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HIV Infection/Disease
  Lipodystrophy

General Reports

Pathogenesis
Diagnostics
Treatment

Lipodystrophy-Syndrome
Adipose Tissue Disorders
Lipodystrophy-Related Disorders
ART/HAART and Lipodystrophy
Quality of Life

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Last Update: February 13, 2017
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General Reports

       

      Journal Papers, Abstracts, and Commentaries
 
 

FULL-TEXT ARTICLE
People living with HIV on ART have accurate perception of lipodystrophy signs: a cross-sectional study .[Brazil]
Alencastro PR, Barcellos NT, Wolff FH,
BMC Res Notes. 2017 Jan 13;10(1):40.
Paper

Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART).
Dai Z, Cai W, Hu F, et al  
Curr Mol Med
. 2015;15(10):975-9.
Abstract

Novel Approaches to Targeting Visceral and Hepatic Adiposities in HIV-Associated Lipodystrophy.
Tien PC.

Curr
Atheroscler Rep. 2015 Dec;17(12):73.
Abstract

Threats to identity: lipodystrophy and identity changes in people with HIV/AIDS (PWA). [Italy]
Mancini T, Secchiaroli G.
Acta Biomed. 2015 Mar 13;86 Suppl 1:29-39.

Abstract

HIV/AIDS and lipodystrophy: Implications for clinical management in resource-limited settings.
Finkelstein JL, Gala P, Rochford R,  et al

J Int AIDS Soc
. 2015 Jan 15;18(1):19033.
Abstract

Lipid Metabolism and Lipodystrophy in HIV-1-Infected Patients: The Role Played by Nonnucleoside Reverse Transcriptase Inhibitors.
Sension M, Deckx H.
AIDS Rev. 2014 Dec 4;17(
Abstract

Proposed ratios and cutoffs for the assessment of lipodystrophy in HIV-seropositive individuals.
Beraldo RA, Vassimon HS, Aragon DC, et al
Eur J Clin Nutr. 2014 Jul 30.
Abstract

FULL-TEXT ARTICLE
Lipodystrophy among patients with HIV infection on antiretroviral therapy: a systematic review protocol.
Lana LG, Junqueira DR, Perini E,  et al

BMJ Open
. 2014 Mar 13;4(3):e004088.
Paper

Prevalence and factors associated with lipodystrophy in AIDS patients.
Justina LB, Luiz MC, Maurici R, et al

Rev Soc Bras Med Trop
.
2014 Jan-Feb;47(1):30-7.
Abstract

CD8 T-cell activation is associated with lipodystrophy and visceral fat accumulation in ART-treated virologically-suppressed HIV-infected patients.
Guaraldi G, Luzi K, Bellistrì GM,  et al

J Acquir Immune Defic Syndr
. 2013 Oct 14.
Abstract

Plasma homocysteine levels in HIV-infected men with and without lipodystrophy.
Deminice R, Vassimon HS, Machado AA,  et al
Nutrition. 2013 Sep 14
Abstract

Small-Dense LDL Cholesterol/Large-Buoyant LDL Cholesterol Ratio as an Excellent Marker for Indicating Lipodystrophy in HIV-Infected Patients.
Srisawasdi P, Suwalak T, Sukasem C, Chittamma A,  et al

Am J Clin Pathol
. 2013 Oct;140(4):506-15..

Abstract

Differentially altered molecular signature of visceral adipose tissue in HIV-1-associated lipodystrophy.
Gallego-Escuredo JM, Villarroya J, et a

J Acquir Immune Defic
Syndr
. 2013 May 24
Abstract

FULL-TEXT PDF ARTICLE
Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose disturbances and insulin resistance.
Freitas P, Carvalho D, Santos AC,  et al

BMC Infect Dis
. 2012 Aug 6;12(1):180.
Paper

Leptin in congenital or HIV-associated lipodystrophy and metabolic syndrome: A need for more mechanistic studies and large, randomized, placebo-controlled trials.
Foo JP, Mantzoros CS.
Metabolism
.
2012 May 14.
Abstract

