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idovudine (Retrovir)
 
Perinatal Data
New and Noteworthy
Animal; Studies
General Reports
Guidelines
Pharmacokinetics
Safety
Resistance
Adverse Events
Patient Perceptions
Adherence
Efficacy







 

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Last Update:  August 25, 2017  
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New and Noteworthy
 

August  2017


Animal Studies
 

         Journal Papers, Abstracts, and Commentaries
 
  Mitochondrial Damage Revealed by Morphometric and Semiquantitative Analysis
of Mouse Pup Cardiomyocytes Following in Utero and Postnatal Exposure to
Zidovudine and Lamivudine.
Bishop JB, Tani Y, Witt K, et al.
Toxicol Sci.
2004 Jun 30
Abstract

General Reports/Reviews
 

        Journal Papers, Abstracts, and Commentaries

 
High plasma concentrations of zidovudine (AZT) do not parallel intracellular concentrations of AZT-triphosphates in infants during prevention of mother-to-child HIV-1 transmission.
Kinai E, Kato S, Hosokawa S, S
adatsuki M, et al
J Acquir Immune Defic Syndr
. 2016 Feb 8
Abstract

Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine.
Neumanova Z, Cerveny L, Ceckova M, Staud F.
Biopharm Drug Dispos
. 2015 Sep 21.
Abstract

 The changes in bone organic and inorganic matrix in newborn rats after maternal application of antiretroviral agents: Indinavir and zidovudine.
Maciejewska K, Drzazga Z, Kaszuba M.
Biofactors
. 2015 May 6;41(3):198-208. d
Abstract

Economic Evaluation of 3-Drug Antiretroviral Regimens for the Prevention of Mother-to-Child HIV Transmission in Thailand.
Werayingyong P, Phanuphak N, Chokephaibulkit K, wt al
Asia Pac J Public Health. 2013 May 30
Abstract

Is Intrapartum Intravenous Zidovudine for Mother-to-Child HIV-1 Transmission Still Useful in the cART Era?
Briand N, Warszawski J, Mandelbrot L, et al
Clin Infect Dis
. 2013 May 31

Abstract

High exposure to zidovudine during the two first weeks of life and concentration - toxicity relationships.
Hirt D, Warszawski J, Firtion G, Giraud C,
J Acquir Immune Defic Syndr
. 2013 Mar 11.
Abstract

FULL-TEXT ARTICLE
Maternal CD4+ Cell Count Decline after Interruption of Antiretroviral Prophylaxis for the Prevention of
Mother-to-Child Transmission of HIV.
Ekouevi D, Abrams EJ, Schlesinger M, et al
PLoS One
. 2012;7(8):e43750.
Paper

FULL-TEXT ARTICLE
Zidovudine Exposure in HIV-1 Infected Tanzanian Women Increases Mitochondrial DNA Levels in Placenta and Umbilical Cords.
Kunz A, von Wurmb-Schwark N, Sewangi J, et al  
PLoS One
. 2012;7(7):e41637
Paper

Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine.
Micek MA, Blanco AJ, Carlsson J,  et al
J Infect Dis
. 2012 Apr 5.
Abstract

Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand.
Briand N, Pornprasert S, Ngo-Giang-Huong N, Galactéros F  
Antivir Ther
. 2009;14(1):117-22.
Abstract
 

Factors associated with zidovudine receipt and prenatal care among HIV-infected pregnant women in New Jersey.
Abatemarco DJ, Catov JM, Cross H, et al 
J Health Care Poor Underserved.
2008 Aug;19(3):814-28.
Abstract
 
High levels of AZT and its intracellular phosphate metabolites in AZT and
AZT/3TC-treated newborns of HIV-infected mothers.

Durand-Gasselin L, Pruvost A, et al  
Antimicrob Agents Chemother. 2008 Apr 21
Abstract

AZT Availability in Illinois Birthing Hospitals: Is the Perinatal HIV Prevention Safety Net in
Place?

Eary RL, Borders AE, Handler A, et al
Matern Child Health J. 2007 Jan 23
Abstract
 

HIV Infection and Zidovudine Use in Childbearing Women.
Sia J, Paul S, Martin RM, Cross H.
Pediatrics.
2004 Nov 15

Abstract

Determinants of mother-to-infant human immunodeficiency virus 1 transmission before and
after the introduction of zidovudine prophylaxis
.
The Italian Register for Human Immunodeficiency Virus Infection in Children
Arch Pediatr Adolesc Med 2002 Sep;156(9):915-2

Abstract

Zidovudine: A Review of its Use in the Management of Vertically-Acquired Pediatric
HIV infection.
 
