Medical Advocates

Lopinavir/Ritonavir (Kaletra/Aluvia)
 
Adolescent/Adult Journal Citations
Drug Comparison Trials

LPV/RTV/ATZ vs LPV/RTV/3TC       LPV/RTV/LMV vs LPV/RTV/2NRTIs  
LPV/RTV vs  Atazanavir                 LPV/RTV vs  Misc/Combinations
LPV/RTV vs  Efavirenz
LPV/RTV vs  Fosamprenavir
LPV/RTV vs  Indinavir
LPV/RTV vs 
Maraviroc
LPV/RTV vs  Nelfinavir  
LPV/RTV vs  Nevirapine
LPV/RTV vs  Saquinavir 
LPV/RTV vs  Tenofovir


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Last Update: August 27, 2016
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LPV/RTV/ATZ vs LPV/RTV/3TC
 

  FULL-TEXT ARTICLE
A Multicenter, Open Labeled, Randomized, Phase III Study Comparing Lopinavir/Ritonavir
Plus Atazanavir to Lopinavir/Ritonavir Plus Zidovudine and Lamivudine in Naive HIV-1-Infected
Patients: 48-Week Analysis of the LORAN Trial.

Ulbricht KU, Behrens GM, Stoll M, et al
Open AIDS J. 2011;5:44-50.
Paper

LPV/RTV/LMV vs LPV/RTV/2NRTIs
 

  Dual therapy with lopinavir and ritonavir plus lamivudine versus triple therapy with lopinavir and ritonavir plus two nucleoside reverse transcriptase inhibitors in antiretroviral-therapy-naive adults with HIV-1 infection: 48 week results of the randomised, open label, non-inferiority GARDEL trial.
Cahn P, Andrade-Villanueva J, Arribas JR,  et al
Lancet Infect Dis. 2014 Apr 25.

Abstract

LPV/RTV vs Atazanavir
 

 
Boosted lopinavir vs. boosted atazanavir-containing regimens and immunologic, virologic and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries.
Cain LE, Hernán MA; The HIV-CAUSAL Collaboration.

Clin Infect Dis
. 2015 Jan 6. pii: ciu1167
Abstract

Comparison of Body Composition Changes Between Atazanavir/Ritonavir and Lopinavir/Ritonavir Each in Combination with Tenofovir/Emtricitabine in Antiretroviral-Naïve Patients with HIV-1 Infection.
Moyle GJ, Hardy H, Farajallah A, et al

Clin Drug Investig
. 2014 Apr;34(4):287-96.
Abstract

Lopinavir/ritonavir, atazanavir/ritonavir, and efavirenz in antiretroviral-naïve HIV-1-infected individuals over 144 weeks: An open-label randomized controlled trial.
Andersson LM, Vesterbacka J, Blaxhult A,  et al
Scand J Infect Dis
. 2013 Jan
Abstract

Economic and Health-related Quality of Life (HRQL) Comparison of Lopinavir/ritonavir (LPV/r) and
Atazanavir plus Ritonavir (ATV+RTV) based Regimens for Antiretroviral Therapy (ART)-Naïve and -
Experienced United Kingdom (UK) Patients in 2011.
Simpson K, Baran R, Collomb D,  et al 
J Med Econ
. 2012 May 7.
Abstract

Post-exposure prophylaxis for HIV infection: a clinical trial comparing lopinavir/ritonavir versus
atazanavir each with zidovudine/lamivudine.
Diaz-Brito V, León A, Knobel H,  et al
Antivir Ther. 2011 Nov 25.

Abstract


The relation between treatment outcome and efavirenz, atazanavir or lopinavir
exposure in the NORTHIV trial of treatment-naïve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al 
Eur J Clin Pharmacol
. 2009 Dec 5.
Abstract

The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients.
Chetchotisakd P.
Expert Rev Anti Infect Ther. 2009 Sep;7(7):801-5.
Abstract

Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic
interaction and predictors of drug exposure.

Di Giambenedetto S, De Luca A, Villani P, et al
HIV Med. 2008 Apr;9(4):239-45.
Abstract

Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease
inhibitor failure: a randomized multinational trial.