Hypermetabolism and altered substrate oxidation in HIV-infected patients with lipodystrophy.
Vassimon HS, Albuquerque de Paula FJ, et al

Nutrition
. 2012 Apr 12.
Abstract

Lipodystrophy in HIV patients: its challenges and management approaches.
Singhania R, Kotler DP.
HIV AIDS
(Auckl)
. 2011;3:135-43.
Abstract

Beneficial effects of physical activity in an HIV-infected woman with lipodystrophy: a case report.
Mendes EL, Andaki AC, Brito CJ,  et al

J Med Case Reports
. 2011 Sep 5;5(1):430.
Abstract

FULL-TEXT ARTICLE
Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy.
Segatto AF, Freitas Junior IF,  et al
Rev Soc Bras Med Trop. 2011 Aug;44(4):420-4..
Paper

The Effect of polymorphisms in candidate genes on the Long-Term Risk of Lipodystrophy and Dyslipidemia in HIV-infected Caucasians Starting Antiretroviral Therapy.
Marzocchetti A, Schwarz J, DI Giambenedetto S,   et al

AIDS Res Hum Retroviruses
. 2011 May 20.
Abstract

HIV-associated lipodystrophy: from fat injury to premature aging.
Caron-Debarle M, Lagathu C, Boccara F,  et al
 
Trends Mol Med
. 2010 Apr 16
Abstract

The Association of Lipodystrophy and Oxidative Stress Biomarkers in HIV-Infected Men.
Vassimon HS, Deminice R, Machado AA,  et al
 
Curr HIV Res
. 2010 Mar 19
Abstract

 

     Conference Reports, Abstracts, and Posters

 
Understanding lipodystrophy among men and women living with HIV: a metasynthesis of qualitative research
M. Gagnon, L. Cormier
(XIX
International AIDS Conference)
Abstract

Epidemiological aspect, clinical and psychosocial impact of lipodystrophy related to antiretroviral drugs in people living with HIV followed up at the center of care CRIPS-TOGO in Lome
K.M. Aho, D. Idimama Kotoudi, A. Patassi, B. Saka
(XIX
International AIDS Conference)
Abstract
 

Upregulation of the mitochondrial PRSS15/LON during lipodistrophy: ex vivo and in vitro detection
Pinti M, Gibellini L, Guaraldi G, et al
(4th IAS Conference)
Abstract

Pathogenesis

       

         Journal Papers, Abstracts, and Commentaries

 
The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular  Mechanisms and Clinical Implications.
Flint OP, Noor MA, Hruz PW, et al 
Toxicol Pathol. 2009 Jan 26.
Abstract
 
Pathogenesis of lipodystrophy and metabolic syndromes associated with HIV infection
Munoz-Sanz A, Rodriguez-Vidigal FF, Domingo P.
Med Clin (
Barc). 2006 Sep 30;127(12):465-74.
Abstract

Do oestrogen receptors play a role in the pathogenesis of HIV-associated lipodystrophy?
Barzon L, Zamboni M, Pacenti M, et al   
AIDS. 2005 Mar 25;19(5):531-3.
Abstract


Lipodystrophy-Related Disorders
       

         Journal Papers, Abstracts, and Commentaries

 
The successful use of lipectomy in the management of airway obstruction in a woman with HIV-associated lipodystrophy.
Tsui E, Bogdasarian R, Blomain E.

MJ Case Rep
. 2015 Feb 18;201
Abstract

Lipodystrophy and reversal of facial lipoatrophy in perinatally HIV-infected children and adolescents after discontinuation of stavudine.
Sawawiboon N, Wittawatmongkol O, Phongsamart W, et al
Int J STD AIDS. 2012 Jul;23(7):497-501
Abstract

"Bullfrog Neck," a Unique Morphologic Trait in HIV Lipodystrophy: Case Series and Review of the Literature.
Tierney EP, Hanke CW.

