Medical Advocates

Pegylated Interferon alfa-2a
(Pegasys)
 
HCV Indications

New and Noteworthy      HIV/HCV Coinfection
General Reports             Children
Pharmacokinetics          Pharmacoeconomics 
Viral Dynamics
Diagnostics
Efficacy
Adverse Events
Transplants
Treatment Strategies
Discontinuation of Therapy
Special Populations
Quality of Life

 

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Last Update:  March 27, 2018
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New and Noteworthy
     

March 2018

 


General Reports
 

      Journal Papers, Abstracts, and Commentaries

 
Patient characteristics associated with peglyated interferon alfa-2a induced neutropenia in chronic hepatitis C patients.|
Hindi NN, Saleh MI.|
Clin Exp Pharmacol Physiol
. 2018 Mar 25.
Abstract

Effects of Smoking on Pegylated Interferon alpha 2a and First Generation Protease Inhibitor-based Antiviral Therapy in Naďve Patients Infected with Hepatitis C Virus Genotype 1.
Zimmermann T, Hueppe D, Mauss S, et al
J Gastrointestin Liver Dis
. 2016 Mar;25(1):15-2
4.
Abstract

FULL-TEXT ARTICLE
A Predictive Model for Selecting Patients with HCV Genotype 3 Chronic Infection with a High Probability of Sustained Virological Response to Peginterferon Alfa-2a/Ribavirin.
Asselah T, Thompson AJ, Flisiak R
PLoS One. 2016 Mar 18;11(3):e0150569.
Paper

Hepatitis C Viral Kinetic Changes in a Retrospective Cohort Study of Chronic Hepatitis C Virus Egyptian Patients on Pegylated Interferon and Ribavirin Therapy.
Esmat GE, Al Akel W, Abdel Aziz RA, et al
J Interferon Cytokine Res. 2016 Mar;36(3):149-58
Abstract

Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C.
Morishima C, Shiffman ML, Dienstag JL, et al
Am J Gastroenterol
. 2012 Jun 12.
Abstract

Factor VIII and IX deficiencies related to acquired inhibitors in a patient with chronic hepatitis C virus infection receiving treatment with pegylated interferon plus ribavirin.
Campos-de-Magalhăes M, Eduardo Brandăo-Mello C, et al
Hematology
. 2011 Mar;16(2):80-5.
Abstract

Nitric oxide levels and sustained virological response to pegylated-interferon alpha2a plus ribavirin in
chronic HCV genotype 4 hepatitis: A prospective study.
Ibrahim M, Gomaa W, Ibrahim Y,  et al 
J Gastrointestin Liver Dis. 2010 Dec;19(4):387-92.
Abstract

HBsAg profiles in patients receiving peginterferon alfa-2a plus ribavirin for the treatment
of dual chronic infection with hepatitis B and C viruses.
Yu ML, Lee CM, Chuang WL,  et al
J Infect Dis
. 2010 Jul 1;202(1):86-92.

Abstract

Human leukocyte antigen alleles and the response to pegylated interferon/ribavirin
therapy in chronic hepatitis C patients.
Dai CY, Chuang WL, Hsieh MY, et al
Antiviral Res
. . [Epub ahead of print]
Abstract

Pharmacotherapy of chronic hepatitis C virus infection - the IDEAL trial: '2b or not 2b (= 2a),
that is the question?'
Toyoda H, Kumada T.
Expert Opin Pharmacother
. 2009 Nov 6.
Abstract

Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic
hepatitis C patients.
Dai CY, Huang JF, Hsieh MY, et al 
J Hepatol
. 2009 Feb 6.
Abstract
 

Weight affect relapse rates in latinos with genotype 2/3 chronic hepatitis C (CHC) treated with
peg IFN alfa-2a (Pegasys) 180 mcg/week and 800 mg daily of ribavirin for 24 weeks.
Rodríguez-Torres M, Ríos-Bedoya CF, et al
J Med Virol.
2008 Jul 22;80(9):1576-1580.
Abstract
 
The impact of combination therapy with peginterferon alfa-2a and ribavirin on the energy intake a
nd body weight of adult hepatitis C patients.
Hamer C.  
J Hum Nutr Diet.
2008 Jul 18
Abstract
 
Clinical trial: exposure to ribavirin predicts EVR and SVR in patients with HCV genotype 1 infection
treated with peginterferon alfa-2a plus ribavirin.

