switching to unboosted atazanavir improves glucose tolerance in highly pretreated HIV-1
infected subjects.

Guffanti M, Caumo A, Galli L, et al
Eur J Endocrino
l. 2007 Apr;156(4):503-509
Abstract

Switching to Atazanavir Improves Metabolic Disorders in Antiretroviral-Experienced
Patients With Severe Hyperlipidemia.
Mobius U, Lubach-Ruitman M, Castro-Frenzel B, et al 
J Acquir Immune Defic Syndr.
2005 Jun 1;39(2):174-180
Abstract


HIV/HCV Coinfection
       

 
Atazanavir-based therapy with pegylated interferon and ribavirin for patients with hepatitis C and HIV.
Rivero-Juarez A, Lopez-Cortes LF, Girón-Gonzalez JA, et al

Lancet Infect Dis
. 2014 Jan;14(1):13-4.
Abstract

Effects of hepatitis C virus infection on the pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected patients.
Di Biagio A, Rosso R, Loregian A, et al
J Infect Chemother. 2012 Mar 16. [
Abstract

Short-Term Effect of Ritonavir-Boosted Atazanavir in Hepatitis B and/or C Co-infected,
Treatment-Experienced HIV Patients.
Pérez-Elías MJ, Gatell JM, Flores J, et al
HIV Clin Trials
. 2009 Jul-Aug;10(4):269-75
Abstract

Increase in serum bilirubin in HIV/hepatitis-C virus-coinfected patients on atazanavir therapy following
initiation of pegylated-interferon and ribavirin.

Rodríguez-Nóvoa S, Morello   
AIDS. 2008 Nov 30;22(18):2535-7

Abstract


Liver Disease
       

 
The use of atazanavir in hiv infected patients with liver cirrhosis: lack of hepatotoxicity and
no significant changes in bilirubin values or meld score.
Rodriguez JM, Hermida JM, Casado JL, et al
AIDS
. 2011 Mar 17.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and Safety of Atazanavir in Patients with End-Stage Liver Disease.
Guaraldi G, Cocchi S, Motta A, et al
Infection
. 2009 May 26.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
A pilot study on the efficacy, pharmacokinetics and safety of atazanavir in patients with end-stage
liver disease.

Guaraldi G, Cocchi S, Motta A,  et al  
J Antimicrob Chemother
. 2008 Dec;62(6):1356-64.

Abstract


HIV/TB Coinfection
       

  Hepatotoxicity and Gastrointestinal Intolerance When Healthy Volunteers Taking Rifampin Add
Twice-Daily Atazanavir and Ritonavir.
Haas DW, Koletar SL, Laughlin L,et al 
J Acquir Immune Defic Syndr
. 2009 Feb 3.
Abstract

HIV/Malaria Coinfection
 

 
Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir
or atazanavir/ritonavir.
van Luin M, Van der Ende ME, Richter C,  et al
AIDS
. 2010 May 15;24(8):1223-6.
Abstract

Switching Therapies/
       

 
FULL-TEXT ARTiCLE
Improved kidney function in patients who switch their protease inhibitor from atazanavir or lopinavir to darunavir.
Jose S, Nelson M, Phillips A, ..et al
AIDS. 2017 Feb 20;31(4):485-492.
Paper

FULL-TEXT ARTICLE
Switch to Ritonavir-Boosted versus Unboosted Atazanavir plus Raltegravir Dual-Drug Therapy Leads to Similar Efficacy and Safety Outcomes in Clinical Practice.
Gantner P, Bani-Sadr F, Garraffo R,  et al
PLoS One
. 2016 Oct 31;11(10):e0164240
Paper

Effects of a switch from tenofovir- to abacavir-based antiretroviral therapy, with or without atazanavir, on renal function.
Guillemi SA, Ling SH, Dahlby JS, et al

J Int AIDS Soc
. 2016 Sep 9;19(1):20995.
Abstract

Simplification to dual therapy (atazanavir/ritonavir + lamivudine) versus standard triple therapy [atazanavir/ritonavir + two nucleos(t)ides] in virologically stable patients on antiretroviral therapy: 96 week results from an open-label, non-inferiority, randomized clinical trial (SALT study).
Perez-Molina JA, Rubio R, Rivero A,  et al

J Antimicrob Chemother
. 2016 Sep 13.
Abstract

Low-dose versus standard-dose ritonavir-boosted atazanavir in virologically suppressed Thai adults with HIV (LASA): a randomised, open-label, non-inferiority trial.
Bunupuradah T, Kiertiburanakul S, Avihingsanon A,  et al

