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Abacavir
(Ziagen)
 
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General Reports  
       

 

Cerebrospinal Fluid Abacavir Concentrations in HIV-positive Patients Following Once-daily Administration.
Calcagno A, Pinnetti C, De Nicolò A, et al
 
Br J Clin Pharmacol
. 2018 Feb 14
Abstract

Enantioselective and Regiodivergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir.
Thieme N, Breit B.
Angew Chem Int Ed Engl. 2017 Feb 1;56(6):
Abstract

Abacavir + dolutegravir + lamivudine for the treatment of HIV.
Comi L, Maggiolo F.
Expert Opin Pharmacother. 2016 Sep 12
Abstract

Abacavir has no prothrombotic effect on platelets in vitro.
Diallo YL, Ollivier V, Joly V,

J Antimicrob Chemother
. 2016 Aug 11.
Abstract

Short-term in vivo modifications of platelet NADPH oxidase 2 (NOX2) and prostaglandin in HIV-1 patients on abacavir-based therapies.
Pastori D, Esposito A, Carnevale R,
et al
HIV Med
. 2016 May 10.
Abstract

Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken.
K A S, Venkata Subbaiah KC, Lavanya R, et al

Appl Biochem Biotechnol
. 2016 May 3
Abstract

Development of albumin-based nanoparticles for the delivery of abacavir.
Wilson B, Paladugu L, Priyadarshini SR, Jenita JJ.
Int J Biol Macromol. 2015 Sep 10.
Abstract

Efficient synthesis of the intermediate of abacavir and carbovir using a novel (+)-γ-lactamase as a catalyst.
Gao S, Zhu S, Huang R, et al 
Bioorg Med Chem Lett. 2015 Jul 26
Abstract

FULL-TEXT ARTICLE
Moving Away from Ritonavir, Abacavir, Tenofovir, and Efavirenz (RATE) - Agents That Concern Prescribers and Patients:
A Feasibility Study and Call for a Trial.
Achhra AC, Boyd MA, Law MG, et al
PLoS One
. 2014 Jun 26;9(6):e99530.
Paper

Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length.
Namanja HA, Emmert D, Hrycyna CA, Chmielewski J.
Medchemcomm
. 2013 Oct;4(10).
Abstract

Abacavir (Ziagen®) use between 2003 and 2008 in France according to the electronic medical record NADIS®
Dellamonica P, Katlama C, Lévy-Bachelot L,  et al
Med Mal Infect. 2013 Nov 18
Abstract

Bioactivation to an aldehyde metabolite-Possible role in the onset of toxicity induced by the anti-HIV drug abacavir.
Grilo NM, Charneira C, Pereira SA,  et al
Toxicol Lett. 2013 Nov 5.
Abstract

Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50.
Mittal S, Bandaranayake RM, King NM, et al
J Virol
. 2013 Jan 30.
Abstract

Clinical pharmacogenetics implementation consortium guidelines for hla-B genotype and abacavir dosing.
Martin MA, Klein TE, Dong BJ,  et al
Clin Pharmacol Ther
.
2012 Apr;91(4):734-8
Abstract

Enantioselective synthesis of the carbocyclic nucleoside (-)-abacavir.
Boyle GA, Edlin CD, Li Y,  et al
Org Biomol Chem
. 2012 Jan 25
Abstract

Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in
coronary endothelial cells.
Kim C, Gupta SK, Green L, et al
Antivir Ther
. 2011;16(8):1335-9.
Abstract

Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.
Baum PD, Sullam PM, Stoddart CA, McCune JM.
AIDS
. 2011 Sep 21.
Abstract

Toward Eradicating HIV Reservoirs in the Brain: Inhibiting P-glycoprotein at the Blood-Brain Barrier with Prodrug Abacavir Dimers.
Namanja HA, Emmert D, Davis DA,  et al
J Am Chem Soc
. 2011 Aug 25.
Abstract