Bain VG, Lee SS, Peltekian K,  et al   
Aliment Pharmacol Ther.
2008 Apr 7
Abstract
 
Inflammatory markers neopterin and alanine aminotransferase in HCV patients treated with HCV NS3*4A protease
inhibitor telaprevir (VX-950) and/or peginterferon alfa-2a.

Gelderblom HC, Zeuzem S, Weegink CJ, et al 
Scand J Gastroenterol.
2008 Apr 10:1-6.
Abstract
 
Exploring differences in response to treatment with peginterferon alpha 2a (40kD) and ribavirin
in chronic hepatitis C between genotypes 2 and 3.

Powis J, Peltekian KM, Lee SS, et al
 J Viral Hepat
. 2008 Jan;15(1):52-7.
Abstract
 
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying
molecular pathways for treatment response.

Feld JJ, Nanda S, Huang Y, et al
Hepatolog
y. 2007 Oct 10;
Abstract
 
Nanomedicines in the treatment of chronic hepatitis C--focus on pegylated interferon alpha-2a.
Thomas T, Foster G.
Int J Nanomedicine. 2007;2(1):19-24.
Abstract
 
FULL-TEXT DOCUMENT
Adult systemic cat scratch disease associated with therapy for hepatitis C.
Bhatti Z, Berenson CS.
BMC Infect Dis. 2007 Feb 23;7:8.
Paper
 
Peginterferon alfa-2a: A review of approved and investigational uses.
Matthews SJ, McCoy C.

Clin Ther. 2004 Jul;26(7):991-1025.
Abstract
 
Pharmacokinetics
 

      Journal Papers, Abstracts, and Commentaries

  A Bayesian Approach for Population Pharmacokinetic Modeling of Pegylated Interferon α-2a in Hepatitis C Patients.
Saleh MI.
Clin Pharmacokinet
. 2017 Apr 10.
Abstract

The pharmacokinetics of peginterferon alfa-2a and ribavirin in African American, Hispanic and Caucasian patients with
chronic hepatitis C.
Brennan BJ, Morcos PN, Wang K,  et al
Aliment Pharmacol Ther
. 2012 May;35(10):1209-20
Abstract

Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: A meta-analysis of
individual patient data.
Camma C, Di Bona D, Schepis F, et al 
H
epatology. 2004 Feb;39(2):333-42.
Abstract


Viral Dynamics
 

      Journal Papers, Abstracts, and Commentaries

 
Early virologic response after peginterferon alpha-2a plus ribavirin or peginterferon alpha-2b
plus ribavirin treatment in patients with chronic hepatitis C.

Di Bisceglie AM, Ghalib RH, Hamzeh FM, Rustgi VK.
J Viral Hepat. 2007 Oct;14(10):72
Abstract
 
Utility of week-4 viral response to tailor treatment duration in hepatitis C virus genotype
3/HIV co-infected patients.

Crespo M, Esteban JI, Ribera E, et al
AIDS.
2007 Feb 19;21(4):477-481.
Abstract
 
Prediction of sustained virological response in chronic hepatitis C patients treated with
peginterferon alfa-2a (40KD) and ribavirin.

Foster GR, Fried MW, Hadziyannis SJ  
Scand J Gastroenterol.
2007 Feb;42(2):247-55.
Abstract

Pegylated interferon alpha therapy in acute hepatitis C: Relation to hepatitis C virus-specific
T cell response kinetics.
Kamal SM, Ismail A, Graham , et al
Hepatology. 2004 Jun;39(6):1721-31.
tract
 

  Prognostic factors and early predictability of sustained viral response with peginterferon alfa-2a
(40KD).
Lee S, Heathcote E, Reddy K,  et al
J Hepatol 2002 Oct;37(4):500

Abstract

Diagnostics
 

  Definition of rapid virologic response with a highly sensitive real-time PCR-based
HCV RNA assay in peginterferon alfa-2a plus ribavirin response-guided therapy.
Sarrazin C, Shiffman ML, Hadziyannis SJ, et al
J Hepatol
. 2010 Mar 15

Abstract

Efficacy
Transplants

Peg Interferon alfa-2a

      Journal Papers, Abstracts, and Commentaries
 

 
Predictors of Virological Response in 3,235 Chronic HCV Egyptian Patients Treated with Peginterferon Alpha-2a Compared with Peginterferon Alpha-2b Using Statistical Methods and Data Mining Techniques.
El Raziky M, Fathalah WF, Zakaria Z, et al
J Interferon Cytokine Res
. 2016 Feb 9.
Abstract