Cohen C, Nieto-Cisneros L, Zala C, et al   
Curr Med Res Opin. 2005 Oct;21(10):1683-92.
Abstract


LPV/RTV vs Efavirenz

 

 
Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women.
Cohan D, Natureeba P, Koss CA, et al
AIDS
. 2014 Nov 25.
Abstract

Immunological function restoration with Lopinavir/ritonavir vs Efavirenz containing regimens in HIV infected patients: a randomized clinical trial.
Torres B, Rallón N, Loncá M,  et al
AIDS Res Hum Retroviruses. 2013 Dec 31
Abstract

A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine
clinical practice in Europe: a EuroSIDA study.
Reekie J, Reiss P, Ledergerber B, Sedlacek D, et al
HIV Med
. 2010 Aug 31
Abstract

The relation between treatment outcome and efavirenz, atazanavir or lopinavir
exposure in the NORTHIV trial of treatment-naïve HIV-1 infected patients.
Josephson F, Andersson MC, Flamholc L, et al 
Eur J Clin Pharmacol
. 2009 Dec 5.
Abstract

Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy
for patients with HIV.

Young J, Bucher HC, Guenthard HF, et al 
Antivir Ther
.
2009;14(6):771-779.
Abstract

Observational Study to Evaluate Clinical, Immunological, and Virological Outcomes
After First-Line Highly Active Antiretroviral Therapy With a Regimen Including
Either Efavirenz or Lopinavir-Ritonavir in Naive Patients in Clinical Practice.
Pérez-Elías MJ, Moreno A, Casado JL, et al
JIAPAC
2009 Aug 31.
Abstract

A 96-Week Comparison of Lopinavir-Ritonavir Combination Therapy Followed by Lopinavir-Ritonavir
Monotherapy versus Efavirenz Combination Therapy.
Cameron DW, da Silva BA, Arribas JR, et al
J Infect Dis. 2008 Jun 9.
Abstract
 

First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside
analogues: the SUSKA study, a non-randomized comparison from the VACH cohort.

Domingo P, Suárez-Lozano I, Torres F, et al 

Antimicrob Chemother.
2008 Mar 20
Abstract
 
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or
lopinavir-ritonavi rwith a backbone of two nucleoside reverse transcriptase inhibitors.

Panagopoulos P, Tsiodras S, Antoniadou A, et al 
Clin Microbiol Infect.
2006 May;12(5):486-9.
Abstract
 
Exploratory analysis for the evaluation of lopinavir/ritonavir-versus efavirenz-based
HAART regimens in antiretroviral-naive HIV-positive patients: results from the Italian
MASTER Cohort.

Torti C, Maggiolo F, Patroni A, et al
J Antimicrob Chemother. 2005 May 25
Abstract

First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy
for naive patients.

Manfredi R, Calza L, Chiodo F.

AIDS.
2004 Nov 19;18(17):2331-3.
Abstract


LPV/RTV vs Fosamprenavir

 

  The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in
combination with abacavir-lamivudine, for initial treatment of HIV infection over
48 weeks: a randomised non-inferiority trial.

Eron J Jr, Yeni P, Gathe J Jr, et al 
Lancet. 2006 Aug 5;368(9534):476-82.
Abstract

LPV/RTV vs Indinavir

 

 
Pharmacokinetics of Two Randomized Trials Evaluating the Safety and Efficacy of
Indinavir, Saquinavir and Lopinavir in Combination with Low-Dose Ritonavir: The
MaxCmin1 and 2 Trials.

Justesen US, Fox Z, Pedersen C, et al
Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):339-44.
Abstract

Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected
patients: immunovirological outcome and side effects.

Bongiovanni M, Bini T, Chiesa E, et al
 
Antiviral Res.
2004 Apr;62(1):53-6
Abstract


LPV/RTV vs Maraviroc

 

 
A randomized clinical trial comparing ritonavir-boosted lopinavir versus maraviroc each with tenofovir plus emtricitabine for post-exposure prophylaxis for HIV infection.
Leal L, León A, Torres B
J Antimicrob Chemother. 2016 Mar 18.

