Medical Advocates

Lopinavir/Ritonavir (Kaletra/Aluvia)
 
Journal Citations: Adolescent/Adult Combination Therapies

LPV/RTV/3rd PI               LPV/RTV/Misc. Combinations
LPV/RTV/ATZ                 
LPV/Amprenavir
LPV/RTV/EFV
LPV/RTV/EFV/2NRTIs
LPV/RTV/F
osamprenavir
LPV/RTV/IND
LPV/RTV/NVP
LPV/RTV/NV
P/2NRTIs
LPV/RTV/D4T/3TC
LPV/RTV/SQV
LPV/RTV/2 NRTIs


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Last Update: September 01, 2016
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LPV/RTV/3rd PI
 

  A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and Treatment-Limiting Toxicity With the Concurrent Use of Lopinavir/
Ritonavir and a Third Protease Inhibitor in Treatment-Experienced HIV-Infected
Patients.

Casau NC, Glesby MJ, Paul S, Gulick RM.
J Acquir Immune Defic Syndr 2003 Apr 15;32(5):494-8
Abstract
 

LPV/RTV/ATZ
 

  A WEEK-IN-REVIEW FEATURED REPORT
Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic
interaction and predictors of drug exposure.

Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.

Abstract

LPV/RTV/EFV
 

  Pharmacokinetics and Safety of the Lopinavir/Ritonavir Tablet 500/125 mg Twice Daily
Coadministered With Efavirenz in Healthy Adult Participants.
Ng J, Chiu YL, Awni W,  et al
J Clin Pharmacol
. 2011 Jun 30.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and Tolerability of a Nucleoside Reverse Transcriptase Inhibitor-Sparing
Combination of Lopinavir/Ritonavir and Efavirenz in HIV-1-Infected Patients.

Allavena C, Ferre V, Brunet-Francois C, et al

J Acquir Immune Defic Syndr.
2005 Jul 1;39(3):300-306.
Abstract


LPV/RTV/EFV/2NRTIs
 

 
A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and safety of an anti-retroviral combination regimen including either
efavirenz or lopinavir-ritonavir with a backbone of two nucleoside reverse
transcriptase inhibitors.

Panagopoulos P, Tsiodras S, Antoniadou A, et al
 
Clin Microbiol Infect.
2006 May;12(5):486-9.
Abstract

Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination
with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively
pretreated human immunodeficiency virus-infected patients

Hsu A, Isaacson J, Brun S, et al.
Antimicrob Agents Chemother 2003 Jan;47(1):350-9
Abstract 

 

LPV/RTV/Fosamprenavir
 

  Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir
and lopinavir exposure: ACTG protocol A5143 results.

Kashuba AD, Tierney C, Downey GF,
AIDS. 2005 Jan 28;19(2):145-152.
Abstract

LPV/RTV/IND
 

  Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and
pharmacodynamics in blood, CSF and semen.

Isaac A, Taylor S, Cane P 
Antimicrob Chemother. 2004 Aug;54(2):498-502.
Abstract

LPV/RTV/NVP
 

  Lopinavir/Ritonavir Plus Nevirapine as a Nucleoside-Sparing Approach in Antiretroviral-
Experienced Patients (NEKA Study).

Negredo E, Molto J, Burger D, et al 
J Acquir Immune Defic Syndr. 2005 Jan 1;38(1):47-52.
Abstract

LPV/RTV/NVP/2NRTIs
 

  Safety and Antiviral Activity at 48 Weeks of Lopinavir/Ritonavir plus Nevirapine
and 2 Nucleoside Reverse-Transcriptase Inhibitors in Human Immunodeficiency
Virus Type 1--Infected Protease Inhibitor--Experienced Patients.

Benson CA, Deeks SG, Brun SC, et al.
J Infect Dis 2002 Mar 1;185(5):599-607
Abstract 

LPV/RTV/D4T/3TC
 

 
A WEEK-IN-REVIEW FEATURED REPORT
Seven-Year Efficacy of a Lopinavir/Ritonavir-Based Regimen in Antiretroviral-Naïve
HIV-1-Infected Patients.

Murphy RL, da Silva BA, Hicks CB, et al 
HIV Clin Trials. 2008 Jan-Feb;9(1):1-10
Abstract

Long-term safety and durable antiretroviral activity of lopinavir/ritonavir in
treatment-naive patients: 4 year follow-up study

Hicks C, King MS, Gulick RM et al.
AIDS
. 2004 Apr 12;18(5):775-779.
Abstract

FULL-TEXT ARTICLE
ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-
naive adults with HIV-1 infection: 48-week results.

Murphy RL, Brun S, Hicks C, et al.
AIDS
2001 Jan 5;15(1):F1-9
Paper  

LPV/RTV/SQV
 

 
A WEEK IN REVIEW FEATURED REPORT
Pharmacokinetics of High-Dose Lopinavir/Ritonavir with and without Saquinavir or Non-Nucleoside
Reverse Transcriptase Inhibitors in HIV Infected Pediatric and Adolescent Patients Previously Treated
with Protease Inhibitors - Study PACTG P1038.
Robbins BL, Capparelli EV, Chadwick EG, et al 
Antimicrob Agents Chemothe
r. 2008 Jul 14.
Abstract
 
A WEEK-IN-REVIEW FEATURED REPORT
The LOPSAQ study: 48 week analysis of a boosted double protease inhibitor regimen
containing lopinavir/ritonavir plus saquinavir without additional antiretroviral therapy.