Low-density lipoprotein size and lipoprotein-associated phospholipase A2 in HIV-infected patients switching to abacavir or tenofovir.
Saumoy M, Ordoñez-Llanos J, Martínez E, et al
Antivir Ther
. 2011;16(4):459-468.
Abstract

Separation and characterization of forced degradation products of abacavir sulphate by LC-MS/MS.
Rao RN, Vali RM, Ramachandra B, Raju SS.
J Pharm Biomed Anal
. 2010 Sep 22
Abstract

Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation.
De Pablo C, Orden S, Apostolova N, et al 
AIDS
. 2010 May 6.
Abstract

Near-Infrared Investigations of Novel Anti-HIV Tenofovir Liposomes.
Zidan AS, Spinks C, Fortunak J,  et al  
AAPS J
. 2010 Mar 3.
Abstract

Abacavir: pretreatment screening: warning. Encouraging method but uncertainties remain.
[No authors listed]
Prescrire Int. 2008 Dec;17(98):239.
Abstract

Current trends in screening across ethnicities for hypersensitivity to abacavir.
Rodriguez-Nóvoa S, Soriano V.
Pharmacogenomics. 2008 Oct;9(10):1531-41.
Abstract

Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility.
Hughes AR, Spreen WR, Mosteller M, et al 
Pharmacogenomics J.
2008 Mar 11
Abstract
 

Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice?
Barber TJ, Marett B, Waldron S, et al 
AIDS.
2007 Aug 20;21(13):1823-1824.
Abstract
 
Incidence and reasons of premature discontinuation of abacavir: results of a hospital investigation among 628 patients.
Foucher N, Pertusa MC, Lahille B, et al 
Med Mal Infect. 2007 Jul 25;
Abstract
 
Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities.
Sriram D, Yogeeswari P, Myneedu NS, Saraswat V.  
Bioorg Med Chem Lett. 2006 Feb 1;
Abstract
 
Lack of Antagonism Between Abacavir, Lamivudine, and Tenofovir Against Wild-Type and Drug-Resistant HIV-1.
Lanier ER, Hazen R, Ross L, Freeman A, Harvey R.
J Acquir Immune Defic Syndr.
2005 Aug 15;39(5):519-22
Abstract
 
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancementof antiviral potency.
McGuigan C, Harris SA, Daluge SM, et al 
J Med Chem. 2005 May 19;48(10):3504-15
Abstract
 
Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects.
King D, Tomkins S, Waters A, et al
J Allergy Clin Immunol. 2005 May;115(5):1081-7.
Abstract
 
Abacavir Compared to Protease Inhibitors as Part of HAART Regimens for Treatment of HIV Infection: Patient Satisfaction and Implications for Adherence.
Jordan J, Cahn P, Goebel F, et al 
AIDS Patient Care STDS. 2005 Jan;19(1):9-18.
Abstract
 
Predictors of adherence and virologic outcome in HIV-infected patients treated with abacavir- or indinavir-based triple combination HAART also containing lamivudine/zidovudine.
Cahn P, Vibhagool A, Schechter M, Soto-Ramirez L, et al
Curr Med Res Opin.
2004 Jul;20(7):1115-23.

Abstract

Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations.
Hughes AR, Mosteller M, Bansal AT, et al 
Pharmacogenomics.
2004 Mar;5(2):203-11.
Abstract

Abacavir: a review of its clinical potential in patients with HIV infection. 
Hervey PS, Perry CM.
 
Drugs
2000; 60(2): 447-479.

Abstract
 
FULL-TEXT ARTICLE
Cellular restoration in HIV infected persons treated with abacavir and a protease inhibitor: age inversely predicts naive CD4 cell count increase.
Lederman M, McKinnis R, Kelleher D,
AIDS. 14(17):2635-2642, December 1, 2000.