FULL-TEXT ARTICLE
Treatment of Naďve Patients with Chronic Hepatitis C Genotypes 2 and 3 with Pegylated Interferon Alpha and Ribavirin in a Real World Setting: Relevance for the New Era of DAA.
Heidrich B, Wiegand SB, Buggisch P,  et al
PLoS One
. 2014 Oct 10;9(10):e108751.
Paper

Pegylated Interferon-α2a With or Without Low-Dose Ribavirin for Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Receiving Hemodialysis: A Randomized Trial.
Liu CH, Huang CF, Liu CJ, et al
Ann Intern Med
. 2013 Dec 3;159(11):729-38.
Abstract

The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children
and Adolescents Chronic Hepatitis C.
Schwarz KB, Gonzalez-Peralta RP, Murray KF, et al
Gastroenterology
. 2010 Oct 28.
Abstract

Efficacy and tolerability of peginterferon alfa-2a or alfa-2b plus ribavirin in
the daily routine treatment of patients with chronic hepatitis C in Germany:
The PRACTICE Study.
Witthoeft T, Hueppe D, John C,  et al
J Viral Hepat
. 2010 Jul;17(7):459-68.
Abstract

Pegylated Interferons for the Treatment of Chronic Hepatitis C: Pharmacological and
Clinical Differences between Peginterferon-alpha-2a and Peginterferon-alpha-2b.
Foster GR. 
Drugs. 2010;70(2):147-65.
Abstract

Spotlight on peginterferon-alpha-2a (40 kD) plus ribavirin in the management of chronic hepatitis C mono-infection.
Keam SJ, Cvetković RS. 
BioDrugs
. 2009;23(1):63-8
Abstract

FULL-TEXT PDF ARTICLE
Symptomatic acute hepatitis C in Egypt: diagnosis, spontaneous viral clearance, and
delayed treatment with 12 weeks of pegylated interferon alfa-2a.

Sharaf Eldin N, Ismail S, et al  
PLoS ONE.
2008;3(12):e4085.
Paper
 

Four-week pegylated interferon alpha-2a monotherapy for chronic hepatitis C with genotype 2
and low viral load: A pilot, randomized study.
Tsubota A, Satoh K, Aizawa M, et al
World J Gastroenterol. 2008 Dec 21;14(47):7220-4
Abstract
 
Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial
treatment of chronic hepatitis C virus: Prospective, non-randomized study.

Escudero A, Rodríguez F, Serra MA, et al 
J Gastroenterol Hepatol. 2008 Apr 19
Abstract
 
Treatment extension to 72 weeks of peginterferon and ribavirin in hepatitis c genotype
1-infected slow responders.

Pearlman BL, Ehleben C, Saifee S.
Hepatology. 2007 Nov 28;46(6):1688-1694
Abstract
 
Peginterferon alfa-2a versus peginterferon alfa-2b as initial treatment of hepatitis C virus
infection: a cost-utility analysis from the perspective of the Veterans Affairs Health Care
system.

Yeh WS, Armstrong EP, Skrepnek GH, Malone DC.
Pharmacotherapy. 2007 Jun;27(6):813-24.
Abstract
 
A short course of pegylated interferon-alpha in acute HCV hepatitis.
Calleri G, Cariti G, Gaiottino F, et al  
J Viral Hepat.
2007 Feb;14(2):116-121.
Abstract

Peginterferon-alpha(2a) (40 kDa) for chronic hepatitis C.
Hadziyannis SJ, Papatheodoridis GV.
Expert Opin Pharmacother 2003 Apr;4(4):541-551
Abstract

Peginterferon alfa-2a (40KD) (Pegasys) for the treatment of patients with chronic hepatitis C.
Ferenci P.
Int J Clin Pract. 2003 Sep;57(7):610-5.
Abstract
 

Peg Interferon alfa-2a/Ribavirin

      Journal Papers, Abstracts, and Commentaries
 

 
Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection
Megahed A, Salem N, Fathy A, et al
World J Pediatr
. 2017 Jan 27
.
Abstract

Optimisation of triple therapy for patients with chronic hepatitis C: a systematic review.
Pecoraro V, Cariani E, Villa E, Trenti T.
Eur
J Clin Invest. 2016 Aug;46(8):737-48.
Abstract

