Medical Advocates
Saquinavir (Fortovase/Invirase)
 
Journal Citations;
Drug/Drug Interactions

General Reports
 Darunavir
Lopinavir/r
Mefloquine
 Methadone
 Rifabutin
 Rifampicin

 
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Last Update:  October 10, 2016
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General Reports
 
 
Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression
and disrupts blood-brain barrier integrity.
 Manda VK, Mittapalli RK, Geldenhuys WJ, Lockman PR.J
Neurochem. 2010 Aug 12
 Abstract

Insight into analysis of interactions of saquinavir with HIV-1 protease in comparison between
the wild-type and G48V and G48V/L90M mutants based on QM and QM/MM calculations.
 Saen-Oon S, Aruksakunwong O, Wittayanarakul K, et al  
 J Mol Graph Model. 2007 May 3;
 Abstract
   
  Interaction between saquinavir and antimycotic drugs on C. albicans and C. neoformans
strains.
 Casolari C, Rossi T, Baggio G, et al  
 Pharmacol Res. 2004 Dec;50(6):605-610
 Abstract
Darunavir
 
  Pharmacokinetic Interaction Between Darunavir and Saquinavir in HIV-negative Volunteers.
 Sekar VJ, Lefebvre E, Mariën K, et al 
Ther Drug Monit. 2007 Dec;29(6):795-801
Abstract
Lopinavir/r
 
  No Significant Influence of Saquinavir Hard-Gel Capsule Administration on Pharmacokinetics
of Lopinavir in Combination With Ritonavir: A Population Approach.
 Dailly E, Gagnieu MC, Allavena C, Raffi F, Jolliet P.
Ther Drug Monit. 2005 Dec;27(6):782-784.
 Abstract
Mefloquine
 
  In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with
mefloquine.
 Owen A, Janneh O, Hartkoorn RC, et al   
 J Pharmacol Exp Ther. 2005 Sep;314(3):1202-9.
Abstract
Methadone
 
  The effects of once-daily saquinavir/minidose ritonavir on the pharmacokinetics of methadone.
 Shelton MJ, Cloen D, DiFrancesco R, et al 
J Clin Pharmacol. 2004 Mar;44(3):293-304.
 Abstract
Rifabutin
 
  Interaction between saquinavir soft-gel and rifabutin in patients infected with HIV.
 Moyle GJ, Buss NE, Goggin T, et al.
Br J Clin Pharmacol 2002 Aug;54(2):178-82
 Abstract
Rifampicin
 
  Pharmacokinetic interaction between rifampicin and the once-daily combination of saquinavir and
low-dose ritonavir in HIV-infected patients with tuberculosis.
 Ribera E, Azuaje C, Lopez RM, et al
J Antimicrob Chemother. 2007 Feb 16;
 Abstract
 
Predictive value of drug levels, HIV genotyping, and the genotypic inhibitory quotient (GIQ) on
response to saquinavir/ritonavir in antiretroviral-experienced HIV-infected patients.
 Valer L, Mendoza CD, Soriano V.
Med Virol. 2005 Oct 27;77(4):460-464
 Abstract

Drug monitoring and viral response to Lopinavir/Ritonavir or Saquinavir/Ritonavir containing
regimens in individuals infected with the human immunodeficiency virus type 1.
 Falkensammer B, Fasser W, Scherer K, et al 
Int J Immunopathol Pharmacol. 2005 January-March;18(1):145-154
 Abstract
 
Determination of saquinavir and ritonavir in human plasma by reversed-phase high-
performance liquid chromatography and the analytical error function.
 Albert V, Modamio P, Lastra CF, Marino EL.
J Pharm Biomed Anal. 2004 Nov 19;36(4):835-840.
 Abstract
 

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