Abstract

Diagnostics/Monitoring/Screening
       

 
FULL-TEXT ARTICLE
Comparison of Methods for In-House Screening of HLA-B*57:01 to Prevent Abacavir Hypersensitivity in HIV-1 Care
De Spiegelaere W, Philippé J, Vervisch K, et al 
PLoS One
. 2015 Apr 15;10(4):e0123525

Paper

Reducing hypersensitivity reactions with HLA-B*5701 genotyping before abacavir prescription: clinically useful but is it cost-effective in Singapore?
Kapoor R, Martinez-Vega R, Dong D,  et al
Pharmacogenet Genomics
. 2014 Nov 28
Abstract

A micellar liquid chromatography method for the quantification of abacavir, lamivudine and raltegravir in plasma.
Peris-Vicente J, Villareal-Traver M, Casas-Breva I, et al
J Pharm Biomed Anal
. 2014 Jun 13;98C:351-355.
Abstract

Simultaneous analysis of antiretroviral drugs abacavir and tenofovir in human hair by liquid chromatography-tandem mass spectrometry.
Shah SA, Mullin R, Jones G,  et al
J Pharm Biomed Anal
. 2013 Feb 23;74:308-13
Abstract

Detection of abacavir hypersensitivity by ELISpot method.
Esser S, Jablonka R, Heinemann FM, Reuter
Inflamm Allergy Drug Targets. 2012 Feb 15
Abstract

Rapid HCP5 single-nucleotide polymorphism genotyping: A simple allele-specific PCR method for prediction of hypersensitivity reaction to Abacavir.
Galván CA, Elbarcha OC, Fernández EJ,  et al C
lin Chim Acta
. 2011 Apr 14.
Abstract
 

Novel sensitive, specific and rapid pharmacogenomic test for the prediction of abacavir hypersensitivity reaction: HLA-B*57:01 detection by real-time PCR.
Russo CD, Lisi L, Lofaro A, Di Giambenedetto S,  et al
Pharmacogenomics
. 2011 Apr;12(4):567-76.
Abstract

HLA-B*5701 testing to predict abacavir hypersensitivity.
Ma JD, Lee KC, Kuo GM.
PLoS Curr
. 2010 Dec 7;2:RRN1203.
Abstract

Hla-b*5701 genetic screening prior to abacavir prescription in georgia.
Dvali N, Chkhartishvili N, Sharvadze L, et al

Georgian Med News
. 2010 Dec;(189):16-20
Abstract

A fluorescence-based sequence-specific primer PCR for the screening of HLA-B(*)57:01.
Giardina E, Stocchi L, Cuzzola VF,  et al
Electrophoresis
. 2010 Oct 5.
Abstract

Development and Validation of a Selective and Rapid LC-MS-MS Method for the Quantification of Abacavir in Human Plasma.
Yadav M, Gupta A, Singhal P, Shrivastav PS.
J Chromatogr Sci
. 2010;48(8):654-62.
Abstract

HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects.
Nolan D.
Crit Rev Clin Lab Sci
. 2009;46(3):153-65.|
Abstract

Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study.
Rauch A, Nolan D, Thurnheer C, et al  
Antivir Ther
. 2008;13(8):1019-28.
Abstract
 

Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
Park WB, Choe PG, Song KH, et al  
Clin Infect Dis. 2009 Feb 1;48(3):365-7.
Abstract

Twenty-four-week safety and tolerability of nevirapine vs. abacavir in combination with zidovudine/lamivudine as first-line antiretroviral therapy: a randomized double-blind trial (NORA).
Dart Trial Team 
Trop Med Int Health. 2008 Jan;13(1):6-16.

Abstract

Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF.
Notari S, Mancone C, Alonzi T, et al
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jan 16
Abstract
 
Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience.
Waters LJ, Mandalia S, Gazzard B, Nelson M. 
AIDS.
2007 Nov 30;21(18):2533-2534.
Abstract
 
External quality assessment of HLA-B*5701 reporting: an international multicentre survey.
Hammond E, Almeida CA, Mamotte C, et al   
Antivir Ther
. 2007;12(7):1027-32.