 Lancet HI
V
. 2016 Aug;3(8):e343-50.
Abstract

Switching Lopinavir/Ritonavir to Atazanavir/Ritonavir vs Adding Atorvastatin in HIV-Infected Patients Receiving Second-Line Antiretroviral Therapy With Hypercholesterolemia: A Randomized Controlled Trial.
Wangpatharawanit P, Sungkanuparph S.
Clin Infect Dis. 2016 Jul 11
Abstract

Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: ATAzanavir & GLUcose metabolism (ATAGLU) sudy.
d'Ettorre G, Ceccarelli G, Zaccarelli M, et al

Int J STD AIDS
. 2015 Jun 10
Abstract

Immunological and Virological Outcomes of Patients Switched from LPV/r to ATV/r-Containing Second- Line Regimens.
Akanmu AS, Adeyemo T, Lesi F, et al
Curr HIV Res. 2015;13(3):176-83.
Abstract

Long term effectiveness of once-daily unboosted atazanavir plus abacavir/lamivudine as a switch strategy in subjects with virological suppression.
Llibre JM, Cozzi-Lepri A, La Rosa JA,  et al

J Int AIDS Soc
. 2014 Nov 2;17(4(Suppl 3)):19810.
Abstract

Unboosted atazanavir with lamivudine/emtricitabine for patients with long-lasting virological suppression.
Carbone A, Galli L, Bigoloni A,  et al
J Int AIDS Soc. 2014 Nov 2;17(4(Suppl 3)):19811.
Abstract

Boosted or unboosted atazanavir as a simplification of lopinavir/ritonavir-containing regimens.
Castagna A, Galli L, Gianotti N, et al
New Microbiol. 2013 Jul;36(3):239-49.
Abstract

ATV/r-based regimens: durable virological suppression and good tolerability as switch strategy from NNRTI-containing regimens in a real-life cohort.
Michalik C, Sönnerborg A, Jansen K, et al
J Int AIDS Soc
. 2012 Nov 11;15(6):18352.
Abstract

Switching to unboosted atazanavir combined with tenofovir and emtricitabine is effective as maintenance therapy.
Maeland A, Skeie L.
J Int AIDS Soc
. 2012 Nov 11;15(6):18441
Abstract

Virological efficacy and safety of antiretroviral therapy-switch to atazanavir-based regimen: a review of the literature.
Stephan C.
Expert Opin Pharmacother
. 2012 Oct 10
Abstract

Switching to unboosted atazanavir reduces bilirubin and triglycerides without compromising treatment efficacy i
n UGT1A1*28 polymorphism carriers.

Ferraris L, Viganò O, Peri A, et al

J Antimicrob Chemother
. 2012 Jun 2.
Abstract

Impact of Switching from Lopinavir/Ritonavir to Atazanavir/Ritonavir on Body Fat Redistribution in Virologically
Suppressed HIV-Infected Adults.

Ferrer E, Rio LD, Martínez E, Curto J,  et al
AIDS Res Hum Retroviruses. 2011 Oct;27(10):1061-5.
Abstract

Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in
HIV-1-infected patients with virological suppression under antiretroviral therapy.
Pavie J, Porcher R, Torti C, Medrano J,  et al
J Antimicrob Chemother
. 2011 Aug 5.
Abstract

Pharmacokinetics of switching unboosted atazanavir coadministered with tenofovir disoproxil
fumarate from 400 mg once daily to 200 mg twice daily in HIV-positive patients.
Bonora S, Gonzalez de Requena D, D'Avolio A,  et al
Antivir Ther
. 2011;16(4):499-504.
Abstract

Outcomes of switch to atazanavir-containing combination antiretroviral therapy in HIV-1-infected
patients with hyperlipidemia.
Lu CL, Lin YH, Wong WW, et al
J Microbiol Immunol Infect. 2011 Jan 20
Abstract

Impact of Switching from Lopinavir/Ritonavir to Atazanavir/Ritonavir on Body Fat
Redistribution in Virologically Suppressed HIV-Infected Adults.
Ferrer E, Del Rio L, Martinez E,  et al
AIDS Res Hum Retroviruse
s
. 2010 Dec 19
Abstract


Post-exposure Prophylaxis
       

  Post-exposure prophylaxis for HIV infection: a clinical trial comparing lopinavir/ritonavir versus
atazanavir each with zidovudine/lamivudine.

Diaz-Brito V, León A, Knobel H,  et al
Antivir Ther. 2011 Nov 25.

Abstract

 


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