Stasz
ewski S, Babacan E, Stephan C, et al 
J Antimicrob Chemother.
2006 Sep 6
Abstract

FULL-TEXT ARTICLE
Lopinavir/ritonavir plus saquinavir in salvage therapy; pharmacokinetics,
tolerability and efficacy

la Porte C JL,  Wasmuth J-C,  Schneider K,  et al
AIDS. 17(11):1700-1702, July 25, 2003.
Letter


LPV/RTV/2 NRTIs
 

 
Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy
for patients with HIV.
Young J, Bucher HC, Guenthard HF, et al  
Antivir Ther
.
2009;14(6):771-779.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Efficacy and safety of an anti-retroviral combination regimen including either
efavirenz or lopinavir-ritonavir with a backbone of two nucleoside reverse
transcriptase inhibitors.

Panagopoulos P, Tsiodras S, Antoniadou A, et al
Clin Microbiol Infect. 2006 May;12(5):486-9.
Abstract


LPV/RTV/Misc. Combinations
 

 
Dual treatment with lopinavir-ritonavir plus lamivudine versus triple treatment with lopinavir-ritonavir plus lamivudine or emtricitabine and a second nucleos(t)ide reverse transcriptase inhibitor for maintenance of HIV-1 viral suppression (OLE): a randomised, open-label, non-inferiority trial.
Arribas JR, Girard PM, Landman R,  et al
Lancet Infect Dis. 2015 Jun 5.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
A simplified combination antiretroviral therapy regimen enhances adherence, treatment satisfaction and quality of life: results of a randomized clinical trial.
Langebeek N, Sprenger H, Gisolf E,  et al 
HIV Med. 2013 Nov 11.
Abstract

Ritonavir-boosted lopinavir plus nucleoside or nucleotide reverse transcriptase inhibitors versus ritonavir-boosted lopinavir plus raltegravir for treatment of HIV-1 infection in adults with virological failure of a standard first-line ART regimen (SECOND-LINE): a randomised, open-label, non-inferiority study.
SECOND-LINE Study Group, Boyd MA, Kumarasamy N, Moore CL, et al
Lancet
. 2013 Jun 15;381(9883)
:2091-9.
Abstract

Lopinavir/ritonavir (LPV/r) Combined with Raltegravir (RAL) or Tenofovir/Emtricitabine (TDF/FTC) in Antiretroviral (ARV)-naïve Subjects: 96-Week Results of the PROGRESS Study.
Reynes J, Trinh R, Pulido F,  et al
AIDS Res Hum Retroviruses
. 2012 Jun 25.
Abstract

Examination of Noninferiority, Safety, and Tolerability of Lopinavir/ritonavir and Raltegravir Compared
with Lopinavir/ritonavir and Tenofovir/ Emtricitabine in Antiretroviral-Naïve Subjects: The PROGRESS Study, 48-Week Results.

Reynes J, Lawal A, Pulido F, Soto-Malave R,  et al
HIV Clin Trials. 2011 Sep-Oct;12(5):255-67.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily
atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate
and emtricitabine.
Uy J, Yang R, Wirtz V, et al  
AIDS Care
. 2011 Jul 7.
Abstract

FULL-TEXT PDF ARTICLE
High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at
ESTHER/Calmette Hospital in Phnom Penh, Cambodia.

Ferradini L, Ouk V, Segeral O, et al
J Int AIDS Soc
. 2011 Mar 26;14(1):14
Paper

A WEEK-IN-REVIEW FEATURED REPORT
Short Communication: Comparable Safety and Efficacy with Once-Daily Versus
Twice-Daily Dosing of Lopinavir/Ritonavir Tablets with Emtricitabine + Tenofovir DF
in Antiretroviral-Naïve, HIV Type 1-Infected Subjects: 96 Week Final Results of
the Randomized Trial M05-730.
González-García J, Cohen D, Johnson M, et al
AIDS Res Hum Retroviruses
. 2010 Jul 30
Abstract

Comparison of Once-Daily versus Twice-Daily Combination Antiretroviral
Therapy in Treatment-Naive Patients: Results of AIDS Clinical Trials Group
(ACTG) A5073, A 48-Week Randomized Controlled Trial.
Flexner C, Tierney C, Gross R,  et al 
Clin Infect Dis
. 2010 Mar 1.
Abstract

Pharmacokinetic Evaluation of Rifabutin in Combination with Lopinavir-Ritonavir in
Patients with HIV Infection and Active Tuberculosis.
Boulanger C, Hollender E, Farrell K, et al 
Clin Infect Dis. 2009 Oct 6.
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
Clinical experience with the combined use of lopinavir/ritonavir and rifampicin.
L'homme RF, Nijland HM, Gras L, Aarnoutse RE, et al
AIDS. 2009 Apr 27;27(7):863-5
Abstract

A WEEK-IN-REVIEW FEATURED REPORT
High-Dose Lopinavir/Ritonavir in Highly Treatment-Experienced HIV-1 Patients:
Efficacy, Safety, and Predictors of Response.

Podzamczer D, King MS, Klein CE, et al
HIV Clin Trials. 2007 Jul-Aug;8(4):193-204.
Abstract

Treatment outcomes amongst previously antiretroviral-naive HIV-infected patients
starting lopinavir/ritonavir-containing antiretroviral regimens at the Royal Free
Hospital.

Smith C, Phillips A, Youle M, et al
HIV Med. 2007 Jan;8(1):55-63.
Abstract

 
LPV/Amprenavir   ,,,,,
 

 
Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy
for patients with HIV.

Young J, Bucher HC, Guenthard HF, et al  

Antivir Ther
.
2009;14(6):771-779.
Abstract

 

 

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Lopinavir/Ritonavir
Journal Papers/Abstracts/Commentaries:
Adolescent/Adult Combination Therapies