Abstract
 
HLA-B*5701 clinical testing: early experience in the United States.   
Faruki H, Heine U, Brown T. et al
Pharmacogenet Genomics. 2007 Oct;17(10):857-60.
Abstract
 
A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome.
Martin AM, Krueger R, Almeida CA, et al
Pharmacogenet Genomics. 2006 May;16(5):353-357.
Abstract
 
Determination of abacavir in human plasma by high-performance liquid chromatography with ultraviolet detection and the analytical error function.
Ferrer SM, Modamio P, Lastra CF, Marino EL.
Biomed Chromatogr. 2004 Sep 6
Abstract

Safety
 

  Safety analysis of Ziagen® (abacavir sulfate) in postmarketing surveillance in Japan.
Kurita T, Kitaichi T, Nagao , et al
Pharmacoepidemiol Drug Saf
. 2014 Mar 3
Abstract

FULL-TEXT ARTICLE
Antiretroviral effect and safety of abacavir alone and in combination with zidovudine in HIV-infected adults

Saag MS, Sonnerborg A, Torres R, et al
AIDS: Vol 12(16) 12 Nov 1998 p F203-F209

Paper


Dosing
       

 
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing
Martin MA, Klein TE, Dong BJ
Clin Pharmacol Ther
. 2012 Feb 29
Abstract

FULL-TEXT ARTICLE
Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir  
Sadler BM, Gillotin C, Lou Y, Stein DS.
Antimicrob Agents Chemother 2000 Jun;44(6):1655-1659
Paper

FULL-TEXT ARTICLE
A dose-ranging study to evaluate the safety and efficacy of abacavir alone or in combination with zidovudine and lamivudine in antiretroviral treatment-naive subjects.
Staszewski S, Katlama C,Harrer T, et al
AIDS. 12(16):F197-F202, November 12, 1998.
Paper


Pharmacokinetics   
       

 
Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.
Jackson A, Moyle G, Dickinson L,  et al
Antivir Ther. 2012;17(1):19-24
Abstract

FULL-TEXT ARTICLE
Erequency of HLA B*5701 allele carriers in abacavir treated-HIV infected patients and controls from northeastern Brazil.
Crovella S, Biller L, Santos S, et al
Clinics (Sao Paulo). 2011;66(8):1485-8. |
Paper

Abacavir and Metabolite Pharmacokinetics in HIV-1-Infected Children and Adolescents.
Cross SJ, Rodman JH, Lindsey JC, et al  
J Acquir Immune Defic Syndr. 2009 Mar 11
Abstract
 

Steady-State Pharmacokinetics of Plasma Abacavir and Intracellular Carbovir Triphosphate following Abacavir 600mg Once Daily and 300mg Twice Daily in HIV-Infected Subjects
Moyle G, Boffito M, Fletcher C, et al 
Antimicrob Agents Chemother
. 2009 Feb 2.
Abstract

Abacavir Pharmacokinetics During Chronic Therapy in HIV-1-Infected Adolescents and Young Adults.
Sleasman J, Robbins B, Cross S, et al 
Clin Pharmacol Ther
. 2008 Dec 3
Abstract
 

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.
Capparelli EV, Letendre SL, Ellis RJ, et al   
Antimicrob Agents Chemother. 2005 Jun;49(6):2504-6
Abstract
 
Weight related differences in the pharmacokinetics of abacavir in HIV-infected patients.
Jullien V, Treluyer JM, Chappuy H, et al 
Br J Clin Pharmacol. 2005 Feb;59(2):183-8.
Abstract

Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4(+) CEM cells: comparison with (-)-carbovir.
Mahony WB, Domin BA, Daluge SM, et al 
Biochem Pharmacol.
2004 Nov 1;68(9):1797-805.
Abstract

