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Stavudine (Zerit)
 
Journal Citations: Adverse Events

General Reports  
Cutaneous Disorders
 Guillain-Barre Syndrome
Gynecomastia
 Hepatic Disorders
Metabolic Disorders
Mitochondrial Disorders
Neuropathy
Pancreatitis
Renal Disorders
NRTI Adverse Events
 
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General Reports
         
 
Development of Severe Anemia and Changes in Hemoglobin in a Cohort of HIV-Infected Ugandan Adults Receiving Zidovudine-, Stavudine-, and Tenofovir-Containing Antiretroviral Regimens.
Parkes-Ratanshi R, Katende D,  et al
 J Int Assoc Provid AIDS Care. 2014 Nov 25
 Abstract

Peripheral Blood Mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) Ratio as a Marker of Mitochondrial Toxicities of Stavudine Containing Antiretroviral Therapy in HIV-Infected Malawian Patients.
Kampira E, Dzobo K, Kumwenda J, et al
OMICS. 2014 May 9.
 Abstract

Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.
 Chagoma N, Mallewa J, Kaunda S,  et al
Trans R Soc Trop Med Hyg. 2013 Aug
Abstract
The early effects of stavudine compared with tenofovir on adipocyte gene expression, mitochondrial DNA copy number
and metabolic parameters in South African HIV-infected patients: a randomized trial.
Menezes C, Duarte R, Dickens C,  et al
HIV Med. 2012 Oct 4.
Abstract

FULL=TEXT ARTICLE
Stavudine Toxicity in Adult Longer-Term ART Patients in Blantyre, Malawi.
 van Oosterhout JJ, Mallewa J, Kaunda S,  et al
PLoS One. 2012;7(7):e42029.
Paper

FULL-TEXT ARTICLE
 Incidence of treatment-limiting toxicity with Stavudine-based antiretroviral therapy in Cambodia:
a retrospective cohort study.
 Phan V, Thai S, Choun K,  et al
PLoS One. 2012;7(1):e30647
 Paper

A WEEK-IN-REVIEW FEATURED REPORT
FULL-TEXT PDF ARTICLE
 A longitudinal study of stavudine-associated toxicities in a large cohort of South African
HIV infected subjects.
 Menezes CN, Maskew M, Sanne I, et al 
BMC Infect Dis. 2011 Sep 17;11(1):244
 Paper

Lactic acidosis associated with severe neuromuscular weakness and stavudine therapy.
 Vorasayan P, Phanthumchinda K.
J Med Assoc Thai. 2011 Apr;94(4):501-4.
 Abstract

Stavudine Toxicity in Women Is the Main Reason for Treatment Change in a
3-Year Prospective Cohort of Adult Patients Started on First-Line Antiretroviral
Treatment in Uganda.
 Castelnuovo B, Kiragga A, Kamya MR, Manabe Y.
J Acquir Immune Defic Syndr. 2010 Sep 21.
/b> Abstract

Stavudine- and nevirapine-related drug toxicity while on generic fixed-dose antiretroviral
treatment: incidence, timing and risk factors in a three-year cohort in Kigali, Rwanda.
van Griensven J, Zachariah R, Rasschaert F, et al
Trans R Soc Trop Med Hyg. 2009 Sep 2
 Abstract

Effect of Reducing the Dose of Stavudine on Body Composition, Bone Density, and Markers of
Mitochondrial Toxicity in HIV-Infected Subjects: A Randomized, Controlled Study.
 McComsey GA, Re Iii VL, O'Riordan M, et al 
Clin Infect Dis. 2008 Apr 15;46(8):1290-1296
 Abstract

New questions about an old combination--ddI + d4T.
 Proj Inf Perspect 2003 Jan;(35):13-4
 Abstract
   
  Adherence, side effects and efficacy of stavudine plus lamivudine plus nelfinavir in treatment-
experienced HIV-infected patients.
Roca B, Gomez CJ, Arnedo A
J Infect 2000 Jul;41(1):50-4
 Abstract
Cutaneous Disorders
       