Bhana N,Ormrod D, Perry CM, et al.
Paediatr Drugs 2002;4(8):515-53
Abstract

 

        Conference Reports, Abstracts, and Posters

 

HIV-1 viral kinetics among in utero and intrapartum-infected infants in NICHD HPTN 040/ PACTG 1043
K. Nielsen-Saines, Y. Bryson, D.H. Watts,et al|
(XIX International AIDS Conference)
Abstract

Body weight evolution in HIV-positive patients over two years of antiretroviral treatment: a multiregional analysis of the IeDEA collaboration
D. Huis in 't Veld, E. Balestre, J. Menten, et al
(XIX International AIDS Conference)
Abstract

The HIV NRTI BMS-986001 does not degrade mitochondrial DNA in long term primary cultures of cells isolated from human kidney, muscle and subcutaneous fat
F. Wang, O. Flint
(XIX International AIDS Conference)
Abstract


Pharmacokinetics
 

  Maternal and fetal zidovudine pharmacokinetics during pregnancy and labor: too high dose infused at labor?
Fauchet F, Treluyer JM, Valade E, et al
Br J Clin Pharmacol. 2014 Jul 9.

Abstract

Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children.
Fillekes Q, Kendall L, Kitaka S, Mugyenyi P,  et al
Pediatr Infect Dis J
. 2014 May;33(5):495-498.
A
Abstract

Pharmacokinetics and tolerance of zidovudine in preterm infants.
Capparelli EV, Mirochnick M, Dankner WM, et al
J Pediatr 2003 Jan;142(1):47-52
Abstract

Pharmacokinetics of zidovudine in infants: a population analysis across studies.
Mirochnick M, Capparelli E, Connor
J Clin Pharmacol Ther 1999 Jul;66(1):16-24  
Abstract

 

Safety
 

        Journal Papers, Abstracts, and Commentaries

 
FULL TEXT ARTICLE
Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1-Infected Women in Thailand:
Secondary Analysis of a Randomized Trial.

Briand N, Lallemant M, Jourdain G, et al
PLoS Clin Trials.
2007 Apr 27
Paper

FULL-TEXT ARTICLE
Safety of late in utero exposure to zidovudine in infants born to human Collaborativ
Perinatal HIV Transmission Study Group
.

Chotpitayasunondh T, Vanprapar N, Simonds RJ, et al.
Pediatrics 2001 Jan;107(1):E5 

Paper

   
  Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS
Clinical Trial Group 076 study
.
Sperling RS, Shapiro DE, McSherry GD, et al.
AIDS 1998; 12:1805- 1813

Abstract

Resistance
 

        Journal Papers, Abstracts, and Commentaries

 
Antiretroviral Resistance Patterns and HIV-1 Subtype in Mother-Infant Pairs after the
Administration of Combination Short-Course Zidovudine plus Single-Dose Nevirapine
for the Prevention of Mother-to-Child Transmission of HIV.
Chalermchockcharoenkit A, Culnane M, Chotpitayasunondh T, et al 
Clin Infect Dis. 2009 Jun 12
Abstract

Lower Risk of Resistance After Short-Course HAART Compared With Zidovudine/Single-Dose Nevirapine
Used for Prevention of HIV-1 Mother-to-Child Transmission.
Lehman DA, Chung MH, Mabuka JM, et al
J Acquir Immune Defic Syndr. 2009 Jun 4

Abstract

HIV Type 1 Zidovudine (ZDV) Resistance in Blood and Uterine Cervical Secretions of Pregnant
Women.
Frenkel LM, McKernan J, Dinh PV, et al
AIDS Res Hum Retroviruses.
2006 Sep;22(9):870-3
Abstract
 

Lack of resistant mutation development after receiving short-course zidovudine plus
lamivudine to prevent mother-to-child transmission.
Chokephaibulkit K, Chaisilwattana P, Vanprapar N, et al 
AIDS. 2005 Jul 22;19(11):1231-3.
Abstract
 
Zidovudine Resistance Phenotype and Risk of Perinatal HIV-1 Transmission in Zidovudine
Monotherapy-Treated Mothers With Moderately Advanced Disease.
Bauer GR, Welles SL, Colgrove RR, et al 
J Acquir Immune Defic Syndr. 2003 Nov 1;34(3):312-9.
Abstract

Zidovudine genotypic resistance in HIV-1-infected newborns in the French perinatal
cohort

Masquelier B, Chaix ML, Burgard M, et al. Pediatric HIV Infection Study Group.
J Acquir Immune  Defic Syndr 2001 Jun 1;27(2):99-104

Abstract

HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission
in the women and infants transmission study. The Women and Infants Transmission Study
Group
.
Welles SL, Pitt J, Colgrove R, et al;
AIDS
2000 Feb 18;14(3):263-71
  

Abstract
 
 
Maternal viral genotypic zidovudine resistance and Infrequent failure of zidovudine therapy
 to prevent perinatal transmission of human immunodeficiency virus type I in pediatric AIDS
Clinical Trials Group protocol 076.
Eastman PS, Shapiro DE, Coombs RW,
et al.  
J Infect Dis
1998;177:557-564.