 
The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes.
Walsh JS, Reese MJ, Thurmond LM.
Chem Biol Interact 2002 Nov 10;142(1-2):135-54
Abstract
 
FULL-TEXT ARTICLE
Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System.
Drusano GL, Bilello PA, Symonds WT, et al.
Antimicrob Agents Chemother 2002 Feb;46(2):464-470

Paper
 
Pharmacokinetics of abacavir in hiv-1-infected patients with impaired renal function.
Izzedine H, Launay-Vacher V, Aymard G,
Nephron 2001 Sep;89(1):62-67
Abstract
 
FULL-TEXT ARTICLE
Multiple-Dose Pharmacokinetics and Pharmacodynamics of Abacavir Alone and in Combination with Zidovudine in Human Immunodeficiency Virus-Infected Adults 
McDowell JA, Lou Y, Symonds WS,Stein DS.
Antimicrob. Agents Chemother. 2000 44: 2061-2067
Paper
 
FULL-TEXT ARTICLE
Single-Dose Pharmacokinetics and Safety of Abacavir (1592U89), Zidovudine, and Lamivudine Administered Alone and in Combination in Adults with Human Immunodeficiency
Virus Infection

Wang LH, Chittick GE, McDowell JA.
Antimicrob Agents Chemother 1999 Jul;43(7):1708-1715

Paper
 
FULL-TEXT ARTICLE
Pharmacokinetics of Abacavir, a Human Immunodeficiency Virus Type1 (HIV-1) Reverse Transcriptase Inhibitor ,Administered in a Single Oral Dose to HIV-1-Infected Adults: a
Mass Balance Study

McDowell JA, Chittick GE, Ravitch JR, et al
A
ntimicrob Agents Chemother 1999 Dec;43(12):2855-2861
Paper

 
 

Drug/Drug Interactions    
       

 
MDR1 and BCRP transporter-mediated drug-drug interaction between rilpivirine and abacavir; effect on intestinal absorption.
Reznicek J, Ceckova M, Ptackova Z, et al

Antimicrob Agents Chemother
.
2017 Jul 10.
Abstract

Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients.
Goicoechea M, Jain S, Bi L, et al  
AIDS
. 2010 Mar 13;24(5):707-716.
Abstract

Lack of an effect of atazanavir on steady-state pharmacokinetics of methadone in patients chronically treated for opiate addiction.
Friedland G, Andrews L, Schreibman T, et al
AIDS. 2005 Oct 14;19(15):1635-1641.
Abstract
 

Pharmacokinetics and Pharmacodynamics of Low Dose Mycophenolate Mofetil in HIV-Infected Patients Treated with Abacavir, Efavirenz and Nelfinavir.
Millan O, Brunet M, Martorell J, et al
Clin Pharmacokinet. 2005;44(5):525-38.
Abstract
 
Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir.
Bart PA,  Rizzardi PG, Gallant S et al .
Ther Drug Monit
2001 Oct;23(5):553-5
Abstract
 
A dose-ranging study to evaluate the antiretroviral activity and safety of amprenavir alone and in combination with abacavir in HIV-infected adults with limited antiretroviral
experience.
Schooley RT,Clumeck N, Haubrich R, et al.  
Antivir Ther
2001 Jun;6(2):89-96

Abstract
 
FULL-TEXT ARTICLE
Pharmacokinetic Interaction of Abacavir (1592U89) and Ethanol in Human Immunodeficiency Virus-Infected Adults  
McDowell JA, Chittick GE, Stevens CP, et al.
Antimicrob Agents Chemother 2000 Jun;44(6):1686-1690
Paper

 
 

Predictive value of provirus load and DNA human immunodeficiency virus genotype for successful abacavir-based simplified therapy.
Pellegrin I, Caumont A, Garrigue I,  et al.
J Infect Dis 2003 Jan 1;187(1):38-46
Abstract