Peginterferon alfa-2a plus Weight-Based or Flat-Dose Ribavirin for Treatment-Naďve Hepatitis C Virus Genotype 2 Rapid Responders: A Randomized Trial.
Liu CH, Huang CF, Liu CJ,  et al
Sci Rep
. 2015 Oct 15;5:15255.
Abstract

Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: Prospective study of a chronic hepatitis C cohort.
Whale R, Fialho R, Rolt M, Eccles J,  et al  
J Psychosom Res
. 2015 Jun 18
Abstract

Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: final analysis from the PROPHESYS cohort.
Aronsohn A, Ancuta I, Caruntu F,  et al
J Viral Hepat
. 2013 Oct 17.
Abstract

Faldaprevir combined with peginterferon alfa-2a and ribavirin in treatment-naďve patients with chronic genotype-1 HCV: SILEN-C1 trial.
Sulkowski MS, Asselah T, Lalezari J,  et al
Hepatology
. 2013 Jan 28.
Abstract

FULL-TEXT PDF ARTICLE
Prediction of response to pegylated-interferon-ż and ribavirin therapy in Chinese patients infected with different hepatitis C virus genotype.
Guo X, Zhao Z, Xie J, et ak
Virol J. 2012 Jun 19;9(1):123.
Paper

Randomized controlled trial of pegylated interferon-alfa 2a and ribavirin in treatment-naive chronic
hepatitis C genotype 6.
Lam KD, Trinh HN, Do ST,  et al
Hepatology
. 2010 Nov;52(5):1573-80.
Abstract

Intensified peginterferon alfa-2a/ribavirin therapy for patients with HCV genotype 1,
weight >/=85 kg and high viral load: randomized trial.|
Reddy KR, Shiffman ML, Rodriguez-Torres M,, et al
Gastroenterology
.
2010 Sep 2
Abstract

Individualized respond guidance treatment of chronic hepatitis C with combination of
peginterferon a-2a and ribavirin.
Chen WL, Chen XP, Chen XF, et al

Zhonghua Gan Zang Bing Za Zhi
. 2010 Aug;18(8):585-9
Abstract

A sustained virologic response is durable in patients with chronic hepatitis C
treated with peginterferon alfa-2a and ribavirin.
Swain MG, Lai MY, Shiffman ML, et al
Gastroenterolog
y
. 2010 Jul 13.
Abstract

High rates of sustained virological response in hepatitis C virus-infected injection drug users
receiving directly observed therapy with peginterferon alpha-2a (40KD) (PEGASYS)
and once-daily ribavirin.
Waizmann M, Ackermann G. 
J Subst Abuse Trea
t
. 2010 Mar 31
Abstract

Effect of HCV RNA suppression during peginterferon Alfa-2a maintenance therapy on clinical outcomes
in the HALT-C trial.
Shiffman ML, Morishima C, Dienstag JL, et al  
Gastroenterology
. 2009 Dec;137(6):1986-94.
Abstract

Peginterferon Alpha-2a Plus Ribavirin is More Effective than Peginterferon Alpha-2b Plus Ribavirin
for Treating Chronic Hepatitis C Virus Infection.
Ascione A, De Luca M, Tartaglione MT,  et al
Gastroenterology. 2009 Oct 20.
Abstract

Randomized Study of Peginterferon-alpha2a Plus Ribavirin Versus Peginterferon-alpha2b Plus Ribavirin
in Chronic Hepatitis C.
Rumi M, Aghemo A, Prati GM, et al  |
Gastroenterology
. 2009 Sep 17
Abstract

Effect of HCV RNA Suppression During Peginterferon Alfa-2A Maintenance Therapy on Clinical
Outcomes in the HALT-C Trial.
Shiffman ML, Morishima C, Dienstag JL,  et al
Gastroenterology. 2009 Sep 9.
Abstract

FULL-TEXT PDF ARTICLE
Assessment of the efficacy of reducing peginterferon alfa-2a and ribavirin dose on
virologic response in koreans with chronic hepatitis C.