Arch Dermatol
. 2010 Nov;146(11):1279-1282.
Abstract

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue.
Sutinen J, Kannisto K, Korsheninnikova E, et al 
Diabetologia. 2004 Sep 29
Abstract
 

Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function.
Andersen O, Haugaard SB, Andersen UB, et al

Metabolism.
2003 Oct;52(10):1343-53
Abstract
 
Elevated blood pressure in subjects with lipodystrophy.
Sattler FR, Qian D, Louie S, et al.

AIDS
2001Oct 19;15(15):2001-10

Abstract
 

Antiretroviral Therapy and Lipodystrophy
       

ART/HAART General

        Journal Papers, Abstracts, and Commentaries

 
Lower levels of IL-4 and IL-10 influence lipodystrophy in HIV/AIDS patients under antiretroviral therapy.
Dragović G, Dimitrijević B, Khawla AM, et al
Exp Mol Pathol. 2017 Feb 8.
Abstract

HIV-Associated Lipodystrophy: Impact of Antiretroviral Therapy.
Guaraldi G, Stentarelli C, Zona S, Santoro A.

Drugs
. 2013 Sep 4.
Abstract

FULL-TEXT ARTICLE
Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction.
de Waal R, Cohen K, Maartens G.
PLoS One. 2013 May 28;8(5):e63623

Paper

Lipodystrophies related to antiretroviral treatment of HIV infection
Capeau J, Caron M, Vigouroux C,et al

Med Sci
(Paris). 2006 May;22(5):531-536.
Abstract

Factors related to lipodystrophy and metabolic alterations in patients with human immunodeficiency virus infection receiving highly active antiretroviral therapy.
Saves M, Raffi F, Capeau J, et al.

Clin Infect Dis
2002 May 15;34(10):1396-405
Abstract

Effect of highly active antiretroviral therapy on fat, lean, and bone mass in HIV-seropositive men and women.
McDermott AY, Shevitz A, Knox T, et al.
Am J Clin Nutr 2001 Nov;74(5):679-86
Abstract
 
Antiretroviral treatment simplification with nevirapine in protease inhibitor-experienced patients with hiv-associated lipodystrophy:1-year prospective follow-up of a multicenter, randomized, controlled study.
Ruiz L, Negredo E, Domingo P, Paredes R, et al.

J Acquir
Immune Defic Syndr 2001 Jul 1;27(3):229-36
Abstract
 

 
           Conference Reports, Abstracts, and Posters
 
  "Lipodystrophy" is not what it used to be: data from the Swiss HIV cohort study
Nguyen A, Bernasconi E, Battegay M, et al
(4th IAS Conference)
Abstract

Protease Inhibitors

        Journal Papers, Abstracts, and Commentaries

 
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study.
Carr A, Hudson J, Chuah J, Mallal S, et al
.
AIDS
2001 Sep 28;15(14):1811-1822
Abstract

FULL-TEXT ARTICLE
Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors
Zhang B,  MacNaul,  Szalkowski D,et al.
J Clin Endocrinol Metab 1999 84: 4274-4277
Paper

 

Quality of Life
Also refer to Quality of Life with Lipodystrophy Syndrome      

       Journal Papers, Abstracts, and Commentaries

 
Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders.
Verolet CM, Delhumeau-Cartier C, Sartori M, et al

AIDS Res Ther
. 2015 Jun 20;12:21
Abstract

Social isolation in HIV-infected patients according to subjective patient assessment and DEXA-confirmed severity of lipodystrophy.
Casado JL, Iglesias V, Del Palacio M,  et al

AIDS Care
. 2013 May 7.
Abstract

Lipodystrophy and quality of life in HIV: Symptom management issues.
Nicholas PK, Kirksey KM, Corless IB, et al   
Appl Nurs Re
s. 2005 Feb;18(1):55-8.
Abstract

Factors Associated with Severe Impact of Lipodystrophy on the Quality of Life of Patients Infected with HIV-1.
Blanch J, Rousaud A, Martinez E, et al
Clin Infect Dis. 2004 May 15;38(10):1464-70
Abstract
 


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HIV-Associated Lipodystrophy