Abstract

Adverse Events
 

        Journal Papers, Abstracts, and Commentaries

 
Higher Transplacental Pathogen-Specific Antibody Transfer Among Pregnant Women Randomized to Triple Antiretroviral Treatment Versus Short Course Zidovudine.
Bosire R, Farquhar C, Nduati R,  et al
Pediatr Infect Dis
J
. 2017 Aug 19.
Abstract
 

Zidovudine use in pregnancy and congenital malformations: meta-analysis and Bayesian incorporation of Medicaid data.
Rough K, Sun JW, Seage GR 3rd,  et al  
AIDS. 2017 May 23.
 

Zidovudine treatment in HIV-infected pregnant women is associated with fetal cardiac remodelling.
García-Otero L, López M,  Sitges M,  et al
AIDS. 2016 Feb 25.
Abstract

Prenatal exposure to zidovudine and risk for ventricular septal defects and congenital heart defects: data from the Antiretroviral Pregnancy Registry.
Vannappagari V, Albano JD, Koram N,  
Eur J Obstet Gynecol Reprod Biol
. 2015 Nov 24;197:6-10.
Abstract

Risk factors of preterm delivery in HIV-infected pregnant women receiving zidovudine for the
prevention of perinatal HIV.

Traisathit P, Mary JY, Le Coeur S,  et al
J Obstet Gynaecol Res. 2009 Apr;35(2):225-33.
Abstract

Placental transfer of Zidovudine in first trimester of pregnancy.
Siu SS, Yeung JH, Pang MW, et al
Obstet Gynecol.
2005 Oct;106(4):824-7.
Abstract
 

3'-Azido-3'-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in
human placenta.
Collier AC, Helliwell RJ, Keelan JA
Toxicol Appl Pharmacol. 2003 Oct 15;192(2):164-73
Abstract

Absence of cardiac toxicity of zidovudine in infants. Pediatric  Pulmonary and Cardiac
Complications of Vertically Transmitted HIV Infection Study Group
.
Lipshultz SE, Easley KA, Orav EJ, et al.  
N Engl J Med 2000 Sep 14;343(11):759-66

Abstract

   
  Risk factors for preterm birth, low birth weight, and intrauterine growth retardation in
infants born to HIV-infected pregnant women receiving zidovudine. Pediatric AIDS Clinical
Trials Group 185 Team.

Lambert JS, Watts DH, Mofenson L, Stiehm ER, et al. 
AIDS 2000 Jul 7;14(10):1389-99
Abstract
   
  FULL-TEXT ARTICLE
Lack of Long-term Effects of In Utero Exposure to Zidovudine Among Uninfected Children
Born to HIV-Infected Women.
Culnane M, Fowler M, Lee SS, et al.
JAMA
1999 Jan 13;281(2):151-7

Paper
 
   
  The Ariel Project: A Prospective Cohort Study of Maternal-Child Transmission of Human
Immunodeficiency Virus Type 1 in the Era of Maternal Antiretroviral Therapy

Van Dyke RB, Korber BT, Popek E, et al. 
J Infect Dis
1999 Feb;179(2):319-28

Abstract

        Conference Reports, Abstracts and Posters

 
POSTER
Z
idovudine exposure during pregnancy and hypospadias in infants: data from the antiretroviral pregnancy registry, 1989-2011
V. Vannappagari, S. Roberts, H. Tilson, et al

(XIX International AIDS Conference)
Abstract     Poster

High HbA2 due to zidovudine exposure: implication for β-thalassemia trait screening
P. Kosalaraksa, S. Wiangnon, T. Bunupuradah, et al|
(XIX International AIDS Conference)
Abstract


Patient Perceptions/Knowledge/Attitudes
 

       Journal Papers, Abstracts, and Commentaries

 
Concerns and experiences of women participating in a short-term AZT intervention
feasibility study for prevention of HIV transmission from mother-to-child.
Mawar N, Joshi PL, Sahay S, Bagul RD, Paranjape RS.
Cult Health Sex.
2007 Mar-Apr;9(2):199-207.
Abstract

Factors associated with HIV-infected women's use or intention to use AZT during
pregnancy.
Siegel K, Lekas HM, Schrimshaw EW, Johnson JK.
AIDS Educ Prev 2001 Jun;13(3):189-206 
Abstract

 

Adherence
 

        Journal Papers, Abstracts, and Commentaries

  Prenatal and postpartum zidovudine adherence among pregnant women with HIV: results
of a MEMS substudy from the Perinatal Guidelines Evaluation Project.
Ickovics JR, Wilson TE, Royce RA, et al.

J Acquir Immune Defic Syndr 2002 Jul 1;30(3):311-5
Abstract
 
 
        Conference Reports, Abstracts and Posters
 
  Adherence patterns seen among HIV pregnant women on antiretroviral therapy (ART) and on combination zidovudine/sdNVP prophylaxis for prevention of mother-to-child transmission of HIV (PMTCT), in the Mulago National Referral Hospital, Kampala, Uganda
J. Nabweteme-Mugerwa, Z. Namukwaya, E. Namara-Lugolobi, , et al
XIX International AIDS Conference)
Abstract
 

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Zidovudine Perinatal Data