Kwon JH, Bae SH, Choi JY, et al
Korean J Intern Med. 2009 Sep;24(3):203-11
Paper

Peginterferon alfa-2a (40kDa) and ribavirin: comparable rates of sustained virological response
in sub-sets of older and younger HCV genotype 1 patients.
Reddy KR, Messinger D, Popescu M, Hadziyannis SJ.
J Viral Hepat
. 2009 Mar 25
Abstract

Eradication of hepatitis C virus after a 5-week treatment
Gaundong Mbéthé GL, Foucher J, Deledinghen V, Couzigou VP.
Rev Med Interne. 2009 May 18.
Abstract

Treatment of hepatitis C virus carriers with persistently normal alanine aminotransferase levels
with peginterferon alpha-2a and ribavirin: a multicentric study.
Puoti C, Pellicelli AM, Romano M, et al 
Liver Int
. 2009 Apr 17.
Abstract

Pegylated interferon {alpha}2a plus ribavirin versus pegylated interferon {alpha}2b plus ribavirin for the
treatment of chronic hepatitis C in HIV-infected patients.
Berenguer J, González-García J, López-Aldeguer J, et al
J
Antimicrob Chemother
. 2009 Apr 10
Abstract

Pegylated interferon {alpha}2a plus ribavirin versus pegylated interferon {alpha}2b plus ribavirin for the
treatment of chronic hepatitis C in HIV-infected patients.
Berenguer J, González-García J, López-Aldeguer J, et al
J
Antimicrob Chemother
. 2009 Apr 10
Abstract

Factors affecting early viral load decline of Asian chronic hepatitis C patients receiving pegylated interferon plus
ribavirin therapy.
Hsu CS, Liu CH, Liu CJ, et al 
Antivir Ther
. 2009;14(1):45-54.
Abstract

Peginterferon and ribavirin in HCV: improvement of sustained viral response.
Ferenci P.  
Best Pract Res Clin Gastroenterol. 2008;22(6):1109-22.
Abstract
 

FULL-TEXT ARTICLE
Pegylated interferon 2a and 2b in combination with ribavirin for the treatment of chronic hepatitis C in
HIV infected patients.
Dhillon R, Rossi S, Herrine SK.
Ther Clin Risk Manag. 2008 Aug;4(4):789-96.
Paper
 
Peginterferon alfa-2a relapse rates depend on weight-based ribavirin dosage in HCV-infected
patients with genotype 1: Results of a retrospective evaluation.
Zopf S, Herold C, Hahn EG, Ganslmayer M.  
Scand J Gastroenterol
. 2008 Dec 31:1-5.
Abstract
 
Efficacy and safety of peginterferon alpha-2a/ribavirin in treatment-naive Cameroonian patients with
chronic hepatitis C.
Njouom R, Sartre MT, Timba I,  et al  
J Med Virol
. 2008 Dec;80(12):2079-85.
Abstract
 

Swiss Multicenter Study Evaluating the Efficacy, Feasibility and Safety of Peginterferon-Alfa-2a
and Ribavirin in Patients with Chronic Hepatitis C in Official Opiate Substitution Programs.
Fried R, Monnat M, Seidenberg A, et al 
Digestion. 2008 Nov 21;78(2-3):123-130
Abstract
 
 

Peg Interferon alfa-2a/Ribavirin/Rituximab

      Journal Papers, Abstracts, and Commentaries 

 
  Rituximab plus Peg-Interferon {alpha} /ribavirin compared to Peg- Interferon
{alpha} /ribavirin in Hepatitis C related mixed cryoglobulinemia.
Saadoun D, Resche Rigon M, et al
Blood
. 2010 May
Abstract

Peg Interferon alfa-2a vs Standard Interferon alfa-2a

    Journal Papers, Abstracts, and Commentaries
 

 
Peginterferon vs. standard interferon in the treatment of chronic hepatitis C.
Zaman A, Fennerty MB, Keeffe EB.
Aliment Pharmacol Ther. 2003 Oct;18(7):661-70.
Abstract

Efficacy and safety of two-dose regimens of peginterferon alpha-2a compared with interferon
alpha-2a in chronic hepatitis C: a multicenter, randomized controlled trial.
Pockros PJ, Carithers R, Desmond P, et al  
Am J Gastroenterol.
2004 Jul;99(7):1298-305.
Abstract


Transplants
 

      Journal Papers, Abstracts, and Commentaries

 
An escalating dose regimen of pegylated interferon and ribavirin in HCV cirrhotic patients referred
for liver transplant.
Massoumi H, Elsiesy H, Khaitova V, et al
Transplantation
. 2009 Sep 15;88(5):729-35.
Abstract

A randomised trial of pegylated-interferon-alpha-2a plus ribavirin with or without amantadine
in treatment-naďve or relapsing chronic hepatitis C patients.
Langlet P, D'Heygere F, Henrion J, Adler M, et al
Aliment Pharmacol Ther. 2009 May 26.
Abstract

The treatment of chronic hepatitis C with peginterferon alfa-2a (40kDa) plus ribavirin in
haemodialysed patients awaiting renal transplant.