 

Viral Dynamics
       

 
Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
Lehmann DS, Ribaudo HJ, Daar ES,  et al
Pharmacogenet Genomics. 2014 Nov 28.
Abstract
Virological Response to Initial Antiretroviral Regimens Containing Abacavir or Tenofovir.
Bansi L, Sabin C, Gilson R, et al
J Infect Dis. 2009 Jul 27.
Abstract

Abacavir does not influence the rate of virological response in HIV-HCV-coinfected patients treated with pegylated interferon and weight-adjusted ribavirin.
Laufer N, Laguno M, Perez I, et al   
Antivir Ther
. 2008;13(7):953-7
Abstract
 

  Viral Dynamics and Their Relations to Baseline Factors and Longer Term Virologic Responses in Treatment-Naive HIV-1-Infected Patients Receiving Abacavir in Combination with HIV-1
Protease Inhibitors.
Wu H, Mellors J, Ruan P, et al.
Acquir Immune Defic Syndr. 2003 Aug 15;33(5):557-563.
Abstract

Resistance
       

 
In Vitro HIV-1 Resistance Selections with Combinations of Tenofovir and Emtricitabine or Abacavir
and Lamivudine.
Margot NA, Waters JM, Miller MD.  
Antimicrob Agents Chemother. 2006 Sep 18;
Abstract
 
Genotypic and phenotypic resistance patterns at virological failure in a simplification trial with nevirapine, efavirenz or abacavir.
de Echaguen AO, Arnedo M, Xercavins M, et al
AIDS.
2005 Sep 2;19(13):1385-1391.
Abstract
 
Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutation Selection during In Vitro Exposure to Tenofovir Alone or Combined with Abacavir or Lamivudine.
Stone C, Ait-Khaled M, Craig C, et al   
Antimicrob Agents Chemother. 2004 Apr;48(4):1413-5.
Abstract

FULL-TEXT ARTICLE
Clinically relevant interpretation of genotype for resistance to abacavir.
Brun-Vezinet F, Descamps D, Ruffault A, et al  
AIDS. 2003 Aug 15;17(12):1795-1802
Paper
 
FULL-TEXT ARTICLE
Prediction of abacavir resistance from genotypic data: impact of Zidovudine and Lamivudine resistance in vitro and in vivo.

Walter H, Schmidt B, Werwein M, et al.
Antimicrob Agents Chemother 2002 Jan;46(1):89-94
Paper
 
FULL-TEXT ARTICLE
Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant
to abacavir.

Laethem A, Kristel Van W, MBalzarini J, et al
AIDS. 14(4):469, March 10, 2000.
Paper

 

Pharmacogenetics
 

 
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing
Martin MA, Klein TE, Dong BJ
Clin Pharmacol Ther. 2012 Feb 29
Abstract

FULL-TEXT LETTER
In Mexican Mestizos the HCP5 rs2395029 SNP may be a genetic marker for screening abacavir hypersensitivity.
Sanchez-Giron F, Carnevale A.
Pharmacogenomics
. 2012 Feb;13(3):251-2
Letter
 

FULL-TEXT LETTER
Tag SNPs of the ancestral haplotype 57.1 do not substitute HLA-B*57:01 typing for eligibility to abacavir treatment in the Italian population.
Badulli C, Sestini R, Sbarsi I,  et al
Pharmacogenomics
. 2012 Feb;13(3):247-9.
Letter

Successful translation of pharmacogenetics into the clinic: the abacavir example.
Phillips E, Mallal S.
Mol Diagn Ther
. 2009;13(1):1-
Abstract


Pharmacoeconomics
 

  Economic Efficiency of Genetic Screening to Inform the Use of Abacavir Sulfate
in the Treatment of HIV.
Kauf TL, Farkouh RA, Earnshaw SR, et al
Pharmacoeconomic
s
. 2010 Jun 24

Abstract


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