  Long-term subcutaneous tissue changes among antiretroviral-naive persons initiating stavudine, zidovudine,
or abacavir with lamivudine.
 Shlay JC, Sharma S, Peng G, et al 
J Acquir Immune Defic Syndr. 2008 May 1;48(1):53-62.
 Abstract
Guillain-Barre Syndrome
         
 

Miller fisher variant of guillain-barre syndrome associated with lactic acidosis and Stavudine therapy.
 Shah SS, Rodriguez T, McGowan JP. et al
 Clin Infect Dis 2003 May 15;36(10):E131-3
 Abstract

  
Gynecomastia  
   
  Gynaecomastia in a male patient during stavudine and didanosine treatment for HIV infection.
Aquilina C, Viraben R.
Int J STD AIDS 2001 Jul;12(7):481-2
 Abstract		  
Hepatic Disorders
         
 
Abstract

FULL TEXT PDF ARTICLE
 Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity:
A case report.
 Lapadula G, Izzo I, Costarelli S, et al
J Med Case Reports. 2007 May 8;1(1):19
Paper
 
Depletion of mitochondrial DNA in liver under antiretroviral therapy with didanosine, stavudine, or
zalcitabine.
Walker UA, Bauerle J, Laguno M, et al. 
Hepatology. 2004 Feb;39(2):311-7.
 Abstract
 
Miller fisher variant of guillain-barre syndrome associated with lactic acidosis and Stavudine therapy.
 Shah SS, Rodriguez T, McGowan JP. et al
 Clin Infect Dis 2003 May 15;36(10):E131-3
 Abstract
 
Hypothyroidism
         
  Increased Prevalence of Hypothyroidism among Human Immunodeficiency Virus-Infected Patients:
A Need for Screening.
 Beltran S, Lescure FX, Desailloud R, et al.
Clin Infect Dis. 2003 Aug 15;37(4):579-83.
Abstract
Mitochondrial Disorders
         
 
Effects of a Nucleoside Reverse Transcriptase Inhibitor, Stavudine, on Glucose Disposal and
Mitochondrial Function in Muscle of Healthy Adults.
 Fleischman A, Johnsen S, Systrom DM, et al 
Am J Physiol Endocrinol Metab. 2007 Feb 6;
 Abstract
 
Drug-induced increased mitochondrial biogenesis in a liver biopsy.
 Kamal MA, French SW. 
Exp Mol Pathol. 2004 Dec;77(3):201-4.
 Abstract
Neuropathy
 
 
FULL-TEXT ARTICLE
 Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy.
 Domingo P, Cabeza Mdel C,  et al
PLoS One. 2013;8(2):e57347
 Paper

HIV Neuropathy Risk Factors and Symptom Characterization in Stavudine-Exposed
South Africans.
 Wadley AL, Cherry CL, Price P, Kamerman PR.
J Pain Symptom Manage. 2010 Dec 7
 Abstract

Age and height predict neuropathy risk in patients with HIV prescribed stavudine.
 Cherry CL, Affandi JS, Imran D, et al 
Neurology. 2009 Jul 28;73(4):315-20
 Abstract

Can We Predict Neuropathy Risk before Stavudine Prescription in a Resource-Limited Setting?
 Affandi JS, Price P, Imran D, et al
AIDS Res Hum Retroviruses. 2008 Oct 6.
 Abstract

Peripheral neuropathy during stavudine-didanosine antiretroviral therapy.
Reliquet V, Mussini JM, Chennebault JM, et al  
 HIV Med 2001 Apr;2(2):92-6
Abstract
Pancreatitis
 
  FULL-TEXT ARTICLE
 Association of Thymidylate Synthase Polymorphisms with Acute Pancreatitis and/or Peripheral Neuropathy in HIV-Infected Patients on Stavudine-Based Therapy.
 Domingo P, Cabeza Mdel C,  et al
PLoS One. 2013;8(2):e57347
 Paper

Drug-induced acute pancreatitis: a personal contribution
Battillocchi B, Diana M, Dandolo R, et al
 Chir Ital 2002 Sep-Oct;54(5):605-12
Abstract
Renal Disorders
 
  Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy.
 Nelson M, Azwa A, Sokwala A, et al 
AIDS. 2008 Jul 11;22(11):1374-6.
Abstract

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Stavudine Journal Citations: Adverse Events