Rendina M, Schena A, Castellaneta NM, et al
J Hepatol. 2007 Feb 5;
Abstract


Adverse Events
 

      Journal Papers, Abstracts, and Commentaries

 
Late-Onset Immune Thrombocytopenic Purpura After Withdrawal of Interferon Treatment for Chronic Hepatitis C Infection: A Case Report.
H
siao CH, Tseng KC, Tseng CW, Tung CH.
Medicine (
Baltimo
re). 2015 Aug;94(34):e1296.
bstract

FULL-TEXT PDF ARTICLE
Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report.
Popescu C, Arama V, Gliga S.
BMC Gastroenterol. 2011 Mar 31;11(1):30
Paper

Cognitive function does not worsen during long-term low-dose peginterferon therapy
in patients with chronic hepatitis C.
Fontana RJ, Bieliauskas LA, Back-Madruga C, et al
Am J Gastroenterol
. 2010 Jul;105(7):1551-60.
Abstract

Peripheral polyneuropathy and bilateral optic neuropathy during treatment of chronic hepatitis C
Chrissafidou A, Musch E.
Dtsch Med Wochenschr
. 2009 Apr;134(18):927-30.
Abstract
 

Pneumonitis as A Consequence of (Peg)Interferon-Ribavirin Combination Therapy for Hepatitis C:
a Review of the Literature.
Slavenburg S, Heijdra YF, Drenth JP.
Dig Dis Sci. 2009 Apr 28.
Abstract

Bacterial infection and neutropenia during peginterferon plus ribavirin combination therapy
in patients with chronic hepatitis C with and without baseline neutropenia in clinical practice.
Yang JF, Hsieh MY, Hou NJ, et al 
Aliment Pharmacol Ther
. 2009 Feb 7
Abstract
 

Pegylated interferon alpha and ribavirin therapy may induce working memory disturbances in
chronic hepatitis C patients.
Pawelczyk T, Pawelczyk A, Strzelecki D, Rabe-Jablonska J.
Gen Hosp Psychiatry
. 2008 Nov-Dec;30(6):501-8.
Abstract
 
Prospective study of bone mineral density and metabolism in patients with chronic hepatitis C during
pegylated interferon alpha and ribavirin therapy.
Hofmann WP, Kronenberger B, Bojunga J, et al  
J Viral Hepat.
2008 Jul 28.
Abstract
 
Incidence of Neutropenia and Infections During Combination Treatment of Chronic
Hepatitis C with Pegylated Interferon Alfa-2a or Alfa-2b Plus Ribavirin.
Antonini MG, Babudieri S, Maida I, et al 
Infection.
2008 May 3
Abstract
 
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and
ribavirin.

Vartany E, Caldwell CA, Trow TK. 
Heart Lung.
2008 Mar-Apr;37(2):153-6.
Abstract
 
Bacterial endocarditis in the course of sepsis in 7th month of treatment with peginterferon alfa
and ribavirin in patient with chronic hepatitis C

Bolewska B, Juszczyk J, Wojtacha A.
Wiad Lek. 2007;60(9-10):462-5.
Abstract
 
Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a
therapy for chronic hepatitis C virus infection.
Khiani V, Kelly T, Shibli A, et a
World J Gastroenterol.
2008 Jan 14;14(2):318-21.
Abstract
 
Severe stomatitis complicating treatment with pegylated-interferon alpha-2a and ribavirin in an
HCV-infected patient.

Borrás-Blasco J, Primo J, Rosique-Robles JD, et al  
South Med J.
2008 Jan;101(1):88-90.
Abstract
 
Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a
therapy for chronic hepatitis C virus infection.
Khiani V, Kelly T, Shibli A, et al
World J Gastroenterol.
2008 Jan 14;14(2):318-21

Abstract
 
Severe stomatitis complicating treatment with pegylated-interferon alpha-2a and ribavirin in an
HCV-infected patient.

Borrás-Blasco J, Primo J, Rosique-Robles JD, et al  
South Med J.
2008 Jan;101(1):88-90.
Abstract
 
De novo depression and anxiety disorders and influence on adherence during
peginterferon-alpha-2a and ribavirin treatment in patients with hepatitis C.