Paper
 

LPV/RTV vs Nelfinavir

 

 
A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine
clinical practice in Europe: a EuroSIDA study.
Reekie J, Reiss P, Ledergerber B, Sedlacek D, et al
HIV Med
. 2010 Aug 31
Abstract 

Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection
Walmsley S, Bernstein B, King M, et al.
N Engl J Med 2002 Jun 27;346(26):2039-46
Abstract 

 
 

LPV/RTV vs Nevirapine

 

 
FULL-TEXT ARTICLE
Nevirapine- Versus Lopinavir/Ritonavir-Based Initial Therapy for HIV-1 Infection among Women in Africa: A Randomized Trial.
Lockman S, Hughes M, Sawe F, et al 
PLoS Med
. 2012 Jun;9(6):e1001236.
Paper
 

LPV/RTV vs Saquinavir

 

A WEEK-IN-REVIEW FEATURED REPORT
Abstract
  Pharmacokinetics of Two Randomized Trials Evaluating the Safety and Efficacy of
Indinavir, Saquinavir and Lopinavir in Combination with Low-Dose Ritonavir: The
MaxCmin1 and 2 Trials.

Justesen US, Fox Z, Pedersen C, et al
Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):339-44.
Abstract
 

LPV/RTV vs Tenofovir

 

A WEEK-IN-REVIEW FEATURED REPORT
Abstract
  HIV-1 genital shedding in HIV-infected patients randomized to second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir.
Bunupuradah T, Bowonwattanuwong C, Jirajariyavej S,  et al 
Antivir Ther. 2014 Jan 24
Abstract

A randomized comparison of second-line lopinavir/ritonavir monotherapy vs. tenofovir/lamivudine/lopinavir/ritonavir in patients failing NNRTI-regimens: the HIV STAR study.
Bunupuradah T, Chetchotisakd P, Ananworanich J, et al
Antivir Ther
. 2012 Jul 2.
Abstract

Once-daily antiretroviral therapy among treatment-experienced Muslim patients fasting for the month of Ramadan.
Yakasai AM, Muhammad H, Babashani M, et al
Trop Doct
. 2011 Sep 13

Abstract


LPV/RTV vs Misc. Combinations

 

A WEEK-IN-REVIEW FEATURED REPORT
Abstract
 

FULL-TEXT PDF ARTICLE
Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).
Gianotti N, Galli L, Maserati R, Sighinolfi L, et al

New Microbiol
. 2016 Aug 23;39(3). [
Paper

FULL-TEXT ARTICLE
Comparable Long-Term Efficacy of Lopinavir/Ritonavir and Similar Drug-Resistance Profiles in Different HIV-1 Subtypes.
Grossman Z, Schapiro JM, Levy I, Elbirt D,  et al
PLoS One. 2014 Jan 27;9(1):e86239.

Paper

Ritonavir-boosted lopinavir plus nucleoside or nucleotide reverse transcriptase inhibitors versus ritonavir-boosted lopinavir plus raltegravir for treatment of HIV-1 infection in adults with virological failure of a standard first-line ART regimen (SECOND-LINE): a randomised, open-label, non-inferiority study.
SECOND-LINE Study Group, Boyd MA, Kumarasamy N, Moore CL, et al
Lancet
. 2013 Jun 15;381(9883)
:2091-9.
Abstract

A randomized comparison of second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir in patients failing NNRTI regimens: the HIV STAR study.
Bunupuradah T, Chetchotisakd P, Ananworanich, et al
Antivir Ther
. 2012 Oct 25.
Abstract

Comparative Effectiveness of Initial Antiretroviral Therapy Regimens: ACTG 5095 and 5142 Clinical Trials
Relative to ART-CC Cohort Study.
Mugavero MJ, May M, Ribaudo HJ,  et al
J Acquir Immune Defic Syndr. 2011 Aug 18
Abstract

 

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Lopinavir/Ritonavir
Journal Papers/Abstracts/Commentaries:
Adolescent/Adult Drug Comparison Strategies