Medical Advocates
Stavudine (Zerit)
 
Journal Citations: Metabolic Adverse Events

General Reports                  
Lactic Acid Disorders
Lipoatrophy
Lipodystrophy


 
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General Reports
         
 
Effectiveness and metabolic complications after 96 weeks of a generic fixed-dose combination of stavudine, lamivudine, and nevirapine among antiretroviral-naive advanced
HIV-infected patients in Thailand: A prospective study.
 Manosuthi W, Sungkanuparph S, Tansuphaswadikul S,  et al
Curr Ther Res Clin Exp. 2008 Feb;69(1):90-100
 Abstract

A Longitudinal Study of the Changes in Body Fat and Metabolic Parameters in a South African
Population of HIV-Positive Patients Receiving an Antiretroviral Therapeutic Regimen Containing Stavudine.
 George JA, Venter WD, Van Deventer HE, Crowther NJ.
AIDS Res Hum Retroviruses. 2009 Jul 20
 Abstract

Effects of a Nucleoside Reverse Transcriptase Inhibitor, Stavudine, on Glucose Disposal and
Mitochondrial Function in Muscle of Healthy Adults.
 Fleischman A, Johnsen S, Systrom DM, et al 
Am J Physiol Endocrinol Metab. 2007 Feb 6;
 Abstract
Lactic Acid Disorders
 
 
Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy.
 Nelson M, Azwa A, Sokwala A, et al  
AIDS. 2008 Jul 11;22(11):1374-6.
 Abstract
 
Symptomatic Hyperlactatemia Associated with Nucleoside Analogue Reverse-Transcriptase Inhibitor
Use in HIV-Infected Patients: A Report of 24 Cases in a Resource-Limited Setting (Uganda).
 Songa PM, Castelnuovo B, Mugasha EB, et al 
Clin Infect Dis. 2007 Aug 15;45(4):514-7  
Abstract
 
Matched case-control study to evaluate risk factors for hyperlactataemia in HIV patients on
antiretroviral therapy.
 Datta D, Moyle G, Mandalia S, Gazzard B.
HIV Med. 2003 Oct;4(4):311-4
 Abstract
 
Lactic acidosis related to nucleoside therapy in HIV-infected patients.
Falco V V, Crespo M, Ribera E.
 Expert Opin Pharmacother. 2003 Aug;4(8):1321-1329.
Abstract
 
Metabolic Acidosis and Hepatic Steatosis in Two HIV-Infected Patients on Stavudine (d4T) Treatment.
Cornejo-Juarez P, Sierra-Madero J, Volkow-Fernandez P.
Arch Med Res 2003 Jan-Feb;34(1):64-9
 Abstract
 
Fatal lactic acidosis in a patient infected by HIV and treated with stavudine and didanosine
Megarbane B, Goldgran-Toledano D, et al.
Pathol Biol (Paris) 2000 Jun;48(5):505-7
 Abstract
Lipoatrophy
 
 
Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients.
Kampira E, Kumwenda J, Van Oosterhout JJ, Dandara C.
Pharmacogenomics. 2013 Dec;14(16):1999-2004
 Abstract

Brief Report: Stavudine but not Didanosine as Part of HAART Contributes to Peripheral
Lipoatrophy: A Substudy from the Antiretroviral Regimen Evaluation Study (ARES).
Lowe SH, Hassink EA, van Eck-Smit BL, et al
HIV Clin Trials. 2007 Jan 1;8(5):337-344.
Abstract
 
Assessment of Adipokine Expression and Mitochondrial Toxicity in HIV Patients With Lipoatrophy on
Stavudine- and Zidovudine-Containing Regimens.
 Jones SP, Qazi N, Morelese J, et al 
J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):565-572
Abstract

Increased risk of lipoatrophy under stavudine in HIV-1-infected patients: results of a substudy
from a comparative trial.
 Juky V. Flandre P, Meiffredy V, et al
 AIDS 2002 Dec 6;16(18):2447-54
Abstract
Lipodystrophy
 
 
Relationship between HIV/Highly Active Antiretroviral Therapy (HAART)-
Associated Lipodystrophy Syndrome and Stavudine-Triphosphate
Intracellular Levels in Patients with Stavudine-Based Antiretroviral Regimens.
Domingo P, Cabeza MC, Pruvost A, et al
Clin Infect Dis. 2010 Mar 1.
Abstract

Association between HLA-B*4001 and Lipodystrophy among HIV-Infected Patients
from Thailand Who Received a Stavudine-Containing Antiretroviral Regimen.
Wangsomboonsiri W, Mahasirimongkol S, Chantarangsu S, et al
Clin Infect Dis. 2010 Jan 14
 Abstract

Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in
HIV-infected patients.
Lindegaard B, Keller P, Bruunsgaard H, et al  
Clin Exp Immunol. 2004 Feb; 135(2): 273-9.
 Abstract

Stavudine versus zidovudine and the development of lipodystrophy
 Bogner JR, Vielhauer V, Beckmann RA, et al.
 J Acquir Immune Defic Syndr 2001 Jul 1;27(3):237-244
 Abstract

Lipodystrophy in HIV-infected children is associated with high viral load and low CD4+ -
lymphocyte count and CD4+ -lymphocyte percentage at baseline and use of protease
inhibitors and  stavudine.
 Arpadi SM,Cuff PA, Horlick M, Wang J, Kotler DP.
J Acquir Immune Defic Syndr 2001 May 1;27(1):30-34
 Abstract

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Stavudine Journal Citations: Metabolic Adverse Events