Martín-Santos R, Díez-Quevedo C, Castellví P, et al 
Aliment Pharmacol Ther
. 2007 Nov 6
Abstract
 

Treatment Strategies
 

     Journal Papers, Abstracts, and Commentaries
 
 
FULL-TEXT ARTICLE
Benefit of Treatment Individualization in Patients with Chronic Hepatitis C Receiving Peginterferon Alfa-2a and Ribavirin in a Large Noninterventional Cohort Study.
Hofmann WP, Mauss S, Lutz T, et al
PLoS One
. 2015 Jul 31;10(7):e0134839.
Paper

Real-life experience with first generation HCV protease inhibitor therapy in Germany: The prospective, non-interventional PAN cohort.
Mauss S, Böker K, Buggisch P, et al
Z Gastroenterol
. 2015 Jul;53(7):644-654.

Abstract

Peg-IFNαRibavirin/Protease inhibitor combination in severe hepatitis C virus associated mixed cryoglobulinemia vasculitis.
Saadoun D, Resche Rigon M, Pol S,  et al J
 Hepatol
. 2014 Aug 15.
Abstract

The comparison of the efficacy of pegylated interferon α-2a and α-2b in chronic hepatitis C patients with genotype 1.
Dogan UB, Atabay A, Akin MS, Yalaki S.
Eur J Gastroenterol Hepatol. 2013 Mar 20
Abstract

High-Dose Pegylated Interferon Alfa and Ribavirin in Non-responder Hepatitis C Patients and Relationship with IL28B Genotype (SYREN Trial).
Chevaliez S, Hézode C, Soulier A,  et al
Gastroenterology. 2011 Mar 23.
Abstract

Low-dose peginterferon alfa-2a (40KD) is safe and produces a SVR in Patients with chronic
hepatitis C and End-Stage Renal Disease.
Peck-Radosavljevic M, Boletis J, Besisik F, Ferraz ML, et al
Clin Gastroenterol Hepatol
. 2010 Nov 4
Abstract

Intensified Peginterferon Alfa-2a/Ribavirin Therapy for Patients With HCV Genotype 1,
Weight ≥85 kg, and High Viral Load: Randomized Trial.
Reddy KR, Shiffman ML, Rodriguez-Torres M, et al 
Gastroenterology
. 2010 Sep 29.
Abstract

Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha2b:
a randomized trial.
Jensen DM, Marcellin P, Freilich B, et al 
Ann Intern Med
. 2009 Apr 21
Abstract

Re-treatment with peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have
relapsed or not responded to a first course of pegylated interferon-based therapy.
Yoshida EM, Sherman M, Bain VG, et al 
Can J Gastroenterol. 2009 Mar;23(3):180-184.
Abstract

HCV Response in Patients With End Stage Renal Disease Treated With Combination
Pegylated Interferon alpha-2a and Ribavirin.
Hakim W, Sheikh S, Inayat I, et al
J Clin Gastroenterol
. 2009 Jan 12.
Abstract
 

Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon.
Di Bisceglie AM, Shiffman ML, Everson GT ,et al
N Engl J Med
. 2008 Dec 4;359(23):2429-41.
Abstract
 
Optimizing dosage and duration therapy for chronic hepatitis C difficult-to-treat patients.
Ladero JM.
Ann Hepatol
. 2008 Oct-Dec;7(4):392-4.
Abstract
 
Swiss Multicenter Study Evaluating the Efficacy, Feasibility and Safety of Peginterferon-Alfa-2a and Ribavirin
in Patients with Chronic Hepatitis C in Official Opiate Substitution Programs.
Fried R, Monnat M, Seidenberg A, et al 
Digestion
. 2008 Nov 21;78(2-3):123-130
Abstract
 
Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks
in chronic hepatitis C virus-1 infection.

von Wagner M, Hofmann WP, Teuber G, et al
Hepatology. 2008 Jun 19.
Abstract
 
Improved outcomes in patients with hepatitis C with difficult-to-treat characteristics: Randomized study
of higher doses of peginterferon alpha-2a and ribavirin.
Fried MW, Jensen DM, Rodriguez-Torres M, et al
Hepatology. 2008 Jun 9.
Abstract
 
Clinical trial: individualized treatment duration for hepatitis C virus genotype 1 with peginterferon-alpha 2a plus
ribavirin.

Tang KH, Herrmann E, Pachiadakis I, et al
Aliment Pharmacol Ther
. 2008 May;27(9):810-9
Abstract

Safety, tolerability, and efficacy of pegylated-interferon alfa-2a plus ribavirin in hcv-related
decompensated cirrhotics.

Tekin F, Gunsar F, Karasu Z, et al  
Aliment Pharmacol Ther
. 2008 Mar 14
Abstract
 

Long-Term Efficacy of Pegylated Interferon Alpha-2a in HCV-Positive Hemodialysis Patients.
Uçmaky H, Kökoğlu OF, Hosoglu S, et al  
Ren Fail
. 2008;30(2):227-32.
Abstract
 
Efficacy and safety of pegylated-interferon alpha-2a in hemodialysis patients with chronic
hepatitis C.

Ayaz C, Celen MK, Yuce UN, Geyik MF. et al 
World J Gastroenterol.
2008 Jan 14;14(2):255-9.
Abstract
 

Discontinuation of Therapy
 

 
Early discontinuation of ribavirin in HCV-2 and HCV-3 patients responding to Peg-interferon
alpha-2a and ribavirin.
Andriulli A, Cursaro C, Cozzolongo R, et al 
J Viral Hepat.
2008 Aug 28.
Abstract

Discontinuation of pegylated interferon plus ribavirin in patients who are not responding to
therapy - patients' views of early cessation of therapy.
D'Souza R, Main J, Crossey M, et al
Aliment Pharmacol Ther. 2005 Jan 1;21(1):43-7.
Abstract


Special Populations
 

 
Long-term Pegylated Interferon-α-2a Treatment for Chronic Hepatitis C in an Elderly Renal Transplant Recipient: Case Report and Literature Review.
Zheng M, Chen Y.
Medicine
(Baltimore)
. 2015 Jan;94(1):e390
Abstract

The clinical effectiveness and cost-effectiveness of peginterferon alfa and ribavirin for the treatment of chronic hepatitis C in children and young people: a systematic review and economic evaluation.
Hartwell D, Cooper K, Frampton GK,  et al
Health Technol Assess. 2014 Oct;18(65):i-xxii, 1-202
Abstract

Peginterferon alfa-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 2 receiving haemodialysis: a randomised trial.
Liu CH, Liu CJ, Huang CF,  et al
Gut
.
2014 Apr 19.
Abstract

Peginterferon alpha-2a and ribavirin treatment of patients with haemophilia and
hepatitis C virus infection: a single-centre study of 367 cases.
Alavian SM, Tabatabaei SV, Keshvari M,  et al
Liver Int
. 2010 Jul 8
Abstract

Peginterferon alpha-2a Plus Ribavirin in Latino and Non-Latino Whites With
HCV Genotype 1: Histologic Outcomes and Tolerability From the LATINO Study.
Balart LA, Lisker-Melman M, Hamzeh FM, et al
Am J Gastroenterol. 2010 Apr 13
Abstract

HCV Response in Patients With End Stage Renal Disease Treated With Combination
Pegylated Interferon alpha-2a and Ribavirin.
Hakim W, Sheikh S, Inayat I, et al
J Clin Gastroenterol. 2009 Jan 12.
Abstract


Quality of Life Studies
 

  The impact of peginterferon alfa-2a plus ribavirin combination therapy on health-related quality
of life in chronic hepatitis C.

Hassanein T, Cooksley G, Sulkowski M, et al
J Hepatol. 2004 Apr;40(4):675-81.
Abstract
 
Comparison of quality of life, work productivity and medical resource utilization of peginterferon
alpha 2a vs the combination of interferon alpha 2b plus ribavirin as initial treatment in patients
with chronic hepatitis C.
Perrillo R, Rothstein KD, Rubin R, ET AL
J Viral Hepat. 2004 Mar;11(2) :157-65
Abstract

Pharmacoeconomics
 

 
A health economic model to assess the cost-effectiveness of pegylated interferon alpha-2a and
ribavirin in patients with moderate chronic hepatitis C and persistently normal alanine
aminotransferase levels.

Gerkens S, Nechelput M, Annemans L, et al
Acta Gastroenterol Belg. 2007 Apr-Jun;70(2):177-87.
Abstract
 
Cost comparison of two combination therapies with peginterferon alfa and ribavarin for the
treatment of hepatitis C
Telser H, Mulhaupt B, Helbling B, Zweifel P. 
Schweiz Rundsch Med Prax.
2005 Aug 10;94(32):1207-14.
Abstract


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